Corrigendum to “New acylated iridoid glucosides from Scutellaria glaphyrostachys Rech.f. and chemotaxonomic importance for the genus Scutellaria” [Phytochem. Lett. 32 (August) (2019) 157–161]
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Zeynep Dogan, Kan’ichiro Ishiuchi, Toshiaki Makino, Iclal Saracoglu (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 25, 2020 Category: Chemistry Source Type: research

Three new C-geranylated flavonoids from Paulownia catalpifolia T. Gong ex D.Y. Hong seeds with their inhibitory effects on xanthine oxidase
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Cheng-mei Xiao, Xian-hui Jia, Hong-fang Du, Huan-xin Zhao, Cheng-lin Du, Wen-zhao Tang, Xiao-jing WangAbstractThree new C-geranylated flavonoids named as paucatalinones L (1), M (2), and N (3) were isolated from the seeds of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, MS, NMR and CD techniques. Among them, paucatalinone N (3) was the fifth C-geranylflavone derivative obtained from Paulownia genus, and its geranyl variation was firstly displayed in Paulownia C-geranylated flavonoids. Moreover...
Source: Phytochemistry Letters - February 21, 2020 Category: Chemistry Source Type: research

Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Fahd M. Abdelkarem, Ezz-Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Maki Nagata, Tomofumi Miyamoto, Kuniyoshi ShimizuAbstractFurther chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structu...
Source: Phytochemistry Letters - February 21, 2020 Category: Chemistry Source Type: research

Three new polyketides produced by Penicillium crustosum, a mycoparasitic fungus from Ophiocordyceps sinensis
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Dan Feng, Lu Tan, Ling Qiu, Feng Ju, Qi-Xuan Kuang, Jing-Feng Chen, Xiao-Nian Li, Yu-Cheng Gu, Da-Le Guo, Yun DengAbstractA pair of novel benzannulated enantiomers, penilactone C [(+)-1 and (-)-1], a known related analogue 6-acetyl-2α,5-dihydroxy-2-(2-hydroxypropyl)-3α,8-dimethylchroman (3), and a novel polyketide, penilactone D (2), were obtained from the liquid-state and solid-state fermentation broth of Penicillium crustosum, a mycoparasitic fungus isolated from the fruiting body of Ophiocordyceps sinensis. The structures of thes...
Source: Phytochemistry Letters - February 21, 2020 Category: Chemistry Source Type: research

Jatrophainolides A–C, new cembrane-type diterpenoids with PTP1B inhibitory activity from the root bark of Jatropha integerrima
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Dong-Bo Zhang, Zheng Wang, Yan-Ni Liang, Jin-Gao Yu, Zhen Zhang, Shi-Jun Liu, Zhao Zhang, Zhong-Xing Song, Zhi-Shu Tang, Dong-Zhu DuanAbstractThree new 14-membered cembrane-type diterpenoids, jatrophainolides A–C (1−3), were isolated from the root bark of Jatropha integerrima Jacq. Thier structures were established on the basis of extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. Of these isolates, compounds 1 and 2 were a pair of isomers with the E/Z configurations of Δ1,2 double bond. All c...
Source: Phytochemistry Letters - February 21, 2020 Category: Chemistry Source Type: research

Protein tyrosine phosphatase 1B inhibitory triterpene glycosides from Mussaenda pilosissima Valeton
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Vu Kim Thu, Nguyen Xuan Bach, Nguyen Thi Thu Hien, Hua Thi Son, Tran Hong Quang, Youn-Chul Kim, Hyuncheol Oh, Phan Van KiemAbstractThree new triterpene glycosides, mussapilosides A–C (1-3) together with six known triterpene glycosides, cincholic acid-28-O-β-d-glucopyranosyl ester (4), mussaendoside S (5), quinovic acid 28-O-β-d-glucopyranosyl ester (6), glycoside A (7), glycoside B (8), and quinovic acid 3-O-β-d-glucopyranosyl(1→2)-β-d-glucopyranoside (9) were isolated from the leaves of Mussaenda pilosissima. The...
Source: Phytochemistry Letters - February 21, 2020 Category: Chemistry Source Type: research

