Morus alba leaf extract: Metabolite profiling and interactions with antibiotics against Staphylococcus spp. including MRSA
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Petruta Aelenei, Simon Vlad Luca, Cristina Elena Horhogea, Cristina Mihaela Rimbu, Gabriel Dimitriu, Irina Macovei, Mihaela Silion, Ana Clara Aprotosoaie, Anca MironAbstractHPLC-DAD-ESI-Q-TOF-MS/MS metabolite profiling of Morus alba leaf extract led to the annotation of 25 constituents (two stilbene derivatives, 11 prenylflavonoids, five 2-arylbenzofurans, seven Diels–Alder type adducts). The extract was found to contain 57.83 mg/g flavonoids, 15.42 mg/g kuwanon G and 10.47 mg/g morusin. Despite its moderate antibacterial activity wi...
Source: Phytochemistry Letters - April 17, 2019 Category: Chemistry Source Type: research

Glucosinolates profiles in Maca phenotypes cultivated in Peru and China (Lepidium peruvianum syn. L. meyenii)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Henry O. Meissner, Lijia Xu, Wenting Wan, Fan YiAbstractHPLC glucosinolate (GCSN) profiles and concentration levels were examined in hypocotyls of the four prime Maca phenotypes (Lepidium peruvianum synonym L. meyenii) labelled as “Yellow”, “Black”, “Red” and “Purple”, grown in Peru (Pe) and/or China (Cn). In Trial I, glucotropaeolin (GLCT) and m-methoxyglucotropaeolin (MGLCT) content, and their ratios, was determined in commercial Maca products of Pe origin and compared with similar products decla...
Source: Phytochemistry Letters - April 16, 2019 Category: Chemistry Source Type: research

Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Fernanda Majolo, Luciana Knabben de Oliveira Becker Delwing, Diorge Jônatas Marmitt, Ivan Cunha Bustamante-Filho, Márcia Inês GoettertAbstractCancer is one of the largest causes of morbimortality in the world and due to its prevalence the discovery of novel anticancer drugs in of great importance. The past century brought great advances in the field of plant and microbiology research, with the development of several compounds used in cancer treatment protocols. Many successful anticancer drugs that are in clinical use and have...
Source: Phytochemistry Letters - April 13, 2019 Category: Chemistry Source Type: research

Cytotoxic chalcones and isoflavones from the stems of Dalbergia velutina
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Sutin Kaennakam, Edwin Risky Sukandar, Kitiya Rassamee, Pongpun Siripong, Santi Tip-pyangAbstractFour new compounds, including two new chalcones, veluchalcone A and B (1 and 2), and two new isoflavones, veluisoflavone A and B (3 and 4), together with five known chalcones (5–9) and ten known isoflavones (10–19), were isolated from the stems of Dalbergia velutina. The structures of these compounds were determined by spectroscopic analysis. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines...
Source: Phytochemistry Letters - April 11, 2019 Category: Chemistry Source Type: research

Evaluation of anti-melanoma and tyrosinase inhibitory properties of marchantin A, a natural macrocyclic bisbibenzyl isolated from Marchantia species
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Katarzyna Gaweł-Bęben, Paweł Osika, Yoshinori Asakawa, Beata Antosiewicz, Kazimierz Głowniak, Agnieszka LudwiczukAbstractMacrocyclic bisbibenzyl compound, marchantin A, naturally occurring in liverworts belonging to genus Marchantia, was isolated and assessed for their cytotoxicity against two different lines of human skin cells - immortalized human keratinocytes HaCaT and human malignant melanoma cells A375. The purpose of the studies was also to examine the anti-hyperpigmentation effect of marchantin A, especially used in concentrations as...
Source: Phytochemistry Letters - April 11, 2019 Category: Chemistry Source Type: research

Antioxidant activity of five new phenolic compounds from Cirsium creticum subsp. creticum
In this study, five new alkyl catechol derivatives, 1, 2, 3, 4 and 5 were isolated for the first time from Cirsium creticum subsp. creticum L. and their structures were determined by using spectroscopic techniques, including mass spectrometry, 1D and 2D NMR. All of the isolated compounds were primarily evaluated for antioxidant activity against BHA and tocopherol. All compounds which were isolated from C. creticum subsp. creticum exhibited antioxidant activity, however it was noticed that the presence of a pentose sugar increased the antioxidant activity.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 10, 2019 Category: Chemistry Source Type: research

