Editorial Board
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 27, 2019 Category: Chemistry Source Type: research

Graphical Abstract TOC
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 27, 2019 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 27, 2019 Category: Chemistry Source Type: research

A new carotenoid, 6′-hydroxy-3′-didehydrolutein, produced by recombinant Escherichia coli that expresses the violaxanthin biosynthesis and chaperone AtCYO1 genes — Its structure and antioxidant activities
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Saki Shimode, Kana Miyata, Miho Takemura, Hiroshi Shimada, Norihiko Misawa, Kazutoshi ShindoAbstractRecombinant Escherichia coli cells, which express the higher-plant CaZEP (zeaxanthin epoxidase) and AtCYO1 (molecular chaperone) genes and an NADPH regeneration system in addition to the IDI, crtE, crtB, crtI, crtY, and crtZ genes for zeaxanthin biosynthesis, were cultured in 2 × YT medium for the efficient production of antheraxanthin and violaxanthin. The carotenoids accumulated in the cells were purified by two-phase partition, si...
Source: Phytochemistry Letters - November 27, 2019 Category: Chemistry Source Type: research

Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Inga Zinicovscaia, Svetlana Gundorina, Konstantin Vergel, Dmitrii Grozdov, Alexandru Ciocarlan, Aculina Aricu, Ion Dragalin, Nina CiocarlanAbstractThe elemental composition of 45 species of medicinal plants of Lamiaceae family growing in the Republic of Moldova was determined by neutron activation analysis. The following elements were determined in analysed samples: Al, As, Ba, Br, Ca, Ce, Cl, Co, Cr, Cs, Fe, Hf, K, La, Mg, Mo, Mn, Na, Rb, Sb, Sc, Sr, Sm, Th, U and Zn. The essential, rare earth and trace elements are present in herb at conce...
Source: Phytochemistry Letters - November 27, 2019 Category: Chemistry Source Type: research

Phytochemistry and pharmacology of Harungana madagascariensis: mini review
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Gervais Mouthé Happi, Gesquiere Laure M. Tiani, Bel Youssouf M. Gbetnkom, Hidayat Hussain, Ivan Robert Green, Bonaventure Tchaleu Ngadjui, Simeon Fogue KouamAbstractThis mini review describes the research between 1962 and 2019 on ethnobotany, chemistry and pharmacology of Harungana madagascariensis (Hypericaceae), the unique plant species in the genus Harungana. The plant is mainly distributed in Africa and Europe, where it has been used in the traditional medicine to cure several diseases. The first chemical investigation of H. madag...
Source: Phytochemistry Letters - November 26, 2019 Category: Chemistry Source Type: research

Coumarins and acridone alkaloids with α-glucosidase inhibitory and antioxidant activity from the roots of Paramignya trimera
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Duong H. Trinh, Phuong T. Tran, Binh T.D. Trinh, Hieu T. Nguyen, Hiep D. Nguyen, Ly D. Ha, Lien-Hoa D. NguyenAbstractThree new compounds comprising two coumarins, paramicoumarins A (1) and B (2), and an acridone alkaloid, paramiacridone (3), together with seven known compounds, were isolated from the n-hexane extract of the roots of Paramignya trimera (Rutaceae). Their structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR. α-Glucosidase inhibition and DPPH radical scavenging activity of the compounds and fifteen ...
Source: Phytochemistry Letters - November 23, 2019 Category: Chemistry Source Type: research

Sulfated flavanones and dihydroflavonols from willow
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Clarice Noleto-Dias, Claudia Harflett, Michael H. Beale, Jane L. WardAbstractPhytochemical profiling of a hybrid species of willow, Salix × alberti L. (S. integra Thunb. × Salix suchowensis W.C. Cheng ex G.Zhu) revealed four sulfated flavonoids, which were then isolated from young stem tissue. The structures of dihydroflavonols (flavanonols) taxifolin-7-sulfate (1) and dihydrokaempferol-7-sulfate (2) and flavanones, eridictyol-7-sulfate (3) and naringenin-7-sulfate (4) were elucidated through NMR spectroscopy and high-resolution ...
Source: Phytochemistry Letters - November 23, 2019 Category: Chemistry Source Type: research

Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Weihao Chen, Haiyi Liu, Jieyi Long, Huaming Tao, Xiuping Lin, Shengrong Liao, Bin Yang, Xuefeng Zhou, Yonghong Liu, Junfeng WangAbstractAsperpentenone A (1), a novel polyketide with a rare cyclopentenone-tetrahydrofuran moiety, was isolated along with eight known compounds (2–9) from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and X-ray crystallography. Biological evaluation results revealed that kojic a...
Source: Phytochemistry Letters - November 23, 2019 Category: Chemistry Source Type: research

New coumarins isolated from the stem bark of Fraxinus rhynchophylla inhibit human neutrophil elastase and LPS-induced inflammation in RAW 264.7 cells
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Beom Zoo Lee, Ki Mo Kim, Sungwook Chae, Soon-Kyu Jeong, Sulhae Lee, KwangWon Hong, Ik Soo LeeAbstractTwo new coumarins (1 and 2), together with six known compounds (3–8), were isolated from the stem bark of Fraxinus rhynchophylla. The structures of these compounds were established by extensive spectroscopic studies and chemical evidence. The inhibitory activities of the isolated compounds (1–8) against human neutrophil elastase (HNE) were evaluated in vitro; all compounds tested exhibited inhibitory effects against HNE activity, ...
Source: Phytochemistry Letters - November 22, 2019 Category: Chemistry Source Type: research

Bistachybotrysins W-Y, three new phenylspirodrimane dimers with a 6/7 oxygen heterocycle from Stachybotrys chartarum
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Jimei Liu, Jiamin Feng, Xiaona Jia, Jinlian Zhao, Ridao Chen, Kebo Xie, Dawei Chen, Yan Li, Jungui DaiAbstractBistachybotrysins W-Y (1–3), three new phenylspirodrimane dimers with a 6/7 oxygen heterocycle as the linkage, were isolated from Stachybotrys chartarum CGMCC 3.5365. The structures of 1–3 were elucidated through extensive spectroscopic data analysis, including 1D/2D NMR, HR-ESI-MS, and ECD spectra. Compounds 1 and 3 displayed moderate cytotoxic activity against human tumor cell lines HCT116, Daoy, and HepG2 with IC50 val...
Source: Phytochemistry Letters - November 22, 2019 Category: Chemistry Source Type: research

Flavonol glycosides and their α-glucosidase inhibitory effect from Camellia sinensis
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Nguyen Thi Cuc, Luu The Anh, Nguyen The Cuong, Nguyen Hoang Anh, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Thi Hoai, Pham Hai Yen, Chau Van Minh, Phan Van KiemGraphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 22, 2019 Category: Chemistry Source Type: research

New sesquiterpenoid derivatives from Ganoderma sinense with nitric oxide inhibitory activity
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Dun Wang, Ya-Li Wang, Peng Zhang, Xing-Zhou Li, Hua Li, Li-Xia ChenAbstractOne new sesquiterpenoid, ganosinensol K (1) and one new norsesquiterpenoid, ganosinensol L (2) were isolated from 95 % EtOH extract of the fruiting bodies of Ganoderma sinense. Their structures were determined on the basis of extensive spectroscopic analyses including HRESIMS, 1D and 2D NMR, and optical rotation value. Compound 1 should be a mixture of two enantiomers. We attempted to resolve compound 1 into one pair of enantiomers by HPLC using a Daicel Chiralpak IE ...
Source: Phytochemistry Letters - November 22, 2019 Category: Chemistry Source Type: research

New cytotoxic limonoids from the stem bark of Chisocheton pentandrus (Blanco) Merr
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Unang Supratman, Supriatno Salam, Wiro Naibaho, Mohamad Fajar, Nurlelasari, Dewa Gede Katja, Desi Harneti, Rani Maharani, Ace Tatang Hidayat, Ronny Lesmana, Mohamad Azlan Nafiah, Yoshihito ShionoAbstractThree new limonoids namely pentandricines B–D (1–3), were isolated from n-hexane extract of the stem bark of Chisocheton pentandrus, along with four known limonoids (4-7). The chemical structures of pentandricines B–D, were fully elucidated based on UV, IR, HR-TOFMS, 1D- and 2D-NMR spectra. Furthermore, compounds 1-7 were ev...
Source: Phytochemistry Letters - November 22, 2019 Category: Chemistry Source Type: research

