Structural Shifts of the Parvovirus B19 Capsid Receptor-binding Domain: A Peptide Study
CONCLUSION: Loss of function Y20W substitution in VP1 capsid protein prevents the shift into the beta-structural state by way of alpha helix stabilization and the decrease of its ability to turn into the disordered state.PMID:38053353 | DOI:10.2174/0109298665272845231121064717 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - December 6, 2023 Category: Biochemistry Authors: Vladislav Victorovich Khrustalev Aleksander Nicolaevich Stojarov Anastasia Aleksandrovna Akunevich Oleg Evgenyevich Baranov Anna Vladimirovna Popinako Elena Olegovna Samoylovich Marina Anatolyevna Yermolovich Galina Valeryevna Semeiko Egor Gennadyevich Sa Source Type: research

Exploring Potential Biomarkers of Early Thymoma based on Serum Proteomics
CONCLUSION: CORO1A, SAA1 and LTA4H may be new biomarkers for early screening of thymoma.PMID:38053354 | DOI:10.2174/0109298665275655231103105924 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - December 6, 2023 Category: Biochemistry Authors: Min Jin Peng Liu Guoyan Qi Source Type: research

KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1 α Axis
CONCLUSION: KIF20A, being a crucial regulator in the progression of CRC, has the potential to be a promising therapeutic target for the treatment of CRC.PMID:38037834 | DOI:10.2174/0109298665256238231120093150 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - December 1, 2023 Category: Biochemistry Authors: Min Wu Xianqiang Wu Jie Han Source Type: research

KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1 α Axis
CONCLUSION: KIF20A, being a crucial regulator in the progression of CRC, has the potential to be a promising therapeutic target for the treatment of CRC.PMID:38037834 | DOI:10.2174/0109298665256238231120093150 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - December 1, 2023 Category: Biochemistry Authors: Min Wu Xianqiang Wu Jie Han Source Type: research

KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1 α Axis
CONCLUSION: KIF20A, being a crucial regulator in the progression of CRC, has the potential to be a promising therapeutic target for the treatment of CRC.PMID:38037834 | DOI:10.2174/0109298665256238231120093150 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - December 1, 2023 Category: Biochemistry Authors: Min Wu Xianqiang Wu Jie Han Source Type: research

KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1 α Axis
CONCLUSION: KIF20A, being a crucial regulator in the progression of CRC, has the potential to be a promising therapeutic target for the treatment of CRC.PMID:38037834 | DOI:10.2174/0109298665256238231120093150 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - December 1, 2023 Category: Biochemistry Authors: Min Wu Xianqiang Wu Jie Han Source Type: research

The Role of circRNA-miRNA-mRNA Regulatory Network and its Potential Biomarker Function in Colorectal Cancer
CONCLUSION: Our study suggests that circRNA_0001573 and circRNA_0001573/miR-382-5p/FZD3 regulatory networks might provide a potential diagnosis for colorectal cancer.PMID:38031269 | DOI:10.2174/0109298665263662231108053654 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 30, 2023 Category: Biochemistry Authors: Xutang Fu Pengpeng Chen Hao Wang Source Type: research

MicroRNA3650 Promotes Gastric Cancer Proliferation and Migration through the PTEN/PI3K-AKT-mTOR and Hippo Pathways
CONCLUSION: Therefore, we concluded that miR-3650/PTEN/PI3K-AKT-mTOR and miR-3650/hippo pathways are vital in the progression of GC and serve as novel targets for GC therapy.PMID:38031771 | DOI:10.2174/0109298665265642231020043809 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 30, 2023 Category: Biochemistry Authors: Xiansheng Yang Juncai Wen Qingjun He Shuoshan Wang Qiang Ruan Quanxing Liao Jinfu He Shuxian Fang Chang Liu Hongsheng Tang Source Type: research

