Exogenous apelin-13 administration ameliorates cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in rat lungs
CONCLUSION: Exogenous Apelin-13 treatment protected lung tissue against injury by inhibiting cyclophosphamide-induced oxidative stress, inflammation, and apoptosis. This protective effect of apelin-13 was accompanied by upregulation of the Sirt1 and downregulation of NF-kB/p53 in the lungs.PMID:37622713 | DOI:10.2174/0929866530666230824142516 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - August 25, 2023 Category: Biochemistry Authors: Arzu Keskin-Aktan Özden Kutlay Source Type: research
Binding Affinity Studies of Nicotinamide N-methyltransferase and Ligands by Saturation Transfer Difference NMR
CONCLUSION: The binding affinity of nicotinamide and SAH to NNMT and its mutants were obtained by STD NMR in this study. It was found that nicotinamide and SAH bind to WT in a particular orientation, and Y20 is critical for their binding orientation and affinity to NNMT.PMID:37622714 | DOI:10.2174/0929866530666230824153356 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Fang Jianyu Zhang Source Type: research
Biochemical Aspects of the Spiral Grain Formation in Scots Pine (Pinus Sylvestris L.) Wood. Some Differences and Similarities with Biochemical Indicators of Abnormal Xylogenesis in Karelian Birch (Betula Pendula Roth Var. Carelica (Mercl.) H ämet-Ahti)
CONCLUSION: The study showed that the differences in the AOS enzyme's activity in P. sylvestris during the formation of straight-grained and spiral-grained wood were revealed for the first time. The increased CAT, POD and PPO activities in xylem with a decrease in SS and an increase in ApInv during spiral-grained wood formation can be biochemical markers of these structural anomalies. Metabolic regularities found in the AOS enzyme complex during spiral-grained wood formation do not contradict those found earlier during figured wood formation in B. pendula var. carelica. The identified patterns can form the base for diagnos...
Source: Protein and Peptide Letters - August 25, 2023 Category: Biochemistry Authors: Kseniya Mihajlovna Nikerova Natalia Alekseevna Galibina Sergey Mihajlovich Sinkevich Irina Nikolaevna Sofronova Marina Nikolaevna Borodina Yuliya Leonidovna Moshchenskaya Tatiana Vladimirovna Tarelkina Anna Vladimirovna Klimova Source Type: research
Exogenous apelin-13 administration ameliorates cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in rat lungs
CONCLUSION: Exogenous Apelin-13 treatment protected lung tissue against injury by inhibiting cyclophosphamide-induced oxidative stress, inflammation, and apoptosis. This protective effect of apelin-13 was accompanied by upregulation of the Sirt1 and downregulation of NF-kB/p53 in the lungs.PMID:37622713 | DOI:10.2174/0929866530666230824142516 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - August 25, 2023 Category: Biochemistry Authors: Arzu Keskin-Aktan Özden Kutlay Source Type: research
Binding Affinity Studies of Nicotinamide N-methyltransferase and Ligands by Saturation Transfer Difference NMR
CONCLUSION: The binding affinity of nicotinamide and SAH to NNMT and its mutants were obtained by STD NMR in this study. It was found that nicotinamide and SAH bind to WT in a particular orientation, and Y20 is critical for their binding orientation and affinity to NNMT.PMID:37622714 | DOI:10.2174/0929866530666230824153356 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Fang Jianyu Zhang Source Type: research
Biochemical Aspects of the Spiral Grain Formation in Scots Pine (Pinus Sylvestris L.) Wood. Some Differences and Similarities with Biochemical Indicators of Abnormal Xylogenesis in Karelian Birch (Betula Pendula Roth Var. Carelica (Mercl.) H ämet-Ahti)
CONCLUSION: The study showed that the differences in the AOS enzyme's activity in P. sylvestris during the formation of straight-grained and spiral-grained wood were revealed for the first time. The increased CAT, POD and PPO activities in xylem with a decrease in SS and an increase in ApInv during spiral-grained wood formation can be biochemical markers of these structural anomalies. Metabolic regularities found in the AOS enzyme complex during spiral-grained wood formation do not contradict those found earlier during figured wood formation in B. pendula var. carelica. The identified patterns can form the base for diagnos...
Source: Protein and Peptide Letters - August 25, 2023 Category: Biochemistry Authors: Kseniya Mihajlovna Nikerova Natalia Alekseevna Galibina Sergey Mihajlovich Sinkevich Irina Nikolaevna Sofronova Marina Nikolaevna Borodina Yuliya Leonidovna Moshchenskaya Tatiana Vladimirovna Tarelkina Anna Vladimirovna Klimova Source Type: research
Exogenous apelin-13 administration ameliorates cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in rat lungs
CONCLUSION: Exogenous Apelin-13 treatment protected lung tissue against injury by inhibiting cyclophosphamide-induced oxidative stress, inflammation, and apoptosis. This protective effect of apelin-13 was accompanied by upregulation of the Sirt1 and downregulation of NF-kB/p53 in the lungs.PMID:37622713 | DOI:10.2174/0929866530666230824142516 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - August 25, 2023 Category: Biochemistry Authors: Arzu Keskin-Aktan Özden Kutlay Source Type: research
Binding Affinity Studies of Nicotinamide N-methyltransferase and Ligands by Saturation Transfer Difference NMR
CONCLUSION: The binding affinity of nicotinamide and SAH to NNMT and its mutants were obtained by STD NMR in this study. It was found that nicotinamide and SAH bind to WT in a particular orientation, and Y20 is critical for their binding orientation and affinity to NNMT.PMID:37622714 | DOI:10.2174/0929866530666230824153356 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Fang Jianyu Zhang Source Type: research
Understanding the Molecular Basis for Enhanced Glutenase Activity of Actinidin using Structural Bioinformatics
In this study, we aimed to understand the structural basis for the elevated protease action of actinidin against gliadin peptides by using an in silico approach. Docking experiments revealed key differences between the binding of gliadin peptide to actinidin and papain, which may be responsible for their differential digestive action. Sequence comparison of different plant cysteine proteases highlights amino acid residues surrounding the active site pocket of actinidin that are unique to this molecule and hence likely to contribute to its digestive properties.PMID:37592795 | DOI:10.2174/0929866530666230817141100 (Source: P...
