Tardive Dyskinesia Suppression Seen During Catatonic State: A Case Report
A 53 year old female with a history of schizophrenia and tardive dyskinesia presented with catatonia following several weeks of disorganized behavior and delusional beliefs. According to history obtained by family, her schizophrenia had been successfully treated for approximately 30 years with clozapine. Upon admission, the patient had no physical signs of tardive dyskinesia or extrapyramidal symptoms (EPS). With the administration of lorazepam over the next few days, the patient's catatonia improved greatly. (Source: Psychosomatics)
Source: Psychosomatics - July 28, 2018 Category: Psychiatry & Psychology Authors: Aaron Pierce, Douglas Coker Tags: Case Report Source Type: research

Thirty years of both ignorance and clinical experience suggest that clozapine intoxication during co-occurring infections and inflammation may have higher morbidity and mortality than is currently believed
We1 previously described a massive increase in clozapine serum concentrations during pneumonia. Based on that case, prior published cases, and our clinical experience, we recommended that for clozapine patients with severe infections or inflammations, the clinician order clozapine therapeutic drug monitoring (TDM) and, when TDM is not possible, consider cutting the clozapine dose in half. Leung2 provided an intelligent commentary on our case. We only disagree with two of his statements: 1) a dose reduction by half may not be appropriate for all patients with infection, especially in the absence of adverse drug reactions (A...
Source: Psychosomatics - July 25, 2018 Category: Psychiatry & Psychology Authors: Can-Jun Ruan, Jose de Leon Tags: Letter to the Editor Source Type: research

Hospital length of stay with a proactive psychiatric consultation model in the medical intensive care unit: a prospective cohort analysis
Previous studies have demonstrated that proactive psychiatric consultation reduces hospital length of stay (LOS) in the general medical setting, however this model has not been studied in intensive care units (ICU). (Source: Psychosomatics)
Source: Psychosomatics - July 25, 2018 Category: Psychiatry & Psychology Authors: Melissa Bui, Robyn P. Thom, Shelley Hurwitz, Nomi C. Levy-Carrick, Molly O'Reilly, Dara Wilensky, Daniel Talmasov, Bonnie Blanchfield, Vineeta Vaidya, Rose Kakoza, Michael Klompas, Elizabeth Stanley, David Gitlin, Anthony Massaro Tags: Original Research Article Source Type: research

A survey of clinical approaches to suicide risk assessment for patients intoxicated on alcohol
This study aims to describe practice patterns among expert practitioners for timing the suicide risk assessment for an intoxicated patient. (Source: Psychosomatics)
Source: Psychosomatics - July 23, 2018 Category: Psychiatry & Psychology Authors: Scott A. Simpson Tags: Original research article Source Type: research

Autoimmune Encephalopathy Beyond Anti-NMDAR Encephalitis: The Case of an Adolescent Male with AntiAcetylcholine Receptor Ganglionic Neuronal Antibody Encephalitis
Autoimmune encephalitis is an increasingly recognized disease process in the differential assessment of youth presenting with acute altered mental status or psychosis. Much of the recent evidence relating to autoimmune encephalitis in the past 10 years relates to anti-N-methyl D-aspartate receptor (anti-NMDAR) encephalitis. Anti-NMDAR encephalitis was first reported by Dalmau et al. in 2007 and is the most common noninfectious cause of encephalitis.1,2 However, there are other less common causes of autoimmune encephalitis that are important to consider in the differential of acute altered mental status in youth. (Source: Psychosomatics)
Source: Psychosomatics - July 20, 2018 Category: Psychiatry & Psychology Authors: Ferdnand C. Osuagwu, Sarah S. Mohiuddin, Nasuh Malas Tags: Case Report Source Type: research

The neuroanatomy of Somatoform Disorders: a Magnetic Resonance Imaging study
Somatoform Disorders (SD) are a heterogeneous group of psychiatric syndromes characterized by common symptoms, which may mimic a physical condition but they are not explained by a medical condition. Although the biological nature of this disorder has been widely accepted, the neuroanatomical correlates characterizing SD are still inconclusive. Therefore, this study aims to explore GM volume alterations in SD patients compared to HC and their possible association with clinical and cognitive measures. (Source: Psychosomatics)
Source: Psychosomatics - July 20, 2018 Category: Psychiatry & Psychology Authors: G Delvecchio, MG Rossetti, E Caletti, A Arighi, D Galimberti, P Basilico, M Mercurio, RA Paoli, C Cinnante, F Triulzi, AC Altamura, E Scarpini, P Brambilla Tags: Original Research Article Source Type: research

Autoimmune Encephalopathy Beyond Anti-NMDAR Encephalitis: The Case of an Adolescent Male with Anti-Acetylcholine Receptor Ganglionic Neuronal Antibody Encephalitis
Since the discovery of anti-N-Methyl D-Aspartate Receptor (anti-NMDAR) encephalitis in 2007, there has been a growing awareness of autoimmune encephalitis as a diagnostic consideration in the patient presenting with altered mental status. Anti-acetylcholine receptor ganglionic neuronal antibody (Anti-AchR GN Ab) encephalitis is a rare cause of autoimmune encephalitis only previously reported in a large epidemiologic study of an adult cohort. It is characterized with prominent dysautonomia and rarely considered in the differential of autoimmune encephalitis, particularly in youth. (Source: Psychosomatics)
Source: Psychosomatics - July 20, 2018 Category: Psychiatry & Psychology Authors: Ferdnand C. Osuagwu, Sarah S. Mohiuddin, Nasuh Malas Tags: Case Report Source Type: research

