Announcements of the Phytochemical Society of Europe
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 23, 2019 Category: Chemistry Source Type: research

Mosquito larvicidal limonoids from the fruits of Chisocheton erythrocarpus Hiern
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Soon-Lim Chong, Arshia Hematpoor, Hazrina Hazni, Mohd Sofian-Azirun, Marc Litaudon, Unang Supratman, Michio Murata, Khalijah AwangAbstractA phytochemical investigation on the fruits of Chisocheton erythrocarpus Hiern (Meliaceae) afforded four new limonoids, erythrocarpines F–H (1–3) and 14-deoxy-Δ1415-xyloccensin K (4), along with seven known compounds (5-11). Erythrocarpines 1–3 are phragmalin-type limonoids with an 1,29-oxymethylene bridge, while 4 is a mexicanolide-type limonoid possessing a rare 3β,8β-ether...
Source: Phytochemistry Letters - January 21, 2019 Category: Chemistry Source Type: research

α-Furanones, secondary metabolites from the fungus Cephalotrichum microsporum and their antibacterial activities
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Yue An, He Zhu, Sa Deng, Shanshan Huang, Mengyue Zhang, Dawei Li, Chao Wang, Yingying Wu, Xiaochi Ma, Yixuan ZhangAbstractCephalotrichum microsporum is a fungus isolated from the rhizosphere soil of Panax notoginseng. Four secondary metabolites (three new and one known α-furanones) of this fungus cultivated on a sterilized moistened-rice medium were isolated using an EtOAc extract. The structures of these compounds were determined by extensive spectroscopic data analysis using 1D- and 2D-NMR, ECD, and HRESIMS. In the antibacterial bioassa...
Source: Phytochemistry Letters - January 20, 2019 Category: Chemistry Source Type: research

Structural modification, fungicidal and insecticidal activity of 5-arylbenzofuran neolignan from Magnolia officinalis
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ding Lin, Zhongzhong Yan, Yangjie Yi, Kangming Li, Jiao Ye, Aixi Hu, Chuyun Long, Aiping LiuAbstractAs shown in a number of previous researches, the extracts of Magnolia officinalis exhibited broad-spectrum fungicidal and insecticidal activity. In our preliminary study, 5-arylbenzofuran neolignans, the secondary metabolite of Magnolia officinalis, was found to inherit the activity of Magnolia officinalis. For developing novel agrochemicals, natural 5-arylbenzofuran neolignan was selected as lead compound. After structural optimization, the fung...
Source: Phytochemistry Letters - January 20, 2019 Category: Chemistry Source Type: research

Selective 1D-TOCSY and chemometrics to evaluate authenticity of Turnera diffusa and related botanical extracts
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): J. Ricardo Lucio-Gutiérrez, Cecilia Delgado-Montemayor, Jordi Coello-Bonilla, Noemí Waksman-Minsky, Alma L. SaucedoAbstractNuclear magnetic resonance (NMR) spectroscopy has emerged as a powerful tool for the development of new analytical methods in metabolomics and metabolic profiling of a plethora of biological samples, including natural products. NMR-based metabolomics enables characterisation of metabolites and biomarkers in plant extracts. Selective 1D- Total Correlation Spectroscopy TOCSY (1D-TOCSY) has been used in metabolom...
Source: Phytochemistry Letters - January 20, 2019 Category: Chemistry Source Type: research

Comparison of steroids and triterpenoids in leaf cuticular waxes of selected Polish and Russian cultivars and genotypes of edible honeysuckle
Publication date: Available online 18 January 2019Source: Phytochemistry LettersAuthor(s): Rafał Becker, Soyol Dashbaldan, Cezary Pączkowski, Tomasz Golis, Anna SzakielAbstractLonicera caerulea, known as edible honeysuckle, honeyberry, blue honeysuckle, sweet berry honeysuckle, or haskap, is a perennial fruit-bearing plant belonging to the Caprifoliaceae family. Currently, the cultivation of this plant species is becoming increasingly popular due to its early fruit ripening, exceptional resistance to frost, pests, and diseases, as well as its potential health-promoting and therapeutic properties. GC–MS analysis of ...
Source: Phytochemistry Letters - January 19, 2019 Category: Chemistry Source Type: research

Thymol derivatives from the roots of Xerolekia speciosissima an endemic species of the pre-Alpine area
Publication date: Available online 16 January 2019Source: Phytochemistry LettersAuthor(s): Natalia Kłeczek, Janusz Malarz, Maja Kosecka-Strojek, Bogdan Musielak, Anna StojakowskaAbstractA chloroform extract from roots of Xerolekia speciosissima, except for commonly distributed phenolic compounds, i.e.: syringaldehyde and 2,6-dimethoxy-p-benzoquinone, yielded five thymol derivatives. Two of the compounds, namely: 8-hydroxy-9-isobutyryloxy-10-isovaleryloxythymol (1) and 8-hydroxy-9,10-diisovaleryloxythymol (2) have not been previously reported and their structures were elucidated based on 1D and 2D NMR, HRESIMS and other sp...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