Source: Protein and Peptide Letters - August 18, 2023 Category: Biochemistry Authors: Shivangi Puja Shreya Seth Rachna Hora Satinder Kaur Prakash Chandra Mishra Source Type: research
Understanding the Molecular Basis for Enhanced Glutenase Activity of Actinidin using Structural Bioinformatics
In this study, we aimed to understand the structural basis for the elevated protease action of actinidin against gliadin peptides by using an in silico approach. Docking experiments revealed key differences between the binding of gliadin peptide to actinidin and papain, which may be responsible for their differential digestive action. Sequence comparison of different plant cysteine proteases highlights amino acid residues surrounding the active site pocket of actinidin that are unique to this molecule and hence likely to contribute to its digestive properties.PMID:37592795 | DOI:10.2174/0929866530666230817141100 (Source: P...
Source: Protein and Peptide Letters - August 18, 2023 Category: Biochemistry Authors: Shivangi Puja Shreya Seth Rachna Hora Satinder Kaur Prakash Chandra Mishra Source Type: research
Understanding the Molecular Basis for Enhanced Glutenase Activity of Actinidin using Structural Bioinformatics
In this study, we aimed to understand the structural basis for the elevated protease action of actinidin against gliadin peptides by using an in silico approach. Docking experiments revealed key differences between the binding of gliadin peptide to actinidin and papain, which may be responsible for their differential digestive action. Sequence comparison of different plant cysteine proteases highlights amino acid residues surrounding the active site pocket of actinidin that are unique to this molecule and hence likely to contribute to its digestive properties.PMID:37592795 | DOI:10.2174/0929866530666230817141100 (Source: P...
Source: Protein and Peptide Letters - August 18, 2023 Category: Biochemistry Authors: Shivangi Puja Shreya Seth Rachna Hora Satinder Kaur Prakash Chandra Mishra Source Type: research
Understanding the Molecular Basis for Enhanced Glutenase Activity of Actinidin using Structural Bioinformatics
In this study, we aimed to understand the structural basis for the elevated protease action of actinidin against gliadin peptides by using an in silico approach. Docking experiments revealed key differences between the binding of gliadin peptide to actinidin and papain, which may be responsible for their differential digestive action. Sequence comparison of different plant cysteine proteases highlights amino acid residues surrounding the active site pocket of actinidin that are unique to this molecule and hence likely to contribute to its digestive properties.PMID:37592795 | DOI:10.2174/0929866530666230817141100 (Source: P...
Source: Protein and Peptide Letters - August 18, 2023 Category: Biochemistry Authors: Shivangi Puja Shreya Seth Rachna Hora Satinder Kaur Prakash Chandra Mishra Source Type: research
Understanding the Molecular Basis for Enhanced Glutenase Activity of Actinidin using Structural Bioinformatics
In this study, we aimed to understand the structural basis for the elevated protease action of actinidin against gliadin peptides by using an in silico approach. Docking experiments revealed key differences between the binding of gliadin peptide to actinidin and papain, which may be responsible for their differential digestive action. Sequence comparison of different plant cysteine proteases highlights amino acid residues surrounding the active site pocket of actinidin that are unique to this molecule and hence likely to contribute to its digestive properties.PMID:37592795 | DOI:10.2174/0929866530666230817141100 (Source: P...
Source: Protein and Peptide Letters - August 18, 2023 Category: Biochemistry Authors: Shivangi Puja Shreya Seth Rachna Hora Satinder Kaur Prakash Chandra Mishra Source Type: research
Understanding the Molecular Basis for Enhanced Glutenase Activity of Actinidin using Structural Bioinformatics
In this study, we aimed to understand the structural basis for the elevated protease action of actinidin against gliadin peptides by using an in silico approach. Docking experiments revealed key differences between the binding of gliadin peptide to actinidin and papain, which may be responsible for their differential digestive action. Sequence comparison of different plant cysteine proteases highlights amino acid residues surrounding the active site pocket of actinidin that are unique to this molecule and hence likely to contribute to its digestive properties.PMID:37592795 | DOI:10.2174/0929866530666230817141100 (Source: P...
Source: Protein and Peptide Letters - August 18, 2023 Category: Biochemistry Authors: Shivangi Puja Shreya Seth Rachna Hora Satinder Kaur Prakash Chandra Mishra Source Type: research
Comprehensive analysis of lncRNA and mRNA expression profile of macrophage RAW264.7 stimulated by antimicrobial peptide BSN-37
CONCLUSION: This study provides the lncRNA and mRNA expression profiles of RAW264.7 macrophages stimulated by antimicrobial peptide BSN-37 and helps to provide a reference value for subsequent studies on lncRNA regulation of antimicrobial peptide BSN-37 immune function.PMID:37587823 | DOI:10.2174/0929866530666230816110009 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - August 17, 2023 Category: Biochemistry Authors: Ting Qin Mingcheng Liu Yanhe Lv Airong Zheng Lei Wang Yundi Wu Oksana Kasianenko Xiaobing Wei Zhanwei Teng Xiaojing Xia Jianhe Hu Source Type: research
