A phenanthroindolizidine glycoside with HIF-1 inhibitory activity from Tylophora atrofolliculata
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Cheng-Yu Chen, Guo-Yuan Zhu, Tang-Gui Xie, Ping-Chuan Jiang, Jing-Rong Wang, Zhi-Hong JiangAbstractA phenanthroindolizidine glycoside 6-O-β-D-glucopyranosyl-tylophorinidine (1), the first glycoside of phenanthroindolizidine alkaloid in nature, was isolated from whole plants of Tylophora atrofolliculata (Asclepiadaceae). Its structure was elucidated by means of spectral and chemical evidences. Compound 1 showed potent inhibitory effect (IC50: 69 ± 13 nM) on hypoxia induced factor-1 (HIF-1) activation. It was disco...
Source: Phytochemistry Letters - March 16, 2019 Category: Chemistry Source Type: research

Metabolites and biological activities of Phoenix dactylifera L. pulp and seeds: A comparative MS and NMR based metabolomics approach
This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the ...
Source: Phytochemistry Letters - March 15, 2019 Category: Chemistry Source Type: research

Antimicrobial gastrodin derivatives isolated from Bacopa procumbens
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Manasés González-Cortazar, Valentín López-Gayou, Jaime Tortoriello, Blanca E. Domínguez-Mendoza, Ada M. Ríos-Cortes, Raúl Delgado-Macuil, Elías E. Hernández-Beteta, Ever A. Blé-González, Alejandro ZamilpaAbstractThe bioassay-guided fractionation of the hydroalcoholic extract from aerial parts of Bacopa procumbens (Mill.) Greenm., allowed to isolate the known phenolic compound arbutin (1) as well as three new gastrodin derivatives which were denominated procumgastrodin A...
Source: Phytochemistry Letters - March 15, 2019 Category: Chemistry Source Type: research

Effect of LED illumination and amino acid supplementation on phenolic compounds profile in Agastache rugosa in vitro cultures
In conclusion, the production of phenolic compounds in A. rugosa in vitro shoots was influenced by the age of the shoot cultures, illumination regime and amino acids supplementation.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 15, 2019 Category: Chemistry Source Type: research

Effect of jasmonic acid and chitosan on triterpenoid production in Calendula officinalis hairy root cultures
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Abdulwadood Shakir Mahmood Alsoufi, Cezary Pączkowski, Anna Szakiel, Marek DługoszAbstractTwo lines of Calendula officinalis in vitro hairy root culture, obtained as a result of transformation with the wild type Agrobacterium rhizogenes strain ATCC 15834, were subjected to elicitation by jasmonic acid and chitosan in the context of possible stimulation of biosynthesis, accumulation and secretion of triterpenoids. Jasmonic acid was found to be a very effective elicitor, increasing both the accumulation of oleanolic acid saponins in the hairy ro...
Source: Phytochemistry Letters - March 11, 2019 Category: Chemistry Source Type: research

Four meroterpenoids from Alternaria alternata isolated from Paeonia lactiflora
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Ju-Tao Wang, Zong-Hui Ma, Guo-Kai Wang, Feng-Qing Xu, Lin Chen, Yang Yu, Gang Wang, Jin-Song LiuAbstractFour new natural meroterpenoids, tricycloalternarenes (TCAs)15b‒18b (1‒4) along with four known TCAs (5‒8) have been isolated from the fermentation broth of Alternaria alternata derived from Paeonia lactiflora. The structures of compounds 1‒4 were elucidated by in-depth analyses of NMR spectra, HRESIMS and optical rotation experiments. Cytotoxic activities of 1‒4 against five selected tumor cell lines were evaluated.Graphical abstrac...
Source: Phytochemistry Letters - March 9, 2019 Category: Chemistry Source Type: research

Biological activity of Aesculus hippocastanum flower extracts on vascular endothelial cells cultured in vitro
In conclusion, HF extract exhibits anti-hyaluronidase activity, antimicrobial properties, and reduces ROS production. These observations may partly justify the use of HF in supporting wound healing.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 6, 2019 Category: Chemistry Source Type: research

Inhibition of cytokine secretion by scrophuloside A3 and gmelinoside L isolated from Verbascum blattaria L. by high-performance countercurrent chromatography
Publication date: Available online 6 March 2019Source: Phytochemistry LettersAuthor(s): Simon-Vlad Luca, Monika Ewa Czerwińska, Laurent Marcourt, Anca Miron, Ana Clara Aprotosoaie, Nina Ciocarlan, Jean-Luc Wolfender, Sebastian Granica, Krystyna Skalicka-WoźniakAbstractThe purpose of this study was to analyze the HPLC-DAD-ESI-Q-TOF-MS/MS profile of the methanolic extract obtained from the aerial parts of Verbascum blattaria L. and develop efficient high-performance countercurrent chromatography (HPCCC) methods for isolation of its major iridoid glycosides. Additionally, the potential anti-inflammatory activities of the ex...
Source: Phytochemistry Letters - March 6, 2019 Category: Chemistry Source Type: research

