Interpregnancy interval and adverse pregnancy outcomes among pregnancies following miscarriages or induced abortions in Norway (2008 –2016): A cohort study
by Gizachew A. Tessema, Siri E. H åberg, Gavin Pereira, Annette K. Regan, Jennifer Dunne, Maria C. Magnus
BackgroundThe World Health Organization recommends to wait at least 6 months after miscarriage and induced abortion before becoming pregnant again to avoid complications in the next pregnancy, although the evidence-based underlying this recommendation is scarce. We aimed to investigate the risk of adverse pregnancy outcomes —preterm birth (PTB), spontaneous PTB, small for gestational age (SGA) birth, large for gestational age (LGA) birth, preeclampsia, and gestational diabetes mellitus (GDM)—by interpregnancy inte...
Source: PLoS Medicine - November 22, 2022 Category: Internal Medicine Authors: Gizachew A. Tessema Source Type: research
Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study
ConclusionsThe PINCER intervention, when rolled out at scale in routine clinical practice, was associated with a reduction in hazardous prescribing by 17% and 15% at 6 and 12 months postintervention. The greatest reductions in hazardous prescribing were for indicators associated with risk of GI bleeding. These findings support the wider national rollout of PINCER in England. (Source: PLoS Medicine)
Source: PLoS Medicine - November 16, 2022 Category: Internal Medicine Authors: Sarah Rodgers Source Type: research
The association between multimorbidity and mobility disability-free life expectancy in adults aged 85 years and over: A modelling study in the Newcastle 85+ cohort
by Laurie E. Davies, Stewart W. Mercer, Katie Brittain, Carol Jagger, Louise Robinson, Andrew Kingston
BackgroundMobility disability is predictive of further functional decline and can itself compromise older people ’s capacity (and preference) to live independently. The world’s population is also ageing, and multimorbidity is the norm in those aged ≥85. What is unclear in this age group, is the influence of multimorbidity on (a) transitions in mobility disability and (b) mobility disability-free life exp ectancy (mobDFLE). Methods and findingsUsing multistate modelling in an inception cohort of 714 85-year-olds foll...
Source: PLoS Medicine - November 14, 2022 Category: Internal Medicine Authors: Laurie E. Davies Source Type: research
Infection, immunity, and surveillance of COVID-19
by Amitabh Bipin Suthar, Christopher Dye
Dr Amitabh Suthar and Dr Christopher Dye give their perspective on infection, immunity and surveillance of COVID-19. (Source: PLoS Medicine)
Source: PLoS Medicine - November 10, 2022 Category: Internal Medicine Authors: Amitabh Bipin Suthar Source Type: research
Global SARS-CoV-2 seroprevalence from January 2020 to April 2022: A systematic review and meta-analysis of standardized population-based studies
by Isabel Bergeri, Mairead G. Whelan, Harriet Ware, Lorenzo Subissi, Anthony Nardone, Hannah C. Lewis, Zihan Li, Xiaomeng Ma, Marta Valenciano, Brianna Cheng, Lubna Al Ariqi, Arash Rashidian, Joseph Okeibunor, Tasnim Azim, Pushpa Wijesinghe, Linh-Vi Le, Aisling Vaughan, Richard Pebody, Andrea Vicari, Tingting Yan, Mercedes Yanes-Lane, Christian Cao, David A. Clifton, Matthew P. Cheng, Jesse Papenburg, David Buckeridge, Niklas Bobrovitz, Rahul K. Arora, Maria D. Van Kerkhove, Unity Studies Collaborator Group
BackgroundOur understanding of the global scale of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infec...
Source: PLoS Medicine - November 10, 2022 Category: Internal Medicine Authors: Isabel Bergeri Source Type: research
Post-COVID-19-associated morbidity in children, adolescents, and adults: A matched cohort study including more than 157,000 individuals with COVID-19 in Germany
by Martin Roessler, Falko Tesch, Manuel Batram, Josephine Jacob, Friedrich Loser, Oliver Weidinger, Danny Wende, Annika Vivirito, Nicole Toepfner, Franz Ehm, Martin Seifert, Oliver Nagel, Christina K önig, Roland Jucknewitz, Jakob Peter Armann, Reinhard Berner, Marina Treskova-Schwarzbach, Dagmar Hertle, Stefan Scholz, Stefan Stern, Pedro Ballesteros, Stefan Baßler, Barbara Bertele, Uwe Repschläger, Nico Richter, Cordula Riederer, Franziska Sobik, Anja Schramm, Claudia Schulte, Lothar Wieler, Jochen Walker, Christa Scheidt-Nave, Jochen Schmitt
BackgroundLong-term health sequelae of the Coronavirus Disease 2019 (COVID-19...