Three new compounds from the litters of Casuarina equisetifolia
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Pei Wang, Haisheng Wang, Caihong Cai, Hao Wang, Fandong Kong, Jingzhe Yuan, Haofu Dai, Lei Li, Wenli MeiAbstractTwo new cyclic diarylheptanoids, casuaritriol A (1) and casuaritriol B (2), were isolated from the EtOAc extract of litters (including branches and leaves) of Casuarina equisetifolia, along with a new triterpene casuariene (3), and two known compounds diarylheptanoids adanin (4) and ostryopsitriol (5). Their structures were elucidated by spectroscopic analysis (including HRESIMS, 1D NMR and 2D NMR data), and the absolute configurat...
Source: Phytochemistry Letters - November 19, 2019 Category: Chemistry Source Type: research

Cytotoxic and anti-HIV-1 activities of triterpenoids and flavonoids isolated from leaves and twigs of Gardenia sessiliflora
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Sariyarach Thanasansurapong, Patoomratana Tuchinda, Vichai Reutrakul, Manat Pohmakotr, Pawinee Piyachaturawat, Arthit Chairoungdua, Kanoknetr Suksen, Radeekorn Akkarawongsapat, Jitra Limthongkul, Chanita Napaswad, Narong NuntasaenAbstractA new cycloartane triterpenoid, sessiliflorin (1), together with two new flavanones, 5,3′,5′-trihydroxy-6,7,4′-trimethoxyflavanone (10) and 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavanone (11) were isolated from a methanol extract of leaves and twigs of Gardenia sessiliflora....
Source: Phytochemistry Letters - November 16, 2019 Category: Chemistry Source Type: research

Anti-influenza A (H1N1) viral and cytotoxic sesquiterpenes from Carpesium abrotanoides
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Yu-Qing He, Liang Cai, Qun-Gang Qian, Sheng-Hui Yang, Di-Lu Chen, Bi-Qing Zhao, Zhen-Ping Zhong, Xiao-Jiang ZhouAbstractTwo new sesquiterpenes, named carpabrotalactone A (1) and B (2), together with six known sesquiterpenes, 11(13)-dehydroivaxillin (3), eriolin (4), 2α,5α-dihydroxy-11αH-eudesma-4(15)-en-12,8β-olide (5), (5α)-5-hydroxyasperilin (6), 1α,4α-dihydroxy-guaia-11(13)-ene-12,8α-olide (7) and 4α,5α-dihydroxy-guaia-11(13)-en-12,8α-lactone (8), were isolated from the herb...
Source: Phytochemistry Letters - November 16, 2019 Category: Chemistry Source Type: research

Monoterpenoid indole alkaloids from the fruits of Melodinus henryi
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Qian Shao, Rui Ma, Xing Wu, Fa-Lei Zhang, Zheng-Hui Li, Tao Feng, Juan He, Ji-Kai LiuAbstractFour undescribed monoterpenoid indole alkaloids, melodinines X1‒X4 (1‒4), together with fourteen known ones, have been isolated from the fruits of Melodinus henryi. Their structures with absolute configurations were elucidated by extensive spectroscopic methods and ECD calculations. Compound 1 shows a significant cytotoxicity to HL-60 cancer cell line with an IC50 value of 0.8 μM.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 16, 2019 Category: Chemistry Source Type: research

Phenolic glycosides from Magnolia figo
Publication date: Available online 15 November 2019Source: Phytochemistry LettersAuthor(s): Chutima Srinroch, Poolsak Sahakitpichan, Nitirat Chimnoi, Somsak Ruchirawat, Tripetch KanchanapoomAbstractThree new phenolic glycosides were isolated from the leaves and twigs of Magnolia figo, and identitified to be 3,4-dihydroxy-β-phenylethoxyl-O-[β-D-glucopyranosyl-(1"→2')-α-L-rhamnopyranosyl-(1'"→3')-(4'-O-trans-caffeoyl)-β-D-glucopyranosyl-(1'""→6')]-β-D-glucopyranoside (champikhaekoside, 8), 4-hydroxybenzyl O-β-D-apiofuranosyl-(1"→2')-[β-D-glucopy...
Source: Phytochemistry Letters - November 15, 2019 Category: Chemistry Source Type: research

