LUMINA: Using molecular biomarkers to guide decision making for breast radiotherapy
In this opinion piece, we respond to comments about the LUMINA trial by Meattini and colleagues in the Journal. LUMINA was a prospective cohort study which evaluated the omission of radiotherapy after breast conserving surgery (BCS) in patients treated with endocrine therapy with low risk clinico-pathologic features and luminal A breast cancer. We address their areas of concern including the single cohort design that required careful patient selection, the relatively short follow-up period of 5 years, and the limited follow-up on younger patients. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 30, 2023 Category: Radiology Authors: Timothy J. Whelan, Anthony Fyles, Sameer Parpia, Torsten Nielsen, Mark N. Levine Source Type: research

Oligometastatic Sarcoma treated with Curative intent Ablative Radiotherapy (OSCAR): a multicenter study on behalf of AIRO (Italian Association of Radiotherapy and clinical Oncology)
Soft-tissue sarcomas (STS) are a rare and histologically heterogeneous group of mesenchymal malignancies, accounting for about 1% of adult ’s tumors [1]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 30, 2023 Category: Radiology Authors: D. Franceschini, D. Greto, S. Dicuonzo, F. Navarria, M. Federico, M. La Vecchia, C. Sangalli, A. Allajbej, L. Di Cristina, R. Mazzola, A. Pontoniero, G. Montesi, P. Navarria, D. Baldaccini, E. Clerici, L. Lo Faro, C. Franzese, S. Di Biase, S. Pergolizzi, Tags: Original Article Source Type: research

Pulmonary interstitial lymphography: A prospective trial with potential impact on stereotactic ablative radiotherapy planning for early-stage lung cancer
Stereotactic ablative radiotherapy (SABR) is the standard of care for medically inoperable early-stage non-small cell lung cancer (NSCLC). Extensive evidence demonstrates that SABR is efficacious with low toxicity [1 –2], and an important question is the potential role of SABR in the medically operable setting [3–6]. Several randomized trials comparing SABR to surgical resection continue to accrue (e.g., NCT02468024, NCT02984761, NCT01753414) and preliminary comparisons of SABR vs. lobectomy for early-stage NSCLC indicate that survival is similar and SABR is associated with significantly fewer side effects [3,6]. (Sour...
Source: Radiotherapy and Oncology - December 30, 2023 Category: Radiology Authors: Ryan B. Ko, Jonathan A. Abelson, Dominik Fleischmann, John D. Louie, Gloria L. Hwang, Daniel Y. Sze, Emil Sch üler, Kayla N. Kielar, Peter G. Maxim, Quynh-Thu Le, Wendy H. Hara, Maximilian Diehn, Nishita Kothary, Billy W. Loo Tags: Short Communication Source Type: research

The Organization of Care in Pediatric Radiotherapy across SIOP Europe affiliated centers: A multicenter survey in the Framework of the ‘Joint Action on Rare Cancers’ project
Despite the increased cure rates for pediatric cancers, a significant discrepancy exists in outcomes across Europe. Due to a lack of access to essential and modern components of the multidisciplinary treatment spectrum, disparities in survival rates of more than 20% as well as in late side-effects are a reality [1 –4]. To reduce these inequalities, ‘European Standards of Care for Children with Cancer’ have been defined, consolidating the ideal requirements for pediatric cancer units across the ‘Société Internationale d’Oncologie Pédiatrique’ (SIOP) Europe (SIOPE) affiliated countries [5]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 27, 2023 Category: Radiology Authors: Geert O. Janssens, Beate Timmermann, Anne Laprie, Henry Mandeville, Laetitia Padovani, Cyrus Chargari, Pamela Kearnsh, Olga Kozhaeva, Leila Kameric, Anita Kienesberger, Peter S.N. van Rossum, Tom Boterberg, Yolande Lievens, Gilles Vassal Tags: Original Article Source Type: research

Clinical research for global needs of radiation oncology
The demand for radiotherapy (RT) is increasing worldwide due to population growth as prominently seen in Africa, and increasing population age as prominently seen in Europe. Increasing age, particularly over 60 years, is associated with a significantly increased risk of cancer. Additionally, RT is more often prescribed over other modalities, such as major surgery, for frail, multimorbid and elderly patients. In some regions of the world, more cancers are now being detected earlier and treated more effectively, leading to longer survival but also to the risk of recurrence, new malignancies and late effects. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 27, 2023 Category: Radiology Authors: Michael Baumann, Carol Bacchus, Marianne C. Aznar, Rob P. Coppes, Eric Deutsch, Dietmar Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W.M. Lee, Steffen L öck, Birgitte V. Offersen, David I. Thwaites, Uulke A. van der He Tags: Editorial Source Type: research

