Psychiatry and Clinical Neurosciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Reduced Prefrontal Hemodynamic Response in Adult Attention ‐Deficit/Hyperactivity Disorder as Measured by Near‐Infrared Spectroscopy
ConclusionThe present study suggests that adults with attention‐deficit/hyperactivity disorder have reduced prefrontal hemodynamic response as measured by near‐infrared spectroscopy. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - January 1, 2018 Category: Neuroscience Authors: Shotaro Ueda, Toyosaku Ota, Junzo Iida, Kazuhiko Yamamuro, Hiroki Yoshino, Naoko Kishimoto, Toshifumi Kishimoto Tags: Regular Article Source Type: research

Critical Reappraisal of Mechanistic Links of Copy Number Variants to Dimensional Constructs of Neuropsychiatric Disorders in Mouse Models
Abstract Copy number variants are deletions and duplications of a few thousand to million base pairs and are associated with extraordinarily high levels of autism spectrum disorder, schizophrenia, intellectual disability or attention‐deficit/hyperactivity disorder. The unprecedented levels of robust and reproducible penetrance of copy number variants make them one of the most promising and reliable entry points to delve into the mechanistic bases of many mental disorders. However, the precise mechanistic bases of these associations still remain elusive in humans due to the many genes encoded in each copy number variant a...
Source: Psychiatry and Clinical Neurosciences - January 1, 2018 Category: Neuroscience Authors: Noboru Hiroi Tags: PCN Frontier Review Source Type: research

Zotepine induced convulsion at a low dose in a case of paranoid schizophrenia
We report a case of seizure developed in a patient with paranoid schizophrenia on a low dose of zotepine. A 23 years‐old –man diagnosed with ICD‐10 paranoid schizophrenia at age 19 years and has been treated with adequate dosage and duration of risperidone, olanzapine and aripiprazole before the introduction of zotepine. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - January 1, 2018 Category: Neuroscience Authors: Mustafa Ali, Soumitra Das Tags: Letter to the Editor Source Type: research

Plasma metabolome analysis of patients with major depressive disorder
ConclusionThese results suggest that plasma PEA level could be a candidate biomarker of MDD in the clinical setting. Further studies comparing MDD and mentally healthy controls are needed to confirm the utility of PEA as a biomarker for depression. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - January 1, 2018 Category: Neuroscience Authors: Noriyuki Kawamura, Kosaku Shinoda, Hajime Sato, Kazunori Sasaki, Makoto Suzuki, Kumi Yamaki, Tamaki Fujimori, Hiroyuki Yamamoto, Douglas Osei ‐Hyiaman, Yoshiaki Ohashi Tags: Regular Article Source Type: research

The therapeutic role of Rifampicin in Alzheimer's Disease
Abstract Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarized the underlying mechanisms of the neuroprotective and pro‐cognitive effects of rifampicin that is mediated by its anti‐inflammatory, anti‐tau, anti‐amyloid and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protective effects in preclinical models of Alzheimer's Disease we also have provided substantial clinical evidence for the neuroprotective and pro‐cognitive effects of rifampicin. Future neuroimaging studies in combined with the clinical assessment scores would be the...
Source: Psychiatry and Clinical Neurosciences - January 1, 2018 Category: Neuroscience Authors: Burak Yulug, L ütfü Hanoglu, Mehmet Ozansoy, Dogan Isık, Ulkan Kilic, Ertugrul Kilic, Wolf Rüdiger Schabitz Tags: Review Article Source Type: research

DNA methylation of membrane ‐bound catechol‐O‐methyltransferase in Malaysian schizophrenia patients
Psychiatry and Clinical Neurosciences, EarlyView. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 27, 2017 Category: Neuroscience Source Type: research

Dissociative identity disorder: Restoration of executive functions after switch from alter to host personality
Psychiatry and Clinical Neurosciences,Volume 72, Issue 3, Page 189-189, March 2018. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 27, 2017 Category: Neuroscience Source Type: research

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Psychiatry and Clinical Neurosciences, Ahead of Print. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 27, 2017 Category: Neuroscience Source Type: research

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Psychiatry and Clinical Neurosciences,Volume 72, Issue 3, Page 189-189, March 2018. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 27, 2017 Category: Neuroscience Source Type: research

Randomized, 8 ‐week, double‐blind, placebo‐controlled trial of vortioxetine in Japanese adults with major depressive disorder, followed by a 52‐week open‐label extension trial
ConclusionVortioxetine failed to meet significance versus placebo in the primary efficacy analysis at week 8 in the short‐term study. The extension trial indicated continued improvement of depressive symptoms from baseline of this study throughout the 52‐week treatment period. Vortioxetine treatment was safe and well tolerated in both studies. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 27, 2017 Category: Neuroscience Authors: Takeshi Inoue, Akira Nishimura, Kiyofumi Sasai, Tadayuki Kitagawa Tags: Regular Article Source Type: research

DNA methylation of membrane ‐bound catechol‐O‐methyltransferase in Malaysian schizophrenia patients
ConclusionOur results suggested that the methylation level was affected by the severity of the clinical symptoms of schizophrenia and might also be influenced by pharmacological treatment. The epigenetic alteration of COMT in the peripheral blood could be a potential peripheral biomarker of schizophrenia. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 27, 2017 Category: Neuroscience Authors: Abd Rahim Nour El Huda, Ku Zaifah Norsidah, Mohd Rahim Nabil Fikri, Mohd Noor Hanisah, Abdullah Kartini, A. Talib Norlelawati Tags: Regular Article Source Type: research

Dissociative Identity Disorder: Restoration of Executive Functions After Switch from Alter to Host Personality
Abstract Dissociative Identity Disorder (DID) is a psychiatric illness, presenting with two or more personalities in the same patient, causing an alteration in the sense of self, with amnesia for events of life and personal information1. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 27, 2017 Category: Neuroscience Authors: Teresa Costabile, Leonilda Bilo, Anna De Rosa, Chiara Pane, Francesco Sacc à Tags: Letter to the Editor Source Type: research

Epigenetic mechanisms of major depression: Targeting neuronal plasticity
Psychiatry and Clinical Neurosciences, EarlyView. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 26, 2017 Category: Neuroscience Source Type: research

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Psychiatry and Clinical Neurosciences, Ahead of Print. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 26, 2017 Category: Neuroscience Source Type: research

Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia
(Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 23, 2017 Category: Neuroscience Authors: Ryo Sawagashira, Yoshihisa Sasagawa, Mayumi Matsukura, Yuji Takamaru Tags: Letter to the Editor Source Type: research