Polyphenolic profile, antioxidant activity, and pro-inflammatory enzymes inhibition of leaves, flowers, bark and fruits of Cotoneaster integerrimus: A comparative study
Publication date: Available online 5 March 2019Source: Phytochemistry LettersAuthor(s): Agnieszka Kicel, Aleksandra Owczarek, Paulina Gralak, Pawel Ciszewski, Monika A. OlszewskaAbstractComplementary UHPLC-PDA-ESI-MS3, HPLC-PDA-fingerprint, Folin-Ciocalteau, n-butanol/HCl and hide powder assays were employed to study the qualitative and quantitative differences in phenolic composition between different organs (leaves, flowers, bark and fruits) of Cotoneaster integerrimus. The bark and flowers were the richest source of polyphenols (107.0–113.6 mg GAE/g dw of plant material), with the dominating proanthocyanidi...
Source: Phytochemistry Letters - March 6, 2019 Category: Chemistry Source Type: research

Triterpenoid profiles of the leaves of wild and domesticated grapevines
Publication date: Available online 2 March 2019Source: Phytochemistry LettersAuthor(s): Aleksandra Burdziej, Cezary Pączkowski, Agnès Destrac-Irvine, Tristan Richard, Stéphanie Cluzet, Anna SzakielAbstractThe composition of steroids and triterpenoids in the leaves of eight grapevine species was analyzed in order to assess phenotypic differences. Four wild species (Vitis aestivalis Michx., Vitis labrusca L., Vitis riparia Michx., and Vitis vinifera subsp. sylvestris (Gmelin) Hegi) and four domesticated (Vitis vinifera cultivars: Cabernet Sauvignon, Gamay, Marselan, and Merlot) were studied. Although the main ...
Source: Phytochemistry Letters - March 4, 2019 Category: Chemistry Source Type: research

New triterpenoid saponins with cytotoxic activities from Ligularia przewalskii
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Zhuan-Ning Shi, Yu-Dong Wang, Yuan Gong, Hong-Fang Li, Ying ZhuAbstractTwo new triterpenoid saponins, a cycloartane-type triterpenoid saponin (1) and a oleanane-type triterpenoid saponin (2), were isolated from the whole plant of Ligularia przewalskii. Their structures were elucidated based on extensive spectroscopic studies, including IR, UV, HR-ESI-MS, 1D and 2D NMR experiments. (1H-NMR, 13C-NMR, DEPT, 1H-1H COSY, HMBC, HSQC, and NOESY). Their cytotoxic activities were evaluated against six human cancer (HeLa, HepG2, SGC7901, MDA231, HL60, an...
Source: Phytochemistry Letters - March 1, 2019 Category: Chemistry Source Type: research

Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Zheng-Hong Pan, Ling Cheng, De-Sheng Ning, Li-Yan Peng, Yu-Xia Fu, Lian-Chun LiAbstractAs part of our ongoing search for novel and bioactive natural products in Karst plants, two new sesqui-neolignans, difengpienol A (1) and difengpienol B (2), together with two known analogues (3 and 4), were isolated from the stem bark of Illicium difengpi. Their structures were elucidated by analysis of spectroscopic data. Difengpienol A (1) possessed a unique 1, 4-dibenzodioxocine moiety. All isolates were evaluated for inhibitory effects against lipopolysa...
Source: Phytochemistry Letters - March 1, 2019 Category: Chemistry Source Type: research

2,4,6-Trihydroxyphenanthrene, a trans-resveratrol photoreaction byproduct: First evidences of genotoxic risk
In this study we investigated the cytotoxicity and genotoxicity of 2,4,6-trihydroxyphenanthrene (THP), derived from trans-resveratrol photochemical isomerization and electrocyclization. To achieve this goal, we used Caulobacter crescentus as the experimental model for evaluating the colony-forming ability and the SOS response induction of cells exposed to THP. DNA-strand breaks and oxidative damage were assessed by the cell-free pCMut plasmid.The obtained data demonstrated that THP induces a cytotoxic and genotoxic effect of THP even at sub-micromolar concentrations, through a pro-oxidant mechanism leading to DNA damage.Gr...
Source: Phytochemistry Letters - February 26, 2019 Category: Chemistry Source Type: research

