Recent Patents on Phytoconstituents based Formulations for Treatment of Acne Infection: A Review.
CONCLUSION: It has been concluded that the herbal anti-acne formulation not only used to treat the acne but also acts in the prevention of this disease in a safely and economically manner. PMID: 32990540 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - October 1, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Fecal Microbiota Transplant: Latest Addition to Arsenal Against Recurrent Clostridium Difficile Infection.
Authors: Gulati M, Singh SK, Corrie L, Chandwani L, Singh A, Kapoor B, Kumar R, Pandey NK, Kumar B, Awasthi A, Khursheed R Abstract An infectious disease of colon, recurrent Clostridium difficile infection (RCDI) is hitherto considered insurmountable leading to significant morbidity and mortality. Gut dysbiosis, generally resulting from frequent use of antibiotics is considered to be responsible for the etiopathogenesis of rCDI. Ironically, the conventional treatment strategies for the disease also include the use of anti-infective drugs such as metronidazole, vancomycin and fidaxomycin. As a result of the efforts ...
Source: Recent Patents on Anti-Infective Drug Discovery - September 30, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Understanding the Role of Corona Virus based on Current Scientific Evidence - a Review with Emerging Important in Pandemic.
Authors: Mukherjee S, Ray SK Abstract Coronavirus disease is a potentially deadly disease and of significant apprehension for global communal health potentially because of its lethality. Vaccines and antiviral medications are still under trial to prevent or treat infections of human coronavirus (HCoV) till date. The virus HCoV originate in 2003, SARS-CoV, which causes respiratory syndrome having distinctive pathogenesis and causes infections of the respiratory tract. A mechanism was projected for the evolution of SARS virus and a handy association with bats was found. When this virus reaches respective host system,...
Source: Recent Patents on Anti-Infective Drug Discovery - September 24, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

The Role of Tocilizumab in Cytokine Storm and Improving Outcomes in COVID-19.
Authors: Ali A, Kamjani MH, Kesselman MM Abstract To date, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of individuals around the world. This virus causes coronavirus disease 2019 (COVID-19) and has led to numerous deaths worldwide. A large percentage of infected patients present asymptomatically, augmenting the spread of the virus. Symptomatic COVID19 commonly causes mild to severe respiratory disease and fever, but some individuals experience serious complications that can result in death. Immune compromised, high risk, and elderly individuals are at an increased risk of more...
Source: Recent Patents on Anti-Infective Drug Discovery - September 24, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Neurobrucellosis: a Case Report with an Unusual Presentation.
CONCLUSIONS: We encourage physicians to consider the diagnosis of neurobrucellosis with any neurologic sign without a known cause. Our case highlights the importance of occupational history in clinical medicine. PMID: 32942980 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 20, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Transmissibility and Epidemicity of COVID-19 in India: A Case Study.
CONCLUSION: The transmissibility of COVID-19 and its epidemicity in India is discussed. In specific, a case study on COVID -19 cases in the state of Kerala relating the transmissibility is also summarized. Further, data related to patents on corona virus is also discussed. From the analysis, it can be concluded that there is a possibility of COVID-19 transmission even during incubation period. The preventive measures to overcome COVID-19 and methods to increase the immunity are discussed. PMID: 32933464 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 17, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Is ocular toxicity expected in chloroquine/hydroxychloroquine prescription as a therapeutic or prophylactic option in COVID-19?
CONCLUSION: This study recommended ophthalmic evaluation before CQ/HCQ prescription for treatment or prophylaxis of COVID-19 only in preexisting maculopathy. PMID: 32814539 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 22, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Development of Emulgel Delivery of Mupirocin for Treatment of Skin Infection.
CONCLUSION: Antimicrobial and anti-inflammatory study proved successful development of stable controlled release mupirocin emulgel. PMID: 32814540 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 22, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

4-Aminoquinoline-ferrocene Hybrids as Potential Antimalarials.
CONCLUSION: The hybrid compounds displayed significant antimalarial activity when compared to the parent drug. However, they were not as effective as chloroquine on drug-sensitive parasite. The findings revealed that 4- aminoquinolines and ferrocene are potential scaffolds for developing potent antimalarials. PMID: 32753021 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 14, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Current Insights for the Management of Acne in the Modern era.
