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Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines.
Authors: Singh A, Kharb V, Saharan VA Abstract Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which dissolve/disintegrate quickly leading to fast distribution of active ingredient at site of administration thereby provides ease of oral ingestion of solid unit dosage forms and have the potential to enhance transmucosal absorption. Objective of this review is to explore the application of various FDDFs to deliver extracts, herbal powders, natural active compounds and nutraceuticals. Scholarly literature from Pubmed, google scholar and directory of open access journals was ret...
Source: Recent Patents on Drug Delivery and Formulation - March 27, 2020 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Effect of Ultrasound Intensity and Mode on Piroxicam Transport Across Three-Dimensional Skin Equivalent Epiderm ™.
CONCLUSION: Sonophoresis has a positive effect on enhancing skin permeability. The enhancement level was largely dependent on the sonication factors; frequency, intensity and the length of treatment. Multiple mechanisms of action might be involved in permeation improvement of the piroxicam molecule. Those mechanisms are largely dependent on the ultrasonic conditions. PMID: 32106808 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 1, 2020 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanoformulations for ocular delivery of drugs - A Patent perspective.
Authors: Dogra A, Kaur K, Ali J, Baboota S, Narang RS, Narang JK Abstract Efficient delivery of ocular therapeutics with improved efficacy, enhanced bioavailablity and acceptable patient compliance presents unique challenges. This can be attributed to the presence of protective mechanisms, physicobiological barriers and structural obstacles in the eye. Nanotherapeutic interventions have been explored extensively over the past few years for to overcome these limitations. The present review focusses on the nanoformulations developed for the diagnosis and treatment of various ocular diseases besides providing...
Source: Recent Patents on Drug Delivery and Formulation - January 28, 2020 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Medicated Chewing Gums: Recent Patents and Patented Technology Platforms.
Authors: Kaushik P, Kaushik D Abstract The reason that the oral route attained such acceptance may be ascribed to its affluence of administration. Over the years, patient convenience- oriented exploration in the area of drug delivery has introduced potential innovative medicine delivery systems. The elegant drug delivery system is an amalgamation of science and dexterity with therapeutic prospect and presentability. It involves the administration of medications in a groundbreaking fashion with the assistance of cosmetics, wearable devices and oral drug delivery system which can also be used for ornamental ...
Source: Recent Patents on Drug Delivery and Formulation - January 23, 2020 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

An Overview on Recent Patents and Technologies on Solid Dispersion.
This article reviews the various approaches for the preparation of solid dispersion such as a solvent melting, hot-melt extrusion method, solvent evaporation method, cryogenic processing approaches etc. from the perspective of patents filed or granted for these techniques. Some of the aspects taken into account before the preparation of solid dispersions are carrier selection and physic-chemical testing along with an insight into the molecular arrangement of medicaments in solid dispersion. The manuscript further highlights various commercial patented technology platforms such as Solumer^tm, Hovione, ...
Source: Recent Patents on Drug Delivery and Formulation - January 19, 2020 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanotherapies for the treatment of age-related macular degeneration (amd) disease: recent advancements and challenges.
NANOTHERAPIES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) DISEASE: RECENT ADVANCEMENTS AND CHALLENGES. Recent Pat Drug Deliv Formul. 2020 Jan 16;: Authors: Rapalli VK, Gorantla S, Waghule T, Mahmood A, Singh PP, Dubey SK, Saha RN, Singhvi G Abstract Age-related Macular Degeneration (AMD) is one of the common diseases affecting the posterior part of the eye, affecting a large population above 45 years old. Anti-Vascular Endothelial Growth Factor-A (Anti-VEGF-A) agents have been considered as approved as therapeutic agents for the treatment of AMD. Due to the large m...
Source: Recent Patents on Drug Delivery and Formulation - January 19, 2020 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Advanced hydrogels based drug delivery systems for ophthalmic delivery.
ADVANCED HYDROGELS BASED DRUG DELIVERY SYSTEMS FOR OPHTHALMIC DELIVERY. Recent Pat Drug Deliv Formul. 2020 Jan 07;: Authors: Gorantla S, Waghule T, Rapalli VK, Singh PP, Dubey SK, Saha RN, Singhvi G Abstract Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and other includes light, thrombin, pressure, ant...
Source: Recent Patents on Drug Delivery and Formulation - January 10, 2020 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective.