A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Appolinaire Kene Dongmo, Raymond Ngansop Nono, Fatma Kaaniche, Isabelle Kamga Mawabo, Marcel Frese, Jean Rodolphe Chouna, Celine Nguefeu Nkenfou, Bruno Ndjakou Lenta, David Ngnokam, Pépin Nkeng-Efouet-Alango, Norbert SewaldAbstractPhytochemical investigation of Canthium venosum fruits led to the isolation of a new doubly linked A-type proanthocyanidin trimer: epicatechin-(2β→O→7, 4β →8)-catechin-(5→O→2β, 6→4β)-epicatechin [venosumtannin A-1 (1)], along with twenty known compounds 2-21. Al...
Source: Phytochemistry Letters - February 21, 2020 Category: Chemistry Source Type: research

Analysis of chemical composition of Inula japonica Thunb. extract and in vitro screening for anti-pulmonary fibrosis active components
In conclusion, chemical components of the extract from Inula japonica Thunb. might be potential agents for the treatment of IPF.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 21, 2020 Category: Chemistry Source Type: research

New phenylethanoid from the flower of Osmanthus fragrans and their bioactivities on human dermal fibroblasts
In conclusion, we demonstrated that the aqueous extract of flower of O. fragrans contained phenylethanoid-rich constituents which revealed bioactivities at the cellular level of HDFs.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 14, 2020 Category: Chemistry Source Type: research

New flavones from the stems of Dracaena angustifolia
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Ting Zhao, Xu-Hua Nong, Bin Zhang, Min-Min Tang, Dan-Yu Huang, Jia-Li Wang, Jun-Lu Xiao, Guang-Ying ChenAbstractFour new flavone derivatives (1–4), together with six known flavones (5-10), were isolated from the stems of Dracaena angustifolia. The complete structures of new compounds were elucidated by analyses of spectroscopic data and quantum chemistry calculations. Compounds 2, 9 and 10 displayed weak anti-inflammatory activity with IC50 values of 45, 33 and 61 μM, respectively.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 13, 2020 Category: Chemistry Source Type: research

Isolation of a new cytotoxic compound, 3-((Z)-heptadec-14-enyl) benzene - 1-ol from Rhus natalensis root extract
ConclusionThe present results provide initial evidence that the root extract of R.natalensis contains compounds with both cytotoxic and antioxidant activity. Further studies are needed to determine activity on other cancer cell lines and to further elucidate the mechanism of cytotoxic activity. (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 13, 2020 Category: Chemistry Source Type: research

Three new C21 steroidal glycosides from Tylophora atrofolliculata
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): An-Cheng Huang, Cheng-Yu Chen, Jing-Rong Wang, Zhi-Hong JiangAbstractThe Asclepiadaceae plant is a rich source of C21 steroidal glycosides. The present study aimed to investigate the C21 steroidal glycosides from the whole plants of Tylophora atrofolliculata (Asclepiadaceae). As a result, three new C21 steroidal glycosides named atrofollicosides A-C (1-3) and four known steroidal glycosides (4-7) were isolated. The structures of these compounds were characterized using NMR spectroscopy. Highlighted here is a new disecopregnane-type steroid with...
Source: Phytochemistry Letters - February 11, 2020 Category: Chemistry Source Type: research

The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Carolina R. Biasetto, Andressa Somensi, Renata Sordi, Vanessa M. Chapla, Samad N. Ebrahimi, Geraldo H. Silva, Helder L. Teles, Vanderlan da S. Bolzani, Maria Cláudia M. Young, Ludwig H. Pfenning, Angela R. AraujoAbstractTwo new polyketides, named koninginin T (1) and U (2), were isolated from Phomopsis stipata - an endophytic fungus isolated from Styrax camporum Pohl. The structures of polyketides 1 and 2 were defined through the analysis of spectroscopic data. Antifungal and acetylcholinesterase inhibitory activities of these compounds ...
Source: Phytochemistry Letters - February 8, 2020 Category: Chemistry Source Type: research

Quinoisobutyride A, an acyclic antibacterial tetrapeptide incorporating an unprecedented heterocyclic amino acid residue from the hypersaline lake-derived fungus Penicillium simplicissimum strain WSH17
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Sherif S. Ebada, Weaam EbrahimAbstractChromatographic refining of the EtOAc extract of a solid rice culture of the hypersaline lake-derived fungus Penicillium simplicissimum strain WSH17 afforded a new linear antibacterial peptide quinoisobutyride A (1) along with three known metabolites (2-4). The chemical structure of 1 was unambiguously determined based on extensive 1D and 2D NMR spectroscopic analyses together with HRESIMS. In addition, Marfey’s derivatization method along with biogenetic considerations were used to determine the abso...
Source: Phytochemistry Letters - February 7, 2020 Category: Chemistry Source Type: research

