A 57-year-old chronic cougher with somatically evoked cough
Publication date: Available online 28 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Federico Lavorini, Giovanni A. Fontana (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 28, 2017 Category: Respiratory Medicine Source Type: research

rHuKGF ameliorates protease/anti-protease imbalance in emphysematous mice
Publication date: Available online 25 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Sudhir Kotnala, Amit Tyagi, Jai Prakash Muyal We attempted to elucidate the beneficial role of rHuKGF supplementation in the amelioration of protease/antiprotease imbalance and TGF-β1 signalling pathway leading to alveolar tissue maintenance in elastase induced emphysematous mice. Thirty two male C57BL mice were divided into four groups i.e. control, emphysema, therapy and rHuKGF only and were oropharyngeally instilled with saline/porcine pancreatic elastase/rHuKGF. Subsequently, lungs from mice were collect...
Source: Pulmonary Pharmacology and Therapeutics - May 26, 2017 Category: Respiratory Medicine Source Type: research

Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma
Publication date: Available online 23 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Henrik Watz, Mohib Uddin, Frauke Pedersen, Anne Kirsten, Torsten Goldmann, Florian Stellmacher, Espen Groth, Bengt Larsson, Gerhard Böttcher, Anna Malmgren, Maarten Kraan, Klaus F. Rabe (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 23, 2017 Category: Respiratory Medicine Source Type: research

Bronchodilator therapy for chronic cough
Publication date: Available online 17 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Maria Gabriella Matera, Paola Rogliani, Alessandro Zanasi, Mario Cazzola Experimental studies indicate that airway calibre increases the sensitivity of the afferents involved in the cough reflex but it has proved difficult to demonstrate that airway calibre increases the sensitivity of the afferents involved in the cough reflex. Therefore, bronchodilators might have a role, although rather minor, in the treatment of cough. However, although bronchodilators represent the standard of care in the treatment of airway...
Source: Pulmonary Pharmacology and Therapeutics - May 18, 2017 Category: Respiratory Medicine Source Type: research

Blocking voltage-gated sodium channels as a strategy to suppress pathological cough
Publication date: Available online 15 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Hui Sun, Marian Kollarik, Bradley J. Undem Pathological cough is thought to be secondary to inappropriate activation of vagal sensory nerves. Sensory nerves can be activated by a large number of disparate stimuli. The most relevant stimuli to block for effective anti-tussive therapy likely depend on the specific underlying pathology that is leading to the coughing. Blocking voltage-gated sodium channels (NaV) will prevent action potential initiation and conduction and therefore prevent sensory communication betwe...
Source: Pulmonary Pharmacology and Therapeutics - May 15, 2017 Category: Respiratory Medicine Source Type: research

TRPA1 receptors in chronic cough
Publication date: Available online 12 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Alyn H. Morice (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 13, 2017 Category: Respiratory Medicine Source Type: research

Adiponectin down-regulates CREB and inhibits proliferation of A549 lung cancer cells
Conclusions Overall, our results represent the first evidence of CREB inhibition by adiponectin and may provide new insight into therapeutic strategies for lung cancer. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 12, 2017 Category: Respiratory Medicine Source Type: research

Cough associated with gastro-oesophageal reflux disease (GORD): Japanese experience
Publication date: Available online 12 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Akio Niimi Differences in the aetiology as well as patient background of chronic cough have been recognised among US, UK, and Japan. One of the marked differences has been the prevalence of gastro-oesophageal reflux disease (GORD), which has been one of the top three causes in Western countries. It was indeed uncommon or rare in Japan, but, with the increasing prevalence of GOR itself, chronic cough associated with GORD seems to have become more common. In this article, cough associated with GORD will be reviewed...
Source: Pulmonary Pharmacology and Therapeutics - May 12, 2017 Category: Respiratory Medicine Source Type: research

Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases
Publication date: Available online 11 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Tinne C.J. Mertens, Harry Karmouty-Quintana, Christian Taube, Pieter S. Hiemstra Asthma and chronic obstructive pulmonary disease (COPD) are considered as two distinct obstructive diseases. Both chronic diseases share a component of airway epithelial dysfunction. The airway epithelium is localized to deal with inhaled substances, and functions as a barrier preventing penetration of such substances into the body. In addition, the epithelium is involved in the regulation of both innate and adaptive immune responses...
Source: Pulmonary Pharmacology and Therapeutics - May 11, 2017 Category: Respiratory Medicine Source Type: research