Phytochemical analysis of Brasolia, Elleanthus, and Sobralia. Three genera of orchids with antibacterial potential against Staphylococcus aureus
Publication date: Available online 17 January 2019Source: Phytochemistry LettersAuthor(s): Max Rykaczewski, Mirosława Krauze-Baranowska, Jerzy Żuchowski, Marta Krychowiak-Maśnicka, Jakub Fikowicz-Krośko, Aleksandra KrólickaAbstractThe purpose of the study was to determine the chemical composition of extracts from three species of orchids: Brasolia cattleya, Elleanthus oliganthus and Sobralia powellii, all belonging to the Sobralieae tribe, evaluate their antistaphylococcal activity and assess possible toxicity towards eukaryotic cells on the model organism Caenorhabditis elegans. The chemical composition of the ...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

Structures and biological activities of new carnosic acid- and carnosol-related compounds generated by heat treatment of rosemary
We examined their antioxidant activities and found that 2 and 3 showed strong activity. Furthermore, in PPARγ−transactivation and adipocyte-differentiation assays, compounds 3 and 5 showed more potent PPARγ agonistic activity than CA.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

New bicyclic [3.2.1] octane neolignans derivatives from Aniba firmula with potent in vivo anti-inflammatory activity on account of dual inhibition of PGE2 production and cell recruitment
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Mario F.C. Santos, Bianca G.V. Alcântara, Cristiane dos R. Feliciano, Aline F. Silva, Tatiane C.S. Maiolini, Albert K. Neto, Michael Murgu, Daniela A. Chagas de Paula, Marisi G. SoaresAbstractTwo new bicyclic octane neolignans, 1, 2, and the known bicyclic octane neolignan 3 were obtained by HPLC fractionation of the crude extract of aerial parts and the stem of Aniba firmula (Lauraceae’s family). The identification of its structures was made by spectroscopic analysis. The Lauraceae is well-known for its anti-inflammatory potential ...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

Three new limonene-derived bis-monoterpenoids from the aerial parts of Illigera cordata
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Min Zhou, Miao Dong, Xiao-Li Zeng, Xiang-Zhong HuangAbstractFrom the aerial parts of Illigera cordata, cordatins A–C (1–3), three limonene-derived bis-monoterpenoids plausibly biosynthesized via hetero-Diels-Alder cyclization and further sequential hydrolyses of monoterpene precursors, together with one known analogue (4), were isolated. The structures, including absolute configurations, were established by spectroscopic analysis and confirmed by X-ray crystallographic analysis of 5 (the common hydrolytic product of 1–4). All ...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

A new chlorinated diphenyl ether and a new sesquilignan from the stems of Mappianthus tomentosus
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Shan-Shan Zhu, Gui-Jie Zhang, Hai-Bing Liao, Heng-Shan Wang, Dong LiangAbstractA new chlorinated diphenyl ether, ethyl dichloroasterrate (1), and a new sesquilignan, mappilignan A (2), along with two known diphenyl ethers (3 and 4) and one known sesquilignan (5), were isolated from the stems of Mappianthus tomentosus. The structures of 1−5 were assigned by spectroscopic data analysis and by comparison with literature data. The absolute configuration of 2 was established using experimental and calculated ECD data. Compound 2 displayed inhi...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

Ligand-based virtual screening and molecular docking of two cytotoxic compounds isolated from Papaver lacerum
This study revealed that the Papaver lacerum extract strongly inhibited HeLa cell proliferation, resulting in 13% cell viability. As a result of phytochemical studies, one known compound, Tyrosol-1-O-β-xylopyranosyl-(1→6)-O-β-glucopyranoside) (I), and one new compound, 5-O-(6-O-α-rhamnopyronosyl-β-glucopyronosyl) mevalonic acid (II), were isolated. Compounds I and II were found to possess a moderate cytotoxic effect with an IC50 of 66.4 μM (p
Source: Phytochemistry Letters - January 12, 2019 Category: Chemistry Source Type: research