CONCLUSION: Novel drug delivery strategies can play a crucial role in the enhancement of topical delivery of antiacne agents by escalating their dermal localization and reducing their adverse effects. Consumption of medicinal plants like Aloe vera, Withania somniferia etc. have clinical evidences regarding the effective management of acne. The current inclination towards nanotechnology is considerable due to several changes in the pharmaceutical research area. To secure the research work in different pharmaceutical fields patents are filed against various agents like Galderma Research & Development have filed for adapa...
Source: Recent Patents on Anti-Infective Drug Discovery - August 1, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Prophylactic activity of biogenic selenium nanoparticles against chronic Toxoplasma gondii infection.
Authors: Keyhani A, Shakibaie M, Mahmoudvand H, Jahanbakhsh S, Kareshk AT, Shojaee S, Ziaali N Abstract BACKGROUND: Studies showed that biogenic selenium nanoparticles (SeNPs) have a number of pharmacological properties such as antimicrobial ones. OBJECTIVE: The present investigation assesses the efficacy of biogenic selenium nanoparticles (SeNPs) as a new patent against latent toxoplasmosis in mice model. METHODS: Male BALB/c mice were orally treated with SeNPs at the doses of 2.5, 5, 10 mg/kg once a day for 14 days. On the 15th day, the mice were infected with the intraperitoneal inoculation of 20-25 tiss...
Source: Recent Patents on Anti-Infective Drug Discovery - June 5, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Perspective in Topical Infective and Non-infective Skin Diseases Therapy with Emergence of Nanomedicine.
Authors: Rahman M, Beg S PMID: 31722657 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 15, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

The Chemical composition and anti-mycobacterial activities of Trachyspermum copticum and Pelargonium graveolens essential oils.
Authors: Kardan-Yamchi J, Mahboubi M, Kazemian H, Hamzelou G, Feizabadi MM Abstract BACKGROUND: Microbial resistance to antibiotics and their adverse effects related to these antibiotics are the matter of global public health in 21th century. Emergence of drug resistant strains has interested the scientists to find the new antimicrobial agents among the medicinal plant's essential oil. METHODS: Anti-mycobacterial effects of Trachyspermum copticum and Pelargonium graveolens essential oils were assessed against multi-drug resistant clinical strains of Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacter...
Source: Recent Patents on Anti-Infective Drug Discovery - October 29, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Investigating The Retention Potential Of Chitosan Nanoparticulate Gel: Design, Development, In-Vitro & Ex-Vivo Characterization.
Investigating The Retention Potential Of Chitosan Nanoparticulate Gel: Design, Development, In-Vitro & Ex-Vivo Characterization. Recent Pat Antiinfect Drug Discov. 2019 Oct 14;: Authors: Kaul S, Jain N, Pandey J, Nagaich U Abstract INTRODUCTION: The main purpose of the research was to develop, optimize and characterize tobramycin sulphate loaded chitosan nanoparticles based gel in order to ameliorate its therapeutic efficacy, precorneal residence time, stability, targeting and to provide controlled release of drug. METHODS: Box-Behnken design was used to optimize formulation by 3-factors (chito...
Source: Recent Patents on Anti-Infective Drug Discovery - October 17, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Conventional formulations, Challenges and Nanomedicines in Infective and Non-Infective Skin Diseases Therapy.
Authors: Rahman M, Beg S, Akhter S Abstract Oral based formulations for treatment of topical infectious and non-infectious disorders causes numerous adverse reactions including of hepatic toxicity, higher metabolism, poor absorption and serious skin events such as drug - drug interactions resulted from metabolism through the cytochrome P450 system [1-3]. Other prefer routes is topical route, in which drug molecules deliver to the SC or epidermis and retained there for an optimum time to exert it therapeutic effect [3, 4-5]. The skin is an ideal site for drug delivery in treatment of topical infective and non-infect...
Source: Recent Patents on Anti-Infective Drug Discovery - August 12, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nano-emulgel: Emerging as smarter topical lipidic emulsion based nanocarrier for skin Healthcare applications.
CONCLUSION: Nanoemulgel preparations of many recently approved drugs are being used successfully in different areas of health care and re-defining the significance of topical route of delivery as compared to other routes. However, along with various improvements in current state of delivery system, it also needs a serious concern related to safety and toxicological studies of the materials used for such formulation. PMID: 31333141 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - July 24, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Identification of quinolone and colistin resistance genes in Escherichia coli strains isolated from mucosal samples of patients with colorectal cancer and healthy subjects.
