Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Spotlight on fatty acids in cell signaling: The 13th FACS Meeting
Publication date: Available online 23 October 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Jan F.C. Glatz, Michel Lagarde (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - October 24, 2019 Category: Lipidology Source Type: research

Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion.
Publication date: Available online 16 October 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Iain Brown, Jisun Lee, Alan A. Sneddon, Maria G. Cascio, Roger G. Pertwee, Klaus W.J. Wahle, Dino Rotondo, Steven D. HeysAbstractThe anticancer effects of the omega-3 long chain polyunsaturated fatty acids (LCPUFA), EPA and DHA may be due, at least in part, to conversion to their respective endocannabinoid derivatives, eicosapentaenoyl-ethanolamine (EPEA) and docosahexaenoyl-ethanolamine (DHEA). Here, the effects of EPEA and DHEA and their parent compounds, EPA and DHA, on breast cancer (BC) cell funct...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - October 17, 2019 Category: Lipidology Source Type: research

Human milk fatty acid profile across lactational stages after term and preterm delivery: a pooled data analysis
ConclusionsThere was high heterogeneity in reported levels of some FAs between individual studies, whereas others are remarkably constant. Our pooled data suggests that there are distinct patterns of content fluctuations for specific FA categories over the course of lactation; many of these patterns are comparable between term and preterm milk. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - October 17, 2019 Category: Lipidology Source Type: research

Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: two systematic reviews.
Publication date: Available online 11 October 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): CAPT Joseph R. Hibbeln, Philip Spiller, J. Thomas Brenna, Jean Golding, Bruce J. Holub, William S. Harris, Penny Kris-Etherton, Bill Lands, Sonja L. Connor, Gary Myers, J.J. Strain, Michael A Crawford, Susan E. CarlsonAbstractAbundant data are now available to evaluate relationships between seafood consumption in pregnancy and childhood and neurocognitive development. We conducted two systematic reviews utilizing methodologies detailed by the Dietary Guidelines for Americans Scientific Advisory Committ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - October 12, 2019 Category: Lipidology Source Type: research

An abundance of seafood consumption studies presents new opportunities to evaluate effects on neurocognitive development
Publication date: Available online 11 October 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Philip Spiller, CAPT Joseph R. Hibbeln, Gary Myers, Gretchen Vannice, Jean Golding, Michael A Crawford, J.J. Strain, Sonja L. Connor, J. Thomas Brenna, Penny Kris-Etherton, Bruce J. Holub, William S. Harris, Bill Lands, Robert K. McNamara, Michael F. Tlusty, Norman Salem, Susan E. CarlsonAbstractThe relationship between seafood eaten during pregnancy and neurocognition in offspring has been the subject of considerable scientific study for over 25 years. Evaluation of this question led two scientific ad...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - October 12, 2019 Category: Lipidology Source Type: research

Effects of Prostaglandin E2 and D2 on cell proliferation and osteogenic capacity of Human Mesenchymal Stem Cells
Publication date: Available online 13 September 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): C. Ern, I. Frasheri, T. Berger, H.G. Kirchner, R. Heym, R. Hickel, M. FolwacznyAbstractThe manifestation of periodontitis-related inflammatory reaction is inevitably bound to the production of prostaglandins E2 and D2 which have been suggested to mediate osteoclastic and osteogenic effects within the affected tissue.We demonstrated the presence of PGE2 and PGD2 receptors on hMSCs on RNA level and with immunofluorescence. For each Prostaglandin, three concentrations were studied: 0.1; 0.5 or 1.0µg/ml...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - September 15, 2019 Category: Lipidology Source Type: research

Maternal polymorphisms in the FADS1 and FADS2 genes modify the association between PUFA ingestion and plasma concentrations of omega-3 polyunsaturated fatty acids
Publication date: Available online 13 September 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): GQ Carvalho, M Pereira-Santos, LD Marcon, ID Louro, MCG Peluzio, DB SantosAbstractThere is a lack of studies about polymorphisms in FADS genes in pregnant women. We aimed to verify the interaction between three FADS gene polymorphisms (rs174561; rs174575; rs3834458) and dietary α-linolenic acid (ALA) or linoleic/α-linolenic acid ratio (LA/ALA) and plasma concentrations of omega-3 (n-3) PUFAs in pregnant women. Of the 250 women evaluated, the homozygous for the rs174561 and rs3834458 minor allele ha...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - September 15, 2019 Category: Lipidology Source Type: research

