Gender differences in trachomatous scarring prevalence in a formerly trachoma hyperendemic district in Tanzania
Conclusions/SignificanceOverall scarring prevalence and more severe scarring prevalence was higher in females compared to males, even adjusting for age and community TF prevalence. The data suggest that processes occur that lead to women preferentially progressing towards more severe scarring compared to men. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 26, 2024 Category: Tropical Medicine Authors: Meraf A. Wolle Source Type: research
Longitudinal analysis of antibody responses to < i > Plasmodium vivax < /i > sporozoite antigens following natural infection
Conclusions/SignificanceThe present study demonstrated the magnitude and longevity of serological responses to multiple PE antigens ofP.vivax after natural infection. This knowledge could contribute to the design of an effectiveP.vivax vaccine. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 26, 2024 Category: Tropical Medicine Authors: Pongsakorn Thawornpan Source Type: research
Epidemiology of < i > Echinococcus granulosus sensu lato < /i > in the Greater Horn of Africa: A systematic review
ConclusionsWe confirm thatE.granulosus s.l. is prevalent throughout the GHA. Nevertheless, despite our efforts to screen grey literature, an accurate assessment of the epidemiology in GHA remains challenging, due to the lack of combined host, in-depth risk factor and behavioural studies, as well as the wide diversity in subpopulations studied and diagnostic tools used. Interdisciplinary and transboundary partnerships would be essential for the design of effective control strategies, tuned to the GHA setting. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 25, 2024 Category: Tropical Medicine Authors: Weldegebrial G. Aregawi Source Type: research
Development of a multivariate predictive model for dapsone adverse drug events in people with leprosy under standard WHO multidrug therapy
ConclusionWe propose a clinical model that could become a helpful tool for physicians in predicting ADEs in DDS-treated leprosy patients. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 25, 2024 Category: Tropical Medicine Authors: Ana Carolina Galv ão dos Santos de Araujo Source Type: research
Correction: Bispidine-Amino Acid Conjugates Act as a Novel Scaffold for the Design of Antivirals That Block Japanese Encephalitis Virus Replication
by V. Haridas, Kullampalayam Shanmugam Rajgokul, Sandhya Sadanandan, Tanvi Agrawal, Vats Sharvani, M. V. S. Gopalakrishna, M. B. Bijesh, Kanhaiya Lal Kumawat, Anirban Basu, Guruprasad R. Medigeshi (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 25, 2024 Category: Tropical Medicine Authors: V. Haridas Source Type: research
Have there been efforts to integrate malaria and schistosomiasis prevention and control programs? A scoping review of the literature
The objective of this scoping review was to identify previous efforts to integrate malaria and schistosomiasis prevention and control programs in the literature and to summarize the strategies and approaches used in these programs following the PRISMA-ScR guidelines. We reviewed published and grey literature using a combination of keywords and search terms following themes surrounding “malaria”, “Plasmodium falciparum ”, “Anopheles”, “schistosomiasis”, “Schistosoma haematobium ”, “Schistosoma mansoni ”,and“snails”. Neither a date limit nor relevant terms for prevention and control were used. Out...
Source: PLoS Neglected Tropical Diseases - January 24, 2024 Category: Tropical Medicine Authors: Claudia Duguay Source Type: research
Updating estimates of < i > Plasmodium knowlesi < /i > malaria risk in response to changing land use patterns across Southeast Asia
DiscussionOur map ofP.knowlesi relative transmission suitability estimates that the risk posed by the pathogen is highest in Malaysia and Indonesia, with localised areas of high risk also predicted in the Greater Mekong Subregion, The Philippines and Northeast India. These results highlight areas of priority forP.knowlesi surveillance and prospective sampling to address the challenge the disease poses to malaria elimination planning. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 22, 2024 Category: Tropical Medicine Authors: Ruarai J. Tobin Source Type: research
Vaccination coverage and adverse events following a reactive vaccination campaign against hepatitis E in Bentiu displaced persons camp, South Sudan
ConclusionsWe found a high coverage of at least one dose of the Hecolin vaccine following three rounds of vaccination, and no severe AEFI. The vaccine was well accepted and well tolerated in the Bentiu IDP camp community and should be considered for use in future outbreak response. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 22, 2024 Category: Tropical Medicine Authors: Robin C. Nesbitt Source Type: research
Efficacy of short-course treatment for prevention of congenital transmission of Chagas disease: A retrospective cohort study
by Guillermo Moscatelli, Samanta Moroni, Juan Carlos Ram írez, Belén Warszatska, Lascano Fernanda, Nicolás González, Andrés Rabinovich, Jaime Altcheh
BackgroundIn regions with controlled vector transmission ofT.cruzi, congenital transmission is the most frequent route of infection. Treatment with benznidazole (BZ) or nifurtimox (NF) for 60 days in girls and women of childbearing age showed to be effective in preventing mother to child transmission of this disease. Reports on short-course treatment ( ≤30 days) are scarce. MethodsRetrospective cohort study. Offspring of women with Chagas disease who received short-cou...