Benzyl and phenylethanoid glycosides from the leaves of Magnolia sirindhorniae
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Chutima Srinroch, Poolsak Sahakitpichan, Supanna Techasakul, Nitirat Chimnoi, Somsak Ruchirawat, Tripetch KanchanapoomAbstractA new benzyl triglycoside, benzyl O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-glucopyranoside (1) together with two diastereomer phenylethanoid glycosides, (7R) and (7S)-campneoside I (10, 11) were isolated from the leaves of Magnolia sirindhorniae in addition to 20 known compounds. The structure elucidation of these compounds was based on analyses of physical and spectroscopic da...
Source: Phytochemistry Letters - February 26, 2019 Category: Chemistry Source Type: research

Phytochemical analysis and biological activity of Lupinus luteus seeds extracts obtained by supercritical fluid extraction
Publication date: Available online 23 February 2019Source: Phytochemistry LettersAuthor(s): Bogusław Buszewski, Katarzyna Rafińska, Aleksandra Cvetanović, Justyna Walczak, Aneta Krakowska, Joanna Rudnicka, Zoran ZekovićAbstractThe article describes a possible application of Sc-CO2 extraction for isolation of polyphenols from germinated lupin seeds. Efficiency of germination duration was valorized, and the obtained results suggest that six-day-long germination process provides samples with the highest polyphenolic yield. Optimization of extraction parameters was done by using response surface methodology (RSM). Extracts...
Source: Phytochemistry Letters - February 25, 2019 Category: Chemistry Source Type: research

Phosphodiesterase-1 inhibitory potential of several natural products by molecular docking approach
Publication date: Available online 23 February 2019Source: Phytochemistry LettersAuthor(s): Abdur Rauf, Muslim Raza, Muhammad Saleem, Ilkay Erdogan Orhan, Ufuk Ozgen, Esen Sezen Karaoglan, Gulin Renda, Erhan PalaskaAbstractNatural products of herbal origin are well-known to exhibit diverse biological activities. In the present study, a number of natural compounds of plant origin; luteolin 5-O-β-glucoside (1), methyl rosmarinate (2), apigenin (3), vicenin 2 (4), lithospermic acid (5), soyasaponin II (6), and rubiadin 3-O-β-primeveroside (7) were tested at 0.5 mM using ELISA microtiter assay against phosphod...
Source: Phytochemistry Letters - February 25, 2019 Category: Chemistry Source Type: research

MS/MS and UPLC-MS profiling of triterpenoid saponins from leaves and roots of four red beet (Beta vulgaris L.) cultivars
Publication date: Available online 21 February 2019Source: Phytochemistry LettersAuthor(s): Agnieszka Mroczek, Ireneusz Kapusta, Anna Stochmal, Wirginia JaniszowskaAbstractTriterpene saponins from the leaves of red beet (Beta vulgaris L.) were qualitatively profiled using electrospray ionization tandem mass spectrometry (ESI-MS/MS). Results indicated that red beet leaves contain 11 saponins, including oleanolic acid aglycone and a varying number of sugars plus acetyl or methyl groups. We identified and studied two additional saponins other than the nine reported previously from red beets. Relative quantification was undert...
Source: Phytochemistry Letters - February 23, 2019 Category: Chemistry Source Type: research

Glucagon-like peptide-1 secretagogues from the leaves of Oparanthus teikiteetinii
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Clément Huguet, Opeyemi Joshua Olatunji, Eleonore Real, Phila Raharivelomanana, Aurélie UrbainAbstractIn our search for natural compounds that stimulate glucagon-like peptide-1 secretion, an extract from the leaves of Oparanthus teikiteetinii (Asteraceae) was found to increase significantly GLP-1 secretion in vitro in a model cell line (mouse intestinal STC-1 cells). The phytochemical investigation of this extract resulted in the isolation of two new dihydrobenzofuran derivatives (1–2) identified as (2R)-2-(prop-1-en-2-yl)-2...
Source: Phytochemistry Letters - February 23, 2019 Category: Chemistry Source Type: research

Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (L.F.) Sol. Ex roem. & schult
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ruth Anyango Omole, Mainen Julius Moshi, Matthias Heydenreich, Hamisi Masanja Malebo, Jeremiah Waweru Gathirwa, Sharon Alice Ochieng’, Leonida Kerubo Omosa, Jacob Ogweno MidiwoAbstractBioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2:MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydroheliobuphthalmin (2); and two fusicoccane diterpenoids: 11(12)-epoxyhypoestenone (3) and 3(11)-epoxyhypoestenone (4). The chemical structures w...
Source: Phytochemistry Letters - February 23, 2019 Category: Chemistry Source Type: research