The Role of circRNA-miRNA-mRNA Regulatory Network and its Potential Biomarker Function in Colorectal Cancer
CONCLUSION: Our study suggests that circRNA_0001573 and circRNA_0001573/miR-382-5p/FZD3 regulatory networks might provide a potential diagnosis for colorectal cancer.PMID:38031269 | DOI:10.2174/0109298665263662231108053654 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 30, 2023 Category: Biochemistry Authors: Xutang Fu Pengpeng Chen Hao Wang Source Type: research

MicroRNA3650 Promotes Gastric Cancer Proliferation and Migration through the PTEN/PI3K-AKT-mTOR and Hippo Pathways
CONCLUSION: Therefore, we concluded that miR-3650/PTEN/PI3K-AKT-mTOR and miR-3650/hippo pathways are vital in the progression of GC and serve as novel targets for GC therapy.PMID:38031771 | DOI:10.2174/0109298665265642231020043809 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 30, 2023 Category: Biochemistry Authors: Xiansheng Yang Juncai Wen Qingjun He Shuoshan Wang Qiang Ruan Quanxing Liao Jinfu He Shuxian Fang Chang Liu Hongsheng Tang Source Type: research

Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic Pathway-linked Anti-depressive-like Effects in Mice
CONCLUSION: WSMoL elicits an anti-depressant-like effect that is dependent on monoaminergic signaling.PMID:38018205 | DOI:10.2174/0109298665270366231031052629 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 29, 2023 Category: Biochemistry Authors: Leydianne Patriota Barbara Lima Amanda Marinho Jainaldo Costa Luana Coelho Moacyr R êgo Maira Pitta Patr ícia Paiva Michelly Pereira Thiago Napole ão Michelle Rosa Source Type: research

Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic Pathway-linked Anti-depressive-like Effects in Mice
CONCLUSION: WSMoL elicits an anti-depressant-like effect that is dependent on monoaminergic signaling.PMID:38018205 | DOI:10.2174/0109298665270366231031052629 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 29, 2023 Category: Biochemistry Authors: Leydianne Patriota Barbara Lima Amanda Marinho Jainaldo Costa Luana Coelho Moacyr R êgo Maira Pitta Patr ícia Paiva Michelly Pereira Thiago Napole ão Michelle Rosa Source Type: research

Antiviral Peptides Derived from Plants: Their Designs and Functions
Protein Pept Lett. 2023 Nov 27. doi: 10.2174/0109298665278148231106052509. Online ahead of print.ABSTRACTIn recent years, plant-derived bioactive compounds have been developed as antiviral agents. Plants synthesize a variety of compounds, especially peptides, which possess antimicrobial activity. Current studies have shown that some antimicrobial peptides have antiviral activity against a wide range of human DNA and RNA viruses and play an effective role in the treatment of human viral diseases. These peptides act through different mechanisms. They can integrate into the envelope of the target virus or cell membrane of the...
Source: Protein and Peptide Letters - November 28, 2023 Category: Biochemistry Authors: Haleh Feyzyab Nikoo Fathi Azam Bolhassani Source Type: research

Unleashing Breast Cancer Progression: miR-455-5p's Targeting of SOCS3 Drives Proliferation, Migration, and Invasion
CONCLUSION: MiR-455-5p promotes breast cancer progression by targeting the SOCS3 pathway and may be a potential therapeutic target for breast cancer.PMID:38013437 | DOI:10.2174/0109298665245603231106050224 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 28, 2023 Category: Biochemistry Authors: Xin Li Bing Peng Jian Li Mi Tian Lili He Source Type: research

STAM-binding Protein-like 1 Promotes Growth and Migration of Colorectal Cancer by NF- κB Pathway
CONCLUSION: Knockdown of STAMBPL1 inhibited cell growth and metastasis of CRC through inactivation of the NF-κB pathway.PMID:38008943 | DOI:10.2174/0109298665272785231103104118 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - November 27, 2023 Category: Biochemistry Authors: Xinghua Zhou Yue Cheng Jian Kang Gang Mao Source Type: research