A New Measure of Health Numeracy: Brief Medical Numbers Test (BMNT)
Approximately half of Americans have inadequate health literacy, which leads to poorer health outcomes. Health numeracy is an important component of literacy, which reflects one's ability to understand and manipulate numbers. This is especially important for transplant candidates, as adherence to medical recommendations is essential for post-transplant care. Although validated measures of numeracy exist, they can be inconvenient and timely to administer. (Source: Psychosomatics)
Source: Psychosomatics - July 19, 2018 Category: Psychiatry & Psychology Authors: Kate E. Dykhuis, Linda Slowik, Kelly Bryce, Maren E. Hyde-Nolan, Anne Eshelman, Lisa Renee Miller-Matero Tags: Original Research Article Source Type: research

Tianeptine Abuse and Dependence: Case Report and Literature Review
Tianeptine (Stablon, Coaxil) abuse and dependence has become increasingly prominent worldwide with recent presence in the United States. However, no comprehensive review of cases has been conducted focusing on acute presentation to fatal intoxication and methods of management. In this article, we add a case to the growing literature on tianeptine dependence, the first of which is concerning for the presence of an adulterant, and present a comprehensive literature review. (Source: Psychosomatics)
Source: Psychosomatics - July 19, 2018 Category: Psychiatry & Psychology Authors: Rahul Lauhan, Alan Hsu, Al Alam, Kristin Beizai Tags: Review Article Source Type: research

The 2018 ISHLT/APM/AST/ICCAC/STSW recommendations for the psychosocial evaluation of adult cardiothoracic transplant candidates and candidates for long-term mechanical circulatory support
The psychosocial evaluation is well-recognized as an important component of the multifaceted assessment process to determine candidacy for heart transplantation, lung transplantation, and long-term mechanical circulatory support (MCS). However, there is no consensus-based set of recommendations for either the full range of psychosocial domains to be assessed during the evaluation, or the set of processes and procedures to be used to conduct the evaluation, report its findings, and monitor patients ’ receipt of and response to interventions for any problems identified. (Source: Psychosomatics)
Source: Psychosomatics - July 10, 2018 Category: Psychiatry & Psychology Authors: Mary Amanda Dew, Andrea F. DiMartini, Fabienne Dobbels, Kathleen L. Grady, Sheila G. Jowsey-Gregoire, Annemarie Kaan, Kay Kendall, Quincy-Robyn Young, Susan E. Abbey, Zeeshan Butt, Catherine C. Crone, Sabina De Geest, Christina T. Doligalski, Christiane K Tags: Editorial Source Type: research

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(Source: Psychosomatics)
Source: Psychosomatics - July 10, 2018 Category: Psychiatry & Psychology Authors: author name Tags: Original Research Article Source Type: research

Severe aggression after perampanel overdose: case report
Perampanel (PER) is a non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, first in its pharmacologic class to be proposed as an anticonvulsant. As a relatively new agent, systematic reviews and reports on this drug's benefits and adverse effects are still quite limited. This is the first case report of PER overdose in a patient without a previously documented history of seizure disorder or existing prescription of PER, and it is the second case report of any PER overdose. (Source: Psychosomatics)
Source: Psychosomatics - July 10, 2018 Category: Psychiatry & Psychology Authors: Carrie C. Wu, Michael McShane, Eileen A. Huttlin, Kenneth C. Novoa Tags: Case Report Source Type: research

Clozapine-Associated Aspiration Pneumonia: Case Series and Review of the Literature: Reply
We read with interest the recent report by Dr. Jonathan Kaplan and colleagues,1 in which they describe 2 patients who developed aspiration pneumonia in the context of clozapine initiation. They rightly underscore the need for clinicians to be alert to the increased risk of pneumonia with the use of antipsychotic medications, especially second generation agents, and review emerging evidence that aspiration pneumonia in particular is a potential complication of treatment with clozapine. In addition to their own cases, they identified 4 prior reports of clozapine-associated pneumonia in which aspiration was strongly implicate...
Source: Psychosomatics - July 9, 2018 Category: Psychiatry & Psychology Authors: Ronald J. Gurrera, Nicole L. Perry Tags: Letter to the Editor Source Type: research

Clozapine-Associated Aspiration Pneumonia: Case Series and Review of the Literature. Reply
We read with interest the recent report by Dr. Jonathan Kaplan and colleagues,1 in which they describe 2 patients who developed aspiration pneumonia in the context of clozapine initiation. They rightly underscore the need for clinicians to be alert to the increased risk of pneumonia with the use of antipsychotic medications, especially second generation agents, and review emerging evidence that aspiration pneumonia in particular is a potential complication of treatment with clozapine. In addition to their own cases, they identified 4 prior reports of clozapine-associated pneumonia in which aspiration was strongly implicate...
Source: Psychosomatics - July 9, 2018 Category: Psychiatry & Psychology Authors: Ronald J. Gurrera, Nicole L. Perry Tags: Letter to the Editor Source Type: research

Low plasma cholinesterase activity is associated with postoperative delirium after noncardiac surgery in elderly patients: A prospective observational study
Postoperative delirium (POD) commonly occurs in elderly patients after noncardiac surgery, resulting in increased morbidity and greater risk of death. However, its pathophysiology is currently unknown. Cholinergic dysfunction has been implicated in delirium pathophysiology, and low plasma cholinesterase activity has been reported as a risk marker of POD. Therefore, the aim of this study was to investigate the link between plasma cholinesterase activity and POD in elderly Han Chinese patients after noncardiac surgery. (Source: Psychosomatics)
Source: Psychosomatics - July 9, 2018 Category: Psychiatry & Psychology Authors: Bao Zhao, Yuhua Ni, Xingsong Tian Tags: Original Research Article Source Type: research