Isolation and structure elucidation of two antiprotozoal bisbenzylisoquinoline alkaloids from Triclisia gilletii stem bark
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): R. Cimanga Kanyanga, C. Kikweta Munduku, S. Nsaka Lumpu, M. Tshodi Ehata, F. Makila Bool-Miting, O. Kambu Kabangu, B. Mbamu Maya, P. Cos, L. Maes, A.J. Vlietinck, E. Tuenter, K. Foubert, L. PietersAbstractAn aqueous decoction of stem bark of Triclisia gilletii (De Wild.) Staner (Menispermaceae) is used in several African countries to treat various diseases including malaria. The aqueous extract and the total alkaloid extract were evaluated in vitro for their antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum stra...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Deoxyschizandrin attenuates Aβ1–42-induced cognitive impairments through up-regulation of AMPA receptors in mice
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Tingxu Yan, Mengjie Xu, Shutong Wan, Bo Wu, Feng Xiao, Kaishun Bi, Ying JiaAbstractThe present study was undertaken to investigate the possible effect of deoxyschizandrin (DSD) on improving cognitive impairment in mice induced by β-amyloid (Aβ). The Aβ1-42 was injected into the hippocampus of male mice and the mice were treated by DSD (0.01 or 0.1 mg/kg) or their vehicles into the lateral ventricle until the start of behavioral tests. The cognitive improvement effect was assessed by the Y-maze, shuttle box and the Morri...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Cytotoxic neo-clerodane diterpenes from Stachys aegyptiaca
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Tarik A. Mohamed, Abdelsamed I. Elshamy, Ahmed R. Hamed, Khaled A. Shams, Mohamed-Elamir F. HegazyAbstractTwo new E/Z neo-clerodane diterpene isomers, trivially named stachaegyptin D (1) and E (2), together with known compounds, stachysolon monoacetate (3) and stachysolon diacetate (4), were isolated from an organic-solvent extract of the medicinal herb Stachys aegyptiaca. Structures were elucidated by a combination of spectroscopic methods, including HREIMS, 1H, 13C, DEPT, and 2D NMR analysis, as well as, first time X-ray analysis for stach...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Iridoid and phenylethanol glycosides from Scrophularia umbrosa with inhibitory activity on nitric oxide production
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Man-Fei Han, Xing Zhang, Liu-Qiang Zhang, Yi-Ming LiAbstractThree new iridoid glycosides, namely umbrosides A–C (1–3); ten known iridoid glycosides (4–8 and 16–20); and seven known phenylethanoid glycosides (9–15) were isolated from Scrophularia umbrosa Dumortier, and their structures were established through spectroscopic methods including 1D and 2D NMR experiments and ESIMS analysis. The inhibitory activities of the isolated compounds on LPS-stimulated nitric oxide (NO) production in RAW 264.7 cells were inves...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Cephalotaxus alkaloids from Torreya fargesii Franch and their cytotoxicities
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Meng Wang, Xian-Dong Zhang, Yue-Ling Peng, Zheng-Hui Li, Hong-Lian Ai, Ping Li, Tao Feng, Ji-Kai LiuAbstractTwo new cephalotaxus alkaloids, torreyafargesines A (1) and B (2), along with sixteen known ones (3‒18), were isolated from the leaves and barks of Torreya fargesii Franch. The structures were established on the basis of spectroscopic methods. All compounds were evaluated for their cytotoxicities against human A549 and Hela cell lines. As a result, compound 5 exhibited weak cytotoxicities against both two cell lines, while compounds ...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Benzofurans, benzoic acid derivatives, diterpenes and pyrrolizidine alkaloids from Peruvian Senecio
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Liliana Ruiz-Vásquez, Lastenia Ruiz Mesia, Matías Reina-Artiles, M. López-Rodríguez, J. González-Platas, Cristina Giménez, Raimundo Cabrera, Azucena González-ColomaAbstractSixteen compounds incluiding four benzofurans (1–4), three benzoic acid derivatives (6–8), one eremophilane (9), four diterpenes (10–13) and four pyrrolizidine alkaloids (14–17) were isolated from Senecio subcandidus, S. klugii and S. ayapatensis from Perú. Compounds 1–4 and 6–9 hav...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Two new monoterpene lactones from Ligularia rumicifolia (J.R.Drumm.) S.W.Liu and their anti-proliferative activities