Butenolides, triterpenoids and phenylethanoid glycosides from Plantago depressa
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Xiu-Qing Song, Jie Bao, Jia Sun, Zhi-Qiang Cheng, Yuying Zhang, Jin-Hai Yu, Cheng-Shi Jiang, Hua ZhangAbstractFour new compounds, including two butenolides (1 and 2), an arborinane-type triterpenoid (3) and a phenylethanoid glycoside (4), along with the known triterpenoids (5–17) and phenylethanoid glycosides (18–29), were isolated from whole plants of Plantago depressa. The structures of the isolated compounds were elucidated by comprehensive spectroscopic analyses and were evaluated for their anti-inflammatory or antiradical activ...
Source: Phytochemistry Letters - January 11, 2019 Category: Chemistry Source Type: research

Oxidation of flavonolignan silydianin to unexpected lactone-acid derivative
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): David Biedermann, Veronika Moravcová, Kateřina Valentová, Marek Kuzma, Lucie Petrásková, Ivana Císařová, Vladimír KřenAbstractOne of the main flavonolignans from silymarin, an extract of the fruits of the milk thistle (Silybum marianum), is silydianin possessing an unusual bicyclic structure with the keto group next to the hemiacetal moiety. As its oxidation product 2,3-dehydrosilydianin was found to display strong chemoprotective activity and Na+/K+ ATPase inhibitory activity, the present wor...
Source: Phytochemistry Letters - January 9, 2019 Category: Chemistry Source Type: research

Sesquiterpenoids from the stems and leaves of Gochnatia decora
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Qihui Cao, Weifeng Dai, Baocai Li, Mi ZhangAbstractFour new lindenane sesquiterpenoid lactones (1-4), along with two known sesquiterpenoids (5 and 6) and one monoterpenoid (7), were isolated from the stems and leaves of Gochnatia decora (Kurz) A. L. Cabrera. Their 1D and 2D structures were ascertained on the basis of spectroscopic evidence, mainly including NMR, HRESIMS, and ECD spectra. All the compounds were found for the first time in this plant.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 6, 2019 Category: Chemistry Source Type: research

Adjunctive role of Calyptranthes tricona extract with probiotic Kluyveromyces marxianus on colorectal adenocarcinoma Caco-2 cells
In conclusion, this preliminary study demonstrates that C. tricona extract has effects on enzyme inhibition and immune function. In addition, when associated with K. marxianus, C. tricona may possess beneficial properties for application as enhancer of probiotic’s protective role on CRC cells. However, further studies are necessary in order to elucidate the mechanisms involved.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 6, 2019 Category: Chemistry Source Type: research

Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ritesh Raju, Ahilya Singh, Dhanushka Gunawardena, Paul Reddell, Gerald MünchAbstractThree new metabolites, 1-(4′′-Methoxyphenyl)-7-(3′,4′-di-hydroxyphenyl)-(E)-hept-2-ene (1), 1-(4′′-Methoxyphenyl)-7-(3′,4′-di-methoxyphenyl)-(E)-hept-2-ene (2), 1-(4′′-Methoxyphenyl)-7-(4′-methoxyphenyl)-(E)-hept-2-ene (3), and the known diaryl heptanoid (4) were identified following anti-inflammatory activity guided fractionation from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae...
Source: Phytochemistry Letters - January 6, 2019 Category: Chemistry Source Type: research

Anthocyanins from mauve flowers of Erlangea tomentosa (Bothriocline longipes) based on erlangidin – The first reported natural anthocyanidin with C-ring methoxylation
In this study two new anthocyanins, erlangidin 5-O-(4″-(E-caffeoyl)-6″-(malonyl)-β-glucopyranoside)-3′-O-(6‴-(3II-(β-glucopyranosyl)-E-caffeoyl)-β-glucopyranoside) and erlangidin 5-O-(6″-(malonyl)-β-glucopyranoside)-3′-O-(6‴-(3II-(β-glucopyranosyl)-E-caffeoyl)-β-glucopyranoside) were isolated from purple flowers of Erlangea tomentosa (Bothriocline longipes) Oliv. & Hiern (Asteraceae) in amounts of ∼1.6 and 0.6 mg/g fr. wt., respectively. They were found to contain the first reported natural anthocyanidin with a methoxy-group on the heterocyclic ...
Source: Phytochemistry Letters - December 26, 2018 Category: Chemistry Source Type: research

Anti-angiogenic activities of glycoalkaloids isolated from Solanum lyratum in tumor-derived vascular endothelial cells
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Lin Han, Jian-nong Wang, Cai-xia Sun, Xiao-qiang Cao, Xiao DuAbstractWe previously identified alkaloids as being the main antitumor constituents of Solanum lyratum Thunb. In this follow-up study to identify the specific active principles, three new glycoalkaloids (1–3) were isolated from S. lyratum with one known glycoalkaloid (4). The structures of the four compounds were determined by means of integrated spectroscopic techniques, as well as by comparison with those in literature. Furthermore, the effects of compounds 1–4 were i...
Source: Phytochemistry Letters - December 20, 2018 Category: Chemistry Source Type: research