A unique acyclic sesquiterpene-flavanone adduct and a new cyclic diarylheptanoid from Alpinia katsumadai
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Chang-Shui Yang, Hou-Li Jiang, Heng-Yuan Li, Xiao-Yun DongAbstractTwo new compounds, sumadain D (1), and (3S,5S,6R,7S)-5,6-dihydroxy-1,7-diphenyl-methylcentrolobine (2), together with three known compounds, (lR,4S, 6R)1,4-dihydroxy-menthene (3), rhodomollein XI (4) and β-daucosterol (5), were isolated from the seeds of Alpinia katsumadai. The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic techniques (UV, IR, MS, and 1D and 2D NMR), and the absolute configurations were established by comparing experimental and...
Source: Phytochemistry Letters - February 23, 2019 Category: Chemistry Source Type: research

Phytochemistry and biological activities of Polemonium caeruleum L.
Publication date: Available online 20 February 2019Source: Phytochemistry LettersAuthor(s): Grażyna Łaska, Elwira Sieniawska, Łukasz Świątek, Jordan Zjawiony, Shabana Khan, Anastazja Boguszewska, Marcin Stocki, Mirosław Angielczyk, Małgorzata Polz-DacewiczAbstractPolemonium caeruleum L. is a Chinese medicinal plant used in the treatment of tuberculosis, whooping cough, fever, infertility, epilepsy, endometritis and insomnia. It was also used as sedative and anaesthetic agent. In this work the phytochemical investigation using LC-ESI-QTOF-MS and GC–MS techniques was done for chemical characterization of methano...
Source: Phytochemistry Letters - February 21, 2019 Category: Chemistry Source Type: research

Megastigmane derivatives from Corispermum mongolicum and their anti-inflammatory activities
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Yi Zhou, Mei Jin, Chunshi Jin, Chao Ye, Jiaming Wang, Rongshen Wang, Chengxi Wei, Wei Zhou, Gao LiAbstractPhytochemical investigation of the ethanol extract of the whole plant of Corispermum mongolicum Iljin led to the isolation of a new megastigmane, (―)-(3R)-hydroxysulfonyloxy-β-ionone (1), a new megastigmane glucoside, (3S,6S,9R)-3,9,13-trihydroxymegastigman-4-ene-3-O-β-d-glucopyranoside (2), as well as four known compounds (3–6). The structures of these new compounds were elucidated mainly by using NMR, HR-ESI-MS, and modi...
Source: Phytochemistry Letters - February 21, 2019 Category: Chemistry Source Type: research

Two new prenylated isoflavones from Deguelia costata
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Bruno Brito Lemes, Lilian da Silva Miguêz, Rebeca Lopes Santos, João Carlos da Rocha Bastos Serafim, Juliana Medrado Ribeiro Figueiredo, Islam Farias Tavares, Madson de Godoi Pereira, Edson de Jesus Marquês, Florisvaldo da Silva Ramos, Ramon Santos El-Bachá, Alany Ingrid Ribeiro, Maria Fátima das Graças Fernandes da Silva, Lourdes Cardoso de Souza NetaAbstractPhytochemical investigation of the roots, leaves and stems of Deguelia costata resulted in the isolation of two new prenylated isoflavones, 5,5&rdqu...
Source: Phytochemistry Letters - February 21, 2019 Category: Chemistry Source Type: research

Accumulation of phenolic compounds in different in vitro cultures of Salvia viridis L. and their antioxidant and antimicrobial potential
Publication date: Available online 20 February 2019Source: Phytochemistry LettersAuthor(s): Izabela Grzegorczyk-Karolak, Łukasz Kuźma, Paweł Lisiecki, Anna KissAbstractDifferent in vitro cultures of the Turkish origin medicinal plant species, Salvia viridis, were estimated in order to investigate their potential for the accumulation of phenolic compounds. Among the seventeen detected compounds, thirteen phenolic acid derivatives and four phenylethanoids were identified in extracts from shoot and/or callus cultures using the UPLC-DAD/ESI-MS method. The accumulation of the compound depended on the type of culture (callus,...
Source: Phytochemistry Letters - February 21, 2019 Category: Chemistry Source Type: research

New dihydrostilbenes from Macaranga heynei I.M. Johnson, biological activities and structure-activity relationship
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Aisyah Salihah Kamarozaman, Norizan Ahmat, Siti Nursyahirah Mohd Isa, Zetty Zulikha Hafiz, Mohd Ilham Adenan, Mohd Izwan Mohamad Yusof, Nik Fatini Nik Azmin, Jalifah LatipAbstractFour new dihydrostilbenes, malayheyneiins A–D (1–4) along with three known analogues, laevifolins A–B (5–6) and macarubiginosin C (7) were isolated from the leaves of Macaranga heynei. The structures of the compounds were elucidated using 1D and 2D NMR, UV, IR, MS as well as comparison with literature data. Compounds 2, 3 and 7 exhibited signifi...
Source: Phytochemistry Letters - February 21, 2019 Category: Chemistry Source Type: research