Chemical profiling of herbarium samples of solanum (Solanaceae) using mass spectrometry
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): João Victor Mendes Resende, Najla M.D. de Sá, Marcelo Trovó Lopes de Oliveira, Rosana Conrado Lopes, Rafael Garrett, Ricardo Moreira BorgesAbstractHerbarium collections are broadly available for scientific evaluations but surprisingly few studies explored their rich chemical diversity. Considering the systematic organization and the storage conditions Herbarium collections are kept, we wonder if there are still secondary metabolites of interest after years of storage and how this data could be used to discriminate different...
Source: Phytochemistry Letters - February 7, 2020 Category: Chemistry Source Type: research

Triterpenoid alkaloids from Buxus rugulosa and their cytotoxic activities
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Yong-Long Wang, Zhi-Nan Xiang, Yan Yuan, Jie-Wen Zhou, Luan-Yuan Tian, Jia-Chun Chen, Luo-Sheng WanAbstractPhytochemical study of the twigs and leaves of Buxus rugulosa resulted in the isolation of eight triterpenoid alkaloids, including four new triterpenoid alkaloids, namely buxruguloids A–D (1–4), together with four known analogues 5–8. The structures of 1–4 were identified by the analysis of NMR and MS spectroscopic data. All the new compounds were assessed in vitro for their cytotoxic activities against five human t...
Source: Phytochemistry Letters - January 30, 2020 Category: Chemistry Source Type: research

Two new flavonoids from Dracaena usambarensis Engl.
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Vaderament-A. Nchiozem-Ngnitedem, Leonidah Kerubo Omosa, Solomon Derese, Pierre Tane, Matthias Heydenreich, Michael Spiteller, Ean-Jeong Seo, Thomas EfferthAbstractInvestigations of the root extract of Dracaena usambarensis Engl. for anticancer principles led to the characterization of one new homoisoflavonoid, (3S)-3,4ʹ,5,6-tetrahydroxy-7-methoxyhomoisoflavanone (1) and a new retrodihydrochalcone, 4ʹ,4-dihydroxy-2,3-dimethoxydihydrochalcone (2) along with six previously reported compounds, including two homoisoflavonoids, 7-O-methyl-8-demeth...
Source: Phytochemistry Letters - January 30, 2020 Category: Chemistry Source Type: research

Four new quinolizidine alkaloids from the flowers of Sophora viciifolia
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Dan-Dan Gao, Zhi-Jun Zhang, Hong-Mei Li, Xuan-Qin Chen, Dan Liu, Rong-Tao LiAbstractFour new quinolizidine alkaloids, including three matrine-type alkaloids, 8α-hydroxysophocarpine (1), 13β-hydroxyoxymatrine (2), 9α-acetoxymatrine (3), and one sparteine-type alkaloid, 14β-hydroxylupanine (4), together with four known ones, were isolated from the flowers of Sophora viciifolia. Their structures were elucidated by extensive spectroscopic methods including 1D-, 2D-NMR, and HR-ESI-MS. All of the isolates were evaluated for thei...
Source: Phytochemistry Letters - January 30, 2020 Category: Chemistry Source Type: research

Dihydro-β-agarofuran-type sesquiterpenes from the roots of Tripterygium wilfordii and their cytotoxic activity
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Yi-Yu Jiang, Ban-Ban Li, Na Li, Xiao Meng, Xin Lin, Dong Wang, Da-Xi Xiong, Ya-Nan Sun, Li Chen, Long CuiAbstractTwenty-one β-dihydroagarofuran-type sesquiterpenes compounds were isolated from the dry roots of Tripterygium wilfordii, including eight new β-dihydroagarofuran-type sesquiterpenes nature products (2, 6, 8-13) and thirteen known compounds, the structure of these compounds were elucidated by extensive NMR spectroscopic and mass spectrometric analysis. Among all isolated compound 10 exhibited cytotoxicity toward five carcinom...
Source: Phytochemistry Letters - January 29, 2020 Category: Chemistry Source Type: research