In silico identification and evolutionary analysis of candidate genes involved in the biosynthesis methylproline genes in cyanobacteria strains of Iran
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Bahareh Nowruzi, Saúl BlancoAbstractCyanobacteria have the ability to produce a wide variety of natural bioactive compounds. In order to reveal the diversity of Cyanobacteria in Iran, and their potential to synthesise various natural products, we isolated 25 strains from different climatic/geographic regions and habitats, and screened the genes that are responsible for the synthesis of natural products (such as nonribosomal peptide synthetase or polyketide synthase and 4-methylproline) by means of PCR. In addition, we analysed ...
Source: Phytochemistry Letters - December 20, 2018 Category: Chemistry Source Type: research

New tirucallane triterpenoids from the dried latex of Euphorbia resinifera
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Shu-Yun Wang, Chao Huang, Ren-Kuan Sun, Li-Na Lu, Hong-Gang Liang, Le Gao, Jian Huang, Jin-Hui Wang, Bao-Feng YangAbstractAs a part of our ongoing search for bioactive compounds from the dried latex of Euphorbia resinifera (Euphorbium), a new rearranged tirucallane triterpene with a spiro [5,6] ring system, euphorol K (1), and a novel euphane triterpene hydroperoxide, euphorol J (2), together with a known compound, kansuinone (3) have been isolated. Their structures were established on the basis of extensive analyses of their spectroscopic, ...
Source: Phytochemistry Letters - December 20, 2018 Category: Chemistry Source Type: research

Four new honokiol derivatives from the stem bark of Magnolia officinalis and their anticholinesterase activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Baobao Zhang, Haitao Yu, Wei Lu, Bo Yu, Lei Liu, Weijuan Jia, Zongtao Lin, Hong Wang, Shizhong ChenAbstractFour new honokiol derivatives, namely 8′,9′-dihydroxymagnaldehyde E (1), 8′,9′-dihydroxyhonokiol (2), erythro-7-O-methylhonokitriol (3), and threo-7-O-methylhonokitriol (4), together with seven known compounds, erythro-honokitriol (5), threo-honokitriol (6), magnaldehyde E (7), magnotriol B (8), magnaldehyde B (9), honokiol (10), and magnolol (11), were isolated from the stem bark of Magnolia officinalis. Their s...
Source: Phytochemistry Letters - December 19, 2018 Category: Chemistry Source Type: research

Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae)
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Clara Steinbrueck, Nohelia Mora-Ugalde, Carlos Morales, Randall Loiaza, Alfonso J. García-Piñeres, Juan J. ArayaAbstractBioassay-guided fractionation of Acnistus arborescens (Solanaceae) organic extract afforded two anti-inflammatory withanolides: 2,3-Dihydro-3β-O-sulfate withacnistin (1) and 2,3-Dihydro-3β-O-sulfate withaferin A (2) showing IC50 values of 1.0 ± 0.1 and 14 ± 1 μM respectively in a LPS-stimulated RAW 264.7 murine macrophage assay. These compounds were also e...
Source: Phytochemistry Letters - December 18, 2018 Category: Chemistry Source Type: research

Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Michael G. Knott, Jo-Anne de la Mare, Adrienne L. Edkins, Angel Zhang, Martin J. Stillman, John J. Bolton, Edith M. Antunes, Denzil R. BeukesAbstractThe endemic South African red seaweed Plocamium maxillosum (Poiret) Lamouroux produces two unusual isomeric dichlorinated cyclohexenone monoterpenes, plaxenone A and B (1 and 2). The structures of the isolated compounds were determined from spectroscopic data and their absolute configuration was determined by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 inhibit th...
Source: Phytochemistry Letters - December 15, 2018 Category: Chemistry Source Type: research

Fomitopsins I and J, 24-methyl-lanostane triterpenoids from fruiting bodies of the wood-rot basidiomycete Fomitopsis sp.
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Masahiko Isaka, Panida Chinthanom, Rapheephat Suvannakad, Tuksaporn Thummarukcharoen, Tao Feng, Ji-Kai LiuAbstractTwo new 24-methyl-lanostane triterpenoids, fomitopsins I (1) and J (2), were isolated together with seven known compounds (3–9), from fruiting bodies of the basidiomycete Fomitopsis species. The structures were elucidated by spectroscopic analysis. Their antibacterial and cytotoxic activities were evaluated. One of the known compounds (6) exhibited antibacterial activity against Gram-positive bacteria, Bacillus cereus (MIC ...
Source: Phytochemistry Letters - December 15, 2018 Category: Chemistry Source Type: research

Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp.
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Beiye Yang, Qingyi Tong, Shuang Lin, Jieru Guo, Jinwen Zhang, Junjun Liu, Jianping Wang, Hucheng Zhu, Zhengxi Hu, Yonghui ZhangAbstractChemical investigation of the plant endophytic fungus Pestalotiopsis sp. afforded two new butenolides, pestalolides B and C (1 and 2), two new diphenyl ethers, pestalotethers E and F (3 and 4), together with seven known compounds (5–11). Their structures were established by extensive spectroscopic analyses and the absolute configuration of 1 was further confirmed by ECD calculation. Structurally, compou...
Source: Phytochemistry Letters - December 15, 2018 Category: Chemistry Source Type: research

Gut microbiota-assisted isolation of flavonoids with a galloyl moiety from flowers of meadowsweet, Filipendula ulmaria (L.) Maxim
Publication date: Available online 13 December 2018Source: Phytochemistry LettersAuthor(s): Dominik Popowski, Karolina A. Pawłowska, Jakub P. Piwowarski, Sebastian GranicaAbstractThe consideration of natural product metabolism by human gut microbiota has become a crucial issue, which needs to be addressed during examinations of their bioactivity. The gut microbiota metabolism of Filipendulae ulmariae flos extract was studied. Differences in the dynamics of the deconjugation of flavonoid glycosides depending on their chemical structure were observed. The metabolism of galloylated flavonol glycosides was slower than that of...
Source: Phytochemistry Letters - December 14, 2018 Category: Chemistry Source Type: research

Two new bisabolane-type sesquiterpenoids from the cooking liquid of Curcuma longa rhizomes
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Xiaoli Cheng, Hanxiang Li, Ping Wu, Liangxiong Xu, Jinghua Xue, Xiaoyi WeiAbstractTwo new bisabolane-type sesquiterpenoids, (3R,4S,5R,7S)-3,4,5-trihydroxybisabola-10-ene-9-one (1), (1R,2S,5R,7R,8S)-2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one (2), together with seven known anologues (3–9), were isolated from the cooking liquid of Curcuma longa rhizomes. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. The absolute configurations of compounds 1 and 2 were assigned by electronic circular ...
Source: Phytochemistry Letters - December 14, 2018 Category: Chemistry Source Type: research

Thymol derivatives from the roots of Eupatorium chinense and their cytotoxic activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Qing-Qing Zhang, Zhi-Ying Sun, Xue-Yun Feng, Run-Jie Chen, Wen Deng, Yong-Li Tang, Zhi-Yong Guo, Cheng-Xiong Liu, Jian-Feng Chen, Kun ZouAbstractTwo new thymol derivatives (compounds 1–2) were isolated from the roots of Eupatorium chinense. Their structures were elucidated by analysis of MS data and extensive 1D and 2D NMR spectroscopy (1H-1H COSY, HMBC, HSQC and NOESY). The absolute configuration of compound 1 was assigned based on a comparison of calculated and experimental ECD. Compounds 1–2 were tested in vitro for their cyto...
Source: Phytochemistry Letters - December 14, 2018 Category: Chemistry Source Type: research

Four new steroidal components from Smilacina henryi and their cytotoxic activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Fan Qiao, Jie Yang, Jie Lin, Sheng YaoAbstractFour new steroidal components (1−4) along with two known analogues (5−6) were obtained from the roots and rhizomes of Smilacina henryi. The components’ structures were determined as (25S)-5α-spirost-9(11)-ene-3β, 17α, 21-triol (1), (24S, 25S)-5α-spirost-9(11)-ene-3β, 17α, 24-triol (2), (25S)-5α-spirost-9(11)-ene-3β, 17α-dihydroxy-12-one (3), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione (4), (25S)-5α-spiros...
Source: Phytochemistry Letters - December 14, 2018 Category: Chemistry Source Type: research

Bioassay-guided isolation of lanostane-type triterpenoids as α-glucosidase inhibitors from Ganoderma hainanense
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Lie-Feng Ma, Jia-Jie Yan, Huang-Yan Lang, Li-Chao Jin, Fei-Jun Qiu, Yue-Jun Wang, Zhi-Fang Xi, Wei-Guang Shan, Zha-Jun Zhan, You-Min YingAbstractGanoderma hainanense, an edible mushroom mainly distributed in Southern China, has long been used as a functional food with considerable health benefits. Bioassay-guided phytochemical research on the fruiting bodies of G. hainanense led to the isolation of 22 lanostane-type triterpenoids, including two new compounds 3-acetyl-ganodermadiol (1) and 3-acetyl-lucidumol B (2). In an in-vitro assay, sixte...
Source: Phytochemistry Letters - December 12, 2018 Category: Chemistry Source Type: research