Corrigendum to “Rebaudioside A and other unreported steviol glycoside isomers found in the sweet tea (Rubus suavissimis) leaf” [Phytochem. Lett. 28 (December) (2018) 93–97]
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Brandon Uhler, Zheng Yang (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 18, 2019 Category: Chemistry Source Type: research

Letenketals A and B, two novel spirocyclic polyketides from a marine crab-derived Letendraea sp. fungus
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ruibao Huang, Yan Xu, Bin Ye, Wanjing Ding, Pinmei Wang, Jinzhong XuAbstractTwo novel spiroketals, named as letenketals A and B, had been isolated from the cultural broth of marine fungal Letendraea sp. Two compounds were stereoisomers and contained the new carbon skeleton including benzodihydropyran ring and one tetrahydrofuran ring, which connected as spiro-fused ring system through one ketal carbon. Their relative and absolute configurations were determined by the 2D-NMR analysis together with single-crystal X-ray diffraction. The antibacter...
Source: Phytochemistry Letters - February 17, 2019 Category: Chemistry Source Type: research

Antiplasmodial prenylated flavonoids from stem bark of Erythrina latissima
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Emmy Tuenter, Yancho Zarev, An Matheeussen, Esameldin Elgorashi, Luc Pieters, Kenn FoubertAbstractThe antiplasmodial activity against Plasmodium falciparum strain K1 as well as cytotoxicity against MRC-5 cells of 15 prenylated flavonoids obtained from Erythrina latissima E. Mey (Leguminosae) from South Africa was determined. Although initially some promising activities were observed, with 5′-prenyl-pratensein being the most selective compound, most IC50 values varied from 1 to 30 μM, with cytotoxicities in the same range, resulting in selectivity indices
Source: Phytochemistry Letters - February 17, 2019 Category: Chemistry Source Type: research

Selective in vitro and in silico cholinesterase inhibitory activity of isoflavones and stilbenes from Belamcandae chinensis rhizoma
In conclusion, the TCM and pharmacopoeial drug – Belamcandae chinensis rhizoma is rich in potential cholinesterase inhibitors that can provide lead structures for further development of selective drugs. Moreover, the in vitro results would suggest a novel indication of this traditional anti-inflammatory, phytoestrogenic and antiallergic herb.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 15, 2019 Category: Chemistry Source Type: research

New insights into antioxidant activity of Prunus spinosa flowers: Extracts, model polyphenols and their phenolic metabolites in plasma towards multiple in vivo-relevant oxidants
Publication date: Available online 14 February 2019Source: Phytochemistry LettersAuthor(s): Anna Marchelak, Aleksandra Owczarek, Magdalena Rutkowska, Piotr Michel, Joanna Kolodziejczyk-Czepas, Pawel Nowak, Monika Anna OlszewskaAbstractPrunus spinosa L. flowers are a traditional herbal medicine recommended for the adjunctive treatment of oxidative stress-related diseases. In search of the main bioactive constituents of the flowers, the antioxidant activity of dry extracts obtained thereof by fractionated extraction was tested in vitro towards primary in vivo-relevant reactive oxygen species (O2–, OH, NO, H2O2, ONOO&nd...
Source: Phytochemistry Letters - February 15, 2019 Category: Chemistry Source Type: research

Further sesquiterpenoids and phenolics from two species of Taraxacum F.H. Wigg. and cytotoxic activity of taraxinic acid and its derivatives
Publication date: Available online 13 February 2019Source: Phytochemistry LettersAuthor(s): Klaudia Michalska, Agnieszka Galanty, Oskar Michalski, Anna StojakowskaAbstractFrom roots of Taraxacum flavostylum and Taraxacum lucidum, the species included in the section Taraxacum F. H. Wigg. of the genus Taraxacum F. H. Wigg., eight sesquiterpene lactones, including taraxinic acid (1) and 11β,13-dihydrotaraxinic acid (2), taraxinic acid β-glucopyranosyl ester (3) and its 11β,13-dihydroderivative (4), ainslioside (5), deacetylmatricarin (6), 3-epi-11β,13-dihydrodeacylcynaropicrin (7) and ixerin D (8) together...
Source: Phytochemistry Letters - February 14, 2019 Category: Chemistry Source Type: research

The antioxidant and antimicrobial properties of phenol-rich extracts of Dracocephalum forrestii W. W. Smith shoot cultures grown in the nutrient sprinkle bioreactor
Publication date: Available online 13 February 2019Source: Phytochemistry LettersAuthor(s): Izabela Weremczuk-Jeżyna, Ewa Kochan, Piotr Szymczyk, Paweł Lisiecki, Łukasz Kuźma, Izabela Grzegorczyk-KarolakAbstractDracocephalum forrestii is known as a medicinal plant in China. The present work evaluates the potential of its shoots to biosynthesise phenolic compounds during bioreactor cultivation. Qualitative UPLC-PDA-ESI-MS analysis revealed the presence of nine caffeic acid derivatives in the hydromethanolic extract. Quantitative UPLC-PDA analysis then found the predominant compounds to be rosmarinic acid (17.90 m...
Source: Phytochemistry Letters - February 14, 2019 Category: Chemistry Source Type: research