IL-13 and idiopathic pulmonary fibrosis: Possible links and new therapeutic strategies
Publication date: Available online 10 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Giovanni Passalacqua, Marcello Mincarini, Daniele Colombo, Giuseppe Troisi, Marta Ferrari, Diego Bagnasco, Francesco Balbi, Annamaria Riccio, Giorgio Walter Canonica The recent advances in the knowledge of immunological aspects of many pulmonary diseases, allowed to identify cells, biological functions, cytokines, and receptors that are preferentially involved in each disease. This is the case of asthma, where IL-13 (together with IL-4) is recognized as a central mediator. The role of IL-13 is strictly related, v...
Source: Pulmonary Pharmacology and Therapeutics - May 10, 2017 Category: Respiratory Medicine Source Type: research

Adenosine A2A receptors are up-regulated and control the activation of human alveolar macrophages
Publication date: Available online 9 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Tiago Manuel Alfaro, Diana Isabel Rodrigues, Ângelo Ribeiro Tomé, Rodrigo Antunes Cunha, Carlos Robalo Cordeiro Chronic inflammatory lung diseases remain a health concern and new anti-inflammatory treatments are needed. Targeting adenosine A2A receptors (A2AR) affords robust anti-inflammatory effects in animal models, but the translation of this promising strategy to humans has been challenging, possibly due to interspecies differences in receptor distribution and effects. Thus, we now assessed the ef...
Source: Pulmonary Pharmacology and Therapeutics - May 9, 2017 Category: Respiratory Medicine Source Type: research

Lipopolysaccharide (LPS) induced pulmonary neutrophil recruitment and platelet activation is mediated via the P2Y1 and P2Y14 receptors in mice
Publication date: Available online 6 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): R.T. Amison, S. Arnold, B.G. O'Shaughnessy, S.J. Cleary, J. Ofoedu, M. Idzko, C.P. Page, S.C. Pitchford Platelet activation occurs during host defence and in various inflammatory disorders. In animal models of infection and inflammation, experimental depletion of platelets leads to significantly reduced leukocyte recruitment and impaired clearance of pathogens from the lung. It is now appreciated that purinergic receptor activation is required for leukocyte activation, motility and adhesion, and platelet interacti...
Source: Pulmonary Pharmacology and Therapeutics - May 7, 2017 Category: Respiratory Medicine Source Type: research

The role of iNKT cells on the phenotypes of allergic airways in a mouse model
Publication date: Available online 5 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Lennart K.A. Lundblad, Nazey Gülec, Matthew E. Poynter, Victoria L. DeVault, Oliver Dienz, Jonathan E. Boyson, Nirav Daphtary, Minara Aliyeva, Jennifer L. Ather, Felix Scheuplein, Robert Schaub iNKT cells and mast cells have both been implicated in the syndrome of allergic asthma through their activation-induced release of Th2 type cytokines and secretion of histamine and other mediators, respectively, which can promote airways hyperresponsiveness (AHR) to agents such as methacholine. However, a mechanistic l...
Source: Pulmonary Pharmacology and Therapeutics - May 5, 2017 Category: Respiratory Medicine Source Type: research

Losartan, a selective antagonist of AT1 receptor, attenuates seawater inhalation induced lung injury via modulating JAK2/STATs and apoptosis in rat
Publication date: Available online 5 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Congcong Li, Liyan Bo, Pengcheng Li, Xi Lu, Wangping Li, Lei Pan, Yani Sun, Deguang Mu, Wei Liu, Faguang Jin Losartan is a selective antagonist of AngⅠ type (AT1) receptor of Angiotensin Ⅱ (Ang Ⅱ), which is widely used as a clinical medicine for the hypertension. Recent studies have shown that losartan was shown to protect from acute lung injury (ALI). However, the underlying mechanism remains unclear. The aim of this research was to clarify whether Ang Ⅱ participated in the inflammatory response of ALI in...
Source: Pulmonary Pharmacology and Therapeutics - May 5, 2017 Category: Respiratory Medicine Source Type: research

Cough management in primary, secondary and tertiary settings
Publication date: Available online 2 May 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Kay Wang, Nikki Milojevic, Bryan Sheinman, Omar S. Usmani This review reflects upon the management of cough in primary, secondary and tertiary care settings. It reviews the burden of cough, the diagnostic tools employed to investigate the cause of cough and pragmatic treatment strategies. A clinical case vignette presenting in primary care highlights the challenges of managing cough by family practitioners. An approach to establishing a persistent cough clinic service in secondary care is described. Finally, the e...
Source: Pulmonary Pharmacology and Therapeutics - May 2, 2017 Category: Respiratory Medicine Source Type: research