A new constituent against rheumatoid arthritis from the flower buds of Lonicera japonica
In this study, two new compounds named as 8,4′-di-O-methylquercetin-3′-O-β-galactosyl-3-O-β-glucopyranoside (1) and 6-formyl-5-hydroxyl-4-ethyl-2-hydroxymethyl-1H-indene (2), were isolated from the flower buds of Lonicera japonica. Structures of compound 1 and 2 were determined by spectroscopic methods. Additionally, compound 1 showed therapeutic effects against rheumatoid arthritis (RA) in collagen-induced arthritis (CIA) mice through significantly reducing the inflammatory responses in the joint tissues. These results suggested that compound 1 exerted potent chondroprotective and anti-inflammatory e...
Source: Phytochemistry Letters - December 12, 2018 Category: Chemistry Source Type: research

Efficient extraction and isolation of skimmianine from New Caledonian plant Medicosma leratii and evaluation of its effects on apoptosis, necrosis, and autophagy
This study was aimed at improving the current knowledge about the new Caledonian plant species Medicosma leratii, by developing efficient methods of extraction and isolation of specialized metabolites. Ultrasound-assisted extraction (UAE) significantly gave higher yields of the furoquinoline alkaloid skimmianine (22.34 mg/100 g) than accelerated solvent extraction (ASE, 1.37–12.36 mg/100 g). High-performance countercurrent chromatographic (HPCCC) separation of the methanol leaf extract with n-hexane-ethyl acetate-methanol-water (6:5:6:5 v/v) afforded skimmianine (1, 7.55 mg, HPLC-DA...
Source: Phytochemistry Letters - December 11, 2018 Category: Chemistry Source Type: research

Bioactive acridone alkaloids and their derivatives from Citrus aurantium (Rutaceae)
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Samuel Bissim, Sidonie Béatrice Kenmogne, Alain Tadjong Tcho, Mehreen Lateef, Ayaz Ahmed, Emmanuel Ngeufa Happi, Jean Duplex Wansi, Muhammad Shaiq Ali, Alain François Kamdem WaffoAbstractPhytochemical studies on Citrus aurantium led to the isolation and characterization of a new secotirucallane, namely 1β-hydroxy-3,4-secotirucalla-4(28)-7,24-trien-3,21-dioic acid (1), together with the previously reported compounds citracridone I (2), citruisinine II (3), citracridone II (4), 5-hydroxynoracronycine (5), citpressine II (6),...
Source: Phytochemistry Letters - December 11, 2018 Category: Chemistry Source Type: research

Two antiproliferative seco-4,5-abietane diterpenoids from roots of Salvia ceratophylla L.
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Hossein Hadavand Mirzaei, Omidreza Firuzi, Jima N. Chandran, Bernd Schneider, Amir Reza JassbiAbstractTwo previously undescribed rearranged abietanes, ceratol (1) and ceratodiol (2), and three known abietane-diterpenoids, including 1-ketoaethiopinone (3), ferruginol (4) and 12-deoxysalvipisone (5), were isolated from roots of Salvia ceratophylla. The structures of the purified compounds (1–5) were characterized based on analyses of their spectroscopic data, including 1D and 2D NMR and high-resolution electrospray mass spectra. The anal...
Source: Phytochemistry Letters - December 6, 2018 Category: Chemistry Source Type: research

Two novel anthraquinones with cytotoxicity from Hedyotis caudatifolia
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Yi Jing, Hai-Jiang Zhang, Kui-Wu Wang, Xiao-Xin Wang, Ming-Long Chen, Hong Wang, Bin WuAbstractSeven anthraquinones, including two new natural products, hedyanthraquinones A and B (1, 2), were isolated from Hedyotis caudatifolia. The structures were elucidated based on NMR, MS data and physico-chemical properties. Compounds 1 and 2 displayed moderate cytotoxic activities against a panel of cultured tumor cell lines (HL-60, Bcap37, SMMC7721) with IC50 values of 13.71 ∼ 26.29 μM. The result showed that anthraquinones are typical compoun...
Source: Phytochemistry Letters - December 6, 2018 Category: Chemistry Source Type: research

Prenylflavanones isolated from Sophora flavescens
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Jing-Yong Ma, De-Rui Zhao, Tao Yang, Dan Liu, Rong-Tao Li, Hong-Mei LiAbstractIn the ongoing investigation of bioactive compounds from the roots of Sophora flavescens, six prenylflavanones, including two new ones, sophoraflavanones M (1) and N (2), were isolated. The structures of the new compounds were elucidated on the basis of their spectroscopic data. In addition, compound 5 exhibited moderate anti-influenza virus activity, with EC50 value of 43.9 μM.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 6, 2018 Category: Chemistry Source Type: research