Bioactive constituents from marine-derived Streptomyces sp. NB-A13
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Qian-qian Wang, Biao Zhou, Yuan-yuan Ji, Hao-jian Zhang, Zhong-jun Ma, Li Shen, Wan-jing DingAbstractSix new anthracyclines (1-6) were obtained by the investigation of the solid fermented extract of a marine-derived Streptomyces sp. NB-A13. The structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, HRESIMS, UV and IR. The absolute configurations of compounds 1-5 were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. Among the isolates, four compound...
Source: Phytochemistry Letters - February 14, 2019 Category: Chemistry Source Type: research

Flavonol glycosides from Reseda lutea L
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Hatice Kızıltaş, Melis Küçüksolak, Seda Duman, Erdal BedіrAbstractTwo new flavonol glycosides; kaempferol-3-O-[2-O-(β-d-xylopyranosyl)-3-O-(β-d-glucopyranosyl)]-α-l-rhamnopyranosyl-7-O- α-l-rhamnopyranoside (1) and kaempferol-3-O-[2-O-((6-O-trans-p-coumaryl)-β-d-glucopyranosyl)-3-O-( β-d-xylopyranosyl)]-α-l-rhamnopyranosyl-7-O- α-l-rhamnopyranoside (2) were isolated from the aerial parts of Reseda lutea L., together with five known flavonol glycosides. Structu...
Source: Phytochemistry Letters - February 14, 2019 Category: Chemistry Source Type: research

Bioassay-guided isolation of lignanamides with potential anti-inflammatory effect from the roots of Solanum melongena L
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Bing-You Yang, Xin Yin, Yan Liu, Hong-Liang Ye, Mei-Ling Zhang, Wei Guan, Hai-Xue KuangAbstractThree new lignanamides, melongenamide E–G (1–3), together with fourteen known analogues (4-17) were isolated by bioassay-guided fractionation from the roots of Solanum melongena L. The chemical structures of all isolated compounds were elucidated using 1D and 2D NMR experiments and by comparing their spectroscopic and physical data with values from the published literature. These isolated compounds were tested for their inhibitory activiti...
Source: Phytochemistry Letters - February 14, 2019 Category: Chemistry Source Type: research

Syringa vulgaris bark as a source of compounds affecting the release of inflammatory mediators from human neutrophils and monocytes/macrophages
Publication date: Available online 13 February 2019Source: Phytochemistry LettersAuthor(s): Agnieszka Filipek, Joanna Wyszomierska, Barbara Michalak, Anna K. KissAbstractIn traditional European medicine, common lilac (Syringa vulgaris L., Oleaceae) bark has been used in the form of an infusion, decoction or alcoholic extract as an antipyretic and a cold and cough treatment. Our primary study showed that alcoholic extract of the bark was able to decrease the release of interleukin- 8 in an in vitro model The aim of the study was to investigate the phytochemical composition of common lilac bark extract by the HPLC-DAD-MS/MS ...
Source: Phytochemistry Letters - February 13, 2019 Category: Chemistry Source Type: research

Inhibition of CYP450 enzymes by quassinoids from Picrasma quassioides leaves
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Chang Liu, Rong-Rong Cheng, Li Yang, Zhong-Chen Song, Zheng-Tao WangAbstractThree new C20 quassinoids, namely, nigakilactones R (1), S (2), and T (3), along with 13 known ones, were isolated on Picrasma quassioides leaves. Their structures were elucidated by an extensive spectroscopic analysis. All the compounds were tested for their inhibitory activities against the six major CYP450 enzymes CYP1A2, 2C8, 2C9, 2C19, 2D6, and 3A4. Compounds 1, 10, 11, and 12 showed potential as inhibitor of CYP2C19 with IC50 values of 62.6, 160.0, 61.5, and 35.8&...
Source: Phytochemistry Letters - February 13, 2019 Category: Chemistry Source Type: research

Cytotoxic ergosteroids from the fungus Stereum hirsutum
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Zhen-Zhu Zhao, Kai-Yue Han, Zheng-Hui Li, Tao Feng, He-Ping Chen, Ji-Kai LiuAbstractPhytochemical investigation on the fermentation broth of the fungus Stereum hirsutum led to the isolation of ten steroids, including two previously unreported ones, namely steresterones A (1) and B (2). The semi-synthesis products 3a and 3b were prepared by reduction of the known compound 3 with NaBH4. Their structures and absolute configurations were established via 1D & 2D NMR spectroscopic analysis, and TDDFT/ECD calculations as well as single crystal X-r...
Source: Phytochemistry Letters - February 13, 2019 Category: Chemistry Source Type: research

