Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Daniela A. Pereira, Valéria C. Sandrim, Ana C.T. Palei, Jose E. Tanus-Santos, Vanessa A. Belo, Ricardo C. Cavalli, Marcelo R. LuizonAbstractNAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated to nitr...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 12, 2019 Category: OBGYN Source Type: research

Association of arginine vasopressin (AVP) promoter polymorphisms with preeclampsia
ConclusionPolymorphic variants located on the promoter region of AVP are associated with PE. Thus we hypothesize that allelic variation may have a role in increasing the risk of developing PE. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 6, 2019 Category: OBGYN Source Type: research

Levels of syndecan-1 and hyaluronan in early- and late-onset preeclampsia
ConclusionsDegree of endothelium injury is comparable in patients with early- and late-onset PE. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 5, 2019 Category: OBGYN Source Type: research

Combined effects of increasing maternal age and nulliparity on hypertensive disorders of pregnancy and small for gestational age
ConclusionThe combination of increasing maternal age and nulliparity has a more negative impact on the occurrence of SGA than either risk factor alone. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 5, 2019 Category: OBGYN Source Type: research

A randomized-controlled trial to assess the effect of ibuprofen on postpartum blood pressure in women with hypertensive disorders of pregnancy
ConclusionsAmong women with gestational hypertension and preeclampsia without severe features, ibuprofen is an equally safe option as acetaminophen with respect to postpartum blood pressure concerns. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 5, 2019 Category: OBGYN Source Type: research

Oxidative stress in early pregnancy and the risk of preeclampsia
ConclusionCAT is the only antioxidant as shown in our study to be related to the severity of the disease and may be a promising predictor for PE. Further studies are warranted to investigate the use of CAT as a novel therapeutic for PE. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 3, 2019 Category: OBGYN Source Type: research

Association of maternal Toll-like receptor-4 alleles with susceptibility to early-onset preeclampsia in central Greece
DiscussionWe recorded association between common TLR4 gene variants and early-onset preeclampsia. Our findings support the involvement of maternal innate immune system in severe hypertensive disorders of pregnancy and point to the potential value of maternal TLR4 polymorphisms as predictors-risk factors of susceptibility to early-onset preeclampsia in Central Greece. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 3, 2019 Category: OBGYN Source Type: research

Sequential profile of endothelial functions and arterial stiffness in preeclampsia during the course of pregnancy
ConclusionsCompromised arterial functions precede the onset of PE. AIx and carotid femoral PWV constitute potential predictive marker in early pregnancy for later development of PE. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 2, 2019 Category: OBGYN Source Type: research

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Qingyou Du, Sofija Jovanović, Lidija Tulić, Ivan Tulić, Aleksandar JovanovićAbstractIt is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 2, 2019 Category: OBGYN Source Type: research

Association of serum angiogenic factors with bronchopulmonary dysplasia. The ANGIODYS cohort study
ConclusionsIn IUGR preterm babies born before 30 weeks’ gestation from preeclamptic mothers, serum sFlt-1, PlGF and sEng, TGF-β levels were not correlated with BPD. The increased BPD risk in preterm neonates born from preeclamptic mothers cannot be related to high sFlt-1 levels. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - September 29, 2019 Category: OBGYN Source Type: research

Quality of evidence on pre-eclampsia in the last three decades: An analysis of published literature
ConclusionThe yearly number of publications on pre-eclampsia has substantially increased, with a stable number of high-level study types and publications from high-impact journals. The reporting quality and usefulness of RCTs relating to pre-eclampsia have improved over time. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - September 22, 2019 Category: OBGYN Source Type: research

Prediction of adverse maternal outcomes in preeclampsia at term
In this study we were interested in examining the number of patients developing preeclampsia with severe features at term. We also investigated whether factors at admission might be predictive of disease progression.We performed a retrospective cohort study at a tertiary obstetric hospital in Melbourne, Australia from 2015 to 2017. There were 124 participants presenting with preeclampsia at term and included in our study. After admission, 44.4% progressed to preeclampsia with severe features. Disease features at admission associated with disease progression were chronic hypertension, elevated systolic blood pressure, reduc...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - September 22, 2019 Category: OBGYN Source Type: research

CYP1A1, GSTT1, IL-6 and IL-8 transcription and IL-6 secretion on umbilical endothelial cells from hypertensive pregnant women: Preliminary results
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Sandra S. Reyes-Aguilar, Irais Poblete-Naredo, Yury Rodríguez-Yáñez, Rogelio O. Corona-Núñez, Christian D. Ortiz-Robles, Emma S. Calderón-Aranda, Arnulfo AlboresAbstractThe impact of pregnancy hypertension in the offspring endothelia remains unknown. We evaluated the transcriptional expression of four genes that participate in the process of endothelial dysfunction using umbilical vein endothelial cell cultures (HUVEC) from healthy pregnant women (PW) and those with hypertensive disorders (HD). The cytochrome P450 1A1 (CYP1A1), gluthath...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - September 19, 2019 Category: OBGYN Source Type: research

Worrying yourself sick? Association between pre-eclampsia onset and health-related worry in pregnancy
We examined the relationship between worry about pregnancy health and pre-eclampsia. General stress, mental health, and self-reported pregnancy health worry were measured in a study of 10,037 U.S. nulliparous women. Logistic regression found a dose-response relationship between first trimester pregnancy-health worry and subsequent pre-eclampsia onset, controlling for health history (Beta = 0.40, SE = 0.09, P < 1 × 10−6). A machine learning regularized regression found a significant relationship between worry and pre-eclampsia onset, controlling for all other potential predictors of pre-eclampsia meas...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - September 14, 2019 Category: OBGYN Source Type: research

Subclinical cardiac stiffness is associated with arterial stiffness in healthy young nulligravid women: Potential links to preeclampsia
ConclusionsIn healthy nulligravid women there is evidence that markers of decreased left ventricular relaxation are associated with increased peripheral vascular stiffness as is a family history of myocardial infarction or hypertension. These findings raise the possibility that the diastolic dysfunction and arterial stiffness observed in the setting of preeclampsia are driven by underlying properties present prior to pregnancy and contribute to lifetime cardiovascular risk. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - September 13, 2019 Category: OBGYN Source Type: research