Total synthesis of 2'-O-methyl-β-l-arabinosyluridine and reassignment the nucleoside from penicillium sp. as 2'-O-methyl-β-l-uridine
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Chunyang Shen, Haixin Ding, Xueping Tao, Ruchun Yang, Jiang Bai, Ban-Peng Cao, Yi-Yuan Peng, Qiang XiaoAbstractIn order to validate the structure of a rarely reported naturally occurring nucleoside isolated from the broth of Penicillium sp. (NO. 64), practical syntheses of 2′-O-methyl-β-l-arabinosyluridine, 2′-O-methyl-α-l-arabinosyluridine, and 2′-O-methyl-β-l-uridine were accomplished. Comparing their nuclear magnetic resonance (NMR) spectra and physical data, its structure was reassigned as 2′-O-methyl...
Source: Phytochemistry Letters - January 29, 2020 Category: Chemistry Source Type: research

Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae)
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Nathalie S. Jouwa Tameye, Carine Mvot Akak, Gervais Mouthé Happi, Marcel Frese, Hans-Georg Stammler, Beate Neumann, Bruno Ndjakou Lenta, Norbert Sewald, Augustin E. NkengfackAbstractTwo new norbergenin derivatives, 4-O-p-hydroxybenzoylnorbergenin (1) and 11-O-(E)-cinnamoylnorbergenin (2), were isolated from the leaves of Diospyros gilletii De Wild along with nine known compounds, including norbergenin (3), 4-O-galloylnorbergenin (4), betulin (5), betulinic acid (6), lupeol (7), ursolic acid (8), corosolic acid (9), β-sitosterol (10)...
Source: Phytochemistry Letters - January 26, 2020 Category: Chemistry Source Type: research

New pregnane glycosides from Caralluma hexagona Lavranos and their in vitro α-glucosidase and pancreatic lipase inhibitory effects
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Akram A. Shalabi, Ali M. El Halawany, Mouchira A. Choucry, Fatma S. El-Sakhawy, Hiroyuki Morita, Dae-Won Ki, Essam Abdel-SattarAbstractThree new pregnane glycosides in addition to four known compounds were isolated from the methylene chloride fraction of Caralluma hexagona Lavranos using bioassay-guided fractionation. The new compounds were identified as 12,20-di-O-benzoyl-3β,8β,12β,14β,20-pentahydroxy-(20R)-pregn-5-ene-3-O-β-d-glucopyranosyl-(1→4)-β-d-digitaloside (1), 3β,8β,14β,20-tetrahydroxy...
Source: Phytochemistry Letters - January 24, 2020 Category: Chemistry Source Type: research

Isolation and structure elucidation of siliendines A‒D, new β-carboline alkaloids from Silene seoulensis
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Changon Seo, Hyoung Seok Shin, Ji Eun Lee, Yeon Woo Jung, Jin Kyu Kim, Jin Gwan Kwon, Wonsik Jeong, Chun Whan Choi, Joa Sub Oh, Seong Su HongAbstractFour new β-carboline alkaloids, siliendines A–D (1‒4), and four known metabolites (5–8) were isolated from the ethanolic extract of the aerial parts of Silene seoulensis using various chromatographic methods. The structures of the new compounds were established using multiple spectroscopic approaches, with techniques such as HRESIMS and NMR, which included HSQC and HMBC. The know...
Source: Phytochemistry Letters - January 24, 2020 Category: Chemistry Source Type: research

Co-culture of the bacterium Pseudomonas aeruginosa with the fungus Fusarium tricinctum induces bacterial antifungal and quorum sensing signaling molecules
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Mariam Moussa, Weaam Ebrahim, Rainer Kalscheuer, Zhen Liu, Peter ProkschAbstractCo-cultivation of viable cells of the human pathogenic bacterium Pseudomonas aeruginosa with the endophytic fungus Fusarium tricinctum induced silent bacterial biosynthetic gene clusters. Visual and chemical inspection of the co-cultures by comparison with the axenic cultures showed a clear reaction of P. aeruginosa towards its fungal competitor which was reflected by the deep greenish coloration of the co-cultures. Inspection of the HPLC chromatograms of the co-cul...
Source: Phytochemistry Letters - January 23, 2020 Category: Chemistry Source Type: research

Molecular confirmation, constituents and cytotoxicity evaluation of two medicinal Piper species used by the Manobo tribe of Agusan del Sur, Philippines
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Mark Lloyd G. Dapar, Cesar G. Demayo, Ulrich Meve, Sigrid Liede-Schumann, Grecebio Jonathan D. AlejandroAbstractThe Manobo tribe in the Philippines is culturally rich in ethnomedicinal practices and known to use popular plants locally named as “Lunas” (meaning “cure”). One of these is “Lunas-bagon tapol” which was previously identified as Lunasia sp. (Rutaceae) based on vegetative morphology. The other species is “Lunas-buyo” which is similar in ethnomedicinal use and morphology. This broadly-base...
Source: Phytochemistry Letters - January 23, 2020 Category: Chemistry Source Type: research