Two new polyhydroxylated pentacyclic triterpenes with cytotoxic activities from Manilkara pellegriniana (Sapotaceae)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Linda D.K. Mogue, Patrick Y. Ango, Ghislain W. Fotso, Renameditswe Mapitse, Deccaux W.F.G. Kapche, Oğuzhan Karaosmanoğlu, Victor Kuete, Ibrahim Demirtas, Samuel O. Yeboah, Hülya Sivas, Ngadjui T. BonaventureAbstractTwo new polyhydroxylated urs-12(13)-ene pentacyclic triterpenes namely 2α, 3α, 19α, 20β, 23-pentahydroxyurs-12-en-28-oic acid (1) and 1β, 2α, 3α, 5, 19α, 24-hexahydroxyurs-11(12), 20(30)-dien-28-oic acid (2) were isolated from the stem bark of Manilkara pellegriniana together with s...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

New cassane diterpenoids from the root bark of Erythrophleum suaveolens
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Jacques Dibi Konan, Barthélemy Koffi Attioua, Claude Landry Ahmont Kablan, Faustin Aka Kabran, Paul Armand Koffi, Sandrine Aka Any-Grah, Sissouma Drissa, Blandine Seon-Meniel, Karine LeBlanc, Jean-Christophe Jullian, Mehdi A. BeniddirAbstractPhytochemical investigation of the methanol extract from the root barks of Erythrophleum suaveolens (Guill. et Perr.) Brenan led to the isolation of four cassane diterpenoid amides and five cassane diterpenoid amines. Among these compounds, two were considered as new structures: 3β-hydroxy-3-meth...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

Phytochemical investigation of Medicago sativa L. extract and its potential as a safe source for the synthesis of ZnO nanoparticles: The proposed mechanism of formation and antimicrobial activity
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): A. Król, V. Railean-Plugaru, P. Pomastowski, B. BuszewskiAbstractThe main goal of present work was the investigation of Medicago sativa L. aqueous extract as a new, safe and accessible agricultural waste source for the synthesis of zinc oxide bio-nanoparticles (ZnO bio-NPs). Secondly, the phytochemical investigation and determination of M. sativa biologically active compounds content before and during the synthesis has led to the proposal of a possible ZnO NPs plant- mediated synthesis mechanism. In this fact, the present research show th...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

Isolation and structure elucidation of secondary metabolites of two Greek endemic Inula species. Biological activities
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Eleftheria Michalakea, Konstantia Graikou, Nektarios Aligiannis, George Panoutsopoulos, Eleftherios Kalpoutzakis, Christos Roussakis, Ioanna ChinouAbstractIn the framework of phytochemical studies on Greek endemic Inula species, Inula candida subsp. candida and Inula candida subsp. decalvans have been analyzed. The aerial parts were extracted with increasing polarity solvents and sixteen secondary metabolites from I. candida subsp. candida and eight from I. candida subsp. decalvans were isolated. From I. candida subsp. decalvans a sesquiterpene ...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

Four new triterpenoids from the bark of Euonymus alatus forma ciliato-dentatus
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Hiroshi Yamashita, Madoka Matsuzaki, Yuria Kurokawa, Takahisa Nakane, Masuo Goto, Kuo-Hsiung Lee, Toshiro Shibata, Hideo Bando, Koji WadaAbstractFour novel lupane-type lupane-type triterpenoids (including three norlupane-type triterpenoids), 17β-hydroxy-28-norlup-20(29)-en-3-one (1), 3β,17β–dihydroxy-28,30-bisnorlupan-20-one (2), 3β-hydroxy-20-oxo-30-norlupan-28-al (3) and lup-20(29)-ene-3,23,30-triol (4), were isolated together with ten known lupane triterpenoids (5˜14) from the bark of Euonymus alatus forma cili...
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

Dammarane-type saponins from Gynostemma pentaphyllum and their potential anti-AD activity
This study revealed the potent antagonistic effect of dammarane-type saponins 1 and 6 against Alzheimer’s disease.Graphical abstractTwo undescribed dammarane-type saponins were isolated from Gynostemma pentaphyllum. Their anti-Alzheimer’s Disease (AD) activity was evaluated on a transgenic fly AD model. This study provided two potential candidates for anti-AD agents. (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research