Aerosolized tobramycin for Pseudomonas aeruginosa ventilator-associated pneumonia in patients with acute respiratory distress syndrome
Conclusion Aerosolized tobramycin was an effective therapeutic strategy for P. aeruginosa VAP patients with ARDS. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 24, 2017 Category: Respiratory Medicine Source Type: research

Clinical outcome associated with the use of different inhalation method with and without humidification in asthmatic mechanically ventilated patients
Conclusions VMN to deliver aerosol in ventilated patient resulted in trend to decreased ICU-days compared to JN and MDI-AV. Aerosol-delivery with or without humidification did not have any significant effect on any of parameters studied. However, we recommend increasing the number of patients studied to corroborate this finding. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 20, 2017 Category: Respiratory Medicine Source Type: research

Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect
Publication date: Available online 13 April 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Brijeshkumar S. Patel, Michael J. Kugel, Gina Baehring, Alaina J. Ammit The xanthine doxofylline has been examined in clinical trials and shown to have efficacy and greater tolerability than theophylline in asthma and chronic obstructive pulmonary disease. The ‘novofylline’ doxofylline has demonstrated bronchodilatory and anti-inflammatory actions in in vivo and ex vivo experimental models of respiratory disease. However, there are limited studies in vitro. We address this herein and examine whether...
Source: Pulmonary Pharmacology and Therapeutics - April 14, 2017 Category: Respiratory Medicine Source Type: research

Cough in exercise and athletes
This article provides an overview of the current state of knowledge of exercise-associated cough in athletes. The article summarises our understanding of pathophysiological basis of cough in this context and provides a pragmatic clinical approach to this problem. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 12, 2017 Category: Respiratory Medicine Source Type: research

Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients
Conclusions Asthmatic patients exhibit hypersensitivity to aerosolized AMP and ATP, but aerosolized AMP does not mimic the effects of ATP and the effects of ATP are not mediated by adenosine. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 10, 2017 Category: Respiratory Medicine Source Type: research

Response to the article “Sorafenib as a potential strategy for refractory pulmonary arterial hypertension”
Publication date: Available online 4 April 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Jason Weatherald, Marc Humbert, Christophe Guignabert, David Montani (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 4, 2017 Category: Respiratory Medicine Source Type: research

Autophagy induction by celastrol augments protection against bleomycin-induced experimental pulmonary fibrosis in rats: Role of adaptor protein p62/ SQSTM1
This study is aimed to investigate whether impaired autophagic activity leads to fibrosis and pharmacological induction of autophagy provides protection against bleomycin (BLM)-induced PF. A single dose of BLM (3 U/kg body weight) was administered intratracheally to induce fibrosis in rats. Celastrol, a triterpenoid (5 mg/kg/body weight, intraperitoneally) was given in every 81 h for a period of 28 days. Western blot and Confocal microscopic analysis of rat lung tissue samples revealed that celastrol induces autophagy in BLM-induced rats. Transmission electron microscopic analysis supports the above findings. Cel...
Source: Pulmonary Pharmacology and Therapeutics - April 4, 2017 Category: Respiratory Medicine Source Type: research

Role of dual bronchodilators in COPD: A review of the current evidence for indacaterol/glycopyrronium
Publication date: Available online 4 April 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Joachim H. Ficker, Klaus F. Rabe, Tobias Welte In this review, we summarize the rationale for combining long-acting bronchodilators in the management of chronic obstructive pulmonary disease (COPD), and the evidence for the long-acting bronchodilator combination indacaterol/glycopyrronium (IND/GLY). Clinical practice guidelines generally recommend the use of long-acting bronchodilators in the treatment of patients with all severities of COPD, either as a first-choice or alternative-choice therapy. Combining clas...
Source: Pulmonary Pharmacology and Therapeutics - April 4, 2017 Category: Respiratory Medicine Source Type: research

