Serological diagnosis of soil-transmitted helminth ( < i > Ascaris < /i > , < i > Trichuris < /i > and hookworm) infections: A scoping review
ConclusionsWhile a substantial number of assays are employed in epidemiological research, the current state of serological diagnosis for guiding STH prevention and control programs is limited. Only two assays designed for pigs are used to inform efficient deworming practices in pig populations. Regarding human diagnosis, none of the existing assays has undergone extensive large-scale validation or integration into routine diagnostics for MDA programs. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 4, 2024 Category: Tropical Medicine Authors: Sara Roose Source Type: research
Citizens can help to map putative transmission sites for snail-borne diseases
Conclusions and recommendationsOur results demonstrate the potential of citizen science to map putative schistosomiasis transmission sites. We therefore argue that this inclusive, powerful and cost-effective approach can be more sustainable than top-down monitoring and intervention campaigns. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 4, 2024 Category: Tropical Medicine Authors: Julius Tumusiime Source Type: research
Knowledge-attitude and practice of Anthrax and brucellosis: Implications for zoonotic disease surveillance and control in pastoral communities of Afar and Somali region, Ethiopia
ConclusionOur study revealed significant under-reporting of Anthrax and brucellosis, and weak prevention and response in humans, mostly associated with poor disease knowledge of healthcare providers. Ability to respond to animal outbreaks was limited by vaccine and drugs availability, timely vaccine administration and the mobility of pastoralists. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 4, 2024 Category: Tropical Medicine Authors: Rea Tschopp Source Type: research
Programmatic considerations and evidence gaps for chikungunya vaccine introduction in countries at risk of chikungunya outbreaks: Stakeholder analysis
by Megan Auzenbergs, Clara Maure, Hyolim Kang, Andrew Clark, Oliver Brady, Sushant Sahastrabuddhe, Kaja Abbas
Chikungunya can have longstanding effects on health and quality of life. Alongside the recent approval of the world ’s first chikungunya vaccine by the US Food and Drug Administration in November 2023 and with new chikungunya vaccines in the pipeline, it is important to understand the perspectives of stakeholders before vaccine rollout. Our study aim is to identify key programmatic considerations and gaps in Ev idence-to-Recommendation criteria for chikungunya vaccine introduction. We used purposive and snowball...
Source: PLoS Neglected Tropical Diseases - April 4, 2024 Category: Tropical Medicine Authors: Megan Auzenbergs Source Type: research
Snakebite envenoming: A systematic review and meta-analysis of global morbidity and mortality
ConclusionIncidence and mortality rates noted here highlight the global impact of snakebite and underscore the critical need to address the burden of snakebite envenoming. It also reveals that while reported snakebite incidence was higher in lower-middle-income countries, the burden of mortality was greatest among inhabitants of low-income countries, again emphasising the need for greater efforts to tackle this neglected tropical disease. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 4, 2024 Category: Tropical Medicine Authors: Afsana Afroz Source Type: research
Comparative proteomic analysis of the hemolymph and salivary glands of < i > Rhodnius prolixus < /i > and < i > R < /i > . < i > colombiensis < /i > reveals candidates associated with differential lytic activity against < i > Trypanosoma cruzi < /i > Dm28c and < i > T < /i > . < i > cruzi < /i > Y
Conclusions/SignificanceThe lysis resistance observed in the Dm28c strain would be occurring at the DTU I level.T.cruzi I is the DTU with the greatest geographic distribution, from the south of the United States to central Chile and Argentina, a distribution that could be related to resistance to oxidative stress from vectors. Likewise, we can say that lysis against strain Y could occur at the level of DTU II and could be a determinant of the vector inability of these species to transmitT.cruzi II. Future proteomic and transcriptomic studies on vectors and the interactions of the intestinal microbiota with parasites will h...
Source: PLoS Neglected Tropical Diseases - April 3, 2024 Category: Tropical Medicine Authors: Hamilton J. Barbosa Source Type: research
Domestic dogs in indigenous Amazonian communities: Key players in < i > Leptospira < /i > cycling and transmission?
Conclusions/significanceThe high prevalence of antibodies andLeptospira DNA provides strong evidence for high rates of past and current infections. Such high prevalence has not been previously reported for dogs. These dogs live in the peridomestic environment in close contact with humans, yet they are free-ranging animals that interact with wildlife. This complex web of interactions may explain the diverse types of pathogenicLeptospira observed in this study. Our results suggest that domestic dogs are likely to play an important role in the cycling and transmission ofLeptospira. Future studies in areas with complex ecoepid...
