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Patent Selections.
Authors: Abstract PMID: 30424719 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 16, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Ibalizumab and Fostemsavir in the Management of Heavily Pre-Treated HIV-infected Patients.
CONCLUSION: The history of ibalizumab and fostemsavir will be written in next years. Continuing the research will be crucial to obtain evidence based guidelines for the management of heavily treated HIV-1 infected patients with limited therapeutic options. PMID: 30378502 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 1, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Levofloxacin versus Ceftriaxone and Azithromycin Combination in the Treatment of Community Acquired Pneumonia in Hospitalized Patients.
CONCLUSION: We concluded that monotherapy with oral Levofloxacin was as effective as treatment with Ceftriaxone plus Azithromycin combination in patients with CAP who required hospitalization. PMID: 30360748 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - October 28, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

HIV/AIDS Curable Study, New Forms of Therapeutic Trinity.
CONCLUSION: Up date, therapeutic trinity (combined therapy) against HIV/AIDS is generally among chemical drugs. In this article, several forms of other therapeutic attempts for effectively curing efforts against HIV/AIDS are proposed-including the development of next generation therapeutic HIV vaccines and schedules, new categories of bio-therapy, different pathways of immune-modulation, herbal medicines in general (allopathic, Ayurveda and traditional Chinese medicines), high quality of physical exercises, especially therapeutic combinations guided by latest medical discovery and principles (new forms of therapeutic trini...
Source: Recent Patents on Anti-Infective Drug Discovery - October 28, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nanotechnological Carriers For Treatment Of Acne.
CONCLUSIONS: Nanotechnological carriers have opened a new window to design novel, effective and low dose systems for effective eradication acne disease. However, very few nanocarrier based formulations are available in market for topical use and much progress is required in this field to improve anti-acne therapy. PMID: 30227825 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 21, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Ultra structural observations of anti-leishmanial effects of new synthetic 3-imidazolylflavanoneson Leishmania majorusing scanning electron and atomic force microscopes.
CONCLUSION: Our results strongly confirm the Leishmania cell wall as a potent target for the new synthesized azole (IF-2). Accordingly, focus on membrane integrity and glycoconjugates of Leishmania parasite to design new therapeutic agents is recommended. PMID: 30227826 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 21, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nano-based therapy for treatment of skin cancer.
CONCLUSION: We focus especially on the topical lipid formulation approaches combined with chemotherapy, a field which specialises in target specificity, drug release control, and real time monitoring with the goal being to diminish unwanted side effects and their severity, achieving a cheaper treatment and a generally more efficient chemotherapy. PMID: 30205801 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 14, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Amarogentin as topical anticancer and anti-infective potential: Scope of lipid based vesicular in its effective delivery.
Authors: Patel K, Kumar V, Verma A, Rahman M, Patel DK Abstract There is the need of development of liposomes based nanomedicines formulation for the better efficacy and safety of the available drugs in the market. Liposomes have various applications in the field of pharmaceutical and medical field for their drug target potential, diagnostic importance and imaging techniques. Natural plant based drugs and their derivative have been used in the medicine, nutraceuticals, perfumery, cosmetic and beverages industry. More than half of the prescribed drugs in the worldwide are mainly derived from different natur...
Source: Recent Patents on Anti-Infective Drug Discovery - September 14, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Antibacterial activity of gold nanoparticles conjugated by aminoglycosides against A. baumannii isolates from burn patients.
CONCLUSION: our study showed that a combination of amikacin and gentamicin with Gnps has a significant antibacterial efficiency against clinical isolates of A. baumannii. Gnps can be used as extraordinary molecular carriers for the targeting, and delivery the of antibiotic molecules to the specific infection. PMID: 30152290 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 29, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Screening and potential of the incidence of resistance transfer among the multidrug and heavy metal resistant Gram negative isolates from hospital effluents of northern India.
Conclusion: We can recommend that the hospital water is heavily polluted with several types of antibiotics, toxic metals as well as the potentially hazardous bacterial flora because of their capacity to resist one or the other well known antibiotic and chemotherapeutic agents. These studies provide evidence that a wide variety of clinically important antibiotic and metal resistance genes are mobile within aquatic bacterial communities one step ahead of the above, we can envisage the alarming situation prevailing in our system and surrounding in the light of transmissible nature of R-plasmids. PMID: 29984669 [PubMed...
Source: Recent Patents on Anti-Infective Drug Discovery - July 10, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

In vitro anti-mycobacterial activity of three medicinal plants of Lamiaceae family.
CONCLUSION: The studied medicinal plants showed notable effects against mycobacterial strains. Our results indicated that utilization of Lamiaceae family can be helpful for treatment of mycobacterial infections. PMID: 29952265 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 29, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Short Antimicrobial Peptides.
CONCLUSION: Herein, we discussed the arsenal of short peptides and peptidomimetics starting from the smallest unit possible - a dipeptide to a decapeptide along with their activity profiles as antimicrobials. Recently, various SAMPs have paved their ways from in vitro studies to clinical trials, as evident from the most recent patent (EP1951194) on oral hygiene. This step by step growth of SAMPs has restored the hope in peptide-based therapeutics, which may prove an essential tool in eradicating antimicrobial resistance and tackling various microbial infections. PMID: 29952266 [PubMed - as supplied by publisher] (S...
Source: Recent Patents on Anti-Infective Drug Discovery - June 29, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Current State of Nanomedicines in the Treatment of Topical Infectious Disorders.
CONCLUSION: Despite the new emerging technologies and delivery systems, efforts are still needed in the right direction to combat this global challenge. PMID: 29807522 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 30, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Evaluation of fosfomycin activity against ESBL producing Enterobacteriaceae isolated from Iran.
CONCLUSION: In conclusion, fosfomycin showed good antimicrobial activity against multidrug resistance ESBL- positive Enterobacteriaceae. PMID: 29769010 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 19, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Editorial: Nanomedicines for the Treatment of Tuberculosis: Role of Nanocarriers and Functional Excipients.
Authors: Samad A, Nazish I, Beg S PMID: 29745316 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 13, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research