Angelicosides I-IV, four undescribed furanocoumarin glycosides from Angelica dahurica roots and their tyrosinase inhibitory activities
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Penghua Shu, Junping Li, Yingying Fei, Huiqing Zhu, Lingxiang Zhang, Haoying Niu, Yamin Li, Hao Liu, Zhiyu Ju, Xialan Wei, Fugang Xiao, Zhihong XuAbstractAngelica dahurica is an important medicinal plant, which has been widely used in medicines and skin-whitening products. In the investigation of phytochemicals present in A. dahurica roots, three unusual furanocoumarin rhamnosides, angelicosides I–III (1–3), one undescribed furanocoumarin glucoside, angelicoside IV (4), together with eight known compounds (5–12) were isolated....
Source: Phytochemistry Letters - January 23, 2020 Category: Chemistry Source Type: research

Effect of increasing soil carbon content on tobacco aroma and soil microorganisms
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Shen Yan, Guoshun LiuAbstractSoil carbon pool, the largest carbon pool in any terrestrial ecosystems, has been disrupted owing to high rates of fertilization and intensive crop rotation. Reduction of soil carbon caused decreases of tobacco quality. Firstly, the correlations between soil types (purple soil and paddy soil from the tobacco region in southern China) and tobacco aroma compounds were analyzed in this research. It was showed that the soil carbon pool is closely correlated with tobacco aroma. Secondly, effect of the soil carbon content...
Source: Phytochemistry Letters - January 23, 2020 Category: Chemistry Source Type: research

Anti-inflammatory diterpenes and steroids from peels of the cultivated edible mushroom Wolfiporia cocos
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Chen Baosong, Wang Sixian, Liu Gaoqiang, Bao Li, Huang Ying, Zhao Ruilin, Liu HongweiAbstractChemical investigation on the peels of the cultivated edible mushroom Wolfiporia cocos led to the identification of 13 diterpenes and 4 steroids, including two new abietane diterpenes (1 and 2) and one new pregnane steroid (14). Structures of new compounds were determined by analysis of NMR, MS, and electronic circular dichroism (ECD) data. All compounds were evaluated for cytotoxicity (K562 and HepG2), antimicrobial and anti-inflammatory activity. Comp...
Source: Phytochemistry Letters - January 23, 2020 Category: Chemistry Source Type: research

Exposure to artificially damaged goldenrod volatiles increases saponins in seeds of field-grown soybean plants
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Kaori Shiojiri, Rika Ozawa, Ken-Ichi Yamashita, Masayoshi Uefune, Kenji Matsui, Chigen Tsukamoto, Junji TakabayashiAbstractWe previously reported that the exposure of field-grown black soybean seedlings (Glycine max ‘Hyokei Kuro-3’) to artificially damaged goldenrod volatiles (ADGVs) resulted in a significant increase in isoflavonoids in their seeds. Here, we used field-grown soybean seedlings to study the effects of the exposure to ADGVs on the production of seed saponins that are particularly abundant in soybean seeds. We used bla...
Source: Phytochemistry Letters - January 23, 2020 Category: Chemistry Source Type: research

Artemargyinolide E, a new sesquiterpene lactone from Artemisia argyi inhibits inflammatory responses via down-regulating NF-κB signaling pathway
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Lai-Bin Zhang, Hui-Hui Zhu, Li-Min Guo, Jie-Li LvAbstractArtemargyinolide E (AE), a new sesquiterpene lactone was isolated from the traditional Chinese medicine Artemisia argyi. Its structure was elucidated based on the extensive analysis of spectroscopic data. The absolute configuration of AE was assigned by X-ray crystallographic analysis. The effect of AE and its mechanism on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages were investigated. AE displayed the inhibitory activity on the production of nitrogen oxide (NO) ...
Source: Phytochemistry Letters - January 23, 2020 Category: Chemistry Source Type: research

Editorial Board
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 16, 2020 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 16, 2020 Category: Chemistry Source Type: research

Graphical Abstract TOC
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 16, 2020 Category: Chemistry Source Type: research