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Jing Zhang, Wei Jiang, Hong-Jie Cao, Yanbo Qu, Zhi-Xin Liao, Chao Liu, Jin-Yue SunAbstractA phytochemical study of the EtOAc extract of Ligularia rumicifolia (J.R.Drumm.) S.W.Liu led to the isolation of two new monoterpene lactones (1-2) named (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid and (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid methyl ester, along with nine known compounds (3-11). All compounds were isolated from this species for the first time. Their structures were establish...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Terpenes from the gum resin of Boswellia carterii and their NO inhibitory activies
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Jin-Qian Yu, Yan-Ling Geng, Dai-Jie Wang, Hong-Wei Zhao, Lanping Guo, Xiao WangAbstractThree new terpenes, classified as one cembrane-type diterpenoid (rel)-(1S,5R,7E,11E)-1-isopropyl-8,12-dimethyl-4-methylenecyclotetradeca-7,11-diene-1,5-diol (1), one dinortirucallane-type triterpene 20,21-dinortirucalla-8,24-diene-3β-ol-7-one (2) and one ursane-type triterpene 21β-hydroxy-3-O-acetyl-11-keto-boswellic acid (3), respectively, along with four known triterpenes, were isolated from the gum resin of Boswellia carterii. Their structure ...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Chemical constituents from the branches of Alangium barbatum and their anti-inflammatory activities
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Yang-Guo Xie, Sheng-lan Zhu, Ying-ying Huang, Yi-gong Guo, Guo-jing Wu, Ishaq Muhammad, Shi-kai Yan, Hui-zi Jin, Wei-dong ZhangAbstractTwo new sesquiterpenes (1 and 2), one new alkaloid (4), one new neolignan glycoside (14), together with 19 known compounds were isolated from the branches of Alangium barbatum. Their structures were established by spectroscopic analysis. The absolute configuration of 21 was determined for the first time by single-crystal X-ray diffraction analysis with Cu-Kα irradiation. Some of isolates were evaluated ...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Novel saponin and benzofuran isoflavonoid with in vitro anti-inflammatory and free radical scavenging activities from the stem bark of Pterocarpus erinaceus (Poir)
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Paul Djouonzo Toukam, Maurice Fotsing Tagatsing, Lauve Rachel Tchokouaha Yamthe, Gakul Baishya, Nabin Chandra Barua, Alembert Tiabou Tchinda, Joseph Tanyi MbaforAbstractThe phytochemical study of the stem bark of Pterocarpus erinaceus led to the isolation of a new saponin (1) and a new benzofuran isoflavonoid (2) along with seven known compounds namely friedelin (3), triacontanoic acid (4), dotriacontanoic acid (5), 2,3-dihydroxypropyl hexacosanoate (6), octacosanoic acid (7), calycosin (8), stigmasterol glucoside (9). The structures of the ...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Dioic acid glycosides, tannins and methylated ellagic acid glycosides from Morella salicifolia bark
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Edna E. Makule, Birgit Kraus, Guido Jürgenliemk, Jörg Heilmann, Stefan WiesnethAbstractThe bark of Morella salicifolia (Hochst.exA. Rich.) Verdc. &Polhill (Myricaceae) is a common herbal drug and especially utilized by the Maasai community of northeastern Tanzania. It is traditionally used to treat swellings on the cheek and face, cough, toothache, stomach problems, headaches, and skin diseases. Unless, there is still a lack of information considering the specialized metabolites that may be responsible for the traditional use o...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Two new phenylpropanoids from Penthorum chinense Pursh
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Doudou Huang, Xuan Wang, Lei Sun, Wansheng Chen, Lianna SunAbstractThe chemical investigation of Penthorum chinense resulted in the isolation of two new phenylpropanoids (1 and 2) along with three known compounds (3–5). The structures of the compounds 1 and 2 were determined by interpretation of the spectroscopic data, including IR, HR-ESI-MS, 1H NMR, 13C NMR, DEPT, COSY, HMBC and HMQC. Moreover, all the compounds were evaluated for their hepatoprotective activity in H2O2-induced cytotoxicity in HL-7702 cells, and compounds 2–4 (...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Three new phloroglucinol derivatives from the aerial parts of Pogostemon auricularius and their cytotoxic activity