The long-term impact of irradiation on functional connectivity in brain circuits involved in memory processes after pediatric posterior fossa tumor
Memory deficit is one of the main neurocognitive outcomes in pediatric posterior fossa tumor (PFT) survivors [1]. Impairments have been shown in declarative memory [2,3] depending mainly on the hippocampus and cortico-hippocampal circuit, in working memory [4 –6] depending mainly on the cerebellum and prefrontal areas, and in motor procedural memory [3,7] depending on the striatum and the cerebellum [8]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 23, 2023 Category: Radiology Authors: Elo ïse BAUDOU, Patrice PERAN, Fatima TENSAOUTI, Germain ARRIBARAT, Jérémie PARIENTE, Nicolas COURBIERES, Lisa POLLIDORO, Anne-Isabelle BERTOZZI, Marion GAMBART, Annick SEVELY, Margaux ROQUES, Anne DUCASSOU, Jérémy DANNA, Jessica TALLET, Christelle D Tags: Original Article Source Type: research

Statin Use Reduces Radiation-Induced Stroke Risk in Advanced Nasopharyngeal Carcinoma Patients
Key points: (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 22, 2023 Category: Radiology Authors: Chuan-Yi Lin, Chia-Lun Chang, Kuan-Chou Lin, Wan-Ming Chen, Ben-Chang Shia, Po-Hsiu Kuo, Szu-Yuan Wu Tags: Original Article Source Type: research

Machine-learning prediction of treatment response to stereotactic body radiation therapy in oligometastatic gynecological cancer: a multi-institutional study
Stereotactic body radiation therapy (SBRT) has been increasingly adopted as an effective method of treatment of limited cancer metastases, owing to the high rates of local control, low risk of toxicities and its potential to be delivered to almost all anatomic sites [1,2]. In particular, SBRT represents today an alternative to metastasectomy in the oligometastatic scenario [3], defined as an intermediate stage of the disease between locoregionally advanced and wide spread metastatic disease, but still treatable curatively [4]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 22, 2023 Category: Radiology Authors: Savino Cilla, Maura Campitelli, Maria Antonietta Gambacorta, Raffaella Michela Rinaldi, Francesco Deodato, Donato Pezzulla, Carmela Romano, Andrei Fodor, Concetta Laliscia, Fabio Trippa, Vitaliana De Sanctis, Edy Ippolito, Martina Ferioli, Francesca Titon Tags: Original Article Source Type: research

Large Institutional Experience of Early Outcomes and Dosimetric Findings with Postoperative Stereotactic Partial Breast Irradiation in Breast Cancer
Accelerated partial breast irradiation (APBI) has been shown to be effective in carefully selected patients, based on evidence from at least 8 prospective randomized trials enrolling over 10,000 women[1,2]. A variety of APBI techniques have been investigated, with external beam techniques such as 3-dimensional conformal radiation therapy and intensity-modulated radiation therapy (IMRT) being favored due to their noninvasiveness and operator independence[3]. A recent meta-analysis showed that APBI was associated with significantly lower rate of acute adverse events compared to whole breast irradiation (WBI), with no differe...
Source: Radiotherapy and Oncology - December 21, 2023 Category: Radiology Authors: Jee Suk Chang, Jeongshim Lee, Frank A. Vicini, Jin Sung Kim, Jihun Kim, Seo Hee Choi, Ik Jae Lee, Yong Bae Kim Tags: Original Article Source Type: research

Volumetric Brain Assessment of Long-Term Head and Neck Cancer Survivors
Radiation therapy (RT) is an important component of therapy for most patients with locally or regionally advanced head and neck cancer (HNC).[1] Benefits of RT for HNC include the opportunity for organ preservation when used as primary treatment and improved local control when administered after surgery. The benefit of RT is unfortunately tempered by a range of late adverse effects, and neurocognitive problems experienced by HNC survivors are increasingly recognized. The impact of RT for HNC on neurocognitive functioning was first appreciated among patients treated for nasopharyngeal carcinoma, where radiation exposure to ...
Source: Radiotherapy and Oncology - December 21, 2023 Category: Radiology Authors: Donna L. Murdaugh, Desmin Milner, Carlos E. Cardenas, Katherine A. Heinzman, Courtney A. Cooper, Jazmyne N. Tabb, Smita Bhatia, Andrew M. McDonald Tags: Original Article Source Type: research