New azaphilone, isocoumarin and α-pyrone derivatives from the marine-derived gut fungus Paraphaeosphaeria sp. XZD2-1
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Jiaolu Sun, Haojian Zhang, Wanjing Ding, Dao-qiong Zheng, Pin-mei Wang, Jinzhong XuAbstractSix new compounds including two azaphilones, lunatoic acids D–E (1, 2), three isocoumarins, lunatinins B–D (3-5), and one α-pyrone derivative, lunatinin E (6), as well as four known ones, lunatoic acid A (7), lunatinin (8), penicipyran D (9) and chaetoquadrin F (10) were isolated from the rice medium of the gut fungus Paraphaeosphaeria sp. XZD2-1. Their planar structures were elucidated by analysis of 1D and 2D NMR as well as HRESIMS spe...
Source: Phytochemistry Letters - January 8, 2020 Category: Chemistry Source Type: research

Structure characterization and biological activity of 2-arylbenzofurans from an Indonesian plant, Sesbania grandiflora (L.) Pers
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Noviany Noviany, Arash Samadi, Nita Yuliyan, Sutopo Hadi, Muhammad Aziz, Neny Purwitasari, Suriyati Mohamad, Nur Najihah Ismail, Kevin P. Gable, Taifo MahmudAbstractA new 2-arylbenzofuran, sesbagrandiflorain C (1), together with four known compounds, 2-(3,4-dihydroxy-2-methoxyphenyl)-4-hydroxy-6-methoxybenzofuran-3-carbaldehyde (2), 2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxybenzofuran-3-carboxaldehyde (3), sesbagrandiflorain A (4) and sesbagrandiflorain B (5), have been isolated from the stem bark of an Indonesian plant, Sesbania grandiflor...
Source: Phytochemistry Letters - December 31, 2019 Category: Chemistry Source Type: research

A new xanthone and a new benzophenone from the roots of Garcinia hombroniana
In this study, the roots of Garcinia hombroniana were chemically investigated, in which novel derivatives of xanthone and benzophenone, known as garcihomxanthone (1) and garcihombrianone (2), respectively, together with garceduxanthone (3), cheffouxanthone (4), norathyriol (5), and 2,3′,4,5′-tetrahydroxy-6-methoxybenzophenone (6) were isolated.. The structures of these compounds were elucidated by extensive spectroscopic techniques and evaluated based on references with previous literature data.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 31, 2019 Category: Chemistry Source Type: research

Bignanoside A "A new neolignan glucoside" and bignanoside B "A new iridoid glucoside" from Bignonia binata leaves
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Basma Khalaf Mahmoud, Mamdouh Nabil Samy, Ashraf Nageeb Elsayed Hamed, Usama Ramadan Abdelmohsen, Dina Hajjar, Yoshi Yamano, Sachiko Sugimoto, Katsuyoshi Matsunami, Mohamed Salah KamelAbstractOne new neolignan glucoside; bignanoside A (1) and one new iridoid glucoside; bignanoside B (2), and one new lignan rhamnoside; (-)-1yoniresinol 3α-O-α-L-rhamnopyranoside (3) reported for the first time, alongside with seven known compounds were isolated from Bignonia binata leaves. The structures of the isolated compounds were elucidated by...
Source: Phytochemistry Letters - December 24, 2019 Category: Chemistry Source Type: research

Induced production of zinniol analogues by co-cultivation of two endophytic fungi in the same ecological niche
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Zi-Ru Wang, Hong-Xia Yang, Xiao-Ping Peng, Gang Li, Hong-Xiang LouAbstractThree zinniol analogues, pleoniols A–C (1–3), together with a known compound (4), were isolated from a mixed fermentation of two endophytic fungi, Pleosporales sp. F46 and Acremonium pilosum F47, both of which are found the pedicel of the medicinal plant Mahonia fortunei. High-performance liquid chromatography analysis showed that none of compounds 1–4 were detected when either one of the two fungi was cultured alone. The structures of compounds 1&nda...
Source: Phytochemistry Letters - December 24, 2019 Category: Chemistry Source Type: research

The first tripyrrolic chlorophyll catabolites isolated from Crataegus pinnatifida Bge. var. major brown leaves
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Zheming Ying, Xixiang Ying, Guanlin Yang, Didier StienAbstractTwo diastereoisomers, namely, Crataegus pinnatifida tripyrrolic Chl catabolites or Cp-TCC-1 (1) and Cp-TCC-2 (2), were isolated from the leaves of Crataegus pinnatifida Bge. var. major. Compounds 1 and 2 were identified using spectroscopic methods including HR-ESI-TOF-MS, 1D-NMR, 2D-NMR. A probable biosynthetic pathway to Cp-TCC-1 (1) and Cp-TCC-2 (2) is expounded.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 17, 2019 Category: Chemistry Source Type: research