Triterpenes from Echinops spinosissimus Turra subsp. spinosissimus
Publication date: Available online 12 February 2019Source: Phytochemistry LettersAuthor(s): Nikolaos Tsafantakis, Konstantinos Zelianeos, Aikaterini Termentzi, Argyro Vontzalidou, Nektarios Aligiannis, Nikolas FokialakisAbstractThe phytochemical investigation of Echinops spinosissimus aerial parts led to the isolation of nine triterpenoids, one oleanane-type (1), four taraxastane-type (2, 3, 5, 6), three lupane-type (4, 7, 9) and one phytosterol (8). Their structures were elucidated through extensive analysis of NMR and HRMS spectra data. Compound 6, 20-oxo-30-nortaraxast-21-en-3β-ol, represent a previously undescribe...
Source: Phytochemistry Letters - February 12, 2019 Category: Chemistry Source Type: research

Identification of bioactivity markers of Sorbus domestica leaves in chromatographic, spectroscopic and biological capacity tests: Application for the quality control
Publication date: Available online 11 February 2019Source: Phytochemistry LettersAuthor(s): Magdalena Rutkowska, Aleksandra Owczarek, Joanna Kolodziejczyk-Czepas, Piotr Michel, Dorota Gabriela Piotrowska, Paulina Kapusta, Pawel Nowak, Monika Anna OlszewskaAbstractThis work is aimed at establishing analytical and bioactivity markers for the quality control of polyphenol-rich extracts of Sorbus domestica leaves – an antioxidant and anti-inflammatory agent. The potential marker analytes, representative of the main groups of S. domestica polyphenols, were pre-selected by LC–MS/MS analysis of the methanol-water (7:3...
Source: Phytochemistry Letters - February 11, 2019 Category: Chemistry Source Type: research

Bioactive secondary metabolites from Plectranthus glandulosus Hook. (Lamiaceae)
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Jean Paul Tsopmejio, Jean Momeni, Francine Nkouam Tsopjio, Valérie Sielinou Tedjon, Pierre Mkounga, Nuzhat Shehla, M. Iqbal Choudhary, Augustin E. NkengfackAbstractOne new methoxylated flavonoid derivative, plectranmicin (1) and one new monoterpene derivative, plectranmicinol (2), together with seven known compounds including 5-hydroxy-3,7,2′,4′-tetramethoxyflavone (3); 5,7-dihydroxy-3,2′,4′-trimethoxyflavone (4); 7-hydroxy-5,6,4′-trimethoxyflavone (5); 3-epi-betulinic acid (6); 3-O-β-D-glucopyranosyl s...
Source: Phytochemistry Letters - February 11, 2019 Category: Chemistry Source Type: research

Sesquiterpene and monoterpene derivatives from the soil-derived fungus Trichoderma reesei PSU-SPSF013
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Vatcharin Rukachaisirikul, Supaporn Chinpha, Souwalak Phongpaichit, Nanthawath Saikhwan, Jariya Sakayaroj, Sita PreedanonAbstractThree new sesquiterpenes (1-3) and one new monoterpene (4) were isolated from the soil-derived fungus Trichoderma reesei PSU-SPSF013 along with five known compounds including hydroheptelidic acid (5), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (6), adenosine (7), uridine (8) and tyrosol (9). Their structures were elucidated by spectroscopic analyses. The absolute configuration of the secondary alcohol moiety...
Source: Phytochemistry Letters - February 9, 2019 Category: Chemistry Source Type: research

NF-κB inhibitory sesquiterpene lactones from Lebanese Laurus nobilis
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ayman Turk, Jong Hoon Ahn, Yang Hee Jo, Jin Yong Song, Hala K. Khalife, Hala Gali-Muhtasib, Youngsoo Kim, Bang Yeon Hwang, Mi Kyeong LeeAbstractThe leaves of Laurus nobilis, commonly called as bay leaves, have been traditionally used for the treatment of inflammatory symptoms. As a part of the research on the characterization of bioactive constituents from natural products, twenty one sesquiterpene lactones were isolated from the leaves of L. nobilis. Among them, laurenoperoxylides A (1) and B (2) were first reported in nature and sivosinolide ...
Source: Phytochemistry Letters - February 9, 2019 Category: Chemistry Source Type: research

Two new polyacylated germacrane sesquiterpenes from Salvia chinensis
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Qian Liu, Ye-Ling Wang, Jing-Jing Xue, Da-Hong Li, Zhan-Lin Li, Hui-Ming HuaAbstractTwo new polyacylated germacrane sesquiterpenoids, named as salvianols A (1) and B (2), were isolated from the aerial parts of Salvia chinensis. Their structures were established by extensive analysis of HR-ESI-MS and NMR spectra. The polyacylated germacrane sesquiterpenoids are rare in natural products.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 9, 2019 Category: Chemistry Source Type: research