Source: PLoS Medicine - November 10, 2022 Category: Internal Medicine Authors: Martin Roessler Source Type: research
Correction: Presentations of children to emergency departments across Europe and the COVID-19 pandemic: A multinational observational study
by The PLOS Medicine Staff (Source: PLoS Medicine)
Source: PLoS Medicine - November 9, 2022 Category: Internal Medicine Authors: The PLOS Medicine Staff Source Type: research
Evaluation of physical activity calorie equivalent (PACE) labels ’ impact on energy purchased in cafeterias: A stepped-wedge randomised controlled trial
ConclusionOverall, the evidence was consistent with PACE labels not changing energy purchased in worksite cafeterias. There was considerable variation in effects between cafeterias, suggesting important unmeasured moderators. Trial registrationThe study was prospectively registered on ISRCTN (date: 30.03.21; ISRCTN31315776). (Source: PLoS Medicine)
Source: PLoS Medicine - November 8, 2022 Category: Internal Medicine Authors: James P. Reynolds Source Type: research
COVID-19 deaths in children and young people in England, March 2020 to December 2021: An active prospective national surveillance study
by Marta Bertran, Zahin Amin-Chowdhury, Hannah G. Davies, Hester Allen, Tom Clare, Chloe Davison, Mary Sinnathamby, Giulia Seghezzo, Meaghan Kall, Hannah Williams, Nick Gent, Mary E. Ramsay, Shamez N. Ladhani, Godwin Oligbu
BackgroundCoronavirus Disease 2019 (COVID-19) deaths are rare in children and young people (CYP). The high rates of asymptomatic and mild infections complicate assessment of cause of death in CYP. We assessed the cause of death in all CYP with a positive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) test since the start of the pandemic in England. Methods and findingsCYP aged (Source: PLoS Medicine)
Source: PLoS Medicine - November 8, 2022 Category: Internal Medicine Authors: Marta Bertran Source Type: research
Risk and symptoms of COVID-19 in health professionals according to baseline immune status and booster vaccination during the Delta and Omicron waves in Switzerland —A multicentre cohort study
by Baharak Babouee Flury, Sabine G üsewell, Thomas Egger, Onicio Leal, Angela Brucher, Eva Lemmenmeier, Dorette Meier Kleeb, J. Carsten Möller, Philip Rieder, Markus Rütti, Hans-Ruedi Schmid, Reto Stocker, Danielle Vuichard-Gysin, Benedikt Wiggli, Ulrike Besold, Allison McGeer, Lorenz Risch, Andrée Friedl, Matthias Schlegel, Stef an P. Kuster, Christian R. Kahlert, Philipp Kohler, on behalf of the SURPRISE Study Group
BackgroundKnowledge about protection conferred by previous Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and/or vaccination against emerging viral variants allows clinicians, epid...
Source: PLoS Medicine - November 7, 2022 Category: Internal Medicine Authors: Baharak Babouee Flury Source Type: research
Correction: HIV prevention for the next decade: Appropriate, person-centred, prioritised, effective, combination prevention
by The PLOS Medicine Staff (Source: PLoS Medicine)
Source: PLoS Medicine - November 4, 2022 Category: Internal Medicine Authors: The PLOS Medicine Staff Source Type: research
The rapidly evolving monkeypox epidemic: A call to action to leave no one behind
by Steffanie A. Strathdee, Davey M. Smith, Megan Halbrook, Placide Mbala-Kingebeni, Shira Abeles, Francesca Torriani, Anne Rimoin
Author summary: Within 5 months, an emerging human monkeypox virus (MPXV) pandemic has caused>65,000 cases, leading the World Health Organization to declare it a public health emergency of international concern (PHEIC). Applying former United States Secretary of Defense Donald Rumsfeld ’s idiom, we reflect upon the “known knowns,” “known unknowns,” and “unknown unknowns” to improve prevention and treatment for this and future pandemics. (Source: PLoS Medicine)
Source: PLoS Medicine - October 31, 2022 Category: Internal Medicine Authors: Steffanie A. Strathdee Source Type: research
Risk of cervical precancer among HPV –negative women in the Netherlands and its association with previous HPV and cytology results: A follow-up analysis of a randomized screening study
by Federica Inturrisi, Lawrence Rozendaal, Nienke J. Veldhuijzen, Dani ëlle A. M. Heideman, Chris J. L. M. Meijer, Johannes Berkhof
BackgroundHuman papillomavirus (HPV)-based screening programs still use one-size-fits-all protocols but efficiency and efficacy of programs may be improved by stratifying women based on previous screening results. Methods and findingsWe studied the association between cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) and previous screening results in the Population-Based Screening Study Amsterdam (POBASCAM) trial, performed in the Netherlands in the setting of regular screening, wh...
Source: PLoS Medicine - October 28, 2022 Category: Internal Medicine Authors: Federica Inturrisi Source Type: research
Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands: A nationwide prospective cohort study
ConclusionsAfter vaccination with BNT162b2 or mRNA-1273, anti-spike SARS-CoV-2 antibody levels were reduced in PLWH compared to HIV-negative controls. To reach and maintain the same serological responses as HIV-negative controls, additional vaccinations are probably required. Trial registrationThe trial was registered in the Netherlands Trial Register (NL9214). https://www.trialregister.nl/trial/9214. (Source: PLoS Medicine)
Source: PLoS Medicine - October 27, 2022 Category: Internal Medicine Authors: Kathryn S. Hensley Source Type: research
Effectiveness of integrated care for older adults with depression and hypertension in rural China: A cluster randomized controlled trial
by Shulin Chen, Yeates Conwell, Jiang Xue, Lydia Li, Tingjie Zhao, Wan Tang, Hillary Bogner, Hengjin Dong
BackgroundEffectiveness of integrated care management for common, comorbid physical and mental disorders has been insufficiently examined in low- and middle-income countries (LMICs). We tested hypotheses that older adults treated in rural Chinese primary care clinics with integrated care management of comorbid depression and hypertension (HTN) would show greater improvements in depression symptom severity and HTN control than those who received usual care. Methods and findingsThe study, registered with ClinicalTrials.g...
Source: PLoS Medicine - October 24, 2022 Category: Internal Medicine Authors: Shulin Chen Source Type: research
