Synthesis, antibacterial, and cytotoxicity evaluation of oleanolic acid-4-aminoquinoline based hybrid compounds.
CONCLUSION: The present study revealed that the modification of C28 of OA enhanced its biological properties. PMID: 33568035 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - February 13, 2021 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

The Staphylococcal Cassette Chromosome mec (SCCmec) Analysis and Biofilm Formation of Methicillin-Resistant Staphylococcus cohnii Isolated from Clinical Samples in Tehran, Iran.
CONCLUSION: Due to the high antimicrobial resistance and the spread of untypableSCCmecamong the isolates studied, the control and treatment of methicillin-resistantS. cohnii in hospitals and public health centers is a significant concern. PMID: 33568036 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - February 13, 2021 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Secondary metabolites of endophytic fungi from Newbouldia laevis and Cassia tora leaves: prospecting for new antimicrobial agents.
CONCLUSION: Newbouldia laevis and Cassia tora leaves house endophytic fungi capable of yielding secondary metabolites with potential as anti-infective agents. PMID: 33355056 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 29, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Exploring the Potentials of Corn Fiber Gum in Fabricating Mucoadhesive Floating Tablet of Poorly Gastro-retainable Drug.
CONCLUSION: Thus from the research findings, CFG could be concluded to possess potential binder, release retardant and mucoadhesive characteristics which could be successfully employed for the formulation of gastro-retentive floating tablets. PMID: 33183208 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 18, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Oleic Acid Vesicles as a new Approach for Transdermal Delivery of Econazole Nitrate: Development, Characterization, and In-vivo Evaluation in Wistar rats.
CONCLUSION: Developed econazole nitrate loaded oleic acid vesicles could be used effectively in the treatment of cutaneous candidiasis with minimization of side effects of econazole nitrate with increased therapeutic efficacy. PMID: 33176662 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 13, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Recent Patents on Phytoconstituents based Formulations for Treatment of Acne Infection: A Review.
CONCLUSION: It has been concluded that the herbal anti-acne formulation not only used to treat the acne but also acts in the prevention of this disease in a safely and economically manner. PMID: 32990540 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - October 1, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Fecal Microbiota Transplant: Latest Addition to Arsenal Against Recurrent Clostridium Difficile Infection.
Authors: Gulati M, Singh SK, Corrie L, Chandwani L, Singh A, Kapoor B, Kumar R, Pandey NK, Kumar B, Awasthi A, Khursheed R Abstract An infectious disease of colon, recurrent Clostridium difficile infection (RCDI) is hitherto considered insurmountable leading to significant morbidity and mortality. Gut dysbiosis, generally resulting from frequent use of antibiotics is considered to be responsible for the etiopathogenesis of rCDI. Ironically, the conventional treatment strategies for the disease also include the use of anti-infective drugs such as metronidazole, vancomycin and fidaxomycin. As a result of the...
Source: Recent Patents on Anti-Infective Drug Discovery - September 30, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Understanding the Role of Corona Virus based on Current Scientific Evidence - a Review with Emerging Important in Pandemic.
Authors: Mukherjee S, Ray SK Abstract Coronavirus disease is a potentially deadly disease and of significant apprehension for global communal health potentially because of its lethality. Vaccines and antiviral medications are still under trial to prevent or treat infections of human coronavirus (HCoV) till date. The virus HCoV originate in 2003, SARS-CoV, which causes respiratory syndrome having distinctive pathogenesis and causes infections of the respiratory tract. A mechanism was projected for the evolution of SARS virus and a handy association with bats was found. When this virus reaches respective hos...
Source: Recent Patents on Anti-Infective Drug Discovery - September 24, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

The Role of Tocilizumab in Cytokine Storm and Improving Outcomes in COVID-19.
Authors: Ali A, Kamjani MH, Kesselman MM Abstract To date, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of individuals around the world. This virus causes coronavirus disease 2019 (COVID-19) and has led to numerous deaths worldwide. A large percentage of infected patients present asymptomatically, augmenting the spread of the virus. Symptomatic COVID19 commonly causes mild to severe respiratory disease and fever, but some individuals experience serious complications that can result in death. Immune compromised, high risk, and elderly individuals are at an increased ris...
Source: Recent Patents on Anti-Infective Drug Discovery - September 24, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Neurobrucellosis: a Case Report with an Unusual Presentation.
CONCLUSIONS: We encourage physicians to consider the diagnosis of neurobrucellosis with any neurologic sign without a known cause. Our case highlights the importance of occupational history in clinical medicine. PMID: 32942980 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 20, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Transmissibility and Epidemicity of COVID-19 in India: A Case Study.
CONCLUSION: The transmissibility of COVID-19 and its epidemicity in India is discussed. In specific, a case study on COVID -19 cases in the state of Kerala relating the transmissibility is also summarized. Further, data related to patents on corona virus is also discussed. From the analysis, it can be concluded that there is a possibility of COVID-19 transmission even during incubation period. The preventive measures to overcome COVID-19 and methods to increase the immunity are discussed. PMID: 32933464 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 17, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Is ocular toxicity expected in chloroquine/hydroxychloroquine prescription as a therapeutic or prophylactic option in COVID-19?
CONCLUSION: This study recommended ophthalmic evaluation before CQ/HCQ prescription for treatment or prophylaxis of COVID-19 only in preexisting maculopathy. PMID: 32814539 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 22, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Development of Emulgel Delivery of Mupirocin for Treatment of Skin Infection.
CONCLUSION: Antimicrobial and anti-inflammatory study proved successful development of stable controlled release mupirocin emulgel. PMID: 32814540 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 22, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

4-Aminoquinoline-ferrocene Hybrids as Potential Antimalarials.
CONCLUSION: The hybrid compounds displayed significant antimalarial activity when compared to the parent drug. However, they were not as effective as chloroquine on drug-sensitive parasite. The findings revealed that 4- aminoquinolines and ferrocene are potential scaffolds for developing potent antimalarials. PMID: 32753021 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 14, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Current Insights for the Management of Acne in the Modern era.
CONCLUSION: Novel drug delivery strategies can play a crucial role in the enhancement of topical delivery of antiacne agents by escalating their dermal localization and reducing their adverse effects. Consumption of medicinal plants like Aloe vera, Withania somniferia etc. have clinical evidences regarding the effective management of acne. The current inclination towards nanotechnology is considerable due to several changes in the pharmaceutical research area. To secure the research work in different pharmaceutical fields patents are filed against various agents like Galderma Research & Development have filed for adapa...
Source: Recent Patents on Anti-Infective Drug Discovery - August 1, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research