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Evaluation of commonly used tests to measure the effect of single-dose aspirin on mouse hemostasis
Publication date: Available online 8 August 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Benoit Decouture, Alexandre Leuci, Blandine Dizier, Tiphaine Belleville-Rolland, Alexandre Mansour, Fanny Martin, Dominique Pidard, Pascale Gaussem, Christilla Bachelot-LozaAbstractDiscrepancies in preclinical studies of aspirin (ASA) antiplatelet activity in mouse models of bleeding and arterial thrombosis led us to evaluate commonly reported methods in order to propose a procedure for reliably measuring the effects of single dose ASA on mouse hemostasis.FVB and C57Bl6 mice received 100 mg/kg of ASA or ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 9, 2019 Category: Lipidology Source Type: research

High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NFκB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes
Publication date: Available online 12 July 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Kristina Starčević, Petra Roškarić, Marcela Šperanda, Mislav Đidara, Andrea Gudan Kurilj, Maja Maurić, Tomislav MašekABSTRACTWe studied the influence of dietary n6/n3 ratio and docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids supplementation on fatty acid profile, lipid peroxidation and NFκ/p50 expression in diabetes type 2. Treatments consisted of three dietary n6/n3 ratios: 6 (Control), 50 (high n6) and 1 (DHA and EPA supplemented). Half of the rats in each of the dietary treatments were ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 14, 2019 Category: Lipidology Source Type: research

The effects of storage conditions on long-chain polyunsaturated fatty acids, lipid mediators, and antioxidants in donor human milk – a review
Publication date: Available online 13 July 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Isabell Nessel, Minesh Khashu, Simon C DyallAbstractDonor human milk (DHM) is the recommended alternative, if maternal milk is unavailable. However, current human milk banking practices may negatively affect the nutritional quality of DHM. This review summarises the effects of these practices on polyunsaturated fatty acids, lipid mediators and antioxidants of human milk. Overall, there is considerable variation in the reported effects, and further research is needed, particularly with lipid mediators and ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 14, 2019 Category: Lipidology Source Type: research

Survey of the Erythrocyte EPA+DHA Levels in the Heart Attack/Stroke Belt
ConclusionsIndividuals in the CVD “belt” had relatively low O3I levels. Since in other settings, a low O3I is associated with increased risk for CVD, this may be one factor contributing to the higher risk for CVD in this region of the US. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 14, 2019 Category: Lipidology Source Type: research

Effect of weight loss on neutrophil resolvins in the metabolic syndrome
ConclusionFollowing weight loss, human neutrophils from individuals with the metabolic syndrome are capable of releasing larger amounts of RvE1 upon stimulation. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 12, 2019 Category: Lipidology Source Type: research

Degenerative rotator cuff tears are associated with a low Omega-3 Index
Conclusions: Patients with full thickness degenerative rotator cuff tears had a significantly lower Omega-3 Index than controls without rotator cuff tendinopathy. Whether a lower Omega-3 Index represents an independent risk factor for degenerative rotator cuff tears should be further investigated, e.g. in a longitudinal study. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 11, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: August 2019Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 147Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 6, 2019 Category: Lipidology Source Type: research

Evaluation of plasma and erythrocyte fatty acids C15:0, t-C16:1n-7 and C17:0 as biomarkers of dairy fat consumption in adolescents
ConclusionErythrocyte FAs appear to be associated with increasing dairy intakes during adolescence. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 4, 2019 Category: Lipidology Source Type: research

Perinatal and postweaning diets high in omega-3 fatty acids have age- and sex-specific effects on the fatty acid composition of the cerebellum and brainstem of C57BL/6 mice
Publication date: Available online 3 July 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Bradley A. Feltham, Kayode A. Balogun, Sukhinder K. CheemaSummaryThe sex- and age-specific effects of omega (n)-3 polyunsaturated fatty acids (PUFA) enriched diets on brainstem and cerebellar fatty acid composition, and the expression of stearoyl-CoA desaturase (SCD)-1 and myelin basic protein (MBP) were investigated in C57BL/6 mice. Female mice were fed diets (20% fat, w/w) high or low in n-3 PUFA before mating, during pregnancy and lactation; and offspring (both males and females) were weaned onto their ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 4, 2019 Category: Lipidology Source Type: research

Association between PLA2G6 gene polymorphism for calcium-independent phospholipase A2 and nicotine dependence among males with schizophrenia
Publication date: Available online 3 July 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Sergej Nadalin, Jelena Rebić, Vesna Šendula Jengić, Vjekoslav Peitl, Dalibor Karlović, Alena Buretić-TomljanovićAbstractWe investigated the relationship between the rs10798059 (BanI) and rs4375 polymorphisms in the phospholipase A2 (PLA2)G4A and PLA2G6 genes and the risk of nicotine dependence in 263 Croatian patients with schizophrenia. We also examined whether interactions between these polymorphisms and smoking contributed to schizophrenia onset and Positive and Negative Syndrome Scale (PANSS) psy...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 4, 2019 Category: Lipidology Source Type: research

Effect of weight loss on neutrophil resolvins in the metabolic syndrome.
Conclusion: Following weight loss, human neutrophils from individuals with the metabolic syndrome are capable of releasing larger amounts of RvE1 upon stimulation. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 3, 2019 Category: Lipidology Source Type: research

Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U-13C]linoleic acid
This study examined the effects of aging and FADS polymorphisms on LCPUFA biosynthetic capacity via direct quantification using [U-13C]linoleic acid. Healthy young (25–34 years) and elderly (65–74 years) participants were administered [U-13C]linoleate, and its metabolites were monitored for 14 days. The time of maximum plasma concentration of 13C-arachidonic acid (ARA) was 4–5 days. The area under the curve of the 13C-ARA concentration differed by FADS1 rs174547 polymorphism (TT [100%]> TC [57%]> CC [37%]). Among C allele carriers, 13C-ARA formation was 32% lower in elderly than in young participants. This is the fir...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 3, 2019 Category: Lipidology Source Type: research

Serum polyunsaturated fatty acids and risk of psychiatric disorder at 6 months after acute coronary syndrome: A prospective cohort study
Publication date: Available online 3 July 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Hiroko Noguchi, Ryo Okubo, Kei Hamazaki, Akihiro Yamashita, Tomomi Narisawa, Yutaka J. MatsuokaAbstractCardiovascular disease is a known risk factor for the development of psychiatric disorder and about 20% of patients with acute coronary syndrome (ACS) develop depression. Our previous prospective study showed that serum linoleic acid (LA) level at baseline (admission) is a risk factor for the development of psychiatric disorder 3 months later. However, it was unclear whether serum LA could predict psychia...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 3, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: July 2019Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 146Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - June 9, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: June 2019Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 145Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 22, 2019 Category: Lipidology Source Type: research