Concurrent chemoradiotherapy versus radiotherapy alone in older patients with stage II Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy: a propensity score-matched cohort study
Nasopharyngeal carcinoma (NPC) is different from other subtypes of head and (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 5, 2024 Category: Radiology Authors: Fang Wang, Lu Zhou, Li-Jun Zhang, Chang-Bin Xie, Zhi-Wei Liao, Xiao-Dan Lin, Yue-Feng Wen Tags: Original Article Source Type: research
Pulmonary vein dose and risk of atrial fibrillation in patients with non-small cell lung cancer following definitive radiotherapy: an NI-HEART analysis
Radiotherapy (RT) is the only definitive treatment option available to patients with non-small cell lung cancer (NSCLC) deemed to be technically or medically inoperable. Contemporary RT results have been improved by the recent introduction of adjuvant immunotherapy, but outcomes remain poor, with (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 4, 2024 Category: Radiology Authors: Gerard M Walls, Conor McCann, John O'Connor, Anna O'Sullivan, David I Johnston, Jonathan McAleese, Conor K McGarry, Aidan J Cole, Suneil Jain, Karl T Butterworth, Gerard G Hanna Tags: Original Article Source Type: research
Selectively sparing of the supraclavicular area during intensity-modulated radiotherapy in nasopharyngeal carcinoma: A double-center observation study
As a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving IMRT for nasopharyngeal carcinoma (NPC), reducing the toxicity of treatment and improving the patient's quality of life (QoL) is particularly important[1-3]. The lower neck in selective omitting clinical target volume (CTV) is one of the areas being explored[4-7].Published literature have confirmed the feasibility of elective ipsilateral upper-neck irradiation with sparing the lower neck in N0 and the contralateral lower neck in N1 and N3 disease[7-12]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 4, 2024 Category: Radiology Authors: Qiaojuan Guo, Tianzhu Lu, Wanfang Huang, Hanchuan Xu, Quxia Zhang, Yun Xiao, Jing Zhong, Honghui Xie, Jihong Chen, Jingfeng Zong, Xiaochang Gong, Jianji Pan, Jingao Li, Shaojun Lin Tags: Original Article Source Type: research
Aims+Scope/Editorial Board/ Publication information
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 1, 2024 Category: Radiology Source Type: research
Contents
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 1, 2024 Category: Radiology Source Type: research
Brachytherapy for high grade prostate cancer induces distinct changes in circulating CD4 and CD8 T cells – implications for systemic control
Patients with high-grade prostate cancer (PCa) are at significant risk for local and distant relapse post treatment. High dose rate brachytherapy (BT) may improve PCa-specific survival and distant metastasis-free survival (DMFS) compared to external beam radiotherapy (EBRT) in conjunction with androgen deprivation therapy (ADT) in Gleason (Gl) 9-10 patients[1,2]. This suggests that BT, despite being a local treatment, may potentially induce immune activation resulting in enhanced systemic control. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - January 1, 2024 Category: Radiology Authors: H. Wang, L. Mendez, G. Morton, A. Loblaw, H.T. Chung, P. Cheung, A. Mesci, V. Escueta, T.N. Petchiny, X. Huang, S.D. White, M. Downes, D. Vesprini, S.K. Liu Tags: Short Communication Source Type: research
LUMINA: Using molecular biomarkers to guide decision making for breast radiotherapy
In this opinion piece, we respond to comments about the LUMINA trial by Meattini and colleagues in the Journal. LUMINA was a prospective cohort study which evaluated the omission of radiotherapy after breast conserving surgery (BCS) in patients treated with endocrine therapy with low risk clinico-pathologic features and luminal A breast cancer. We address their areas of concern including the single cohort design that required careful patient selection, the relatively short follow-up period of 5 years, and the limited follow-up on younger patients. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 30, 2023 Category: Radiology Authors: Timothy J. Whelan, Anthony Fyles, Sameer Parpia, Torsten Nielsen, Mark N. Levine Source Type: research
Oligometastatic Sarcoma treated with Curative intent Ablative Radiotherapy (OSCAR): a multicenter study on behalf of AIRO (Italian Association of Radiotherapy and clinical Oncology)
Soft-tissue sarcomas (STS) are a rare and histologically heterogeneous group of mesenchymal malignancies, accounting for about 1% of adult ’s tumors [1]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 30, 2023 Category: Radiology Authors: D. Franceschini, D. Greto, S. Dicuonzo, F. Navarria, M. Federico, M. La Vecchia, C. Sangalli, A. Allajbej, L. Di Cristina, R. Mazzola, A. Pontoniero, G. Montesi, P. Navarria, D. Baldaccini, E. Clerici, L. Lo Faro, C. Franzese, S. Di Biase, S. Pergolizzi, Tags: Original Article Source Type: research
Pulmonary interstitial lymphography: A prospective trial with potential impact on stereotactic ablative radiotherapy planning for early-stage lung cancer
Stereotactic ablative radiotherapy (SABR) is the standard of care for medically inoperable early-stage non-small cell lung cancer (NSCLC). Extensive evidence demonstrates that SABR is efficacious with low toxicity [1 –2], and an important question is the potential role of SABR in the medically operable setting [3–6]. Several randomized trials comparing SABR to surgical resection continue to accrue (e.g., NCT02468024, NCT02984761, NCT01753414) and preliminary comparisons of SABR vs. lobectomy for early-stage NSCLC indicate that survival is similar and SABR is associated with significantly fewer side effects [3,6]. (Sour...