CONCLUSION: These findings indicate increased resistance of E. coli to ciprofloxacin in comparison with prior studies. Further research in this field will increase our knowledge and more effective exposure to the antibiotic resistance of the pathogenic microorganisms. PMID: 31198116 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 16, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics".
Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics". Recent Pat Antiinfect Drug Discov. 2019 Mar 26;: Authors: Chavda V, Patel S Abstract Lyme's Disease (LD) is a severe rapidly growing broad spectrum chronic infection caused by the bacterium 'Borrelia (B.) burgdoferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in present scenario in many countries from species to species. Although Lyme's infection is now detectable via serologic examination of early and late Lyme neuroborreliosi...
Source: Recent Patents on Anti-Infective Drug Discovery - March 30, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Promising role of Wolbachia as anti-parasitic drug target and eco-friendly biocontrol agent.
CONCLUSION: Wolbachia has opened a new window to design costly, potent and eco-friendly for effective treatment and elimination of vector-borne parasitic diseases. PMID: 30747079 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - February 14, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nanomedicine Advances in Topical Infective and Non-Infective Skin Diseases Therapy.
Authors: Rahman M, Akhter S, Beg S Abstract PMID: 30556494 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 19, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Patent Selections.
Authors: Abstract PMID: 30556495 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 19, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Biological efficacy of carvacrol analogues.
CONCLUSION: Based on several reports on cavarcrol analogues, more research on the development of carvacrol analogues will result in potent compounds that can overcome drug resistance which is currently a challenge in the treatment of diseases such as bacterial infections, cancer, fungal infections etc. However more biological evaluation is required in order to fully understand the mode of action of these analogues on selected pathogens. PMID: 30516115 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 7, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Topical nano-emulgel for skin disorders: Formulation approach and characterization.
CONCLUSIONS: From the above studies, it concluded that aqueous-based gel vehicle of the developed formulation system exploited for topical delivery has moisturising properties which can improve local tolerability also. PMID: 30488798 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 1, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Polymyxin resistance mechanisms: from intrinsic resistance to mcr genes.
Authors: Meletis G, Skoura L Abstract The global spread of carbapenemase-encoding genes among Gram-negative nosocomial pathogens, has led to the revival of polymyxins. Colistin and polymyxin B, despite their serious adverse effects, have become last resort treatment options for multi- or even extensively-drug-resistant bacterial infections due to Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. Their use however has been followed by an increase in polymyxin resistance rates and the spread of transferable resistance genes limiting further the treatment options and contributing to the emerge...
Source: Recent Patents on Anti-Infective Drug Discovery - November 27, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Preface.
Authors: Kabelitz D Abstract PMID: 30424718 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 16, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Patent Selections.
Authors: Abstract PMID: 30424719 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 16, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Ibalizumab and Fostemsavir in the Management of Heavily Pre-Treated HIV-infected Patients.
CONCLUSION: The history of ibalizumab and fostemsavir will be written in next years. Continuing the research will be crucial to obtain evidence based guidelines for the management of heavily treated HIV-1 infected patients with limited therapeutic options. PMID: 30378502 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 2, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Levofloxacin versus Ceftriaxone and Azithromycin Combination in the Treatment of Community Acquired Pneumonia in Hospitalized Patients.
CONCLUSION: We concluded that monotherapy with oral Levofloxacin was as effective as treatment with Ceftriaxone plus Azithromycin combination in patients with CAP who required hospitalization. PMID: 30360748 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - October 28, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

HIV/AIDS Curable Study, New Forms of Therapeutic Trinity.
CONCLUSION: Up date, therapeutic trinity (combined therapy) against HIV/AIDS is generally among chemical drugs. In this article, several forms of other therapeutic attempts for effectively curing efforts against HIV/AIDS are proposed-including the development of next generation therapeutic HIV vaccines and schedules, new categories of bio-therapy, different pathways of immune-modulation, herbal medicines in general (allopathic, Ayurveda and traditional Chinese medicines), high quality of physical exercises, especially therapeutic combinations guided by latest medical discovery and principles (new forms of therapeutic trini...
Source: Recent Patents on Anti-Infective Drug Discovery - October 28, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nanotechnological Carriers For Treatment Of Acne.
CONCLUSIONS: Nanotechnological carriers have opened a new window to design novel, effective and low dose systems for effective eradication acne disease. However, very few nanocarrier based formulations are available in market for topical use and much progress is required in this field to improve anti-acne therapy. PMID: 30227825 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 21, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Ultra structural observations of anti-leishmanial effects of new synthetic 3-imidazolylflavanoneson Leishmania majorusing scanning electron and atomic force microscopes.