The novel indole glucoalkaloid and secoiridoid glucoside from Tripterospermum chinense
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Tao Zhang, Chuan-Jiang Ma, Yong-Li Wei, Jin-Guang Si, Lu Fu, Jun-Xing Dong, Zhong-Mei ZouAbstractTripterospermumcin F (1), a novel indole glucoalkaloid, and tripterospermumcin G (2), a new iridoid tetramer, were isolated from the aerial parts of Tripterospermum chinense. Their structures were determined by analysis of 1D and 2D NMR data, as well as by comparison with model compounds. Their cytotoxicities were tested, but neither of them showed obvious activity.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 15, 2019 Category: Chemistry Source Type: research

Iridoids from Vitex negundo var. heterophylla and their antioxidant activities
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Ying-Xue Niu, Dun Wang, Xin-Yue Chu, Su-Yu Gao, Dong-Xin Yang, Li-Xia Chen, Hua LiAbstractTwo new iridoids (1-2) together with eight known iridoid glycosides (3-10) were isolated from the 70% EtOH extract of the dried leaves of Vitex negundo var. heterophylla. Their structures were elucidated by extensive spectroscopic analyses. Iridoid aglycones were found for the first time from this plant. All of these compounds were tested for their antioxidant activities. Among them, compound 9 showed moderate radical-scavenging effect on the stable fre...
Source: Phytochemistry Letters - December 14, 2019 Category: Chemistry Source Type: research

Identification of multiple components in deep eutectic solvent extract of Acanthopanax senticosus root by ultra-high-performance liquid chromatography with quadrupole orbitrap mass spectrometry
In this study, DES was synthesized from choline chloride and lactic acid, which was used as a substitute for a strong organic solvent to extract saponins, phenylpropionic acid, and terpenoids from Acanthopanax senticosus root. The phytochemicals extracted from Acanthopanax senticosus were analyzed by ultra-high-performance liquid chromatography with quadrupole orbitrap mass spectrometry in positive and negative ionization modes. A total of 91 types of phytochemicals were identified from DES extracts and 17 chemical constituents were newly identified in the root of Acanthopanax senticosus via primary and secondary high-reso...
Source: Phytochemistry Letters - December 13, 2019 Category: Chemistry Source Type: research

Schisandrin B and Schisandrol B induce mouse CYP2b10 associated with CAR not PXR
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Minzhu Xie, Jiao Lin, Jinyu Kang, Xiuting Zheng, Kailu Fang, Yishuang Luo, Aiming Liu, Julin YangAbstractSchisandrin B (SinB) and Schisandrol B (SolB) are two abundant compounds with similar structures in Schisandra sphenanthera widely used for hepatic diseases in Asian countries. They are also pharmacologically active components in many other traditional Chinese medicines. However, induction features of cytochrome P450 (CYP) by SinB and SolB were not well established. The present study aimed to investigate the CYP profile induced by SinB an...
Source: Phytochemistry Letters - December 11, 2019 Category: Chemistry Source Type: research

Antimicrobial metabolites from the endophytic fungus Aspergillus versicolor
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Gamal A. Mohamed, Sabrin R.M. Ibrahim, Hani Z. AsfourAbstractTwo new diaryl ether derivatives [aspergillethers A (4) and B (5)] and five known metabolites [(22E,24R)-stigmasta-5,7,22-trien-3-β-ol (1), stigmasta-4,6,8(14),22-tetraen-3-one (2), orcinol (3), and butyrolactones I (6) and VI (7)] were separated from the endophytic fungus Aspergillus versicolor (Aspergillaceae) isolated from the roots of Pulicaria crispa Forssk (Asteraceae) growing in Saudi Arabia. The structures of these compounds were determined by various spectral techniqu...
Source: Phytochemistry Letters - December 11, 2019 Category: Chemistry Source Type: research

Further 2R-Benzylmalate derivatives from the undergrounds parts of Arundina graminifolia (Orchidaceae)
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Florence Auberon, Opeyemi Joshua Olatunji, Pierre Waffo-Teguo, Emmanuel Ayobami Makinde, Ozioma Forstinus Nwabor, Frédéric Bonté, Jean-Michel Mérillon, Annelise LobsteinAbstractNine new glucosyloxybenzyl 2R-benzylmalate derivatives, named arundinosides R–Z (1-9) were isolated from the underground parts of Arundina graminifolia. The structures of the new compounds were elucidated by in-depth spectroscopic data analysis including 1D and 2D NMR experiments, in combination with mass spectrometry data.Graphical a...
Source: Phytochemistry Letters - December 11, 2019 Category: Chemistry Source Type: research