Reviewers' acknowledgement 2019
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 15, 2019 Category: Chemistry Source Type: research

Bio-guided isolation of new phenolic compounds from Hippocrepis emerus flowers and investigation of their antioxidant, tyrosinase and elastase inhibitory activities
This study presents the bio-guided chemical investigation of a 80% methanol extract of Hippocrepis emerus flowers, a perennial non-climbing shrub. Liquid-liquid partitioning in solvents of increasing polarity combined to biological screening enabled to determine the EtOAc and n-BuOH soluble fractions as the most active parts of the extract. These fractions were chemically profiled by using a 13C NMR-based dereplication method, resulting in the identification of twenty-six compounds. The dereplication process was completed by purification of some unknown or minor compounds of the n-BuOH fraction. Three new glycosylated flav...
Source: Phytochemistry Letters - November 12, 2019 Category: Chemistry Source Type: research

Andropaniosides A and B, two new ent-labdane diterpenoid glucosides from Andrographis paniculata
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Nguyen Thi Thuy My, Tran Thi Hong Hanh, Pham Thi Cham, Nguyen Xuan Cuong, Tran Thu Huong, Tran Hong Quang, Nguyen Hoai Nam, Chau Van MinhAbstract•Two new ent-labdane diterpenoid glucosides, andropaniosides A and B, along with five known analogs, andrographiside, neoandrographolide, andropanoside, 14-deoxy-11,12-didehydroandrographiside, and 19-O-β-D-glucopyranosyl-ent-labda-8(17),13-dien-15,16,19-triol were isolated from a methanol extract of the aerial parts of Andrographis paniculata. Their chemical structures were identified by ...
Source: Phytochemistry Letters - November 12, 2019 Category: Chemistry Source Type: research

New limonoids from the fruits of Melia toosendan and their autophagic activities
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Guanyu Yan, Jie Li, Shengshuang Chen, Ying Liu, Jian-Lin Wu, Xiao-Ming Zhu, Na LiAbstractLimonoids are a kind of bioactive triterpenoids and mainly exist in the Meliaceae and Rutaceae plants. In this research, two new nimbolinin-type limonoids (1 and 2), one new trichilin-type limonoid (3), and one new havanensin-type limonoid (4), along with 11 known nimbolinin-type limonoids (5–15) were obtained from the fruits of Melia toosendan. Their structures were elucidated by a combination of high-resolution ESI-MS, 1D and 2D NMR spectra. Nimb...
Source: Phytochemistry Letters - November 12, 2019 Category: Chemistry Source Type: research

New trihydroxybriarane diterpenoids from an octocoral Briareum sp
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Chiung-Chin Hu, Nai-Cheng Lin, Bo-Rong Peng, You-Ying Chen, Zhi-Hong Wen, Yu-Chia Chang, Gene-Hsiang Lee, Yang-Chang Wu, Ping-Jyun SungAbstractChemical investigation of the extract from the supercritical CO2 extraction of an octocoral identified as Briareum sp., afforded a known briarane-type diterpenoid, excavatolide B (1), and a pair of new briaranes, briaviolides Y (2) and Z (3). The absolute configuration of 1 was determined by a single-crystal diffraction analysis and the structures of briaranes 2 and 3 were elucidated by using spectros...
Source: Phytochemistry Letters - November 12, 2019 Category: Chemistry Source Type: research

Rare sulfated purine alkaloid glycosides from Bruchidius dorsalis pupal case
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Yuri Uyama, Emi Ohta, Yui Harauchi, Tatsuo Nehira, Hisashi Ômura, Hiroyuki Kawachi, Aya Imamura-Jinda, Mylene M. Uy, Shinji OhtaAbstractThree new sulfated isoguanine alkaloid glycosides, locustoside A disulfate (1), saikachinoside B disulfate (2), and saikachinoside A trisulfate (3), have been isolated from the pupal case of the wild bruchid seed beetle Bruchidius dorsalis (Chrysomelidae, Bruchinae) infesting the seed of Gleditsia japonica Miquel (Fabaceae) along with the known compounds 9–11. The structures of the new compounds ...
Source: Phytochemistry Letters - November 9, 2019 Category: Chemistry Source Type: research

