Rapid Communications in Mass Spectrometry : RCM This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Inclusion of deuterated glycopeptides provides increased sequence coverage in hydrogen/deuterium exchange mass spectrometry analysis of SARS-CoV-2 spike glycoprotein
CONCLUSION: Inclusion of deuterated glycopeptides improves the analysis of the conformational dynamics of glycoproteins such as viral surface antigens and cellular receptors.PMID:38355883 | DOI:10.1002/rcm.9690 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - February 14, 2024 Category: Chemistry Authors: Christopher A Haynes Theodore R Keppel Betlehem Mekonnen Sarah H Osman Yu Zhou Adrian R Woolfitt Jakub Baudys John R Barr Dongxia Wang Source Type: research

A fixed-charge model of the N-protomer of 4-aminobenzoic acid to facilitate the study of the unimolecular and bimolecular chemistry of its "neutral" carboxylic acid group
CONCLUSIONS: The free carboxylic group of 7 is not very reactive toward neutral reagents in the gas phase.PMID:38355884 | DOI:10.1002/rcm.9681 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - February 14, 2024 Category: Chemistry Authors: Beiang Zhang Laura Burchill Weam A O Altalhi Howard Z Ma Richard A J O'Hair Source Type: research

Accurate measurement of K/Ca in low-[K] carbonate samples using laser-ablation sector-field inductively coupled plasma mass spectrometry
CONCLUSION: Our [K] measurement protocol is demonstrably precise and accurate and applicable to a wide range of materials. The measurement of K/Ca in relatively low-[K] marine carbonates is presented here as a key example of a new application opened up by these advances.PMID:38355885 | DOI:10.1002/rcm.9692 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - February 14, 2024 Category: Chemistry Authors: Romi Nambiar Jorit F Kniest Alexander Schmidt Jacek Raddatz Wolfgang M üller David Evans Source Type: research

Establishment of high-performance liquid chromatography-photodiode array method for 43 weight loss agents and effect of basic environment on bisacodyl degradation
CONCLUSIONS: The developed method could be used to regulate slimming products that threaten public health, and knowledge of bisacodyl degradation will be used as the basis for developing an analytic method.PMID:38343169 | DOI:10.1002/rcm.9705 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - February 12, 2024 Category: Chemistry Authors: Ji Hyun Lee Hyeon Joo Ham Hye-Min Bae Kyoung-Moon Han Jongkook Lee Hyung Il Kim Source Type: research

Characterization of Regolith And Trace Economic Resources (CRATER): An Orbitrap-based laser desorption mass spectrometry instrument for in situ exploration of the Moon
CONCLUSION: An engineering test unit of the flight model is currently in development to serve as a pathfinder for near-term mission opportunities.PMID:38342682 | DOI:10.1002/rcm.9657 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - February 11, 2024 Category: Chemistry Authors: Soumya Ray Ricardo Ar évalo Adrian Southard Lori Willhite Anais Bardyn Ziqin Ni Ryan Danell Andrej Grubisic Cynthia Gundersen Julie Llano Anthony Yu Molly Fahey Emanuel Hernandez Jacob Graham Jane Lee Akif Ersahin Christelle Briois Laurent Thirkell Fabri Source Type: research

Identification and quantification of both isomers of hexahydrocannabinol, (9R)-hexahydrocannabinol and (9S)-hexahydrocannabinol, in three different matrices by mass spectrometry
CONCLUSION: This research contributes analytical insights into differentiating and simultaneously analyzing (9R)-HHC and (9S)-HHC, using widely applicable mass spectrometric methods. The study emphasizes the need for vigilance among toxicologists, as new semisynthetic cannabinoids continue to emerge in Europe, with potential health implications. The findings underscore the importance of reliable analytical methods for monitoring these compounds in forensic and clinical settings.PMID:38342829 | DOI:10.1002/rcm.9711 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - February 11, 2024 Category: Chemistry Authors: Charline Bottinelli Pauline Baradian Am élie Poly Guillaume Hoizey Camille Chatenay Source Type: research

Native mass spectrometry interrogation of complexes formed during targeted protein degradation
Rapid Commun Mass Spectrom. 2023 Feb;38 Suppl 1:e9702. doi: 10.1002/rcm.9702.NO ABSTRACTPMID:38299262 | DOI:10.1002/rcm.9702 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - February 1, 2024 Category: Chemistry Source Type: research

Atmospheric solids analysis probe mass spectrometry: An easy bolt-on for the synthetic undergraduate teaching laboratory
CONCLUSIONS: ASAP-MS provided spectra that both complement and enhance intended learning outcomes in existing organic chemistry experiments, showing its versatility as a bolt-on technique. Moving forward, ASAP-MS will be integrated into the University of Surrey's undergraduate teaching laboratory.PMID:38248910 | DOI:10.1002/rcm.9689 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - January 22, 2024 Category: Chemistry Authors: Nathaniel M Bingham James S Wright Simone C Mathias David Douce Patrick Sears Source Type: research