Secondary metabolites from the fungus Stereum gausapatum ATCC60954
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Jun-Ran Huang, Bang-Ju Yang, Ming-He Mo, Ke-Qin Zhang, Guo-Hong LiAbstractA phytochemical investigation of basidiomycete Stereum gausapatum ATCC60954 led to the isolation of five compounds. They are determined to be strobilol N (1), strobilol O (2), strobilol P (3), strobilol E (4) and stereumin D (5) based on the spectral data. Compounds 1-3 are new metabolites. Compound 1 was active against nematode Caenorhabditiselegans with the mortality 75.8 % at 200 μg/ml in 36 h. This is the first report about the chemical constituent...
Source: Phytochemistry Letters - December 11, 2019 Category: Chemistry Source Type: research

Tetrasubstituted α-pyrone derivatives from the endophytic fungus, Neurospora udagawae
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Allan Patrick G. Macabeo, Allaine Jean C. Cruz, Abolfazl Narmani, Mahdi Arzanlou, Asadollah Babai-Ahari, Luis Agustin E. Pilapil, Katherine Yasmin M. Garcia, Volker Huch, Marc StadlerAbstractTwo new α-pyrone derivatives, udagawanones A (1) and B (2), along with the known compounds (Z)-4-hydroxy-3-(3-hydroxy-3-methylbut-1-en-1-yl)benzoic acid (3), isosclerone (4), cyclo-(L-Leu-L-Pro) (5), and cyclo-(L-Pro-L-Tyr) (6), were isolated from cultures of the endophyte Neurospora udagawae. Their structures were elucidated by extensive spectrosc...
Source: Phytochemistry Letters - December 7, 2019 Category: Chemistry Source Type: research

Structural characterization, hepatoprotective and antihyperlipidemic activities of alkaloid derivatives from Murraya koenigii
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Rongrui Wei, Qinge Ma, Guoyue Zhong, Yulun Su, Jianbo Yang, Aiguo Wang, Tengfei Ji, Hongxia Guo, Meiling Wang, Ping Jiang, Haichao WuAbstractThree new alkaloids (1-3) and a new natural alkaloid (4), named (1′R,3′R,4′R,6′S)-endocycliomurrayamine-A (1), 3-formyle-7-hydroxy-9H-carbazole-1-O-β-d-glucopyranoside (2), 4′-hydroxyphenyl-6-ethyl-1H-pyrrole-2-carboxaldehyde (3), and 4-hydroxyphenoxy-N-methyl-propanamide (4), together with thirteen known alkaloid derivatives (5–17) were isolated from Murraya koe...
Source: Phytochemistry Letters - November 29, 2019 Category: Chemistry Source Type: research

Drimane sesquiterpenoids from cultures of the basidiomycete Gymnopilus sp. BCC 19384
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Masahiko Isaka, Malipan Sappan, Rapheephat Suvannakad, Thitiya Boonpratuang, Tuksaporn ThummarukcharoenAbstractSeven previously undescribed drimane sesquiterpenoids, gymnodrimanes A–G (1–7), were isolated from cultures of the basidiomycete Gymnopilus sp. BCC 19384. The structures were elucidated by spectroscopic analysis. The absolute configurations of 1 and 2 were determined by application of the modified Mosher’s method.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 29, 2019 Category: Chemistry Source Type: research

Neo-clerodane diterpenoids from Scutellaria barbata and their reversal multidrug resistance activity in HepG2/Adr cells
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Wei Yan, Dan-Dan Li, Dan Liu, Hong-Mei Li, Zhi-Jun Zhang, Rong-Tao Li, Xuan-Qin ChenAbstractBioassay-guided isolation of the aerial part of Scutellaria barbata (Labiatae) yielded six new neo-clerodane diterpenoids scutegxbatines A–F (1-6), together with thirteen known analogues (7-20). Their structures were elucidated on the basis of extensive spectroscopic analyses. Compounds 3, 7, 12, and 15 at 20 μmol/L were able to reverse multi-drug resistance of HepG2/Adr cells to adriamycin (reversal fold: 5.2–20.3).Graphical abstractSi...
Source: Phytochemistry Letters - November 28, 2019 Category: Chemistry Source Type: research