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Linh Thuy Thi Tran, Duc Viet Ho, Dung Viet Le, Tran Manh Hung, Hoai Thi Nguyen, Ain RaalAbstractPogostemonons A–C (1–3), three new phloroglucinol derivatives were isolated from the aerial parts of Pogostemon auricularius (L.) Hassk. Their chemical structures were established by 1D, 2D NMR and HRESIMS data. These compounds showed weak to moderate growth inhibitory activities against lung adenocarcinoma (LU-1), oral epidermoid carcinoma (KB), liver hepatocellular carcinoma (Hep-G2), colon adenocarcinoma (SW-480), and gastric adenoc...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Rebaudioside A and other unreported steviol glycoside isomers found in the sweet tea (Rubus suavissimis) leaf
In this study, we conducted an analysis of sweet tea leaves by using high performance liquid chromatography coupled with a mass spectrometer (LC–MS), and reported for the first time that rebaudioside A, one of the major steviol glycosides in Stevia rebaudiana Bertoni, was detected in Rubus suavissimis, along with a few other isomers of stevioside or rebaudioside B. This finding has potential implications on selective plant breeding, an effort already in place in an attempt to increase the abundance of desirable steviol glycosides, such as rebaudioside D and M, the concentrations of which are very low in current stevi...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Xylariaopyrones A-D, four new antimicrobial α-pyrone derivatives from endophytic fungus Xylariales sp
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Zhi-Yong Guo, Li-Wen Lu, Shang-Song Bao, Cheng-Xiong Liu, Zhang-Shuang Deng, Fei Cao, Shi-Ping Liu, Kun Zou, Peter ProkschAbstractFour new α-pyrone derivatives, xylariaopyrones A-D (1-4), together with four known compounds were isolated from the PDB broth of endophytic fungus xylariales sp. (HM-1). Their structures were identified by comprehensive analysis of NMR, MS and CD spectra. The absolute configurations of compounds B-D were determined by calculating their ECD spectra. Compound C (3) and D (4) was a pair of epimer with a ketal f...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Isolation of 3,4-seco-27-norlanostane triterpenoids from cultivated fruiting bodies of Ganoderma orbiforme
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Wei Li, Panida Chinthanom, Pranee Rachtawee, Kamolphan Intereya, Tao Feng, Ji-Kai Liu, Masahiko IsakaAbstractFour new 3,4-seco-27-norlanostane triterpenoids, ganoboninketals E (1) and F (2), and ganoboninones G (3) and H (4), and two known derivatives (5 and 6), a new C30 lanostane, (24Z)-3β,27-dihydroxylanosta-7,9(11),24-triene (7), and twelve known lanostanes (8–19), together with three known meroterpenoids, fornicin A (20) and ganomycins B (21) and I (22), were isolated from cultivated fruiting bodies of the basidiomycete Ganod...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Identification and bioactivity evaluation of ingredients from the fruits of Amomum tsaoko Crevost et Lemaire
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Hang Liu, Qingsong Yan, Deli Zou, Xialing Bu, Baojing Zhang, Xiaochi Ma, Aijing Leng, Houli Zhang, Dawei Li, Chao WangAbstractTwo new fatty acids, together with ten known compounds, were isolated from the fruits of Amomum tsaoko. Their structures were determined by extensive spectroscopic data analysis. The extracts and all the discovered compounds were tested for inhibition of Klebsiella pneumoniae (K. pneumoniae). The results showed that 95% ethanol and ethyl acetate extracts of the fruits of A. tsaoko had excellent inhibitory activities a...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Overexpression of and RNA interference with hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase affect the chlorogenic acid metabolic pathway and enhance salt tolerance in Taraxacum antungense Kitag