The unusual conformational preference of N1,N5,N10-tri-p-coumaroylspermidine E-Z isomers from the Japanese apricot tree, Prunus mume, for the (ZZZ)-form
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Shinnosuke Mori, Miki Akamatsu, Hiroshi Fukui, Junko Tsukioka, Katsumi Goto, Nobuhiro HiraiAbstractThe Japanese apricot tree, Prunus mume (Siebold) Siebold & Zucc. cv. Nanko, bears two types of flowers: those with anthers that fluoresce under UV irradiation, and those that do not. The chemical composition of both types of anthers has been investigated: the non-fluorescent anthers contained eight E-Z isomers of N1,N5,N10-tri-p-coumaroylspermidine as major constituents; whereas the fluorescent anthers contained only a limited amount of (ZZZ)-i...
Source: Phytochemistry Letters - April 6, 2019 Category: Chemistry Source Type: research

New acetylenic compounds and lignans from Dolomiaea berardioidea (Franch.) Shih
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Ying-Ying Huang, Xin Qiu, Yang-Guo Xie, Guo-Jing Wu, Sheng-Lan Zhu, Wei-Dong Zhang, Yan Zhang, Chen Dai-Jie, Hui-Zi JinAbstractTwo new acetylenic compounds (1 and 2), two new lignans (3 and 4) along with eight known lignans (5−12), ten known terpenoids (13−22) and one known aromatic compound (23) were isolated from the whole plants of Dolomiaea berardioidea (Franch.) Shih. Structures of new compounds were elucidated by combined use of HRESIMS, 1D and 2D NMR and CD spectroscopic methods. The absolute structures of 1 and 3 were further...
Source: Phytochemistry Letters - April 6, 2019 Category: Chemistry Source Type: research

Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Lin-Fen Ding, Jiang-Xin Liu, Zhang-Qiao Xie, De-Shen Wang, Wei Nie, Liu-Dong Song, Xing-De Wu, Qin-Shi ZhaoAbstractFour new elemane sesquiterpenoids, magnograndins J-M (1-4), and one known sesquiterpenoid, 12,13-diacetoxyelema-1,3-dien-6α,11-diol (5), were obtained from 70% acetone extract of the leaves of Magnolia grandiflora. Their structures were determined with extensive spectroscopic (HRMS, IR, 1D and 2D NMR) analyses. Compound 1 represented the first example of elemane sesquiterpenoid with an orthoacetate unit. Compound 4 inhibited n...
Source: Phytochemistry Letters - April 5, 2019 Category: Chemistry Source Type: research

Two new antiplasmodial flavonolignans from the leaves of Cecropia obtusifolia
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Andrés Rivera-Mondragón, Emmy Tuenter, Sebastiaan Bijttebier, Paul Cos, Sandra Apers, Catherina Caballero-George, Kenn Foubert, Luc PietersAbstractCecropia species are traditionally used in several Latin American countries to treat various diseases including malaria. A phytochemical investigation on the leaves of Cecropia obtusifolia Bertol (Urticaceae) afforded two new flavonolignans, i.e. ent-mururin A (1) and ent-vaccinin A (2). They were isolated by means of chromatographic techniques and elucidated based on their spectroscopic...
Source: Phytochemistry Letters - April 4, 2019 Category: Chemistry Source Type: research

Cyclopalitins A and B, nortriterpenoids from aerial parts of Cyclocarya paliurus
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Wenwen Peng, Simeng Zhao, Changjiu Ji, Guanghua Huo, Chunpeng Wan, Yuyan Li, Yanling ZhangAbstractTwo novel nortriterpenoids, cyclopalitins A and B (1 and 2), were isolated from aerial parts of Cyclocarya paliurus. Their structures were elucidated on the basis of extensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1D NMR and 2D NMR. Compounds 1 and 2 were tested for their cytotoxicity towards B16F10. The results revealed that they didn’t show cytotoxic activity against B16F10 wi...
Source: Phytochemistry Letters - April 4, 2019 Category: Chemistry Source Type: research

Evaluation of the variables altitude, soil composition and development of a predictive model of the antibacterial activity for the genus Hypericum by chromatographic fingerprint
The objectives of this research were, to develop a predictive model for the antibacterial potential of the genus Hypericum using chromatographic fingerprinting with three Hypericum species collected at Ecuadorian Andes (H. laricifolium, H. quitense R. Keller and H. decandrum Turcz); and to evaluate the influence of natural variables such as altitude and soil composition on the pharmacological effect of lipophilic extracts of H. laricifolium. Antibacterial activity of the plants extracts was assessed by plate microdilution technique against Methicillin-resistant Staphylococcus aureus (MRSA). The fingerprint was obtained by ...
Source: Phytochemistry Letters - April 2, 2019 Category: Chemistry Source Type: research

