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Wounding the stroma: Docetaxel ’s role in dormant breast cancer escape
by Tyler T. Cooper, Lynne-Marie Postovit The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. A new study in PLOS Biology reveals that docetaxel-induced injury of tumour stromal cells stimulates the release of cytokines that support dormancy escape of breast cancer cells. The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. This Primer explores a new study in PLOS Biology which reveals that docetaxel-induced injury of tumor stromal cells stimulates the release of cytokines that support dormancy escape...
Source: PLoS Biology: Archived Table of Contents - September 13, 2023 Category: Biology Authors: Tyler T. Cooper Source Type: research

Taxane chemotherapy induces stromal injury that leads to breast cancer dormancy escape
by Ramya Ganesan, Swati S. Bhasin, Mojtaba Bakhtiary, Upaasana Krishnan, Nagarjuna R. Cheemarla, Beena E. Thomas, Manoj K. Bhasin, Vikas P. Sukhatme A major cause of cancer recurrence following chemotherapy is cancer dormancy escape. Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing proliferating cancer cells. Here, we demonstrate that docetaxel injures stromal cells, which release protumor cytokines, IL-6 and granulocyte colony stimulating factor (G-CSF), that in turn invoke dormant cancer outgrowth both in vitro and in vivo. Single-cell transcriptomics shows a reprogramming of awa...
Source: PLoS Biology: Archived Table of Contents - September 12, 2023 Category: Biology Authors: Ramya Ganesan Source Type: research

Systematic characterization of photoperiodic gene expression patterns reveals diverse seasonal transcriptional systems in < i > Arabidopsis < /i >
by Chun Chung Leung, Daniel A. Tart é, Lilijana S. Oliver, Qingqing Wang, Joshua M. Gendron Photoperiod is an annual cue measured by biological systems to align growth and reproduction with the seasons. In plants, photoperiodic flowering has been intensively studied for over 100 years, but we lack a complete picture of the transcriptional networks and cellular processes that are photoperiodic. We performed a transcriptomics experiment onArabidopsis plants grown in 3 different photoperiods and found that thousands of genes show photoperiodic alteration in gene expression. Gene clustering, daily expression integral calcula...
Source: PLoS Biology: Archived Table of Contents - September 12, 2023 Category: Biology Authors: Chun Chung Leung Source Type: research

The genetic identity of neighboring plants in intraspecific mixtures modulates disease susceptibility of both wheat and rice
by R émi Pélissier, Elsa Ballini, Coline Temple, Aurélie Ducasse, Michel Colombo, Julien Frouin, Xiaoping Qin, Huichuan Huang, David Jacques, Fort Florian, Fréville Hélène, Violle Cyrille, Jean-Benoit Morel Mixing crop cultivars has long been considered as a way to control epidemics at the field level and is experiencing a revival of interest in agriculture. Yet, the ability of mixing to control pests is highly variable and often unpredictable in the field. Beyond classical diversity effects such as dispersal barrier generated by genotypic diversity, several understudied processes are involved. Among them is the rec...
Source: PLoS Biology: Archived Table of Contents - September 12, 2023 Category: Biology Authors: R émi Pélissier Source Type: research

Applying an evolutionary mismatch framework to understand disease susceptibility
by Amanda J. Lea, Andrew G. Clark, Andrew W. Dahl, Orrin Devinsky, Angela R. Garcia, Christopher D. Golden, Joseph Kamau, Thomas S. Kraft, Yvonne A. L. Lim, Dino J. Martins, Donald Mogoi, P äivi Pajukanta, George H. Perry, Herman Pontzer, Benjamin C. Trumble, Samuel S. Urlacher, Vivek V. Venkataraman, Ian J. Wallace, Michael Gurven, Daniel E. Lieberman, Julien F. Ayroles Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular disease, and type 2 diabetes are among a long list of “lifestyle” diseases that were rare throughout human history but are now common. The evolutionary mismatch hypoth...
Source: PLoS Biology: Archived Table of Contents - September 11, 2023 Category: Biology Authors: Amanda J. Lea Source Type: research