This study aimed to determine the regulatory mechanism of CGA biosynthesis and the role of the CGA biosynthetic gene (HQT), encoding hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase, in T. antungense. Quantitative real-time polymerase chain reaction revealed significant changes in the tissue distribution of HQT expression in T. antungense transgenic lines overexpressing HQT. CGA but not CA concentrations differed significantly between the wild-type T. antungense and transgenic lines overexpressing HQT. Further, the CGA concentration was significantly higher in the leaves than in the roots. The upregulation of TaHQ...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Non-destructive chemical analysis of a Garcinia mangostana L. (Mangosteen) herbarium voucher specimen
We present herein a non-destructive method to analyze the metabolites of herbarium voucher specimens with the droplet-liquid microjunction-surface sampling probe (droplet probe) coupled to ultra-performance liquid chromatography and high-resolution mass spectrometry. As proof of concept, a herbarium voucher specimen of Garcinia mangostana (mangosteen) was utilized due to the well-characterized xanthones biosynthesized by this plant, which are of interest as potential anticancer agents. Also, the juice of the fruits of this plant is used widely in the United States and in other countries as a botanical dietary supplement. M...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Four new flavonoids with DGAT inhibitory activity from Psoralea corylifolia
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Hao-Ze Li, Xiao Meng, Yi-Yu Jiang, Xin Lin, Da-Xi Xiong, Dong Wang, Hyun-Sun Lee, Long CuiAbstractFour new compounds, 3′'-methoxy-bavacoumestan C (1), 6,7-furanbavachinone B (2), 3,4- furanbavachalcone A (3) and 4,5- furanbavachalcone A (4), together with seven known flavonoids were isolated from the Psoralea corylifolia. Their structures were determined by extensive spectroscopic and physicochemical analyses. All the compounds (1–11) were evaluated for in vitro inhibitory activity against DGAT. Among them, compounds 1, 6, 7, 10 ...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Indole and flavonoid from the herbs of Kalimeris shimadai
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Nan Zhang, Wen-Fang Jin, Yun-Peng Sun, Gang Wang, Yang Yu, Zhong-Yu Zhou, Guo-Kai Wang, Jin-Song LiuAbstractA new indole, kalshiliod A (1), a new flavonoid glycoside, isorhamnetin-3-O-β-D- glucuronide-6′′-ethyl ester (2), and ten known compounds (3–12) were isolated from the herbs of Kalimeris shimadai. The compounds’ structures were elucidated through comprehensive spectroscopic techniques. All of the compounds were isolated from K. shimadai for the first time. Furthermore, the new compounds’ cytotoxicitie...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Bioactive isoquinoline alkaloids from Glaucium arabicum
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Ahmed Elbermawi, Amal Sallam, Hazem A. Ghabbour, Mahmoud F. Elsebai, Mohamed F. Lahloub, Hassan-Elrady A. SaadAbstractPhytochemical investigation of the aerial parts of Glaucium arabicum Fresen. (Papaveraceae) led to the isolation of two previously undescribed isoquinoline alkaloids araglaucine A, and araglaucine B, together with seven known ones 1-[(3`,4`-dimethoxy-2`-methylcarboxy)benzoyl]-6,7-methylenedioxy isoquinoline (araglaucine C), (7R,14S)-trans-N-methylcanadinium nitrate, (R,S)-trans-N-methylstylopine, 14-hydroxy-N-methyl canadine,...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

New iridoid glycosides from Viburnum punctatum
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Yuan Gao, Wan-Qiu Yang, Ku Yang, Xian-Jun Jiang, Xiang-Mei Li, Fei WangAbstractThree hitherto unknown valeriana-type iridoid glycosides (1−3) were isolated from Viburnum punctatum, and their structures were elucidated by extensive spectroscopic analysis. The new compounds, designated as viburpunosides A − C (1−3), are characterized by having a mono- or triacylated α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl moiety linked to C-11. This is the second report of an iridoid attached to a disacchari...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Spiro-isoxazolines from the flowers of Xanthoceras sorbifolia
