Common Sense (Radiation) Oncology: Redefining Targets in Radiotherapy
In 2023, the Common Sense Oncology (CSO) movement was launched with the goal of recalibrating cancer care to focus on outcomes that matter to patients. We extend the three CSO pillars – evidence generation, interpretation and communication – to radiation oncology and advocate for better evidence demonstrating the value of our modality. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 2, 2024 Category: Radiology Authors: Nina N. Sanford, Yolande Lievens, Ajay Aggarwal, Timothy Hanna, Laura Dawson, Jeffrey White, Bishal Gyawali, Christopher Booth, Fabio Ynoe de Moraes Tags: Short Communication Source Type: research
Definitive single fraction spine stereotactic radiosurgery for metastatic sarcoma: Simultaneous integrated boost is associated with high tumor control and low vertebral fracture risk
Sarcoma spinal metastases (SSM) are particularly difficult to manage given their poor response rates to chemotherapy and inherent radioresistance. We evaluated outcomes in a cohort of patients with SSM uniformly treated using single-fraction simultaneous-integrated-boost (SIB) spine stereotactic radiosurgery (SSRS). (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 2, 2024 Category: Radiology Authors: Mihir D. Shanker, Adriana P. Cavazos, Jing Li, Thomas H. Beckham, Debra N. Yeboa, Chenyang Wang, Mary Frances McAleer, Tina M. Briere, Behrang Amini, Claudio E. Tatsui, Robert Y. North, Christopher A. Alvarez-Breckenridge, Phillip Cezayirli, Laurence D. R Tags: Original Article Source Type: research
Paediatric Radiation Therapy without Anaesthesia – Are the Children Moving?
Although generally safe [1], use of anaesthesia in paediatric radiation oncology can be costly [2] and cumbersome, and adds to the burden of cancer treatment in children and adolescents.[3,4] In many institutions, a substantial proportion of young children and some adolescents undergo general anaesthesia for radiation treatments.[2,5] At our institution, a multi-faceted approach has been used to reduce anaesthesia utilization as part of standard-of-care radiotherapy (RT): presence of a dedicated paediatric nurse for procedural preparation, comfort objects (e.g., stuffed animal), and most importantly, audiovisual distractio...
Source: Radiotherapy and Oncology - February 2, 2024 Category: Radiology Authors: Tatiana Ritchie, Susan Awrey, Manjula Maganti, Rehab Chahin, Michael Velec, David C. Hodgson, Hitesh Dama, Sameera Ahmed, Jeff D. Winter, Normand Laperriere, Derek S. Tsang Tags: Original Article Source Type: research
Survival outcomes and toxicity of adjuvant immunotherapy after definitive concurrent chemotherapy with proton beam radiation therapy for patients with inoperable locally advanced non-small cell lung carcinoma
For 20 years, the standard therapy for inoperable locally advanced non-small cell lung carcinoma (LA-NSCLC) was definitive concurrent chemotherapy and photon radiation therapy (RT). In 2018, based on the findings from the landmark PACIFIC trial demonstrating an overall survival (OS) benefit from adding adjuvant durvalumab to standard chemotherapy and photon RT, the US Food and Drug Administration approved the adjuvant ICI durvalumab as a new standard of care in such cases.[1,2] Nevertheless, RT-related cardiac and pulmonary toxicity remains a significant source of morbidity and mortality in LA-NSCLC survivors,[3,4] and rad...