Cycloartane triterpenoids from the leaves of Euphorbia neriifolia
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Siwattra Choodej, Khanitha PudhomAbstractThree new cycloartane terpenoids, neriifolins A–C (1-3), together with one known compound, 24-methylenecycloartane (4), were isolated from the EtOAc extract of the leaves of Euphorbia neriifolia Linn (Euphorbiaceae). The structures of the new compounds were elucidated based on extensive spectroscopic analyses, particularly 1D and 2D NMR, and HR-ESI-MS. Compounds 1-3 showed cytotoxicity against breast cancer cells MCF-7 with IC50 values of 13.14, 7.12 and 9.50 μM, respectively.Graphical abstra...
Source: Phytochemistry Letters - November 9, 2019 Category: Chemistry Source Type: research

Two new phenanthrenequinones with cytotoxic activity from the tubers of Pleione bulbocodioides
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Si-Yuan Shao, Chao Wang, Shao-Wei Han, Shuai LiAbstractTwo new phenanthrenequinones, bulbocodioidins I–J (1 and 2), were isolated from the tubers of Pleione bulbocodioides. They possess a 9(10)H-phenanthren-10(9)-one structure, which is relatively rare from natural sources. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of them were determined by comparison of the experimental and calculated ECD curves. Compound 2 exhibited cytotoxic activity against human breast cancer cell lines...
Source: Phytochemistry Letters - November 9, 2019 Category: Chemistry Source Type: research

Two new dihydro-β-agarofuran sesquiterpenes from Monimopetalum chinense
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Xingzeng Zhao, Shu Xu, Qizhi Wang, Min Yin, Xiaodong Jia, Linwei Li, Xu FengAbstractTwo new dihydro-β-agarofuran sesquiterpenes, named monichinines G and H (1 and 2), were isolated from the stems and leaves of Monimopetalum chinense Rehd., and their structures were elucidated by spectroscopic analysis including 1D (1H-NMR and 13C-NMR) and 2D (HSQC, HMBC, and NOESY) NMR. The absolute configuration of 2 was determined by using quantum chemical ECD calculations. In addition, the anti-microbial activities of 1 and 2 were tested against seve...
Source: Phytochemistry Letters - November 6, 2019 Category: Chemistry Source Type: research

Epicuticular wax analysis of wild and agronomically important Agave species
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Kelly M. Monja-Mio, Fabiola Escalante-Erosa, Xochil M. Eb-Puc, Miguel Á. Herrera-Alamillo, Luis M. Peña-Rodríguez, Manuel L. RobertAbstractAgaves are cultivated in Mexico as a source of industrial products such as fibers, nutritional supplements and alcoholic beverages. A particularly important trait present in all agaves, which makes them economically viable crops for certain geographic regions, is their ability to grow under water limiting conditions. One of the anatomical characteristics that contributes to this adapt...
Source: Phytochemistry Letters - November 3, 2019 Category: Chemistry Source Type: research

Two new glycoalkaloids from Stephania succifera
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Shi-Ting Wang, Wen-Qi Qian, Peng He, Mei-Qing Feng, Yun Kang, Ya-Qin Wang, Jian-Ming HuangAbstractTwo new glycoalkaloids, manshurienine C (1) and 8-oxotetrahy-corydalmine-1-O-β-D-glucopyranoside (2), along with eleven known alkaloids (3–13), were isolated from the tubers of Stephania succifera. Their structures were elucidated by spectroscopic methods, including NMR and MS spectra. Compounds 5, 6, 8, and 10 showed in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).Graphical abstract (Source:...
Source: Phytochemistry Letters - October 19, 2019 Category: Chemistry Source Type: research