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Zhan-Lin Li, Dan-Dan Zhao, Dan-Yi LiAbstractFour tyrosine-derived spiro-isoxazoline analogues, including two new ones (3–4), were isolated from the flowers of Xanthoceras sorbifolia Bunge. The planar structures and the conformations were established by the analyses of the 1D and 2D NMR spectroscopic data, and the absolute configuration of compound 4 was determined via ECD calculation by time-dependent density functional theory (TDDFT). The biosynthetic pathway involving oxidative cyclization of the aldoxime precursor and the substrate-...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Three new 2,4′-epoxy-8,5′/8,3′-neolignans from Penthorum chinense
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Fei Liu, Ya-Cong He, Huan Zhu, Li Guo, Cheng Peng, Liang XiongAbstractThree new neolignans (1−3), including one 2,4′-epoxy-8,5′-neolignan and two 2,4′-epoxy-8,3′-neolignan glycosides, were isolated from the EtOAc-soluble portion of the water decoction of Penthorum chinense Pursh. Their structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and electronic circular dichroism (ECD) calculations. Notably, the unusual 2,4′-epoxy-8,3′-neolignan glycosides are...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Modulation of polyketide biosynthetic pathway of the endophytic fungus, Anteaglonium sp. FL0768, by copper (II) and anacardic acid
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Jair Mafezoli, Ya-ming Xu, Felipe Hilário, Brandon Freidhof, Patricia Espinosa-Artiles, Lourdes C. dos Santos, Maria C.F. de Oliveira, A.A. Leslie GunatilakaAbstractIn an attempt to explore the biosynthetic potential of endosymbiotic fungi, the secondary metabolite profiles of the endophytic fungus, Anteaglonium sp. FL0768, cultured under a variety of conditions were investigated. In potato dextrose broth (PDB) medium, Anteaglonium sp. FL0768 produced the heptaketides, herbaridine A (1), herbarin (2), 1-hydroxydehydroherbarin (3), sco...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Two new steroidal glycosides from Anemarrhena asphodeloides rhizome, and their cytotoxic activity in vitro
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Pham Van Khang, Ngo Duc Hieu, Nguyen Thi Hien Lan, Sida Shen, Lei MaAbstractTwo new steroidal glycosides 1 and 2 have been isolated from the n-butanol extract portion of Anemarrhena asphodeloides Bunge (A.asphodeloides), a widely used plant as Traditional Chinese Medicine. Their structures have been confirmed through a variety of analytic approaches including 1D and 2D-NMR spectroscopic techniques as well as mass spectrometry data. Moreover, cytotoxic activity evaluation demonstrated that compound 2 exhibited micromole level cytotoxic effect...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Phytochemical characterization of the Chinese endemic species Stemona mairei and five other Stemona species
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Gao Chen, Lothar Brecker, Katharina Maria Sandler, Xiang-Hai Cai, Sumet Kongkiatpaiboon, Karin Valant-Vetschera, Johann SchinnerlAbstractComparative HPLC-PDA analyses of methanolic root extracts of the almost unstudied Chinese endemic species Stemona mairei, collected from nine locations throughout its natural habitat in northern Yunnan, led to the identification of the pyrrolo[1,2-α]azepine-type alkaloid protostemonine (1) as the main alkaloid and 3,4-dehydro-δ-tocopherol (9) as the main tocopherol derivative. Analysis of the fi...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Triterpene saponins of the root bark of Olax obtusifolia De Wild
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): David Pertuit, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Clément Delaude, Marie-Aleth Lacaille-DuboisAbstractFour undescribed triterpenoid saponins together with five known and oleanolic acid were isolated from root bark of Olax obtusifolia De Wild. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, in combination with mass spectrometry as 3-O-α-l-rhamnopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→3)-β-d-glucuronopyranosyloleanolic acid, 3-O-α-l-...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Corrigendum to “Nitrophenyl dihydropyridine-derivatives from Seriphidium oliverianum” [Phytochem. Lett. 21 (September) (2017) 226–229]
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Liaquat Ali, Muhammad Imran Tousif, Naheed Riaz, Mamona Nazir, Hidayat Hussain, Ahmed Al-Harrasi, Nusrat Shafiq, Abdul Jabbar, Rasool Bakhsh Tareen, Muhammad Saleem (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Inside Front Cover (Editorial Board)