Association between fat-soluble nutrient status and auditory and visual related potentials in newly diagnosed non-screened infants with cystic fibrosis: A case-control study
Conclusions: Newly diagnosed non-screened CF infants with PI showed alterations in sensory responses mimicking an immature auditory processing. The role of lower DHA status as a potential contributing factor warrants further investigation. As CF neonatal screening becomes widespread, this study emphasizes the importance of early nutritional intervention and neurodevelopmental follow-up in CF newborns to protect brain development.SummaryNutritional deficiencies often precede the diagnosis of cystic fibrosis (CF) in infants, and occur at a stage where the rapidly developing brain is more vulnerable to insult. We aim to compa...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - September 7, 2019 Category: Lipidology Source Type: research

Branched chain fatty acid composition of yak milk and manure during full-lactation and half-lactation
ConclusionsBCFA in yak manure especially anteiso BCFA are positively correlated with yak milk from the same animal, indicating that these BCFA come from dietary sources. Yak milk delivers 777 mg BCFA compared to 158 mg per cup of whole U.S. dairy milk. QTP herders known to consume up to 2 kg of yak yogurt take in an estimated 3,500-5,000 mg BCFA per day. We conclude that BCFA intake for yak milk consumers is among the highest known in the world, higher when drawn from half lactating yaks. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - September 5, 2019 Category: Lipidology Source Type: research

Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma
CONCLUSIONThese findings suggest that certain plasma oxylipins can be measured with reasonable accuracy despite delayed processing for up to two hours when blood is stored on ice prior to centrifugation. 12-lipoxygenase- and platelet-derived oxylipins may be particularly sensitive to post-collection artifact with delayed processing at room temperature. Future studies are needed to determine impacts of duration and temperature of centrifugation on oxylipin concentrations. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - September 5, 2019 Category: Lipidology Source Type: research

Docosahexaenoic acid varies in rat skeletal muscle membranes according to fibre type and provision of dietary fish oil
ConclusionThe exquisite responsiveness of all skeletal muscles to as little fish oil as the equivalent of 1-2 fish meals per week in a human diet and the selective relationship to fatigable muscle fibre-types supports an integral role for DHA in muscle physiology, and particularly in fatigue resistance of fast-twitch muscles.SummarySkeletal muscle fibres vary according to structural, metabolic and neurological characteristics and ultimately influences contractile function. This study sort to determine if the composition of phospholipid polyunsaturated fatty acids (PUFA), incorporated in their membranes, might also differ a...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 30, 2019 Category: Lipidology Source Type: research

Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with Rheumatoid Arthritis
This study investigates potential causes of the decreased disease activity by analysing fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in the participants of the MIRA trial. Twenty-three women completed the randomized 2 × 11-week cross-over dietary intervention, exchanging one cooked meal per day, five days a week, with a meal including 75 g blue mussels or 75 g meat. Fatty acid composition in erythrocytes and plasma and 1H-Nuclear Magnetic Resonance (1H-NMR) metabolomics data were analysed with multivariate data analysis. Orthogonal Projections to Latent Structures with Discrimi...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 25, 2019 Category: Lipidology Source Type: research

Effects of the rs3834458 Single Nucleotide Polymorphism in FADS2 on Levels of n-3 Long-chain Polyunsaturated Fatty Acids: A Meta-analysis
Conclusion: This meta-analysis indicates that minor allele of rs3834458 in FADS2 may result in lower activity of delta-6 desaturases leading to higher ALA and lower EPA, DPA and DHA in blood. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 25, 2019 Category: Lipidology Source Type: research

Influence of iron-deficient diets during gestation and lactation on cerebral fatty acids and eicosanoids in guinea pig offspring – comparison of studies with different sources of dietary lipids
Publication date: Available online 9 August 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Jean-Luc Jougleux, France M. Rioux, Sylvain Fiset, Luc H. Boudreau, Marc E. SuretteAbstractPrevious studies showed that mild iron deficiency anaemia (IDA) induced by feeding an iron deficient (ID) diet to female guinea pigs during gestation and lactation to alters the auditory functions of the offspring when corn oil is the only source of dietary lipids. Conversely, feeding an ID diet with a dietary fatty acid composition similar to that of typical human western diets induced minor impairments. Since tis...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 9, 2019 Category: Lipidology Source Type: research

Involvement of H+-gradient dependent transporter in PGE2 release from A549 cells
Publication date: Available online 8 August 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Nobuaki Tanaka, Hiroaki Yamaguchi, Nariyasu ManoAbstractThe purpose of this study was to identify the transporter involved in the release of prostaglandin E2 (PGE2). In the present study, transport assays were conducted using membrane vesicles prepared from human lung adenocarcinoma A549 cells, thus enabling identification of the novel exporter present in A549 cells. PGE2 transport into A549 vesicles was higher in the presence of a proton (H+)-gradient, thus suggesting the involvement of PGE2-H+ symporte...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 9, 2019 Category: Lipidology Source Type: research