New NO production inhibitors from Hyssopus cuspidatus in LPS-induced RAW264.7 cells
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Dan Liu, Qiang Yin, Qihua Zhang, Jin Xiang, Changlei Ruan, Huili Liu, Bo Li, Weiliang Zhu, Chun-ping Yin, Jinbo FangAbstractTwo new sesquiterpenes, including 7-epi-3-eudesmene-1β,11-diol (1) and (7S,10R)-11-hydroxy-4,5-seco-guai-1-ene-4-one (2); one new natural product (11-hydroxy-1-oxo-4β,5β,7β,10β-eremophilane); (3) and nine known compounds were isolated from the aerial parts of Hyssopus cuspidatus Boriss. Their structures as well as their absolute configurations were elucidated by extensive spectroscopic analyses ...
Source: Phytochemistry Letters - October 11, 2019 Category: Chemistry Source Type: research

Two new aminoethylstilbene isoquinoline alkaloids with glucose consumption increasing activity from the root barks of Litsea glutinosa
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Wanying Sun, Yan Jin, Lu Zhang, Yinfeng Tan, Caiyun Zhang, Lin Dong, Xiaopo ZhangAbstractTwo new aminoethylstilbene isoquinoline alkaloids denoted litsine B (1) and Litsine C (2) were isolated from an ethanol extract from the root bark of Litsea glutinosa. The structures of the new chemical entities were established using 1D and 2D NMR spectroscopy in combination with high resolution mass spectrometry. Both compounds were tested for their effect on glucose consumption in HepG2 cells at different concentrations. The results showed that compou...
Source: Phytochemistry Letters - October 11, 2019 Category: Chemistry Source Type: research

Tamariscinols U–W, new dihydrobenzofuran-type norneolignans with tyrosinase inhibitory activity from Selaginella tamariscina
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Xiao-Ru He, Liu-Yun Xu, Chen Jin, Peng-Fei Yue, Zhi-Wang Zhou, Xin-Li LiangAbstractThree minor new dihydrobenzofuran-type norneolignans, tamariscinols U–W (1–3), and two known phenolics were isolated from the ethanolic extract of Selaginella tamariscina. Their structures were elucidated on the basis of extensive spectroscopic analysis. All isolates were evaluated for their inhibitory effects against the mushroom tyrosinase. Compounds 1 was the most potent compound (IC50 = 5.75 μM), which exhibited a threefold activity as that ...
Source: Phytochemistry Letters - October 10, 2019 Category: Chemistry Source Type: research

New phenolics, cytotoxicity and chemosystematic significance of Atriplex semibaccata
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Abdelsamed I. Elshamy, Tarik A. Mohamed, Midori Suenaga, Masaaki Noji, Akemi Umeyama, Thomas Efferth, Mohamed-Elamir F. HegazyAbstractThe chemical characterization of the 70% hydromethanolic extract of Atriplex semibaccata (family: Chenopodiaceae) afforded a new methoxylated flavonol triglycoside, atrisemibaccatoside A (1), and a new lignanamide, (N-[(E)-m-hydroxycinnamoyl]tyramine (7), as well as, five known flavonols (2–6) and two lignanamides (8–9). The structures of the isolated compounds were established depending upon LR&am...
Source: Phytochemistry Letters - October 10, 2019 Category: Chemistry Source Type: research

Eremophilane sesquiterpenes from the mangrove fungus BCC 60405
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Seangaroon Yoiprommarat, Panida Unagul, Rapheephat Suvannakad, Anupong Klaysuban, Satinee Suetrong, Taridaporn BunyapaiboonsriAbstractEight eremophilanolides (1, 2, 5–8, 10, and 12), 7-epi-tessaric acid (13), an eremophilane (14), and five known compounds, mairetolide F (3), 13-hydroxymairetolide F (4), 3α-hydroxymairetolide A (9), xylareremophil (11), and (3R,4R)-4-hydroxy-5-methylmellein (15), were isolated from the mangrove fungus BCC 60405 belonging to the family Xylariaceae. The structures of these compounds were elucidated ...
Source: Phytochemistry Letters - October 10, 2019 Category: Chemistry Source Type: research