Source: PLoS Neglected Tropical Diseases - April 3, 2024 Category: Tropical Medicine Authors: Diego A. Guzm án Source Type: research
Impact of < i > Strongyloides stercoralis < /i > infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study
ConclusionOur findings indicate that Ss infection reduces complement activation, potentially mitigating inflammatory processes in individuals with T2D. The study underscores the complex interplay between helminth infections, complement regulation, and diabetes mellitus, offering insights into potential therapeutic avenues. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 2, 2024 Category: Tropical Medicine Authors: Anuradha Rajamanickam Source Type: research
Biased virus transmission following sequential coinfection of < i > Aedes aegypti < /i > with dengue and Zika viruses
Conclusions/significanceOur findings suggest that, in contrast to simultaneous arbovirus coinfection in mosquitoes that can promote the transmission and co-circulation of these viruses, sequential coinfection appears to have limited influence on arbovirus transmission dynamics. However, it is important to note that more experimental investigations are needed to refine and expand upon this conclusion. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 1, 2024 Category: Tropical Medicine Authors: Jiameng Peng Source Type: research
Venom diversity in < i > Naja mossambica < /i > : Insights from proteomic and immunochemical analyses reveal intraspecific differences
Conclusions/SignificanceOur findings reveal a substantial presence of neurotoxic proteins inN.mossambica venoms, challenging previous understandings of their composition. Additionally, the detection of numerous peptides aligning to uncharacterized proteins or proteins with unknown functions underscores a critical issue with existing venom protein databases, emphasizing the substantial gaps in our knowledge of snake venom protein components. This underscores the need for enhanced research in this domain. Moreover, ourin vitro immunological assays suggest EchiTAb+ICP ’s potential as an alternative to SAIMR antivenom, requi...
Source: PLoS Neglected Tropical Diseases - April 1, 2024 Category: Tropical Medicine Authors: Konrad K. Hus Source Type: research
Development of a computational model to inform environmental surveillance sampling plans for < i > Salmonella enterica < /i > serovar Typhi in wastewater
This study presents a computational model combining dynamic and probabilistic modeling techniques to estimate–on a spatial and temporal scale–the approximate probability of detectingS. Typhi within a wastewater system. This model may be utilized to inform environmental surveillance sampling plans and may provide useful insight into selecting appropriate sampling locations and times and interpreting results. A simulated applied modeling scenario is presented to demonstrate the model ’s functionality for aiding an environmental surveillance study in a typhoid-endemic community. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 29, 2024 Category: Tropical Medicine Authors: Elisabeth Burnor Source Type: research
Assessment of < i > Culicidae < /i > collection methods for xenomonitoring lymphatic filariasis in malaria co-infection context in Burkina Faso
Conclusions/SignificanceThis study revealed that HLC indoor and outdoor remained the most effective collection method. Likewise, the results showed the probability to use Window Exit-Trap and PSC collection methods to sampleAnopheles infected. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 29, 2024 Category: Tropical Medicine Authors: Sanata Coulibaly Source Type: research
Proceedings of the 6th Asia Dengue Summit, June 2023
by Nattachai Srisawat, Duane J. Gubler, Tikki Pangestu, Umaporn Limothai, Usa Thisyakorn, Zulkifli Ismail, Daniel Goh, Maria Rosario Capeding, Lulu Bravo, Sutee Yoksan, Terapong Tantawichien, Sri Rezeki Hadinegoro, Kamran Rafiq, Valentina Sanchez Picot, Eng Eong Ooi
The 6th Asia Dengue Summit (ADS) themed “Road Map to Zero Dengue Death” was held in Thailand from 15th–16th June 2023. The summit was hosted by Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand in conjunction with Queen Saovabha Memorial Institute, The Thai Red Cross Society; Faculty of Tropical Medicine, Mahido l University; and the...
Source: PLoS Neglected Tropical Diseases - March 29, 2024 Category: Tropical Medicine Authors: Nattachai Srisawat Source Type: research
Mixed methods to evaluate knowledge, attitudes and practices (KAP) towards rabies in central and remote communities of Moramanga district, Madagascar
by Claire Leblanc, Daouda Kassi é, Mendrika Ranaivoharimina, Elliot Fara Nandrasana Rakotomanana, Reziky Tiandraza Mangahasimbola, Anjasoa Randrianarijaona, Ravo Ramiandrasoa, Alphonse José Nely, Nivohanitra Perle Razafindraibe, Soa Fy Andriamandimby, Dany Bakoly Ranoaritiana, Virginie Rajaonarivony, Laurence Randrianasolo, Laur ence Baril, Chiarella Mattern, Rila Ratovoson, Hélène Guis
Control of dog-mediated rabies relies on raising awareness, access to post-exposure prophylaxis (PEP) and mass dog vaccination. To assess rabies awareness in Moramanga district, Madagascar, where rabies is endemic, two complementary qu...
Source: PLoS Neglected Tropical Diseases - March 29, 2024 Category: Tropical Medicine Authors: Claire Leblanc Source Type: research
Human myiasis in Sub-Saharan Africa: A systematic review
ConclusionThe findings of this study reveals that international travelers to Sub-Saharan Africa were mostly infested therefore, we recommend that both international travelers and natives of SSA be enlightened by public health officers about the disease and its risk factors at entry points in SSA and the community level respectively. Clinicians in Sub-Saharan Africa often misdiagnose the disease and most of them lack the expertise to properly identify larvae, so we recommend the extensive use of molecular identification methods instead. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 28, 2024 Category: Tropical Medicine Authors: Binta J. J. Jallow Source Type: research
