Fats in maternal and child health: Regional ISSFAL congress in India
Publication date: May 2020Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 156Author(s): S. Ahamed Ibrahim, Sanjay Basak (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 7, 2020 Category: Lipidology Source Type: research

Fats in maternal & child health: regional ISSFALcongress in India
Publication date: Available online 17 March 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): S. Ahamed Ibrahim, Sanjay Basak (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - March 18, 2020 Category: Lipidology Source Type: research

Editorial Board
Publication date: March 2020Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 154Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - March 9, 2020 Category: Lipidology Source Type: research

Concentrates of buttermilk and krill oil improve cognition in aged rats
Publication date: April 2020Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 155Author(s): Alba García-Serrano, Joao Tomé-Carneiro, M. Carmen Crespo, M. Visitación Calvo, Inmaculada Pereda-Pérez, Shishir Baliyan, Emma Burgos-Ramos, Olimpio Montero, Alberto Dávalos, César Venero, Francesco Visioli, Javier Fontecha (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - March 4, 2020 Category: Lipidology Source Type: research

An association between niacin skin flush response and plasma triglyceride levels in patients with schizophrenia
Publication date: Available online 21 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Sergej Nadalin, Suzana Jonovska, Vesna Šendula Jengić, Alena Buretić-TomljanovićABSTRACTThe available data suggest that abnormalities of arachidonic acid-related signaling may be of relevance in attenuated niacin-induced flush responses and lipid and glucose metabolism disturbances, which are all common among individuals with schizophrenia. We previously demonstrated attenuated skin flush responses to niacin in patients with schizophrenia. Here we investigated whether these niacin responses might ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 22, 2020 Category: Lipidology Source Type: research

Maternal dietary fatty acids and their roles in human placental development
Publication date: Available online 21 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Asim K. Duttaroy, Sanjay BasakAbstractFatty acids are essential for feto-placental growth and development. Maternal fatty acids and their metabolites are involved in every stage of pregnancy by supporting cell growth and development, cell signaling, and modulating other critical aspects of structural and functional processes. Early placentation process is critical for placental growth and function. Several fatty acids modulate angiogenesis as observed by increased tube formation and secretion of angio...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 22, 2020 Category: Lipidology Source Type: research

Concentrates of buttermilk and krill oil improve spatial memory in aged rats
In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with polar lipids’ concentrates from buttermilk or krill oil at doses that approximate human consumption. No other behavioral parameter was significantly influenced by the supplements calling for further research to confirm or not the purported salubrious activities of polar lipids, namely those rich in ω3 long-chain polyunsaturated fatty acids on ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 22, 2020 Category: Lipidology Source Type: research

The regulatory mechanism involved in the prostaglandin E2 disposition in carbon tetrachloride-induced liver injury
Publication date: Available online 21 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Hiroaki Shimada, Ryota Hashimoto, Aya Aoki, Saya Yamada, Ken-ichi Oba, Atsushi Kawase, Takeo Nakanishi, Masahiro IwakiAbstractProstaglandin E2 (PGE2) exhibits hepatoprotective effects against various types of liver injury. However, there is little information on the disposition of endogenous PGE2 during liver injury. In the present study, we attempted to elucidate the mechanism involved in regulating PGE2 distribution during liver injury. Carbon tetrachloride (CCl4) was used to establish a liver injur...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 22, 2020 Category: Lipidology Source Type: research

The impact of PUFA on cell responses: caution should be exercised when selecting PUFA concentrations in cell culture
In this study, human carcinoma and leukemia cell lines (MCF-7, HepG2, THP-1, Jurkat) were incubated for 3 days in the presence of up to 150 μM of exogenous arachidonic or eicosapentaenoic acids. At concentrations up to 20 μM these PUFA were enriched in cellular phospholipids, but at concentrations of 20 μM or higher cells accumulated large quantities of these PUFA and their elongation products into triglycerides. This coincided with decreased cell proliferation and enhanced apoptosis. Inhibition of DGAT1 but not DGAT2 enhanced the cytotoxic effect of exogenous PUFA suggesting a protective role of PUFA sequestration into...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 22, 2020 Category: Lipidology Source Type: research

LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells
This study investigated the control of 5-LO expression and leukotriene biosynthesis following the maturation of human monocytic cells. MonoMac-1 (MM1) and THP-1 cells were incubated for up to 72h with or without LPS and TGF-β. LPS, but not TGF-β, increased CD14 expression in both MM1 and THP-1 cells. Incubation with LPS (100 ng/ml) and TGF-β (1 ng/ml) synergistically increased the capacity of MM1 cells to produce 5-LO products from undetectable levels to 40±5 pmol/106 cells. 5-LO product biosynthesis in THP-1 cells increased 25-fold. A synergistic effect of LPS and TGF-β was measured with increases in 5-LO mRNA of 54-...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 22, 2020 Category: Lipidology Source Type: research

Diets with Low n-6:n-3 PUFA Ratio Protects Rats from Fructose-Induced Dyslipidemia and Associated Hepatic Changes: Comparison between 18:3 n-3 and Long-Chain n-3 PUFA
Publication date: Available online 22 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Anil Sakamuri, Siva S.V.P. Sakamuri, Suryam Reddy Kona, Sugeedha Jayapal, Ahamed IbrahimAbstractIn the present study, we investigated the impact of substituting alpha-linolenic acid (ALA) or long-chain n-3 PUFA (eicosapentaenoic acid and docosahexaenoic acid) for linoleic acid and hence decreasing n-6:n-3 PUFA ratio on high-fructose diet-induced hypertriglyceridemia and associated hepatic changes. Weanling male Wistar rats were divided into four groups and fed with starch-diet (n-6:n-3 PUFA ratio 215:...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 22, 2020 Category: Lipidology Source Type: research

Changes in behavior and fatty acid composition induced by long-term reduction in murine Δ6-desaturation activity
Publication date: Available online 21 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Akiko Harauma, Toshiaki Sueyasu, Hisanori Tokuda, Hidemi Yasuda, Yukino Hoshi, Yoshihisa Kaneda, Tomohiro Rogi, Hiroshi Shibata, Manabu T. Nakamura, Toru MoriguchiAbstractPolyunsaturated fatty acids (PUFAs), especially arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), play an important role in biological regulation. In our previous study using mice deficient in Δ6 desaturase (D6D), we reported that ARA is required for body growth, while DHA is necessary for function...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 21, 2020 Category: Lipidology Source Type: research

Publisher's Note
Publication date: February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 153Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 8, 2020 Category: Lipidology Source Type: research

Editorial Board
Publication date: February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 153Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 8, 2020 Category: Lipidology Source Type: research

Influence of clinical characteristics on maternal DHA and other polyunsaturated fatty acid status in pregnancy: A systematic review
DiscussionInconsistent findings between studies make it difficult to draw clear conclusions about the relationship between clinical factors and maternal omega-3 DHA status. However, maternal overweight and associated metabolic conditions may increase lipid metabolism. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - January 30, 2020 Category: Lipidology Source Type: research