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Contents (graphical abstracts and research highlights)
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Briaviolides O and P, new briaranes from a cultured octocoral Briareum violaceum
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jing-Hao Xu, Yu-Chia Chang, Guo-Qiang Li, Zhi-Hong Wen, Yang-Chang Wu, Ping-Jyun SungAbstractChemical investigation of the EtOAc-soluble fraction from the MeOH/DCM extract of a cultured octocoral Briareum violaceum afforded two new briarane diterpenoids, briaviolides O (1) and P (2). The structures of briaranes 1 and 2 were elucidated on the basis of spectroscopic analysis, and 1 was shown to inhibit the accumulation of pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Carboline alkaloids and isocoumarins from the wasp pathogenic fungus Ophiocordyceps sphecocephala BCC 2661
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jittra Kornsakulkarn, Siriporn Saepua, Sukitaya Veeranondha, Pranee Rachtawee, Masahiko Isaka, Chawanee ThongpanchangAbstractTen β-carboline alkaloids, including five new and two new naturally occurring compounds, sphecolines A–G (1–7), together wit2h four known isocoumarins were isolated from a wasp-pathogenic fungus Ophiocordyceps sphecocephala BCC 2661. Structures of these compounds were determined by NMR spectroscopic and MS spectrometric analyses. Sphecolines A (1) and C (3) exhibited cytotoxic activity against human sma...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Two new stilbenoids from the whole herb of Sphaerophysa salsula
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Li Jin Jiao, Wei Dong Wang, Yan Duo Tao, Yun Shao, Li Juan Mei, Zeng Gen Liu, Qi Lan Wang, Jun DangAbstractTwo new compounds, gnetuhainins Fa (1) and cassigarols Ea (2), were isolated from the whole herb of Sphaerophysa salsula along with eight known compounds (3-10). The compounds (4) were isolated for the first time from this species. Their structures were elucidated by ESI-MS, UV, IR, 1D NMR and 2D NMR data.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Structurally diverse glycoconjugated volatile compounds from Oxytropis falcata Bunge
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Shanshan Wang, Xiaojing Zhang, Sheng Que, Hong Liang, Pengfei Tu, Qingying ZhangAbstractA phytochemical investigation on the whole plant of Oxytropis falcata Bunge yielded 16 glycoconjugated compounds with structurally diverse volatile aglycones but similar sugars. Of these, five were previously undescribed compounds with different volatile aglycones but same glucuronic acid (1 → 2) glucosyl moiety, including three octanol glucuronic acid (1 → 2) glucosides (1–3), one acyclic monoterpenoid glucuronic acid (1 →...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Diarylheptanoids from the root of Curcuma aromatica and their antioxidative effects
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Shengjuan Dong, Xiaodong Luo, Yaping Liu, Mi Zhang, Baocai Li, Weifeng DaiAbstractFour rare diarylheptanoids containing tetrahydropyran moieties (1–4) and five known diarylheptanoids (6–10) were isolated from the n-BuOH fraction of 75% ethanol extract from the root of Curcuma aromatica, along with a new phenol (5). Their planar and stereochemical structures were established using HRESIMS and spectroscopic methods, including ECD data. All compounds (1–10) exhibited antioxidant effects on the model of H2O2-induced damage in PC...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Three new sesquiterpene lactones from Carpesium abrotanoides
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Qiao-Ling Hu, Pei-Qian Wu, Ying-Hong Liu, Feng-Ming Qi, Chun-Xue Yu, Ye Zhao, Yi-Fan Yu, Dong-Qing Fei, Zhan-Xin ZhangAbstractThree new sesquiterpene lactones, 5α-hydroxy-4α,15-epoxy-11αH-eudesman-12,8β-olide (1), carabrol-4-O-palmitate (2) and carabrol-4-O-linoleate (3), along with five known ones, were isolated from the whole plant of Carpesium abrotanoides. The structures of new compounds were determined by extensive spectroscopic analysis, and compound 1 was also elucidated by X-ray single-crystal diffraction analys...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Six new dihydro-β-agarofuran sesquiterpenes from the stems and leaves of Monimopetalum chinense and their antimicrobial activities