Two new indole alkaloids from Tabernaemontana contorta Stapf
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Gertrude Laura Foudjo Melacheu, Emmanuel Mfotie Njoya, Jean-Bosco Jouda, Brussine Nadege Wakeu Kweka, Céline Djama Mbazoa, Fei Wang, Jean WandjiAbstractTwo new indole alkaloid derivatives, 5,6-dioxo-11-methoxy voacangine (1) and (-)-apparicin-21-one (2), together with four known compounds, voacangine (3), ursolic acid (4), 3-methoxyursolic acid (5) and asiatic acid (6) were isolated from the fruits of Tabernaemontana contorta Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR and HRESI-MS measurements. The new indo...
Source: Phytochemistry Letters - February 8, 2019 Category: Chemistry Source Type: research

The chemical constituents of Penianthus longifolius Miers
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Georges Bellier Tabekoueng, Carine Mvot Akak, Moses K. Langat, Anatole Guy Blaise Azebaze, Alain Francois Kamdem Waffo, Dulcie A. Mulholland, Juliette Catherine VardamidesAbstractFourteen compounds were isolated from the roots, leaves and twigs of Penianthus longifolius Miers (Menispermaceae), including two previously unreported neo-clerodane diterpenoids, penianthin (1), its C-8 epimer (2). In addition, the previously reported O-methylmoschatoline (3), taraxerol (4), taraxerone (5), rubrosterone, (6), panuosterone (7), 22-epi-20-hydroxyecdyson...
Source: Phytochemistry Letters - February 7, 2019 Category: Chemistry Source Type: research

Allelochemicals and esters from leaves and inflorescences of Sambucus nigra L
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Josep Basas-Jaumandreu, F. Xavier C. de las HerasAbstractAllelochemical compounds were detected in leaves and inflorescences of Sambucus nigra L. by means of GC-EIMS. The identified compounds were characterized by their mass spectra and relative retention times as their trimethylsilyl derivatives. The pheromone L-isoleucine methyl ester extracted from inflorescences can attract pollinator insects during the flowering period and together with uncommon n-alkyl and benzyl esters were firstly identified in S. nigra. On the other hand, mandelonitril...
Source: Phytochemistry Letters - February 7, 2019 Category: Chemistry Source Type: research

Diphenethylpiperidine alkaloids with tracheal smooth muscle relaxation activity from Hippobroma longiflora (L.) G. Don
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Zi-Yang Chan, Kayatri Govindaraju, Premanand Krishnan, Yun-Yee Low, Kam-Weng Chong, Kien-Thai Yong, Kang-Nee Ting, Kuan-Hon LimAbstractPhytochemical investigations on the whole plant of Hippobroma longiflora (L.) G. Don have resulted in the isolation and elucidation of three new diphenethylpiperidine alkaloids, hippofoline A (1), hippofoline B (2), and (−)-cis-2′,2′′-diphenyllobelidiol N-oxide (5), alongside two known alkaloids, (−)-lobeline (3) and (−)-cis-2′,2′′-diphenyllobelidiol (4). The...
Source: Phytochemistry Letters - February 6, 2019 Category: Chemistry Source Type: research

4-Alkylcoumarins and a phloroglucinol from the stem bark of Calophyllum gracilentum
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Chan Kiang Lim, Yenn Pinn Ham, Li Qing Lim, Vivien Yi Mian JongAbstractThree new 4-alkylcoumarins, gracilenins A–C (1-3) and a new phloroglucinol, gracilenol (4), along with two known compounds, euxanthone and friedelin were isolated from the stem bark of Calophyllum gracilentum. Their structures were established on the basis of 1D and 2D NMR spectroscopic data and HRESIMS analysis. This is the first report of 4-(butan-2-yl)coumarin derivatives in this genus.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 6, 2019 Category: Chemistry Source Type: research

Cytotoxic Triterpenoids from the Bark of Chisocheton patens Blume (Meliaceae)
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Unang Supratman, Wiro Naibaho, Supriatno Salam, Rani Maharani, Ace Tatang Hidayat, Desi Harneti, Nurlelasari, Yoshihito ShionoAbstractFour new triterpenoids, namely, chisopaten A-D (1-4), were isolated from the n-hexane extract of the bark of Chisocheton patens Blume. The chemical structures of new compounds were elucidated on the basis of spectroscopic data interpretation. All isolated compounds were evaluated for their cytotoxic activity against MCF-7 breast cancer lines. Chisopaten A and C, showed strongest cytotoxicity activity with IC50 va...
Source: Phytochemistry Letters - February 4, 2019 Category: Chemistry Source Type: research