Identification of miR-210-5p in human placentae from pregnancies complicated by preeclampsia and intrauterine growth restriction, and its potential role in the pregnancy complications
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Zain Awamleh, Victor K.M. HanAbstractPreeclampsia (PE) and intrauterine growth restriction (IUGR) are pregnancy complications resulting from abnormal placental development. As epigenetic regulators, microRNAs can regulate placental development and contribute to the disease pathophysiology by influencing the expression of genes involved in placental development or disease. Our previous study revealed an increase in miR-210-5p expression in placentae from patients with early-onset pregnancy complications and identified candidate gene targets fo...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 22, 2020 Category: OBGYN Source Type: research

Longitudinal follow-up of kidney function in patients with a history of preeclampsia: From 11 to 18 years postpartum
In conclusion, our data suggests that progression to kidney disease might not be a major concern in women after preeclampsia within 18 years postpartum. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 22, 2020 Category: OBGYN Source Type: research

Epidemiology of pre-eclampsia in the Republic of Kazakhstan: Maternal and neonatal outcomes
ConclusionThe data obtained are needed to tailor public health interventions targeted on a reduction of PE problem in Kazakhstan. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 21, 2020 Category: OBGYN Source Type: research

Methylene tetrahydrofolate reductase and methionine synthase gene polymorphisms as genetic determinants of pre-eclampsia
ConclusionMTHFR C677T and MTR A2756G polymorphisms were associated with pre-eclampsia in a population of pregnant women in Lagos, Nigeria. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 11, 2020 Category: OBGYN Source Type: research

Title. Epidemiology of pre-eclampsia in the Republic of Kazakhstan: maternal and neonatal outcomes
ConclusionThe data obtained are needed to tailor public health interventions targeted on a reduction of PE problem in Kazakhstan. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 11, 2020 Category: OBGYN Source Type: research

PHLDA2 gene polymorphisms and risk of HELLP syndrome and severe preeclampsia
CONCLUSIONGenetic variation in the PHLDA2 gene is not associated with HELLP syndrome or PE with severe features. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 30, 2020 Category: OBGYN Source Type: research

Opportunities for improving hypertensive disorders of pregnancy (HDP) management in primary care settings: a review of international published guidelines in the context of pregnancy care in Indonesia
Publication date: Available online 22 January 2020Source: Pregnancy HypertensionAuthor(s): Fitriana Murriya Ekawati, Ova Emilia, Shaun Brennecke, Jane Gunn, Sharon Licqurish, Phyllis LauAbstractGlobally, almost maternal mortality caused by HDP occurs in low to middle-income countries (LMIC); yet, limited guidance is available to local primary care practitioners who are usually the main health care providers. This review examined existing international practice guidelines to identify potential practices to improve HDP management in Indonesian primary care. We performed a structured literature search strategies and snowballi...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 22, 2020 Category: OBGYN Source Type: research

The flipside of hydralazine in pregnancy: A systematic review and meta-analysis
Publication date: Available online 21 January 2020Source: Pregnancy HypertensionAuthor(s): Christina Antza, Chrisa Dimou, Ioannis Doundoulakis, Evangelos Akrivos, Stella Stabouli, Anna Bettina Haidich, Dimitrios G. Goulis, Vasilios kotsisAbstractThe present systematic review and meta-analysis investigated the effects of hydralazine compared with other antihypertensive drugs in maternal, perinatal and neonatal outcomes of pregnant women with hypertensive disorders. Twenty studies with 1283 participants were included. Of them, 626 received hydralazine and 657 other antihypertensive treatments, such as labetalol, nifedipine, ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 21, 2020 Category: OBGYN Source Type: research

Aspirin modulates STOX1 expression and reverses STOX1-induced insufficient proliferation and migration of trophoblast cells
ConclusionThe present study suggested that inhibition of the expression of STOX1 could promote the effects of aspirin in the treatment of preeclampsia. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 18, 2020 Category: OBGYN Source Type: research

Longitudinal follow-up of Kidney Function in Patients with a History of Preeclampsia: from 11 to 18 years postpartum
In conclusion, our data suggests that progression to kidney disease is not a major concern in women after preeclampsia within 18 years postpartum. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Maternal hypertension, preeclampsia, and risk of neonatal respiratory disorders in a large-prospective cohort study
Conclusion: Maternal hypertension and preeclampsia are risk factors for neonatal respiratory disorders in full-term and preterm newborns. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Identification of microRNA 210-5p in Human Placentae from Pregnancies Complicated by Preeclampsia and Intrauterine Growth Restriction, and its Potential Role in the Pregnancy Complications
Publication date: Available online 14 January 2020Source: Pregnancy HypertensionAuthor(s): Zain Awamleh, Victor K.M. HanAbstractPreeclampsia (PE) and intrauterine growth restriction (IUGR) are pregnancy complications resulting from abnormal placental development. As epigenetic regulators, microRNAs can regulate placental development and contribute to the disease pathophysiology by influencing the expression of genes involved in placental development or disease. Our previous study revealed an increase in miR-210-5p expression in placentae from patients with early-onset pregnancy complications and identified candidate gene t...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

The relationship of a Prothrombsin G20210A mutation or a Factor V Leiden mutation and on-aspirin platelet (re-)activity
ConclusionWe feel these data are suggestive of increased on-aspirin platelet (re-)activity, as measured by the PFA-200 and the VerifyNow, in non-pregnant carriers of a FII-mutation, but not in carriers of FVL-mutation. Interestingly, this increased on-aspirin platelet (re-)activity is present in spite of low sTxB2 levels (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Retrospective evaluation of established cut-off values for the sFlt-1/PlGF ratio for predicting imminent delivery in preeclampsia patients
ConclusionThe sFlt-1/PlGF ratio appears to be a powerful tool for diagnosing and predicting preeclampsia. However, the data do not confirm the cut-off values described earlier, with longer pregnancy durations in this group of patients. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Calcium deficient placental growth restriction is mediated by an increase in non-invasive integrin α5 and β4 phenotype
ConclusionsThe in vitro trophoblast cell integration into endothelial cellular networks could be modified by altering media calcium through integrin switch away from integrins α5 and β4 and towards integrin α1 which may be required for healthy early trophoblast integration. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research