Progress in the treatment of Friedreich ataxia
Publication date: March 2018Source: Neurologia i Neurochirurgia Polska, Volume 52, Issue 2Author(s): Geneieve Tai, Louise A. Corben, Eppie M. Yiu, Sarah C. Milne, Martin B. DelatyckiAbstractFriedreich ataxia (FRDA) is a progressive neurological disorder affecting approximately 1 in 29,000 individuals of European descent. At present, there is no approved pharmacological treatment for this condition however research into treatment of FRDA has advanced considerably over the last two decades since the genetic cause was identified. Current proposed treatment strategies include decreasing oxidative stress, increasing cellular fr...
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Optical coherence tomography in diagnosis and monitoring multiple sclerosis
Publication date: March 2018Source: Neurologia i Neurochirurgia Polska, Volume 52, Issue 2Author(s): Jan Kucharczuk, Zdzisław Maciejek, Bartosz L. SikorskiAbstractThis paper presents application of optical coherence tomography (OCT) for diagnosis and monitoring of multiple sclerosis (MS). The peripapillary retinal nerve fibre layer thinning and the reduced total macular volume analysis are shown. With the course of the MS, the severity of these abnormalities increases which reflects the progressive degeneration of retinal ganglion cells and nerve fibres. The OCT parameters are sensitive, non-invasive indicators useful in ...
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients
ConclusionOur study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

The importance of atrial fibrillation and selected echocardiographic parameters for the effectiveness and safety of thrombolytic therapy in patients with stroke
ConclusionsThe presence of atrial fibrillation worsens the patient's prognosis in terms of the functional status and survival during the acute period of stroke in patients treated with intravenous thrombolysis.Higher NIHSS and CHA2DS2VASc scores and reduced EF in patients with stroke treated with thrombolysis are the predictors of unfavorable short-term prognosis. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Differences in carotid artery atherosclerosis between men and women in the early phase after ischemic event
ConclusionsMen had more often carotid stenosis and higher number of hypoechogenic plaques. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Noninfectious complications of acute stroke and their impact on hospital mortality in patients admitted to a stroke unit in Warsaw from 1995 to 2015
ConclusionsOver the last two decades Polish urban stroke units may have achieved a significant reduction of the occurrence of some noninfectious complications (i.e. MI, exacerbated CHF and DVT). However, the list of conditions associated with stroke unit mortality includes not only MI and exacerbated CHF but also PE, gastrointestinal bleeding and recurrent stroke. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Primary Ewing sarcoma of the axis-C2: A case report and the review of the literature
ConclusionPediatric neck pain and/or torticollis should raise high suspicion for malignancy of cervical spine. Modern diagnostic means and techniques can assist in the screening and diagnosis of these tumors. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Evidence for a relatively high proportion of DM2 mutations in a large group of Polish patients
ConclusionThe relative frequencies of DM1/DM2 among Polish patients were 68% and 32%, respectively, with a relatively high proportion of DM2 mutations (1.6:1). (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Examinations of the methods used to power supply of different light sources and their effect on bioelectrical brain activity
ConclusionsThe highest activity of brain waves concerns the beta band in the frequency range of 21–22 Hz, regardless of the type of the light source (LED, fluorescent tube). The methods used to supply power and color temperature of fluorescent tubes do not significantly affect bioelectrical brain activity during “work”, but previous lighting with fluorescent tubes during work has an essential effect on bioelectrical brain activity during rest. Regardless of the color temperature, LED lighting with PWM power supply leads to the highest bioelectrical activity (mainly in the range of 21–22 Hz) in the brain d...
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Giant intradural cervical spine arteriovenous malformations – A case and review of literature
ConclusionSpinal angiography is the gold standard for all-inclusive assessment of SAVMs. Surgery and endovascular techniques equally have key therapeutic valves in treatment of SAVMs but a combination of the two gives a more accurate and reliable cure to this disorder. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

The evaluation of the effects of steroid treatment on the tumor and peritumoral edema by DWI and MR spectroscopy in brain tumors
ConclusionDexamethasone has no significant effect on the volume of peritumoral edema in glial tumor and metastasis. Moreover, dexamethasone increases the fluid movements in low grade gliomas and metastases, decreases in high grade gliomas. However, more comprehensive clinical studies are needed to show the effects of dexamethasone on brain tumors and peritumoral edema. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Association of depression, anxiety and post-traumatic stress disorder with migraine: Data from Kosovo
ConclusionBased on our data, we can confirm an association between PTSD and migraine in a sample of patients from Kosovo. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Symptomatic medulla compression by vertebral artery
ConclusionVAMCS should be considered as the cause of neurological deficits when other pathological entities are ruled out. In symptomatic conflict of the VA with the medulla, microvascular decompression using a Gore-Tex implant can be an effective method of treatment. Nevertheless, a statistical analysis on all reported cases showed favorable results using the VA repositioning technique when compared with MVD (success rate 91% vs. 58%, p < 0.05). (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Immune-cell BDNF expression in treatment-naïve relapsing-remitting multiple sclerosis patients and following one year of immunomodulation therapy
Publication date: Available online 29 March 2018Source: Neurologia i Neurochirurgia PolskaAuthor(s): Alicja Kalinowska-Łyszczarz, Mikołaj A. Pawlak, Aleksandra Wyciszkiewicz, Krystyna Osztynowicz, Wojciech Kozubski, Sławomir MichalakAbstractAlthough neurons are the main source of neurotrophins in the healthy brain, neurotrophins can also be expressed in the immune system. We have previously shown that in relapsing-remitting multiple sclerosis (RRMS) lower immune-cell neurotrophin levels are associated with brain atrophy and cognitive impairment. The aim of the present study was to assess if immune-cell neurotrophin expr...
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: Association with neurological deficit
ConclusionThe presence of 407Lys allele is associated with better prognosis in cryptogenic cerebrovascular events. Our findings suggest that the α2AP Arg407Lys polymorphism could be involved in the pathogenesis of cerebral ischemia and its outcomes. (Source: Polish Journal of Neurology and Neurosurgery)
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research