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Xingzeng Zhao, Shu Xu, Min Yin, Xiangyun Wang, Qizhi Wang, Yu Shan, Yu Chen, Fei Liu, Shenghu Guo, Xu FengAbstractSix new dihydro-β-agarofuran sesquiterpenes (1-6) were isolated from Monimopetalum chinense Rehd., and their structures were elucidated based on spectroscopic data analyses. Absolute configurations of representative compounds (1 and 3) were also determined by using quantum mechanic CD calculations. In addition, the antimicrobial activities of 1-6 against plant-pathogenic fungi and bacteria were evaluated by in vitro growth in...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Identification of anti-inflammatory active peptide from black soybean treated by high hydrostatic pressure after germination
This study was conducted to isolate and identify the anti-inflammatory active peptide in black soybean treated by high hydrostatic pressure after germination. The anti-inflammatory activity was examined using RAW 264.7 macrophages. Black soybean was germinated for 4 days and subjected to 150 MPa for 24 h, followed by preparation of protein extracts. The extracts were sequentially filtered using membranes with a molecular weight cutoff of 30, 10, and 3 kDa. A strong inhibitory effect was observed with the 3–10 kDa fraction. The active peptide from this fraction was purified by gel permeation column chromatogra...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Two new oleanane-type saponins from Elaeocarpus hainanensis Oliv. growing in Vietnam
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Dao Thu Nga, Pham Quang Duong, Quang Le Dang, Nguyen Huu Tung, Vu Dinh HoangAbstractTwo new oleanane-type saponins, 1α-hydroxy-olean-12-en-3-O-β-D-xylopyranoside (1) and 1α-hydroxy-olean-12-en-3-O-α-L-arabinopyranoside (2), along with six known compounds (3-8), were isolated from the leaves and twigs of Elaeocarpus hainanensis Oliv. Their structures were determined based on chemical and spectroscopic analyses. This is the first report on oleanane-type triterpenoids in the genus Elaeocarpus.Graphical abstract (Source: Ph...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

C19-diterpenoid alkaloids from Aconitum hemsleyanum var. circinatum
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jin-bu Xu, Shuai Huang, Xian-li ZhouAbstractSix new C19-diterpenoid alkaloids, circinatines A–F (1–6), along with eight known compounds, were isolated from the roots of Aconitum hemsleyanum var. circinatum. Their structures were elucidated by extensive spectroscopic methods including NMR, IR, HR-ESI-MS and X-ray experiments. All compounds were evaluated for their cytotoxic activity against MCF-7, A549, HCT-116 and 786-0 human cancer cell lines.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Anti-inflammatory terpenoid derivatives from the twigs of Syringa oblata var. dilatata
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Kyoung Jin Park, Lalita Subedi, Sun Yeou Kim, Kang Ro LeeAbstractAs a part of our ongoing search for bioactive constituents from Korean medicinal sources, chemical investigations of Syringa oblata var. dilatata twigs were carried out, leading to the isolation and characterization of two new terpenoid derivatives (1-2) and five known compounds (3-7). The chemical structures of the compounds 1 and 2 were determined by extensive NMR data (1H and 13C NMR, 1H-1H COSY, HSQC, HMBC, and NOESY), HRMS, and chemical methods. These compounds (1-7) were e...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Cytotoxic phloroglucinol meroterpenoid from Eugenia umbelliflora fruits
This study describe the isolation and structure elucidation of a sesquiterpenyl phloroglucinol (eugenial E), that is described here for the first time. Eugenial E (5) was isolated from the n-hexane extract of fruits, and its structural elucidation was carried out through the combined analysis of MS, IR and 1D-(¹H, ¹³C BB and DEPT, and NOEDIFF) and 2D-(COSY, HSQC, HMBC and ROESY) NMR spectra, with conformational analysis support. Cytotoxicity was assessed using MTT analysis against human leukemic cells (k562 and Nalm-6 cells) and murine melanoma cells (B16F10 cell). The extracts showed high cytotoxicity, whil...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Phytochemical constituents and cytotoxic activity of Physalis angulata L. growing in Vietnam