Physiotherapy and Speech and Language therapy intervention for chronic cough
Publication date: Available online 4 April 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Surinder S. Birring, Sarah Floyd, Charles C. Reilly, Peter Siu Pan Cho There are few effective pharmacological therapies available to treat refractory chronic cough. Functional MRI studies of the brain have recently shown that patients with chronic cough have dysfunctional inhibitory control of cough. Self-management therapies delivered by physiotherapists or speech therapists are effective at suppressing cough. They enable patients to consciously suppress the urge to cough. The intervention consists of educatio...
Source: Pulmonary Pharmacology and Therapeutics - April 4, 2017 Category: Respiratory Medicine Source Type: research

Lung cancer in patients with idiopathic pulmonary fibrosis
Publication date: Available online 1 April 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Theodoros Karampitsakos, Vasilios Tzilas, Rodoula Tringidou, Paschalis Steiropoulos, Vasilis Aidinis, Spyros A. Papiris, Demosthenes Bouros, Argyris Tzouvelekis Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease of unknown etiology. With a gradually increasing worldwide prevalence and a mortality rate exceeding that of many cancers, IPF diagnosis and management are critically important and require a comprehensive multidisciplinary approach. This approach also involves assessment of comorbid c...
Source: Pulmonary Pharmacology and Therapeutics - April 1, 2017 Category: Respiratory Medicine Source Type: research

How to unveil chronic respiratory diseases in clinical practice? A model of alliance between general practitioners and pulmonologists
Conclusion In conclusion, the collaboration between GPs and pulmonologists based on a pro-active approach to the individuals attending the primary care offices followed by an in-house intervention by specialists may largely improve the diagnosis and management of chronic respiratory diseases. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 28, 2017 Category: Respiratory Medicine Source Type: research

Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways
Conclusions UA attenuates CS-induced rat emphysema by down-regulating PERK pathway to alleviate CS-induced apoptosis in lung, and up-regulating Nrf2 pathway to improve cigarette smoke-induced oxidant stress in rat lungs. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 27, 2017 Category: Respiratory Medicine Source Type: research

Asthma management in a specialist setting: Results of an Italian Respiratory Society survey
Conclusions The results of this survey support re-evaluation of asthma management by Italian specialists. More resources should be made available for the initial visit and for more severely ill patients. In addition, more extensive use should be made of validated tools, and available drugs should be used more appropriately. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 22, 2017 Category: Respiratory Medicine Source Type: research

A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices
In this study, we determined the Ki value for inhibition of the MYST type histone acetyltransferase KAT8 by MG149 to be 39 ± 7.7 μM. Upon investigating whether the inhibition of histone acetyltransferases by MG149 correlates with inhibition of histone acetylation in murine precision-cut lung slices, inhibition of acetylation was observed using an LC-MS/MS based assay on histone H4 res 4–17, which contains the target lysine of KAT8. Following up on this, upon treatment with MG149, reduced pro-inflammatory gene expression was observed in lipopolysaccharide and interferon gamma stimulated murine...
Source: Pulmonary Pharmacology and Therapeutics - March 17, 2017 Category: Respiratory Medicine Source Type: research

FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury
Publication date: Available online 16 March 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): David R. Gendron, Anne-Marie Lemay, Pascale Blais Lecours, Valérie Perreault-Vallières, Carole-Ann Huppé, Ynuk Bossé, Marie-Renée Blanchet, Geneviève Dion, David Marsolais Fibrosis complicates numerous pathologies including interstitial lung diseases. Sphingosine analogs such as FTY720 can alleviate lung injury-induced fibrosis in murine models. Contradictorily, FTY720 also promotes in vitro processes normally leading to fibrosis and high doses in vivo foster lung fibro...
Source: Pulmonary Pharmacology and Therapeutics - March 17, 2017 Category: Respiratory Medicine Source Type: research

Involvement of epithelial-mesenchymal transition afforded by activation of LOX-1/ TGF- β1/KLF6 signaling pathway in diabetic pulmonary fibrosis
Conclusions EMT was involved in the pathological process of diabetic pulmonary fibrosis, which was activated by LOX-1/TGF-β1/KLF6 signaling pathway. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 17, 2017 Category: Respiratory Medicine Source Type: research

Vibrating-mesh nebulizer maintenance by CF patients: Results from a French survey
Conclusions Efforts about education, particularly for the maintenance of the mesh, are needed for CF patients using a vibrating-mesh nebulizer at home. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 16, 2017 Category: Respiratory Medicine Source Type: research