Source: PLoS Neglected Tropical Diseases - January 22, 2024 Category: Tropical Medicine Authors: Guillermo Moscatelli Source Type: research
MicroRNA-194 regulates parasitic load and IL-1 β-dependent nitric oxide production in the peripheral blood mononuclear cells of dogs with leishmaniasis
by Sidnei Ferro Costa, Matheus Fujimura Soares, Jaqueline Poleto Bragato, Marilene Oliveira dos Santos, Gabriela Torres Rebech, J éssica Henrique de Freitas, Valéria Marçal Felix de Lima
Domestic dogs are the primary urban reservoirs ofLeishmania infantum, the causative agent of visceral leishmaniasis. In Canine Leishmaniasis (CanL), modulation of the host ’s immune response may be associated with the expression of small non-coding RNAs called microRNA (miR). miR-194 expression increases in peripheral blood mononuclear cells (PBMCs) of dogs with leishmaniasis with a positive correlation with the parasite load and in ...
Source: PLoS Neglected Tropical Diseases - January 19, 2024 Category: Tropical Medicine Authors: Sidnei Ferro Costa Source Type: research
Chagas cardiomyopathy in Boston, Massachusetts: Identifying disease and improving management after community and hospital-based screening
ConclusionsThese data show high rates of cardiac complications in a cohort of migrants living with Chagas disease in a non-endemic setting. We demonstrate that Chagas disease diagnosis prompts cardiac evaluation which often identifies actionable cardiac disease and provides opportunities for prevention and treatment. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 19, 2024 Category: Tropical Medicine Authors: Katherine A. Reifler Source Type: research
Association between arterial stiffness and < i > Loa loa < /i > microfilaremia in a rural area of the Republic of Congo: A population-based cross-sectional study (the MorLo project)
ConclusionA potential link between highL.loa microfilaremia and cardiovascular health deterioration is suggested. Further studies are required to confirm and explore this association. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 19, 2024 Category: Tropical Medicine Authors: J érémy T. Campillo Source Type: research
Development and validation of a minimum requirements checklist for snakebite envenoming treatment in the Brazilian Amazonia
ConclusionThis study joins an international set of evidence advocating for decentralization, adding value in its definition of essential care items; identification of training needs across the care continuum; and demonstration of the validity, reliability, and feasibility provided by engaging local experts. Specific to Brazil, further added value comes in the potential use of the checklist for health unit accreditation as well as its applications to logistics and resource distribution. Future research priorities should apply this checklist to health units in the Amazon region of Brazil to determine which community health c...
Source: PLoS Neglected Tropical Diseases - January 19, 2024 Category: Tropical Medicine Authors: Thiago Serr ão-Pinto Source Type: research
Mpox: The alarm went off. Have we gone back to sleep?
by Piero Olliaro, Josephine Bourner, Yap Boum II, Emmanuel Nakoun é, Elise Pesonel, Amanda Rojek, Yazdan Yazdanpanah, François-Xavier Lescure, Alexandra Calmy, Beatriz Grinsztejn, Peter Horby, Laura Merson, Jake Dunning (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 18, 2024 Category: Tropical Medicine Authors: Piero Olliaro Source Type: research
Deletion of the lipid droplet protein kinase gene affects lipid droplets biogenesis, parasite infectivity, and resistance to trivalent antimony in < i > Leishmania infantum < /i >
by Juliana Martins Ribeiro, Paula Alves Silva, H éllida Marina Costa-Silva, Ana Maria Murta Santi, Silvane Maria Fonseca Murta
The Lipid Droplet Protein Kinase (LDK) facilitates lipid droplet (LD) biogenesis, organelles involved in various metabolic and signaling functions in trypanosomatids. As LDK ’s function has not been previously explored inLeishmania spp., we utilized CRISPR/Cas9 technology to generateLDK-knockout lines ofLeishmania infantum to investigate its role in this parasite. Our findings demonstrate thatLDK is not an essential gene forL.infantum, as its deletion did not impede parasite survival. Furthermo...
Source: PLoS Neglected Tropical Diseases - January 18, 2024 Category: Tropical Medicine Authors: Juliana Martins Ribeiro Source Type: research
