Antiviral Peptides Derived from Plants: Their Designs and Functions
Protein Pept Lett. 2023 Nov 27. doi: 10.2174/0109298665278148231106052509. Online ahead of print.ABSTRACTIn recent years, plant-derived bioactive compounds have been developed as antiviral agents. Plants synthesize a variety of compounds, especially peptides, which possess antimicrobial activity. Current studies have shown that some antimicrobial peptides have antiviral activity against a wide range of human DNA and RNA viruses and play an effective role in the treatment of human viral diseases. These peptides act through different mechanisms. They can integrate into the envelope of the target virus or cell membrane of the...
Source: Protein and Peptide Letters - November 28, 2023 Category: Biochemistry Authors: Haleh Feyzyab Nikoo Fathi Azam Bolhassani Source Type: research
Unleashing Breast Cancer Progression: miR-455-5p's Targeting of SOCS3 Drives Proliferation, Migration, and Invasion
CONCLUSION: MiR-455-5p promotes breast cancer progression by targeting the SOCS3 pathway and may be a potential therapeutic target for breast cancer.PMID:38013437 | DOI:10.2174/0109298665245603231106050224 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 28, 2023 Category: Biochemistry Authors: Xin Li Bing Peng Jian Li Mi Tian Lili He Source Type: research
STAM-binding Protein-like 1 Promotes Growth and Migration of Colorectal Cancer by NF- κB Pathway
CONCLUSION: Knockdown of STAMBPL1 inhibited cell growth and metastasis of CRC through inactivation of the NF-κB pathway.PMID:38008943 | DOI:10.2174/0109298665272785231103104118 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Xinghua Zhou Yue Cheng Jian Kang Gang Mao Source Type: research
Early Growth Response Protein [Egr] Levels in Patients with Fibromyalgia Syndrome
CONCLUSION: EGR1 protein levels were found to be lower in the patient group diagnosed with FMS compared to the control group. It has been suggested that EGR1 protein levels can be important in the diagnosis of FMS disease.PMID:38008944 | DOI:10.2174/0109298665256584231103113328 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Ayca Tas Tugba Agbektas Ahmet Karadag S üleyman Aydin Emrullah Hayta Yavuz Silig Source Type: research
The Implication of Hypocretin in Drug Abuse and Arousal in the Brain Stem
Protein Pept Lett. 2023 Nov 24. doi: 10.2174/0109298665266463231106065557. Online ahead of print.ABSTRACTHypocretin (orexin, Hcrt) neurons located in the lateral hypothalamus (LH) project widely into the brain and are thus responsible for the physiological action of the hypocretin complex. Hypocretin is involved in both arousal and addiction, and brainstem areas such as the locus coeruleus (LC), paragigantocellularis (PGi), and dorsal raphe (DR) contribute to these functions. In the present review, we focus on the effect of Hcrt on drug abuse and arousal in the brainstem.PMID:38008945 | DOI:10.2174/010929866526646323110606...
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Masoumeh Kourosh Kourosh-Arami Alireza Komaki Masoumeh Gholami Source Type: research
Pharmacological Classes of Conus Peptides Targeted to Calcium, Sodium, and Potassium Channels
Protein Pept Lett. 2023 Nov 24. doi: 10.2174/0109298665279447231106072246. Online ahead of print.ABSTRACTThis review describes the specific features of families of Conus venom peptides (conotoxins or conopeptides) that represent twelve pharmacological classes. Members of these conopeptide families are targeted to voltage-gated ion channels, such as calcium, sodium, and potassium channels. The conopeptides covered in this work include omega-conotoxins and contryphans with calcium channels as targets; mu-conotoxins, muO-conotoxins, muP-conotoxins, delta-conotoxins and iota-conotoxin with sodium channels as targets; and kappa...