Chemical constituents from the twigs and leaves of Trichilia sinensis and their biological activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Dong-Hua Cao, Peng Sun, Shang-Gao Liao, Li-She Gan, Lin Yang, Jian-Neng Yao, Zong-Yi Zhang, Jin-Feng Li, Xiao-Ling Zheng, Yi-Dian Xiao, Chun-Fen Xiao, Ping Zhang, Hua-Bin Hu, You-Kai XuAbstractPhytochemical investigation on the twigs and leaves of Trichilia sinensis led to the isolation of two previously undescribed limonoids (i.e., trichiliasinenoids D and E, 1 and 2), two previously undescribed phenolic acids (3 and 4), and one previously undescribed natural phenolic acid dimer (5), together with 11 known compounds (6-16). Their structures...
Source: Phytochemistry Letters - December 6, 2018 Category: Chemistry Source Type: research

Flavone C-glycosides from Vaccaria pyramidata: Structure elucidation by spectroscopy and theoretical calculations
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Ridha Ben Said, Arafa I. Hamed, Milena Masullo, Abdullah S. Al-Ayed, Mahmoud F.M. Moustafa, Usama A. Mahalel, Sonia PiacenteAbstractThe flavone C-glycosides namely apigenin-7-O-β-d-glucopyranosyl-8-C-β-d-glucopyranoside (1) and apigenin-8-C-α-l-rhamnopyranosyl-(1→2)-O-β-d-glucopyranoside (2), along with p-methoxycinnamic acid (3), vaccaroside A (4), vaccaroside D (5), vaccaroside E (6) and abscisic acid glucose ester (7) were isolated from the methanol extract of the aerial parts of Vaccaria pyramidata. Structure el...
Source: Phytochemistry Letters - December 4, 2018 Category: Chemistry Source Type: research

Cyclic sulfur metabolites from Allium schoenoprasum var. foliosum
This study aimed to determine the relative configurations of the new compounds.Graphical abstractAllium schoenoprasum var. foliosum. (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 4, 2018 Category: Chemistry Source Type: research

Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Ahmed Kareem Obaid Aldulaimi, Saripah Salbiah Syed Abdul Azziz, Yuhanis Mhd Bakri, Mohd Azlan Nafiah, Saadon Abdulla Aowda, Khalijah Awang, Marc LitaudonAbstractTwo new isoquinoline alkaloids, iraqiine (1) and kareemine (2), along with five known alkaloids, muniranine (3), kinabaline (4), O-methylmoschatoline (5), atherospermidine (6) and N-methylouregidione (7), were purified from the dichloromethane crude extract of Alphonsea cylindrica bark. The structures of these compounds were elucidated through extensive 1D and 2D NMR, IR and LC&ndash...
Source: Phytochemistry Letters - December 2, 2018 Category: Chemistry Source Type: research

Wortmannine F and G, two new pyranones from Talaromyces wortmannii LGT-4, the endophytic fungus of Tripterygium wilfordii
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Jun-Wen Zhao, Zhong-Duo Yang, Shuan-Yan Zhou, Li-Jun Yang, Jian-Hui Sun, Xiao-Jun Yao, Zong-Mei Shu, Shuo LiAbstractTwo new pyranones, Wortmannine F (1) and G (2), were isolated from Talaromyces wortmannii LGT-4, which is an endophytic fungus from Tripterygium Wilfordii. Their structures were elucidated on the basis of NMR and ESI-MS spectral data, as well as chemical calculation. Additional known compounds (4–8) were also isolated. The isolates were tested for monoamine oxidase (MAO), acetylcholinesterase (AChE) and phosphoinositide 3...
Source: Phytochemistry Letters - December 2, 2018 Category: Chemistry Source Type: research

Anti-inflammatory metabolites from endophytic fungus Fusarium sp
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Maan T. Khayat, Sabrin R.M. Ibrahim, Gamal A. Mohamed, Hossam M. AbdallahAbstractThree new ergosterol derivatives, namely, fusaristerols B [(22E,24R)-3-palmitoyl-19(10→6)-abeo-ergosta-5,7,9,22-tetraen-3β-ol] (1), C [(22E,24R)-ergosta-7,22-diene-3β,6β,9α-triol] (3), and D [(22E,24R)-ergosta-7,22-diene-3β,5α,6β,9α-tetraol 6-acetate] (4), along with (22E,24R)-5β,8β-epidioxyergosta-22-en-3β-yl decanoate (2) and (22E,24R)-ergosta-7,22-dien-3β-ol (5), were isolated and characteriz...
Source: Phytochemistry Letters - December 1, 2018 Category: Chemistry Source Type: research

Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Waka Nakayama, Yukio Fujiwara, Yasuhiro Kosuge, Orawan Monthakantirat, Kazumi Fujikawa, Santi Watthana, Susumu Kitanaka, Toshiaki Makino, Kan’ichiro IshiuchiAbstractTwo new Lycopodium alkaloids, phlenumdines D (1) and E (2), have been isolated from the club moss Phlegmariurus nummulariifolius (Blume) Ching along with ten known compounds (3−12), and the structures were elucidated by spectroscopic analyses. The absolute configurations of 1 and 2 were established by chemical conversion and modified Mosher’s method, respectivel...
Source: Phytochemistry Letters - November 28, 2018 Category: Chemistry Source Type: research

Neolignan and monoterpene glycosides from Magnolia henryi
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Chutima Srinroch, Poolsak Sahakitpichan, Nitirat Chimnoi, Somsak Ruchirawat, Tripetch KanchanapoomAbstractA new neolignan glycoside, (7R,8S)-7′-hydroxy-dihydrodehydrodiconiferyl alcohol 9-O-β-d-glucopyranoside (monthaphuoside A, 1) and a new monoterpene glycoside, (3R,6Z)-9-hydroxylinaloyl 3-O-β-d-glucopyranoside (monthaphuoside B, 2), were isolated from the leaves of Magnolia henryi along with (3R,6S)-6,7-dihydroxy-6,7-dihydrolinaloyl 3-O-β-d-glucopyranoside, hodgsonialloside C, syringin, 3,4,5-trimethoxyphenyl-β-d...
Source: Phytochemistry Letters - November 25, 2018 Category: Chemistry Source Type: research

Brotasic Acid Methyl Ester from the Fruiting Bodies of the Mushroom Auricularia sp
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Juliano Slivinski, Mario F.C. Santos, Antônio G. Ferreira, Roberto G.S. BerlinckAbstractMushroom alkaloids are of a considerable interest as a consequence of their unique secondary metabolites. This work describes the isolation and identification of brotasic acid methyl ester (1) from the fruiting bodies of the mushroom Auricularia sp. After isolation using a series of chromatographic steps, compound 1 was identified by analysis of spectroscopic data and has a novel carbon skeleton. The structure of 1 is related to the structure of the...
Source: Phytochemistry Letters - November 24, 2018 Category: Chemistry Source Type: research

Antioxidant flavan derivatives from the leaves of Morus alba
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Hua-Ran Zhang, Ming Li, Miao-Miao Wang, Xiao-Ning Wang, Tao Shen, Shu-Qi Wang, Dong-Mei RenAbstractTwo pairs of new flavans, moracinflavan A and B (1a/1b and 2a/2b), together with another five new flavan derivatives moracinflavan C–G (3–7), and three known flavans (8–10) were isolated from the leaves of Morus alba. Their structures were elucidated by detailed analyses based on spectroscopic data. Separation of the stereoisomeric mixtures of 1a and 1b, 2a and 2b was achieved using chiral HPLC, and the absolute configurations...
Source: Phytochemistry Letters - November 23, 2018 Category: Chemistry Source Type: research

A new antiviral 14-nordrimane sesquiterpenoid from an endophytic fungus Phoma sp.
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Si-Si Liu, Ju-Xing Jiang, Rong Huang, Ya-Ting Wang, Bo-Guang Jiang, Kai-Xuan Zheng, Shao-Hua WuAbstractA new rare 14-nordrimane-type sesquiterpenoid, named phomanolide (1), together with five known compounds, (–)-6-methoxymellein (2), 7-hydroxy-3, 5-dimethyl-isochromen-1-one (3), norlichexanthone (4), 6-methylsalicylic acid (5), and gentisyl alcohol (6), were obtained from the culture broth of an endophytic fungus Phoma sp. isolated from the roots of Aconitum vilmorinianum. The structure of compound 1 was established based on extensive...
Source: Phytochemistry Letters - November 22, 2018 Category: Chemistry Source Type: research

Chemical constituents of Bergenia crassifolia roots and their growth inhibitory activity against Babesia bovis and B. bigemina
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Orkhon Banzragchgarav, Toshihiro Murata, Bumduuren Tuvshintulga, Keisuke Suganuma, Ikuo Igarashi, Noboru Inoue, Javzan Batkhuu, Kenroh SasakiAbstractBergenia crassifolia is a tea plant from in Northeast Asia, and it used to be a traditional medicine in Asian countries. From the roots of this plant, two new compounds, (2R,3S)-3-O-p-hydroxybenzoyl-5-O-galloylcatechin and 6-O-(3′′-O-methylgalloyl) arbutin, were isolated together with 20 known flavonoids, including catechins, kaemferols, arbutin derivatives, and bergenin derivatives....
Source: Phytochemistry Letters - November 22, 2018 Category: Chemistry Source Type: research