Paecilodepsipeptide D, a cyclohexadepsipeptide from cultures of the whitefly pathogenic fungus Conoideocrella luteorostrata BCC 76664
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Masahiko Isaka, Somporn Palasarn, Pranee Rachtawee, Kitlada Srichomthong, Suchada MongkolsamritAbstractPaecilodepsipeptide D (1), a new cyclohexadepsipeptide was isolated together with known paecilodepsipeptides A–C (2–4) from the whitefly pathogenic fungus Conoideocrella luteorostrata BCC 76664. The structure of 1 was elucidated by spectroscopic analyses and was further confirmed by the chemical correlation to paecilodepsipeptide A (2) by converting both compounds into the same di-O-prenyl derivative (5). A comparison of the ant...
Source: Phytochemistry Letters - October 5, 2019 Category: Chemistry Source Type: research

Aspidsaponins E-H, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their anti-inflammatory activity
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Zhi-Ying Sun, Sheng-Qi Zuo, Xia Yang, Jia-Hui Lan, Cheng-Xiong Liu, Zhi-Yong Guo, Fan Cheng, Kun ZouAbstractFour new furostanol saponins, named aspidsaponins E-H (1–4) were isolated from the rhizomes of Aspidistra elatior Blume. Their structures were determined based on chemical methods and spectral data. Compounds 1 and 2 were a pair of diastereoisomeric furostanol saponins and possessed the highly oxidized structural feature of 1β, 2β, 3β, 4β, 5β, 26-hexanol-steroids, and compounds 3-4 were steroidal glycosid...
Source: Phytochemistry Letters - October 5, 2019 Category: Chemistry Source Type: research

Oleanane-type triterpenoid saponins from the roots of Polygala aureocauda Dunn.
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Tran Hong Quang, Duong Thi Hai Yen, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Thi Thanh Ngan, Hoang Le Tuan Anh, Hyuncheol Oh, Phan Van Kiem, Chau Van MinhAbstractPolygala aureocauda Dunn. (Polygalaceae) has been widely used in Vietnamese traditional medicine for the treatment of hepatitis, nephritis, sonasthenia, anaemia, back pain, and knee fatigue. Chemical investigation of a methanol extract of P. aureocauda roots resulted in the isolation of four new oleanane triterpenoid saponins (polyaureosides A–D) and two known ones (polygalasapo...
Source: Phytochemistry Letters - October 1, 2019 Category: Chemistry Source Type: research

Editorial Board
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 28, 2019 Category: Chemistry Source Type: research

Graphical Abstract TOC
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 28, 2019 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 28, 2019 Category: Chemistry Source Type: research

The newly discovered natural compounds against rheumatoid arthritis-an overview
In this study, we collected 18 natural compounds with potential anti-rheumatoid arthritis effects while these compounds are still far from clinical applications. Herein, we compared the pharmacological characteristics of these compounds in order to search for novel candidate compounds with high clinical potential for anti-rheumatoid arthritis. (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 28, 2019 Category: Chemistry Source Type: research

Lignans from the seeds of Arctium lappa L. (burdock) and their inhibitory effects on nitric oxide production
This study investigated the roots, seeds, and leaves of burdock in view of its popular uses in traditional Chinese medicine. Seven compounds, including three new ones, were isolated from the seeds of Arctium lappa. Structures of these compounds were examined by conducting extensive spectroscopic analysis. Biological analysis showed that compounds 4, 5, 6, and 7 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, and the IC50 values were in the range of 14.7–18.3 μM.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 24, 2019 Category: Chemistry Source Type: research

Metabolites from Excoecaria cochinchinensis Lour.
Publication date: Available online 20 September 2019Source: Phytochemistry LettersAuthor(s): Lai Hop Hieu, Nguyen Phuong Thao, Do Hoang Anh, Tran Thi Hong Hanh, Nguyen Duy Cong, Nguyen The Cuong, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Ngo Dai Quang, Chau Van MinhAbstractA new rhamnofolane-type diterpenoid (1) and a new phenolic derivative (2), together with eleven known compounds, were isolated from the leaves of E. cochinchinensis Lour. The chemical structures of these compounds were elucidated based on extensive spectroscopic analysis, including HR-QTOF-MS and NMR, and comparison with reported data. The in...
Source: Phytochemistry Letters - September 21, 2019 Category: Chemistry Source Type: research