CONCLUSION: Our results strongly confirm the Leishmania cell wall as a potent target for the new synthesized azole (IF-2). Accordingly, focus on membrane integrity and glycoconjugates of Leishmania parasite to design new therapeutic agents is recommended. PMID: 30227826 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 21, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nano-based therapy for treatment of skin cancer.
CONCLUSION: We focus especially on the topical lipid formulation approaches combined with chemotherapy, a field which specialises in target specificity, drug release control, and real time monitoring with the goal being to diminish unwanted side effects and their severity, achieving a cheaper treatment and a generally more efficient chemotherapy. PMID: 30205801 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 14, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Amarogentin as topical anticancer and anti-infective potential: Scope of lipid based vesicular in its effective delivery.
Authors: Patel K, Kumar V, Verma A, Rahman M, Patel DK Abstract There is the need of development of liposomes based nanomedicines formulation for the better efficacy and safety of the available drugs in the market. Liposomes have various applications in the field of pharmaceutical and medical field for their drug target potential, diagnostic importance and imaging techniques. Natural plant based drugs and their derivative have been used in the medicine, nutraceuticals, perfumery, cosmetic and beverages industry. More than half of the prescribed drugs in the worldwide are mainly derived from different natural source...
Source: Recent Patents on Anti-Infective Drug Discovery - September 14, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Antibacterial activity of gold nanoparticles conjugated by aminoglycosides against A. baumannii isolates from burn patients.
CONCLUSION: our study showed that a combination of amikacin and gentamicin with Gnps has a significant antibacterial efficiency against clinical isolates of A. baumannii. Gnps can be used as extraordinary molecular carriers for the targeting, and delivery the of antibiotic molecules to the specific infection. PMID: 30152290 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 29, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Screening and potential of the incidence of resistance transfer among the multidrug and heavy metal resistant Gram negative isolates from hospital effluents of northern India.
Conclusion: We can recommend that the hospital water is heavily polluted with several types of antibiotics, toxic metals as well as the potentially hazardous bacterial flora because of their capacity to resist one or the other well known antibiotic and chemotherapeutic agents. These studies provide evidence that a wide variety of clinically important antibiotic and metal resistance genes are mobile within aquatic bacterial communities one step ahead of the above, we can envisage the alarming situation prevailing in our system and surrounding in the light of transmissible nature of R-plasmids. PMID: 29984669 [PubMed - a...
Source: Recent Patents on Anti-Infective Drug Discovery - July 10, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

In vitro anti-mycobacterial activity of three medicinal plants of Lamiaceae family.
CONCLUSION: The studied medicinal plants showed notable effects against mycobacterial strains. Our results indicated that utilization of Lamiaceae family can be helpful for treatment of mycobacterial infections. PMID: 29952265 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 29, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Short Antimicrobial Peptides.
CONCLUSION: Herein, we discussed the arsenal of short peptides and peptidomimetics starting from the smallest unit possible - a dipeptide to a decapeptide along with their activity profiles as antimicrobials. Recently, various SAMPs have paved their ways from in vitro studies to clinical trials, as evident from the most recent patent (EP1951194) on oral hygiene. This step by step growth of SAMPs has restored the hope in peptide-based therapeutics, which may prove an essential tool in eradicating antimicrobial resistance and tackling various microbial infections. PMID: 29952266 [PubMed - as supplied by publisher] (Sourc...
Source: Recent Patents on Anti-Infective Drug Discovery - June 29, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Current State of Nanomedicines in the Treatment of Topical Infectious Disorders.
CONCLUSION: Despite the new emerging technologies and delivery systems, efforts are still needed in the right direction to combat this global challenge. PMID: 29807522 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 30, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Evaluation of fosfomycin activity against ESBL producing Enterobacteriaceae isolated from Iran.
CONCLUSION: In conclusion, fosfomycin showed good antimicrobial activity against multidrug resistance ESBL- positive Enterobacteriaceae. PMID: 29769010 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 19, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Editorial: Nanomedicines for the Treatment of Tuberculosis: Role of Nanocarriers and Functional Excipients.
Authors: Samad A, Nazish I, Beg S PMID: 29745316 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 13, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Patent Selections.
Authors: PMID: 29745317 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 13, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Ferula gummosa Boiss inhibits Multi drug resistant clinical Pseudomonas aeruginosas.