Choosing the right questions – a systematic review of patient reported outcome measures used in radiotherapy and proton beam therapy
Cancer survival is at its highest due to earlier detection and advancing treatment options ​[1]. By 2030, it is projected that there will be more than 4 million cancer survivors in the United Kingdom (UK), and 13.7 million in the United States (USA)​ ​[1, ​​[2]​. Radiotherapy has been shown to be an effective treatment technique with 40% of cancer patients receiving it as part of their treatment [3]​​. Despite its effectiveness, many patients experience acute and long-term physical and psychological toxicities, impacting their health-related quality of life (HR-QoL) [2]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 21, 2023 Category: Radiology Authors: Danielle Fairweather, Rachel Taylor, Rita Sim ões Source Type: research

Quality assurance of radiation therapy after breast-conserving surgery among patients in the BOOG 2013-08 trial
In patients with clinically node-negative (cN0) breast cancer a sentinel lymph node biopsy (SLNB) is traditionally performed to determine the pathological lymph node (pN) status, to guide adjuvant treatment recommendations.[1] Results from landmark trials such as ACOSOG Z0011 demonstrated that cN0 patients treated with breast-conserving surgery (BCS) and whole breast radiation therapy (WBRT) who have limited sentinel lymph node(s) (SLN(s)) metastases, do not benefit from a completion axillary lymph node dissection (cALND). (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 21, 2023 Category: Radiology Authors: V.M. Wintraecken, L.J. Boersma, L.M. van Roozendaal, J. de Vries, S.M.J. van Kuijk, M.L.G. Vane, T. van Dalen, J.A. van der Hage, L.J.A. Strobbe, S.C. Linn, M.B.I. Lobbes, P.M.P Poortmans, V.C.G. Tjan-Heijnen, K.K.B.T. van de Vijver, A.H. Westenberg, J.H. Tags: Original Article Source Type: research

Phase I dose-escalation study of nab-paclitaxel combined with cisplatin and capecitabin as induction chemotherapy followed by concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a malignant type of cancer arising from the nasopharynx epithelium, which is different from head and neck cancers because of its distinct geographical distribution, high correlation with the Epstein-Barr virus (EBV), and unique pathological types[1]. Radiotherapy is a radical therapy for patients with NPC, with more than 70% of patients having locally advanced disease at first diagnosis; cisplatin concurrent chemotherapy combined with radiotherapy is the cornerstone for locally advanced NPC[2]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 20, 2023 Category: Radiology Authors: Yu-Chen, Mei-Juan Luo, Rong-Ping Liu, Jing Jin, Sheng-Wen Deng, Lin-Quan Tang, Xiao-Yun Li, Li-Ting Liu, Dong-Hua Luo, Rui Sun, Sai-Lan Liu, Ji-Bin Li, Qing Liu, Pan Wang, Qiu-Yan Chen, Hai-Qiang Mai, Shan-Shan Guo Tags: Original Article Source Type: research

Identification of the unfolded protein response pathway as target for radiosensitization in pancreatic cancer
With its high mortality, pancreatic cancer is the fourth highest cause of cancer deaths in developed countries. It is projected to be the second leading reason of cancer-related deaths in the next decade [1,2]. This poor prognosis is affected, among others, by a late diagnosis due to a lack of specific symptoms. The only curative treatment option is surgical resection [3]. Patients with locally advanced pancreatic cancer (LAPC) receive neoadjuvant chemotherapy or radiochemotherapy intending to achieve a secondary resection. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 20, 2023 Category: Radiology Authors: Jana Kern, Daniela Schilling, Christian Schneeweis, Roland M. Schmid, G ünter Schneider, Stephanie E. Combs, Sophie Dobiasch Tags: Original Article Source Type: research

A potential biomarker of radiosensitivity in metastatic hormone sensitive prostate cancer patients treated with combination external beam radiotherapy and radium-223
Prostate cancer is the second most common cancer in men worldwide, with more than 1 million cases diagnosed annually, and is the fifth most common cause of death in men [1]. Treatment options for prostate cancer depend on the stage of the disease at diagnosis and include hormone therapy, surgery, chemotherapy and various radiotherapy techniques, including external beam radiotherapy (EBRT), brachytherapy and radionuclide therapy [2]. Bone metastases are common in advanced prostate cancer patients, with up to 10% of newly diagnosed patients presenting with bone metastases [3,4]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 20, 2023 Category: Radiology Authors: K.M. Redmond, P.G. Turner, A. Cole, S. Jain, K.M. Prise, J.M. O'Sullivan Tags: Original Article Source Type: research