Source: Radiotherapy and Oncology - February 2, 2024 Category: Radiology Authors: Kelsey L. Corrigan, Ting Xu, Yuki Sasaki, Ruitao Lin, Aileen B. Chen, James W. Welsh, Steven H. Lin, Joe Y. Chang, Matthew S. Ning, Saumil Gandhi, Michael S. O'Reilly, Carl M. Gay, Mehmet Altan, Charles Lu, Tina Cascone, Efstratios Koutroumpakis, Ajay She Tags: Original Article Source Type: research
GEC-ESTRO survey of 106Ru eye applicator practice for ocular melanoma – Physicist survey
Uveal melanoma is the most common primary intraocular malignancy in adults. In contrast to enucleation, radiation therapy offers eye preserving treatment options like brachytherapy (BT, also called interventional radiotherapy), generally using Ruthenium-106 or Iodine-125, and external beam radiation therapy (EBRT) using photons or protons. Other options are photo-dynamic therapy (PDT) or transpupillary thermotherapy (TTT). 106Ru ocular plaque BT is a niche treatment performed in only about 100 clinics worldwide [2 –5]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 1, 2024 Category: Radiology Authors: Marisol De Brabandere, Elisa Placidi, Frank-Andr é Siebert, Åsa Carlsson Tedgren, Andrea Slocker Escarpa, Luca Tagliaferri, Michael Andrássy, Carmen Schulz, Lotte S. Fog Tags: Original Article Source Type: research
Aims+Scope/Editorial Board/ Publication information
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 1, 2024 Category: Radiology Source Type: research
Contents
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 1, 2024 Category: Radiology Source Type: research
GEC-ESTRO survey of 106Ru eye applicator practice for ocular melanoma - physicist survey
Uveal melanoma is the most common primary intraocular malignancy in adults. In contrast to enucleation, radiation therapy offers eye preserving treatment options like brachytherapy (BT, also called interventional radiotherapy), generally using Ruthenium-106 or Iodine-125, external beam radiation therapy (EBRT) using photons or protons. Other options are photo-dynamic therapy (PDT) or transpupillary thermotherapy (TTT). 106Ru ocular plaque BT is a niche treatment performed in only about 100 clinics worldwide [2]-[5]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 1, 2024 Category: Radiology Authors: Marisol De Brabandere, Elisa Placidi, Frank-Andr é Siebert, Åsa Carlsson Tedgren, Andrea Slocker Escarpa, Luca Tagliaferri, Michael Andrássy, Carmen Schulz, Lotte S. Fog Tags: Original Article Source Type: research
Magnetic resonance imaging for assessment of rectal cancer nodes after chemoradiotherapy: a single center experience
Accurate nodal restaging is becoming clinically more important in patients with locally advanced rectal cancer (LARC) with the emergence of organ-preserving treatment after a good response to neoadjuvant chemoradiotherapy (nCRT). (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 1, 2024 Category: Radiology Authors: Brunella BARBARO, Maria Rachele Pia CARAFA, Laura Maria MINORDI, Priscilla TESTA, Giulia TATULLI, Davide CARANO, Claudio FIORILLO, Giuditta CHILOIRO, Angela ROMANO, Vincenzo VALENTINI, Maria Antonietta GAMBACORTA Tags: Original Article Source Type: research
Disease and Toxicity Outcomes for a Modern Cohort of Patients with Squamous Cell Carcinoma of Cutaneous Origin Involving the Parotid Gland: Comparison of Volumetric Modulated Arc Therapy and Pencil Beam Scanning Proton Therapy
Cutaneous squamous cell carcinoma (SCC) involving the parotid gland by direct extension or by lymph node involvement is a relatively uncommon clinical scenario and previous research dedicated to this specific clinical scenario is fairly limited with a lack of large, randomized studies.1 –15 This can be a fairly heterogeneous group. Exact diagnostic classification is challenging, particularly given the common difficulty in distinguishing between primary squamous cell carcinoma of the parotid versus lymph node metastasis from occult or previous cutaneous SCC. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 1, 2024 Category: Radiology Authors: Reza Zarinshenas, Peter Campbell, Kai Sun, Jason K. Molitoris, Akshar N. Patel, Matthew E. Witek, Kevin J. Cullen, Ranee Mehra, Kyle M. Hatten, Kelly F. Moyer, Rodney J. Taylor, Kalpesh T. Vakharia, Jeffrey S. Wolf, Matthew J. Ferris Tags: Original Article Source Type: research
Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
We read the paper by Chang and colleagues, titled 'Comparing the Oncologic Outcomes of Proton Therapy and Intensity-Modulated Radiation Therapy for Head and Neck Squamous Cell Carcinoma,' recently published in your journal with great interest [1]. We congratulate for this important real-world (RW) effort attempting to compare proton-beam therapy (PT) with intensity-modulated radiation therapy (IMRT) in head and neck squamous cell carcinoma (HNSCC) patients definitively treated. Pending the initial analysis of the MD Anderson-led IMRT vs IMPT study [NCT02923570], the current results deserve scrutiny. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 1, 2024 Category: Radiology Authors: Ester Orlandi, Giulia Fontana, Lisa Licitra, Carmine Tinelli, Anna Maria Camarda, Cai Grau, Steven Jay Frank Source Type: research
Application of postoperative adjuvant radiotherapy in limited-stage small cell lung cancer: a systematic review and meta-analysis
Small cell lung cancer (SCLC) represents 13% of all lung cancer cases and is divided into limited and extensive stages[1]. Several treatment modalities are available for patients with limited-stage SCLC. The recommended approach in individuals diagnosed with clinical Stages IIB and III involves combining radiation therapy with chemotherapy[2,3]. Patients with clinical Stage I-IIA may be considered for surgical intervention, with the possibility of undergoing surgical resection following a multidisciplinary team consultation. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 1, 2024 Category: Radiology Authors: Chuanhao Zhang, Genghao Zhao, Huajian Wu, Jianing Jiang, Wenyue Duan, Zhijun Fan, Zhe Wang, Ruoyu Wang Tags: Original Article Source Type: research
Dose-dependent changes in cardiac function, strain and remodelling in a preclinical model of heart base irradiation
Advances in conformal radiotherapy (RT) techniques and image-guidance have significantly reduced organs at risk (OAR) exposure, which has been associated with improved safety profiles [1]. However, opportunities remain to further optimise treatments based on the preferential avoidance of discrete radiosensitive subregions of OARs that have functional significance [2]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 30, 2024 Category: Radiology Authors: Mihaela Ghita-Pettigrew, Kevin S. Edgar, Refik Kuburas, Kathryn H. Brown, Gerard M. Walls, Cecilia Facchi, David J. Grieve, Chris J. Watson, Alan McWilliam, Marcel van Herk, Kaye J. Williams, Karl T. Butterworth Tags: Original Article Source Type: research
DNA-dependent protein kinase regulates cytosolic double-stranded DNA secretion from irradiated macrophages to increase radiosensitivity of tumors
Tumor microenvironment is composed of various cell types including not only cancer cells but also endothelial cells, fibroblasts, adipocytes, and immune cells [1]. Macrophages (also known as tumor-associated macrophages, TAM) are a major immune cell population within this microenvironment and have been extensively studied for their role in promoting tumor growth, angiogenesis, and metastasis [2,3]. While TAM are generally associated with poor prognosis in many cancers [4], there are also some reports suggesting their infiltration can be correlated with an improved survival for some types of cancers including the breast [5 ...
Source: Radiotherapy and Oncology - January 26, 2024 Category: Radiology Authors: Taerim Oh, Gi-Sue Kang, Hye-Ju Jo, Hye-Joon Park, Ye-Rim Lee, G-One Ahn Tags: Original Article Source Type: research
Obstructive sleep apnea syndrome: a frequent and difficult-to-detect complication of radiotherapy for oropharyngeal cancers
This pilot study reveals a higher prevalence of obstructive sleep apnea syndrome (OSAS) in patients treated for oropharyngeal squamous cell carcinoma with radiotherapy compared to the general population. OSAS indicators such as the Epworth Sleepiness Scale seem insufficient in the diagnostic approach to OSAS in this population and systematic screenings should be considered. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 25, 2024 Category: Radiology Authors: Florent Carsuzaa, El éonore Chary, Juliette Thariat, Xavier Dufour, Valentin Favier Source Type: research