Authors: Qamar Z, Qizilbash FF, Iqubal MK, Ali A, Sahni JK, Ali J, Baboota S Abstract The structure of the eye is very complex in nature which makes it a challenging task for pharmaceutical researchers to deliver the drug at the desired sites via different routes of administration. The development of the nano-based system has helped in delivering the drug in the desired concentration. Improvement in penetration property, bioavailability, residence time has all been achieved by encapsulating drugs into liposomes, dendrimers, solid lipid nanoparticle, nanostructured lipid carrier, nanoemulsion and nanosuspen...
Source: Recent Patents on Drug Delivery and Formulation - December 31, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Bio-inspired Strategies Against Diabetes and Associated Complications: A Review.
Authors: Choudhary S, Kalra V, Kumar M, Tiwary AK, Sood J, Silakari O Abstract Bio-molecules are the most important target to be considered while designing any drug delivery system. The logic lies in using such bio-sensing or bio-mimicking systems in their formulations that can mimic the active site of those receptors to which the drug is going to bind. Polymers mimicking the active site of target enzymes are regarded as bio-inspired polymers and can be used to ameliorate many diseased conditions. Nowadays, this strategy is also being adopted against diabetes and its complications. Under hyperglycemic cond...
Source: Recent Patents on Drug Delivery and Formulation - December 31, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Formulation and in vitro evaluation of fast dissolving tablets of Febuxostat using co-processed excipients.
Authors: Kaur M, Mittal A, Gulati M, Sharma D, Kumar R Abstract Febuxostat is a novel, orally administered, powerful, non-purine, xanthine oxidase inhibitor used for treating gout and ceaseless tophaceous gout. The drug exhibits low bioavailability (about 49%) which is ascribed to its dissolution rate limited absorption. The aim of the current work was to provide a novel strategy to improve the dissolution profile and thus, bioavailability of Febuxostat. Formulation of fast dissolving tablets (FDT) is anticipated to provide immediate release of drug, which in turn, will improve its dissolution profile to p...
Source: Recent Patents on Drug Delivery and Formulation - December 31, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Next steps in 3D Printing of Fast Dissolving oral Films for Commercial Production.
Authors: Ehtezazi T, Algellay M, Hardy A Abstract 3D printing technique has been utilised to develop novel and complex drug delivery systems that are almost impossible to produce by employing conventional formulation techniques. For example, this technique may be employed to produce tablets or fast dissolving oral films (FDFs) with multilayers of active ingredients, which are personalised to patient's needs. In this article, we compared the production of FDFs by 3D printing to conventional methods such as solvent casting. Then, we evaluated the need for novel methods of producing fast dissolving oral films...
Source: Recent Patents on Drug Delivery and Formulation - December 31, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Optimization of the interaction between Diclofenac and Ibuprofen with Benzalkonium chloride to prepare ocular nanosuspension.
The objective of the present study was to formulate non-irritating, compatible, microbiologically stable ophthalmic formulation with good corneal permeation characteristics. The interaction between diclofenac sodium or ibuprofen with benzalkonium chloride was optimized using central composite experimental design to prepare nanosuspensions by nanoprecipitation. The optimized batches of nanosuspensions were evaluated for ex vivo corneal permeation study, preservative challenge test and physical stability. The optimal concentrations of benzalkonium chloride for diclofenac sodium (0.1%, w/v) and ibuprofen (0.1% w/v) nanosuspen...
Source: Recent Patents on Drug Delivery and Formulation - December 20, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Exploring the protective potential of carboxymethyl Terminalia catappa polysaccharide on blue light light-emitting diode induced corneal damage.
Authors: Chandel L, Sharma R, Rana V Abstract Excessive blue light light-emitting diode (LED) exposure and consequent oxidative stress causes corneal damage and corneal injuries are the major problem arises these days due to excessive use of mobile phone, TV, environment pollution, etc. In the present investigation, the protectiveness of carboxymethyl Terminalia catappa (CTC) from blue light LED-induced corneal damage was explored. For this purpose, Terminalia catappa (TC) was functionalized by carboxymethylation and its structural modification was confirmed by spectral attributes. Further, the CTC protect...
Source: Recent Patents on Drug Delivery and Formulation - December 20, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Recent Patents Concerning the use of Nanotechnology-based Delivery Systems as Skin Penetration Enhancers.
CONCLUSION: Overall results demonstrated the increased interest around the world in patenting products involving skin permeation promotion and nanotechnology for pharmaceutical and, mainly, for cosmetics purposes. PMID: 31696814 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 8, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Recent Patents Containing Permeation Enhancers for Nail Delivery.
CONCLUSION: Nail topical therapy containing permeation enhancers is an attractive option to delivering localized treatments. PMID: 31663846 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 1, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research