Initial Evaluation and External Validation of 68Ga-PSMA-11 PET/CT in Tubarial Gland Characterization
The tubarial glands are a pair of mucosal glands located in the nasopharynx, near the torus tubarius and the posterolateral pharyngeal recess [1] Although they were described by anatomists in 1837 [2,3], these have been reported as na ïve findings in other studies [4,5], and in histological analysis, although referred to as Eustachian tube submucosal glands in such [6,7]. However, these pair of glands were recently named tubarial salivary glands by Valstar et al. in 2021, highlighting their importance as organs at risk in radiot herapy planning and their risk of toxicity [8] (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 30, 2023 Category: Radiology Authors: Luis Adrian Alvarez-Lozada, Estefany Janeth Salinas-Puente, Rodrigo Alejandro Torres-De Le ón, Francisco Javier Arrambide-Garza, Alejandro Quiroga-Garza, Guillermo Elizondo-Riojas, Rodrigo Enrique Elizondo-Omaña, Santos Guzmán-López, José Luis Trevi Tags: Original Article Source Type: research

Pilot Applications of GPT-4 in Radiation Oncology: Summarizing patient symptom intake and targeted chatbot applications
This study explores using GPT-4 for radiation toxicity monitoring in prostate cancer treatments. Two methods were tested: a summarization method and a chatbot interface. Surveyed radiation oncologists preferred the summarization method for its accuracy and potential for adoption (median rating 8 vs 4, p=.002). Both methods saved time. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 30, 2023 Category: Radiology Authors: David JH Wu, Jean-Emmanuel Bibault Source Type: research

On the advice to perform a new MRI within 2  weeks prior to radiotherapy start for glioblastoma according ESTRO-EANO guideline
To the Editor (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 28, 2023 Category: Radiology Authors: M. Maci à i Garau, A. Pons Escoda, N. García Expósito, A. Lucas Calduch Tags: Letter to the Editor Source Type: research

Comparing the Oncologic Outcomes of Proton Therapy and Intensity-Modulated Radiation Therapy for Head and Neck Squamous Cell Carcinoma
To compare the oncologic outcomes between proton therapy and intensity-modulated radiation therapy (IMRT) for head and neck squamous cell carcinoma (HNSCC) patients undergoing curative radiotherapy (RT). (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 28, 2023 Category: Radiology Authors: Chia-Lun Chang, Kuan-Chou Lin, Wan-Ming Chen, Ben-Chang Shia, Szu-Yuan Wu Tags: Original Article Source Type: research

Away from definition and back to the clinic – as response to Kumar et al, ‘Evidence is not sufficient to declare the tubal gland conglomerates as salivary.’
We read with interest the letter of Kumar et al[1]. in response to our recent publication in Radiotherapy and Oncology[2], and our original article describing the tubarial (tubal) glands as a potential new organ at risk in radiotherapy settings[3 –4]. Kumar et al. focus their letter[1], and their previous publication,[4], on their belief that the tubarial glands should be categorized as part of the respiratory tract, and not as salivary gland-like tissue. We would like to take the opportunity to respond to this point. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 28, 2023 Category: Radiology Authors: Sarah Pringle, Floris J Bikker, Wouter Vogel, Bernadette S. de Bakker, Ingrid Hofland, Bert van der Vegt, Hendrika Bootsma, Frans G.M Kroese, Arjan Vissink, Matthijs Valstar Tags: Letter to the Editor Source Type: research

Evidence is not sufficient to declare the tubal gland conglomerates as salivary
We read the article by Pringle et al. [1] presenting histological and immunohistochemical characterization of the submucosal seromucous gland conglomerate at the nasopharyngeal end of the auditory tube (AT) and comparing the same with the major and minor salivary glands. The study aimed to validate a previous work by Valstar et al.[2], which claimed these tubal gland conglomerate as salivary gland. Valstar et al. ’s claim was seen with skepticism in the scholarly community [3,4] as it seemed to challenge the historical recognition of the tubal gland conglomerates as an integral part of AT and, thus, the respiratory tract...
Source: Radiotherapy and Oncology - October 28, 2023 Category: Radiology Authors: Ashutosh Kumar, Ravi Kant Narayan, Chiman Kumari Tags: Letter to the Editor Source Type: research