In this study, we evaluated the antibacterial effects of extracts and essential oils of F. gummosa on 33 P. aeruginosa clinical isolates by microdilution method and assessed the association of antimicrobial activity with the extended spectrum β-lactamase (ESBL) producing, biofilm forming and aliginate production of the strains. In addition, the presence of some genes involved in these properties, including blaGES-1, blaRER-1, blaCTX-M, blaVEB-1, blaOXA-1, blaOXA-4 , blaOXA-10 , ppyR, pslA, pelA, algU, algL, algD, fliC and oxaA was determined using PCR. RESULTS: We revealed that all of our extracts and essential oi...
Source: Recent Patents on Anti-Infective Drug Discovery - April 29, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Macrophage targeted cellular carriers for effective delivery of anti-tubercular drugs.
Authors: Beg S, Agnihotri J, Singh S, Wais M Abstract Newly developed vaccine VPM1002 confers paradigm swing in the prophylactic treatment of tuberculosis (TB).Multi drug resistant and latent TB in adults as well as in underprivileged patients is instigating menace over world population if the host is immune-compromised. One third of the world's population is infected with TB. Recently it is estimated around 9.6 million people around the world became sick with TB disease. There were 1.5 million TB-related deaths worldwide. Therefore with the advent in biotechnology and Nano engineering, newly adapted survival molec...
Source: Recent Patents on Anti-Infective Drug Discovery - December 10, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Recent Patents on Light-Based Anti-Infective Approaches.
CONCLUSIONS: Light-based antimicrobial approaches hold great promise for the future in regards to treating antibiotic-resistant infections and diseases. PMID: 29119936 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 11, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Preface.
Authors: Kabelitz D PMID: 29050545 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - October 22, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nanomedicine for the Treatment of Tuberculosis.
CONCLUSION: The properties of nanomedicine may prove beneficial in developing improved, efficacious or alternative therapies for tuberculosis diseases. PMID: 28990537 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - October 12, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Recent Complications and Issues in Tuberculosis Treatment.
CONCLUSION: Even though numerous prognostic markers have been described which envisage mortality, yet untreated miliary TB has a serious outcome within one year. A high index of clinical thought and early diagnosis and timely institution of anti-tuberculosis treatment can be life-saving. Response to first-line anti-tuberculosis drugs is good. [1, 2.] . Anti -tuberculosis drugs are patent. PMID: 28990538 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - October 12, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

New Drugs And Vaccines For Tuberculosis.
Authors: Beg S, Gaur P, Mishra S Abstract Tuberculosis (TB) is an infectious disease that resulted in estimated 9.6 million new cases in 2014 and 1.5 million deaths. The available drug regimen for TB is time consuming which more often leads to the patient non compliance which then results in occurrence of drug resistant TB (Multi-drug and extremely drug resistant TB) in several portions of the world. The dangerous combinations of TB and HIV is taking its toll on human health. The foremost factor is non- profit associated with the development of anti TB drugs. There is almost 10 different drugs in various levels of ...
Source: Recent Patents on Anti-Infective Drug Discovery - October 12, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Silver Nanoparticles Synthesis Approaches and their Antimicrobial Applications.
Authors: Ahmad F Abstract Silver nanoparticles (AgNPs), are amongst the utmost striking nanosized materials that are extensively applied in a variety of biomedical applications which includes diagnostic use, disease management, medical device coating, drug delivery and for personal health care. With the growing interest and the use of AgNPs in the health care sector, it is becoming essential for a better understanding of AgNPs mechanism of action like biological interaction, their possible toxicity, and safety concern to human exposure. AgNPs have been the subjects of researchers attention and interest due to the u...
Source: Recent Patents on Anti-Infective Drug Discovery - October 12, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Recently patented viral nucleotide sequences and generation of virus-derived vaccines.
Authors: Venkataraman S, Ahmad T, AbouHaidar M, Hefferon KL Abstract With the increased comprehension of the molecular biology of viruses, there has been a recent surge in the application of virus sequences and viral gene expression strategies towards the diagnosis and treatment of diseases. The scope of the patenting landscape has widened as a result and the current review discusses patents pertaining to live / attenuated viral vaccines. The vaccines addressed here have been developed by both conventional means as well as by the state-of-the-art genetic engineering techniques. This review also addresses the applic...
Source: Recent Patents on Anti-Infective Drug Discovery - June 20, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research