Development and application of a multiple reaction monitoring method for the simultaneous quantification of sodium channels Na v 1.1, Na v 1.2, and Na v 1.6 in solubilized membrane proteins from stable HEK293 cell lines, rodents, and human brain tissues
CONCLUSIONS: Multiple reaction monitoring was used to quantify sodium channels Nav 1.1, 1.2, and 1.6 expressed in stably transfected HEK293 cells and brain tissues from mice, rats, and humans. We found significant differences in the expression of these channels in mouse, rat, and human brains. Nav expression ranking among the three species was Nav 1.2 ≫ Nav 1.1 > Nav 1.6, with the human brain expressing much lower concentrations overall compared to rodent brain.PMID:38211346 | DOI:10.1002/rcm.9672 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: Rainbow Kwan Prerna Das Neelan Gerrebos Jenny Li Xin Yin Wang Gina DeBoer Vanessa Emnacen-Pankhurst Sophia Lin Raymond Feng Sam Goodchild Luis E Sojo Source Type: research

A hydrogen isoscape for tracing the migration of herbivorous lepidopterans across the Afro-Palearctic range
CONCLUSION: The δ2 Hwing isoscape is applicable for tracing herbivorous lepidopteran insects that migrate across the Afro-Palearctic range but has limited geolocation potential in the Afro-tropics. The spatial analysis of uncertainty using high-resolution climatic data demonstrated that many African regions with highly variable evaporation rates and relative humidity have δ2 Hwing values that are less related to δ2 HGSP values. Increasing geolocation precision will require new modeling approaches using more time-specific environmental data and/or independent geolocation tools.PMID:38211347 | DOI:10.1002/rcm.9675 (Source...
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: Sana Ghouri Megan S Reich Roger Lopez-Ma ñas Gerard Talavera Gabriel J Bowen Roger Vila Valery N K Talla Steve C Collins Dino J Martins Clement P Bataille Source Type: research

Identification, characterisation and in silico ADMET prediction of ozenoxacin and its degradation products using high-performance liquid chromatography-photodiode array and liquid chromatography-quadrupole time-of-flight-tandem mass spectrometry
CONCLUSION: The drug was found to be stable in neutral, acidic, basic and oxidative degradation conditions with hydrogen peroxide. Liquid chromatography-electrospray ionisation-quadrupole time-of-flight-tandem mass spectrometry- was employed in positive ionisation mode to analyse both the drug and the mass of the identified DP. The mechanism and the pathway of mass fragmentation have been proposed. The developed method was accurate, repeatable, linear and selective for further research. The ADMET Predictor software was applied to predict the in silico toxicity of the drugs and its DPs as well as their physicochemical chara...
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: Ashwinkumar Matta Raja Sundararajan Source Type: research

Tandem mass tag-based quantitative proteomics analyses of the spermatogenesis-ameliorating effect of Youjing granule on rats
CONCLUSIONS: The results demonstrate that our serum proteomics platform is clinically useful in understanding the mechanisms of YG.PMID:38211349 | DOI:10.1002/rcm.9679 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: Xuping Jiang Wenjiao Zhu Yaoxiang Sun Sijia Wang Miaomiao Sun Ruijie Tang Zhian Tang Tieliang Ma Source Type: research

Identification and characterization of the metabolites of sinomenine using liquid chromatography combined with benchtop Orbitrap mass spectrometry and nuclear magnetic resonance spectroscopy
CONCLUSIONS: N-Demethylation and N-oxygenation were the primary metabolic pathways of sinomenine. This study provides new insight into the in vitro metabolism of sinomenine, which would help prospects of sinomenine disposition and safety assessments.PMID:38211350 | DOI:10.1002/rcm.9669 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: Ke Fang Shaoyu Ren Qian Zhang Source Type: research

User-friendly relative quantification procedure for gas chromatography/mass spectrometry-based plasma metabolome analysis
CONCLUSION: The suggested procedure involves the analysis of a plasma standard as a quality control for each batch and the calculation of relative target plasma to quality-control plasma values for each metabolite. This is an easy and low-cost method and could be readily employed by researchers during comprehensive plasma metabolome analysis.PMID:38212648 | DOI:10.1002/rcm.9683 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: Shin Nishiumi Tomonori Yokoyama Noriyuki Ojima Source Type: research

Simultaneous quantification of seven glycols in antifreeze liquids using direct liquid injection gas chromatography coupled with mass spectrometry
CONCLUSIONS: A method that requires only a two-step dilution of antifreeze samples combined with direct liquid injection GC-MS was validated for the simultaneous quantification of seven glycols (and their isomers) in 10 different types of antifreeze liquids. The results obtained in the validation procedure proved that the GC-MS method is sensitive and precise for the quantification of glycols.PMID:38212649 | DOI:10.1002/rcm.9686 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: George Madalin Danila Mihaiella Cretu Cristian Puscasu Source Type: research