Paediatric CBCT protocols for image-guided radiotherapy; outcome of a survey across SIOP Europe affiliated countries and literature review
As overall survival (OS) rates in children ’s cancer improve, the prevalence of long-term survivors in this patient group increases. The need for fine-tuning treatment to achieve best OS with minimal late effects has therefore become increasingly more critical [1–3]. Advancements in modern radiotherapy techniques such as the application of 3D volumetric image-guided radiotherapy (IGRT), adaptive radiotherapy (RT) and, in some cases, motion management techniques (e.g. breath-hold), are essential for enabling the accurate delivery of radiation to the target volume whilst sparing nearby organs at risk (OAR). (Source: Radi...
Source: Radiotherapy and Oncology - October 28, 2023 Category: Radiology Authors: Daniella Elisabet Østergaard, Abigail Bryce-Atkinson, Mikkel Skaarup, Bob Smulders, Lucy Siew Chen Davies, Gillian Whitfield, Geert O. Janssens, Lisa Lyngsie Hjalgrim, Ivan Vogelius Richter, Marcel van Herk, Marianne C Aznar, Maja Vestmø Maraldo Tags: Original Article Source Type: research

On the advice to perform a new MRI within 2 weeks prior to radiotherapy start for glioblastoma according ESTRO-EANO guideline
To the Editor (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 28, 2023 Category: Radiology Authors: M. Maci à i Garau, A. Pons Escoda, N. García Expósito, A. Lucas Calduch Tags: Letter to the Editor Source Type: research

FLASH radiotherapy using high-energy X-rays: Current status of PARTER platform in FLASH research
Cancer is a leading cause of mortality worldwide, with an increasing prevalence in developing countries like China due to the rise in life expectancy. Radiotherapy, which has been a proven cancer treatment for over 50 years, faces significant challenges, particularly in developing nations where there is a lack of advanced radiotherapy machines and medical experts. The emerging ultrahigh dose rate (FLASH,>40 Gy/s) radiotherapy has shown promising results in preclinical studies by demonstrating tissue sparing effects while maintaining anti-tumour efficacy compared to conventional low dose rate (CONV, around 0.1 Gy/s) radioth...
Source: Radiotherapy and Oncology - October 27, 2023 Category: Radiology Authors: Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai Tags: Original Article Source Type: research

Real-time motion management in MRI-guided radiotherapy: Current status and AI-enabled prospects
Continuous technological advancements over nearly two decades have led to the commercialization of MRI-guided radiotherapy (MRIgRT), introducing what may be the epitome of image-guided radiotherapy into the clinic [1,2]. By combining a linear accelerator with the superior soft tissue contrast of MRI, MRIgRT offers higher geometric accuracy and treatment efficacy through online adaptation [3-5]. Furthermore, the availability of functional MRI enables exploration of novel strategies such as targeting aggressive or resistant tumour subregions [6,7]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 27, 2023 Category: Radiology Authors: Elia Lombardo, Jennifer Dhont, Denis Page, Cristina Garibaldi, Luise A. K ünzel, Coen Hurkmans, Rob H.N. Tijssen, Chiara Paganelli, Paul Z.Y. Liu, Paul J. Keall, Marco Riboldi, Christopher Kurz, Guillaume Landry, Davide Cusumano, Marco Fusella, Lorenzo P Source Type: research

GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development
Most cancer related deaths are attributed to the development of metastases, which therefore pose a major clinical challenge in cancer treatment (1 –3). The development of metastases is a complex cascade which requires the migration of cancer cells from the primary tumour, invasion into the surrounding tissues, intravasation, immune evasion, extravasation and colonization (4). Hypoxia is a common feature of solid tumours caused by their conti nuous growth, altered energy metabolism and defective vasculature (5,6). (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 26, 2023 Category: Radiology Authors: Joel E.J. Beaumont, Jinzhe Ju, Lydie M.O. Barbeau, Imke Demers, Kim G. Savelkouls, Kasper Derks, Freek G. Bouwman, Marca H.M. Wauben, Marijke I. Zonneveld, Tom G.H. Keulers, Kasper M.A. Rouschop Source Type: research

Meta-analysis of 5-day preoperative radiotherapy for soft tissue sarcoma (5D-PREORTS)
Soft tissue sarcomas (STSs) are a heterogeneous group of malignant tumors originating from mesenchymal tissues, including muscles, fibrous tissues, adipose tissue, nerves, and blood vessels, most frequently in the extremities, trunk, and retroperitoneum [1,2]. They correspond to approximately 1% of malignant tumors, with 13,190 new cases in the USA in 2022 [3]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 24, 2023 Category: Radiology Authors: Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V.S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes Tags: Original Article Source Type: research

Aims+Scope/Editorial Board/Publication information
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 21, 2023 Category: Radiology Source Type: research

Contents
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 21, 2023 Category: Radiology Source Type: research

Letter regarding “Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy”
To the Editor, (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 21, 2023 Category: Radiology Authors: Gavin Poludniowski, Jens Zimmerman Source Type: research