Neutralization of both IL-1 α/IL-1β plays a major role in suppressing combined cigarette smoke/virus-induced pulmonary inflammation in mice
Publication date: Available online 15 March 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Hannes Bucher, Samuel Mang, Martina Keck, Michèl Przibilla, David Lamb, Felix Schiele, Mareike Wittenbrink, Klaus Fuchs, Birgit Jung, Klaus J. Erb, Daniel Peter Smoking is an important risk factor for the development of chronic obstructive pulmonary disease (COPD) and viral infections are believed to be major triggers of exacerbations, which periodically lead to a worsening of symptoms. The pro-inflammatory IL-1 family members IL-1α and IL-1β are increased in COPD patients and might contribute...
Source: Pulmonary Pharmacology and Therapeutics - March 16, 2017 Category: Respiratory Medicine Source Type: research

Sorafenib as a potential strategy for refractory pulmonary arterial hypertension
In conclusion, sorafenib had favorable effects to improve symptoms and objective variables in patients with refractory PAH, with tolerable adverse events. Sorafenib is an alternative strategy for patients with refractory PAH. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 16, 2017 Category: Respiratory Medicine Source Type: research

XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts
In conclusion, this is the first study describing the involvement of XPLN in the regulation of SPARC. These findings may help uncover the regulatory mechanisms of the mTORC2-SPARC axis. The up-regulation of XPLN by HDAC inhibitors may be a novel therapeutic approach in patients with IPF. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 15, 2017 Category: Respiratory Medicine Source Type: research

Effect of angiotensin 2 receptor blockers on chronic obstructive lung disease mortality: A retrospective cohort study
Discussion ARBs use seems to be associated to a lower mortality in patients with COPD. Additional studies are needed to corroborate this finding. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 15, 2017 Category: Respiratory Medicine Source Type: research

Immunomodulatory effects of pidotimod in adults with community-acquired pneumonia undergoing standard antibiotic therapy
We examined the immunomodulatory activity of Pidotimod (PDT), a synthetic dipeptide molecule in adult patients hospitalized for CAP. Sixteen patients with a diagnosis of CAP and a PSI score III or IV and/or a CURB-65 0–2 were randomized to receive either levofloxacin 500 mg b.i.d. alone or levofloxacin plus PDT (800mg, 2 daily doses). Blood samples were drawn at baseline (T0), before initiation of therapy, as well as 3 (T3), and 5 (T5) days after initiation of therapy. Immunologic and clinical parameters were analyzed at each time point. Supplementation of antibiotic therapy with PDT resulted in an upregula...
Source: Pulmonary Pharmacology and Therapeutics - March 14, 2017 Category: Respiratory Medicine Source Type: research

Can the response to Omalizumab be influenced by treatment duration? A real-life study
Conclusion In real-life, the positive Omalizumab response remained stable for over 60 months. Long term Omalizumab treatment may lead to a discontinuation of some associated medications and to a slowing down of FEV1 decline. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 14, 2017 Category: Respiratory Medicine Source Type: research

Effects of early administration of acetazolamide on the duration of mechanical ventilation in patients with chronic obstructive pulmonary disease or obesity-hypoventilation syndrome with metabolic alkalosis. A randomized trial
Conclusions Among patients with MA and COPD or OHS, early treatment with ACTZ did not shorten significantly the duration of MV compared with placebo. Trial registry clinical.trials.gov; NCT01499485; URL: www.clinicalrials.gov. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 8, 2017 Category: Respiratory Medicine Source Type: research

Prognostic effects of rosuvastatin in patients with co-existing chronic obstructive pulmonary disease and chronic heart failure: A sub-analysis of GISSI-HF trial
Conclusions Statin use is not associated with a beneficial effects on all cause, CV, non CV mortality and hospitalization in patients with coexistent chronic HF and history of COPD. ClinicalTrials.gov Identifier: NCT00336336 (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 3, 2017 Category: Respiratory Medicine Source Type: research

The earlier, the better: Impact of early diagnosis on clinical outcome in idiopathic pulmonary fibrosis
Conclusions The importance of early and accurate diagnosis of IPF cannot be underestimated and it is the duty of all healthcare professionals to be vigilant to the symptoms of IPF and to involve a multidisciplinary team in diagnosing and managing IPF early in the course of disease. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 1, 2017 Category: Respiratory Medicine Source Type: research