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Hoang Le Tuan Anh, Do Thi Thao, Duong Thi Dung, Phan Van Kiem, Tran Hong Quang, Pham Thi Hai Yen, Do Thanh Tuan, Pham Viet Cuong, Le Canh Viet Cuong, Tran Manh HungAbstractA comprehensive phytochemical investigation of the dichloromethane-soluble fraction of Physalis angulata led to the isolation of eight compounds (1–8) including two new withanolides named physagulin P and Q (compounds 5 and 8). Their chemical structures were established using two-dimensional nuclear magnetic resonance (spectroscopy. The cytotoxic activity of these met...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Anti-inflammatory activity of prenyl and geranyloxy furanocoumarins from Citrus garrawayi (Rutaceae)
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Ritesh Raju, Ahilya Singh, Paul Reddell, Gerald MünchAbstractAnti-inflammatory activity guided isolation from Citrus garrawayi (Rutaceae) led to the discovery of five new garracoumarins A – E (1 - 5), and five known (6 – 10) isoprenylated furanocoumarins and the known sterol bourjotinolone A (11). Discussed herein is the anti-inflammatory structure activity relationship of the ten furanocoumarins and a detailed spectroscopic analysis leading to the structure elucidation of the new and known isoprenylated furanocoumarins.Graph...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Synthesis, antiproliferative activity and autophagic flux inhibition of new arylsparteine derivatives
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Moustafa T. Gabr, Mohammed S. Abdel-RaziqAbstractNew series of arylsparteine derivatives were synthesized and evaluated for their cytotoxic activity against four human cancer cell lines (cervical epithelial carcinoma cells Hela, breast cancer cells MCF-7, lung cancer cells A549, and glioma cells U87 MG) and one normal fibroblast cell line. Structure-activity relationship revealed that introduction of 4-quinolinyl moiety to sparteine afforded a hybrid compound 10 with considerable antiproliferative activity against all tested cancer cell lines...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Four new megastigmane glycosides from the leaves of Eucommia ulmoides Oliver
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jian-Kun Yan, Xu-Liu Shi, Paul Owusu Donkor, Li-Qin Ding, Feng QiuAbstractFour new megastigmane glycosides, eucomegastigsides E1 (1), eucomegastigsides E2 (2), eucomegastigsides F1 (3), and eucomegastigsides F2 (4) were isolated from the leaves of Eucommia ulmoides Oliver. Their structures were elucidated based on extensive spectroscopic analysis and their absolute configurations were determined by comparison of experimental optical rotation (OR) to DFT calculations. In addition, compounds 1-4 were evaluated for their ACE (Angiotensin Convert...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Synthetic and in vitro studies to indicate that the structure of the PTP1B inhibitor isolated from Acanthopanax senticosus requires reinvestigation
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Toshiro Noshita, Ryoya Onishi, Kaori Miura, Yoshitomo Hamada, Yuki Nishino, Hidekazu Ouchi, Akihiro TaiAbstractWe herein describe the syntheses of 3,5-dimethoxy-4-{2-methoxy-4-[(1E)-3-oxoprop-1-en-1-yl]phenoxy}benzaldehyde (1) (the proposed structure for the naturally occurring protein tyrosine phosphatase 1B (PTP1B) inhibitor isolated from Acanthopanax senticosus) and its three positional isomers 3, 4, and 5. The inhibitory activities of these four compounds against PTP1B were also investigated. Comparison of the spectral data for 1, 3, 4, a...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

New biphenyls from Garcinia lancilimba
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Xue-Mei Gao, Di Cui, Shan-Shan Wang, Wen-Zhong Huang, Gan-Peng Li, Guang-Zhi Zeng, Meng-Yuan Jiang, Zhi-Yong JiangAbstractGarcilancibiphenyls A–C (1–3), three new biphenyls, were isolated from the stems of the plant Garcinia lancilimba, which belongs to the family Clusiaceae. Structures of the new compounds feature the acetoxyprenyl group on a benzene ring, and were elucidated by spectroscopic evidence. These compounds showed promising anti-rotavirus activity effects with TI values above 10.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research