Safety, Tolerability, and Effectiveness of Dextromethorphan/Quinidine for Pseudobulbar Affect Among Study Participants With Traumatic Brain Injury: Results From the PRISM-II Open Label Study
Dextromethorphan 20 mg / quinidine 10 mg (DM/Q) was approved to treat pseudobulbar affect (PBA) based on phase 3 trials conducted in participants with amyotrophic lateral sclerosis or multiple sclerosis. PRISM II evaluated DM/Q effectiveness, safety, and tolerability for PBA following stroke, dementia, or traumatic brain injury (TBI). (Source: PM and R)
Source: PM and R - February 22, 2018 Category: Rehabilitation Authors: Flora M. Hammond, William Sauve, Fred Ledon, Charles Davis, Andrea E. Formella Tags: Original Research Source Type: research
Effect of Rear Wheel Suspension on Tilt-in-Space Wheelchair Shock and Vibration Attenuation
Suspension systems are designed to reduce shock and vibration exposure. An aftermarket rear-wheel suspension system is now available for manual tilt-in-space wheelchairs. (Source: PM and R)
Source: PM and R - February 22, 2018 Category: Rehabilitation Authors: Molly Hischke, Raoul F. Reiser Source Type: research
Safety, Tolerability, and Effectiveness of Dextromethorphan/Quinidine for Pseudobulbar Affect Among Study Participants With Traumatic Brain Injury: Results From the PRISM-II Open Label Study
Dextromethorphan 20mg /quinidine 10mg (DM/Q) was approved to treat pseudobulbar affect (PBA) based upon phase 3 trials conducted in participants with amyotrophic lateral sclerosis or multiple sclerosis. PRISM II evaluated DM/Q effectiveness, safety and tolerability for PBA following stroke, dementia or traumatic brain injury (TBI). Objective. To report results from the TBI cohort of PRISM II, including a TBI-specific functional scale. Design. Open-label trial evaluating twice daily DM/Q over 90 days. (Source: PM and R)
Source: PM and R - February 22, 2018 Category: Rehabilitation Authors: Flora M. Hammond, William Sauve, Fred Ledon, Charles Davis, Andrea E. Formella Source Type: research
Evaluation of Performance-Based Outcome Measures for the Upper Limb: A Comprehensive Narrative Review
Objective performance-based outcome measures (OMs) have the potential to provide unbiased and reproducible assessments of limb function. However, very few of these performance-based OMs have been validated for upper limb (UL) prosthesis users. OMs validated in other clinical populations (eg, neurologic or musculoskeletal conditions) could be used to fill gaps in existing performance-based OMs for UL amputees. Additionally, a joint review might reveal consistent gaps across multiple clinical populations. (Source: PM and R)
Source: PM and R - February 20, 2018 Category: Rehabilitation Authors: Sophie Wang, C. Janice Hsu, Lauren Trent, Tiffany Ryan, Nathan T. Kearns, Eugene F. Civillico, Kimberly L. Kontson Tags: Narrative Review Source Type: research
Footwear-Generated Dynamic Biomechanical Manipulation and Perturbation Training for Chronic Nonspecific Low Back Pain
Home-based therapy optimizing biomechanics and neuromuscular control is increasingly recognized as a treatment option for chronic nonspecific low back pain (CNSLBP). However, its impact on pain, function, and gait is limited among patients in a metropolitan area. (Source: PM and R)
Source: PM and R - February 20, 2018 Category: Rehabilitation Authors: Se Won Lee, Ratnakar Veeramachaneni, Ibrahim Abou Saleh, Karen Morice, Timothy Tiu, Yungtai Lo, Kevin Frison, Matthew Bartels Tags: Original Research Source Type: research