Methacholine challenge tests to demonstrate therapeutic equivalence of terbutaline sulfate via different Turbuhaler ® devices in patients with mild to moderate asthma: Appraisal of a four-way crossover design
Conclusions Bronchoprotection using a standardised methacholine challenge model proved to be an effective design to elucidate therapeutic equivalence between devices in patients with mild-to-moderate asthma. The findings indicate that patients may switch from one type of Turbuhaler® to the other without adjustment of therapy. Moreover, they show the robustness and utility of this study design and its suitability for investigating therapeutic equivalence. EudraCT Number 2014-001457-16. Clinicaltrials.gov identifier NCT02322788. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 21, 2017 Category: Respiratory Medicine Source Type: research

Do cystic fibrosis patients on azithromycin need electrocardiogram monitoring?
Publication date: Available online 17 February 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Rachel Sharpton, Mario Cazzola (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 18, 2017 Category: Respiratory Medicine Source Type: research

Advances in mechanisms and management of chronic cough: The Ninth London International Cough Symposium 2016
Publication date: Available online 16 February 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Kian Fan Chung At the Ninth London International Cough Symposium held in June 2016, advances in chronic cough were presented. Chronic cough has been labelled as a cough hypersensitivity syndrome (CHS) with neuroinflammatory mechanisms likely to be the underlying mechanisms. The concept is that there is a stage of peripheral sensitisation induced by inflammatory factors setting up the scene for a central component that can be visualised by functional magnetic resonance imaging. There has also been progress in...
Source: Pulmonary Pharmacology and Therapeutics - February 17, 2017 Category: Respiratory Medicine Source Type: research

Mastery of pMDI technique, asthma control and quality-of-life of children with asthma: A randomized controlled study comparing two inhaler technique training approaches
Conclusions The TH improved the inhalation flow through the pMDI close to the ideal needed for adequate lung deposition. Both methods equally enhanced the children's mastery of pMDI use. This was reflected on better AC and QoL. Accessibility to TH might help maintaining the good inhaler use and decreasing regular VC. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 17, 2017 Category: Respiratory Medicine Source Type: research

Effect of tobacco and electronic cigarette use on cough reflex sensitivity
Publication date: Available online 6 February 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Peter V. Dicpinigaitis Multiple previous studies have shown that otherwise healthy tobacco cigarette smokers have suppressed cough reflex sensitivity compared with nonsmokers and furthermore, that smoking cessation, even after years of tobacco use, leads to prompt enhancement of cough reflex sensitivity. Thus, cough reflex sensitivity is demonstrated to be a dynamic phenomenon, responding to the presence or absence of influences such as tobacco smoke. These studies, however, were unable to identify whether it...
Source: Pulmonary Pharmacology and Therapeutics - February 7, 2017 Category: Respiratory Medicine Source Type: research

Reslizumab in patients with inadequately controlled late-onset asthma and elevated blood eosinophils
Conclusions Compared with placebo, reslizumab produced larger reductions in asthma exacerbations and larger improvements in lung function in patients with late versus early-onset asthma. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 1, 2017 Category: Respiratory Medicine Source Type: research

Effect of calcium channel blockers evaluated by cardiopulmonary exercise testing in idiopathic pulmonary arterial hypertension responding to acute pulmonary vasoreactivity testing
Conclusions Ventilatory efficiency in patients with VR-IPAH is better than that in patients with VNR-IPAH. CCB can improve aerobic capacity and ventilatory efficiency during exercise in patients with VR-IPAH. Clinical trial registration number: ClinicalTrials.gov:NCT02061787. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 1, 2017 Category: Respiratory Medicine Source Type: research

Central mechanisms of airway sensation and cough hypersensitivity
Publication date: Available online 27 January 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Alexandria K. Driessen, Alice E. McGovern, Monica Narula, Seung-Kwon Yang, Jennifer A. Keller, Michael J. Farrell, Stuart B. Mazzone The airway sensory nervous system is composed of two anatomically distinct processing pathways that allow for the production of respiratory reflexes and voluntary evoked respiratory behaviours in response to sensing an airway irritation. Disordered sensory processing is a hallmark feature of many pulmonary disorders and results in the development of cough hypersensitivity syndro...
Source: Pulmonary Pharmacology and Therapeutics - January 28, 2017 Category: Respiratory Medicine Source Type: research

Obituary for Dr Dom Spina (25/11/62 –5/12/16)
Publication date: February 2017 Source:Pulmonary Pharmacology & Therapeutics, Volume 42 (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - January 27, 2017 Category: Respiratory Medicine Source Type: research