Cytotoxic prenylated flavonoids from the leaves of Macaranga indica
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Doan Thi Mai Huonga, Le Tran Nguyen Vu, Luu The Anh, Nguyen Thi Cuc, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Marc Litaudon, Tran Dang Thach, Chau Van Minh, Van Cuong PhamAbstractThree new prenylated flavonoids, macarindicins D–F (1-3) together with eight known compounds, macadenathin B (4), glyasperin A (5), kaempferol (6), quercetin (7), quercitrin (8), (+)-isolariciresinol (9), (–)-woonenoside XI (10), and (+)-lyoniresinol 4-O-β-d-glucopyranoside (11) were isolated from the leaves of Macaranga indica Wight. Their st...
Source: Phytochemistry Letters - September 15, 2019 Category: Chemistry Source Type: research

Three new 3,8-epoxy iridoids from the roots and rhizomes of Valeriana jatamansi
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Li-Qiu Quan, Huan Liu, Rong-Tao Li, Hong-Mei LiAbstractThree new 3,8-epoxy iridoids, jatamanins V–X (1-3), and three known ones (4-6), were obtained from the roots and rhizomes of Valeriana jatamansi. The structures of 1-3 were determined through their NMR and high-resolution mass spectroscopic analysis. Among them, compounds 1 and 2 were a pair of C-4 diastereomers. Additionally, all compounds were evaluated for their cytotoxic effects against glioma stem cells.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 15, 2019 Category: Chemistry Source Type: research

C25 steroids from the marine mussel-derived fungus Penicillium ubiquetum MMS330
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Thi Phuong Thuy Hoang, Catherine Roullier, Grégory Genta-Jouve, Marie-Claude Boumard, Thibaut Robiou du Pont, Hassan Nazih, Yves-François Pouchus, Olivier GrovelAbstractTwo new unusual C25 steroid epimers, 24-O-methyl-24-epi-cyclocitrinol (1) and 24-O-methylcyclocitrinol (2), together with the known oxylipin α-dimorphecolic acid (3), were isolated from the extract of cultures of a Penicillium ubiquetum MMS330 strain sampled from the blue mussel Mytilus edulis. The structures of the new compounds were established based on ...
Source: Phytochemistry Letters - September 13, 2019 Category: Chemistry Source Type: research

Four new phenylethanoid glycosides from Ternstroemia gymnanthera and their analgesic activities
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Hua-Xuan Li, Chao-Jiang Xiao, Min Wang, Shu-Jun Cui, Hai-Feng Li, Kai-Ling Wang, Xiang Dong, Bei JiangAbstractFour new phenylethanoid glycosides, terngymnosides A–D (1–4), together with sixteen known compounds (5–20) were isolated from the aerial parts of Ternstroemia gymnanthera. Structures of the isolated compounds were determined by the comprehensive analyses of the physicochemical properties and spectral data (1D NMR, 2D NMR, and MS). Compounds 1–3, 8 and 10 showed significant analgesic effect with the inhibition ...
Source: Phytochemistry Letters - September 13, 2019 Category: Chemistry Source Type: research

Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Qi Song, Xiao-Ming Li, Xue-Yi Hu, Xin Li, Lu-Ping Chi, Hong-Lei Li, Bin-Gui WangAbstractSix secondary metabolites including a new aminobenzoic peptide seco-clavatustide B (1) and a new clavatoic acid derivative 5-acetyl-2,4-dihydroxy-3-methylbenzoic acid (3), were characterized from the EtOAc extracts of the Ascidian-derived endophytic fungus Aspergillus clavatus AS-107. The absolute configuration of compound 1 was established by electronic circular dichroism quantum calculation and the structure of compound 3 was elucidated on the basis of ...
Source: Phytochemistry Letters - September 13, 2019 Category: Chemistry Source Type: research

Six new ent-abietane-type diterpenoids from the stem bark of Euphorbia neriifolia
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Jian-Chun Li, Zhi-Jun Zhang, Tao Yang, Ming-Yan Jiang, Dan Liu, Hong-Mei Li, Rong-Tao LiAbstractNine ent-abietane diterpenoids (1-9), including six new compounds, eupnerias A–F (1-6), were isolated from Euphorbia neriifolia. Their structures were elucidated on the basis of extensive NMR analysis and high resolution mass spectrometry. Biological activities of these isolates towards anti-inflammatory and anti-influenza virus were evaluated.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 11, 2019 Category: Chemistry Source Type: research