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Elsie C Jimenez Source Type: research
STAM-binding Protein-like 1 Promotes Growth and Migration of Colorectal Cancer by NF- κB Pathway
CONCLUSION: Knockdown of STAMBPL1 inhibited cell growth and metastasis of CRC through inactivation of the NF-κB pathway.PMID:38008943 | DOI:10.2174/0109298665272785231103104118 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Xinghua Zhou Yue Cheng Jian Kang Gang Mao Source Type: research
Early Growth Response Protein [Egr] Levels in Patients with Fibromyalgia Syndrome
CONCLUSION: EGR1 protein levels were found to be lower in the patient group diagnosed with FMS compared to the control group. It has been suggested that EGR1 protein levels can be important in the diagnosis of FMS disease.PMID:38008944 | DOI:10.2174/0109298665256584231103113328 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Ayca Tas Tugba Agbektas Ahmet Karadag S üleyman Aydin Emrullah Hayta Yavuz Silig Source Type: research
The Implication of Hypocretin in Drug Abuse and Arousal in the Brain Stem
Protein Pept Lett. 2023 Nov 24. doi: 10.2174/0109298665266463231106065557. Online ahead of print.ABSTRACTHypocretin (orexin, Hcrt) neurons located in the lateral hypothalamus (LH) project widely into the brain and are thus responsible for the physiological action of the hypocretin complex. Hypocretin is involved in both arousal and addiction, and brainstem areas such as the locus coeruleus (LC), paragigantocellularis (PGi), and dorsal raphe (DR) contribute to these functions. In the present review, we focus on the effect of Hcrt on drug abuse and arousal in the brainstem.PMID:38008945 | DOI:10.2174/010929866526646323110606...
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Masoumeh Kourosh Kourosh-Arami Alireza Komaki Masoumeh Gholami Source Type: research
Pharmacological Classes of Conus Peptides Targeted to Calcium, Sodium, and Potassium Channels
Protein Pept Lett. 2023 Nov 24. doi: 10.2174/0109298665279447231106072246. Online ahead of print.ABSTRACTThis review describes the specific features of families of Conus venom peptides (conotoxins or conopeptides) that represent twelve pharmacological classes. Members of these conopeptide families are targeted to voltage-gated ion channels, such as calcium, sodium, and potassium channels. The conopeptides covered in this work include omega-conotoxins and contryphans with calcium channels as targets; mu-conotoxins, muO-conotoxins, muP-conotoxins, delta-conotoxins and iota-conotoxin with sodium channels as targets; and kappa...
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Elsie C Jimenez Source Type: research
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease
Protein Pept Lett. 2023 Nov 16. doi: 10.2174/0109298665269246231023104904. Online ahead of print.ABSTRACTGap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous sy...
Source: Protein and Peptide Letters - November 17, 2023 Category: Biochemistry Authors: Qiong Xiang Xiao-Lin Liu Jia-Jia Chen Liang Yang Li-Ni Liu Jing Deng Jia-Sheng Tao Xian-Hui Li Source Type: research
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease
Protein Pept Lett. 2023 Nov 16. doi: 10.2174/0109298665269246231023104904. Online ahead of print.ABSTRACTGap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous sy...
Source: Protein and Peptide Letters - November 17, 2023 Category: Biochemistry Authors: Qiong Xiang Xiao-Lin Liu Jia-Jia Chen Liang Yang Li-Ni Liu Jing Deng Jia-Sheng Tao Xian-Hui Li Source Type: research
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease
Protein Pept Lett. 2023 Nov 16. doi: 10.2174/0109298665269246231023104904. Online ahead of print.ABSTRACTGap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous sy...
Source: Protein and Peptide Letters - November 17, 2023 Category: Biochemistry Authors: Qiong Xiang Xiao-Lin Liu Jia-Jia Chen Liang Yang Li-Ni Liu Jing Deng Jia-Sheng Tao Xian-Hui Li Source Type: research
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease
Protein Pept Lett. 2023 Nov 16. doi: 10.2174/0109298665269246231023104904. Online ahead of print.ABSTRACTGap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous sy...
Source: Protein and Peptide Letters - November 17, 2023 Category: Biochemistry Authors: Qiong Xiang Xiao-Lin Liu Jia-Jia Chen Liang Yang Li-Ni Liu Jing Deng Jia-Sheng Tao Xian-Hui Li Source Type: research
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease
Protein Pept Lett. 2023 Nov 16. doi: 10.2174/0109298665269246231023104904. Online ahead of print.ABSTRACTGap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous sy...
Source: Protein and Peptide Letters - November 17, 2023 Category: Biochemistry Authors: Qiong Xiang Xiao-Lin Liu Jia-Jia Chen Liang Yang Li-Ni Liu Jing Deng Jia-Sheng Tao Xian-Hui Li Source Type: research