Source: Radiotherapy and Oncology - December 30, 2023 Category: Radiology Authors: Ryan B. Ko, Jonathan A. Abelson, Dominik Fleischmann, John D. Louie, Gloria L. Hwang, Daniel Y. Sze, Emil Sch üler, Kayla N. Kielar, Peter G. Maxim, Quynh-Thu Le, Wendy H. Hara, Maximilian Diehn, Nishita Kothary, Billy W. Loo Tags: Short Communication Source Type: research
The Organization of Care in Pediatric Radiotherapy across SIOP Europe affiliated centers: A multicenter survey in the Framework of the ‘Joint Action on Rare Cancers’ project
Despite the increased cure rates for pediatric cancers, a significant discrepancy exists in outcomes across Europe. Due to a lack of access to essential and modern components of the multidisciplinary treatment spectrum, disparities in survival rates of more than 20% as well as in late side-effects are a reality [1 –4]. To reduce these inequalities, ‘European Standards of Care for Children with Cancer’ have been defined, consolidating the ideal requirements for pediatric cancer units across the ‘Société Internationale d’Oncologie Pédiatrique’ (SIOP) Europe (SIOPE) affiliated countries [5]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 27, 2023 Category: Radiology Authors: Geert O. Janssens, Beate Timmermann, Anne Laprie, Henry Mandeville, Laetitia Padovani, Cyrus Chargari, Pamela Kearnsh, Olga Kozhaeva, Leila Kameric, Anita Kienesberger, Peter S.N. van Rossum, Tom Boterberg, Yolande Lievens, Gilles Vassal Tags: Original Article Source Type: research
Clinical research for global needs of radiation oncology
The demand for radiotherapy (RT) is increasing worldwide due to population growth as prominently seen in Africa, and increasing population age as prominently seen in Europe. Increasing age, particularly over 60 years, is associated with a significantly increased risk of cancer. Additionally, RT is more often prescribed over other modalities, such as major surgery, for frail, multimorbid and elderly patients. In some regions of the world, more cancers are now being detected earlier and treated more effectively, leading to longer survival but also to the risk of recurrence, new malignancies and late effects. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 27, 2023 Category: Radiology Authors: Michael Baumann, Carol Bacchus, Marianne C. Aznar, Rob P. Coppes, Eric Deutsch, Dietmar Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W.M. Lee, Steffen L öck, Birgitte V. Offersen, David I. Thwaites, Uulke A. van der He Tags: Editorial Source Type: research
The long-term impact of irradiation on functional connectivity in brain circuits involved in memory processes after pediatric posterior fossa tumor
Memory deficit is one of the main neurocognitive outcomes in pediatric posterior fossa tumor (PFT) survivors [1]. Impairments have been shown in declarative memory [2,3] depending mainly on the hippocampus and cortico-hippocampal circuit, in working memory [4 –6] depending mainly on the cerebellum and prefrontal areas, and in motor procedural memory [3,7] depending on the striatum and the cerebellum [8]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 23, 2023 Category: Radiology Authors: Elo ïse BAUDOU, Patrice PERAN, Fatima TENSAOUTI, Germain ARRIBARAT, Jérémie PARIENTE, Nicolas COURBIERES, Lisa POLLIDORO, Anne-Isabelle BERTOZZI, Marion GAMBART, Annick SEVELY, Margaux ROQUES, Anne DUCASSOU, Jérémy DANNA, Jessica TALLET, Christelle D Tags: Original Article Source Type: research
Statin Use Reduces Radiation-Induced Stroke Risk in Advanced Nasopharyngeal Carcinoma Patients
Key points: (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 22, 2023 Category: Radiology Authors: Chuan-Yi Lin, Chia-Lun Chang, Kuan-Chou Lin, Wan-Ming Chen, Ben-Chang Shia, Po-Hsiu Kuo, Szu-Yuan Wu Tags: Original Article Source Type: research
Machine-learning prediction of treatment response to stereotactic body radiation therapy in oligometastatic gynecological cancer: a multi-institutional study
Stereotactic body radiation therapy (SBRT) has been increasingly adopted as an effective method of treatment of limited cancer metastases, owing to the high rates of local control, low risk of toxicities and its potential to be delivered to almost all anatomic sites [1,2]. In particular, SBRT represents today an alternative to metastasectomy in the oligometastatic scenario [3], defined as an intermediate stage of the disease between locoregionally advanced and wide spread metastatic disease, but still treatable curatively [4]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 22, 2023 Category: Radiology Authors: Savino Cilla, Maura Campitelli, Maria Antonietta Gambacorta, Raffaella Michela Rinaldi, Francesco Deodato, Donato Pezzulla, Carmela Romano, Andrei Fodor, Concetta Laliscia, Fabio Trippa, Vitaliana De Sanctis, Edy Ippolito, Martina Ferioli, Francesca Titon Tags: Original Article Source Type: research
Large Institutional Experience of Early Outcomes and Dosimetric Findings with Postoperative Stereotactic Partial Breast Irradiation in Breast Cancer
Accelerated partial breast irradiation (APBI) has been shown to be effective in carefully selected patients, based on evidence from at least 8 prospective randomized trials enrolling over 10,000 women[1,2]. A variety of APBI techniques have been investigated, with external beam techniques such as 3-dimensional conformal radiation therapy and intensity-modulated radiation therapy (IMRT) being favored due to their noninvasiveness and operator independence[3]. A recent meta-analysis showed that APBI was associated with significantly lower rate of acute adverse events compared to whole breast irradiation (WBI), with no differe...
Source: Radiotherapy and Oncology - December 21, 2023 Category: Radiology Authors: Jee Suk Chang, Jeongshim Lee, Frank A. Vicini, Jin Sung Kim, Jihun Kim, Seo Hee Choi, Ik Jae Lee, Yong Bae Kim Tags: Original Article Source Type: research