Justicialosides A and B, two new flavone glycosides from the leaves of Ruspolia hypocrateriformis (Vahl) Milne-Redh. (Acanthaceae)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Stephanie T. Guetchueng, Lutfun Nahar, Kenneth J. Ritchie, Fyaz M.D. Ismail, Nicola M. Dempster, Satyajit D. SarkerAbstractTwo new flavone glycosides, luteolin 7-O-α-l-rhamnopyranosyl-(1→2)-β-d-xylopyranoside (1) and chrysoeriol 7-O-α-l-rhamnopyranosyl-(1→2)-β-d-xylopyranoside (2), along with five known compounds, luteolin 7-O-β-d-apiofuranosyl-(1→2)-β-d-xylopyranoside (3), grandulosides A and B (4 and 5), luteolin 7-O-[β-d-glucopyranosyl-(1→2)-α-l-rhamnosyl-(1→6)]-β-D-gluc...
Source: Phytochemistry Letters - April 2, 2019 Category: Chemistry Source Type: research

Deoxybenzoin and flavan derivatives from the twigs of Artocarpus lakoocha
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Sirada Boonyaketgoson, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Kongkiat TrisuwanAbstractOne new deoxybenzoin, named lakoochanoside A (1), and one new flavan, named lakoochanoside B (2), along with 17 known compounds were isolated and identified from the twigs of Artocarpus lakoocha. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and 2D NMR spectroscopy. Cycloartocarpin (14) exhibited strong antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus with the s...
Source: Phytochemistry Letters - March 31, 2019 Category: Chemistry Source Type: research

Secondary metabolites from the Chinese liverwort Diplophyllum apiculatum
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Shenghua Fan, Yi Li, Jinchuan Zhou, Yanan Qiao, Chunyang Zhang, Yun Gao, Xueyang Jin, Jiaozhen Zhang, Wang Chen, Hongxiang LouAbstractThree new clerodane-type diterpenoids, diplapiculins A–C (1-3), together with five known compounds (4-8) were isolated from the Chinese liverwort Diplophyllum apiculatum (A. Evans) Stephani. Their structures were determined by detailed analysis of HRMS and NMR data, coupled with single-crystal X-ray diffraction crystallography and electronic circular dichroism (ECD). They were found no antifungal and antican...
Source: Phytochemistry Letters - March 31, 2019 Category: Chemistry Source Type: research

Meroterpenoids produced by Pseudocosmospora sp. Bm-1-1 isolated from Acanthus ebracteatus Vahl
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Tomoki Nakamura, Takuma Suzuki, Nanang Rudianto Ariefta, Takuya Koseki, Takako Aboshi, Tetsuya Murayama, Ari Widiyantoro, Rikhsan Kurniatuhadi, Abdul Malik, Suwardi Annas, Desi Harneti, Rani Maharani, Unang Supratman, Junpei Abe, Naoaki Kurisawa, Ken-ich Kimura, Yoshihito ShionoAbstractFractionation of ethyl acetate extract obtained by culturing the endophytic fungus Pseudocosmospora sp. Bm-1-1 resulted in the isolation of four new meroterpenoids, cosmosporin A (1), 6-carboxy-cosmosporin A (2), rel-(6aS,10aR)-Δ9-tetrahydrocannabiorcolic ac...
Source: Phytochemistry Letters - March 30, 2019 Category: Chemistry Source Type: research

Sceletorines A and B, two minor novel dimeric alkaloids of Mesembryanthemum tortuosum (synonym Sceletium tortuosum)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Hongquan Yin, Zulfiqar Ali, Yuanqing Ding, Yan-Hong Wang, Michael. J. Cunningham, Mohamed A. Ibrahim, Amar G. Chittiboyina, Wei Wang, Alvaro M. Viljoen, Ikhlas A. KhanAbstractSceletorines A and B, two unique alkaloids, were isolated for the first time from the aerial parts of Mesembryanthemum tortuosum. Their structures were determined by the extensive spectroscopic methods and their absolute configuration was established with ECD calculations. Plausible biosynthetic pathways for 1 and 2 are proposed and a relationship to the previously assumed ...
Source: Phytochemistry Letters - March 28, 2019 Category: Chemistry Source Type: research

Bufadienolides from the skins of Bufo melanosticus and their cytotoxic activity
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Lingjie Meng, Nian Jiang, Changyan Yu, Sanhua Li, Zeli Chun, Xinting Zhu, Changwei Song, Yi Xiao, Jing Hui, Ying Qin, Yun LiuAbstractThree new bufadienolides, (2β,5β,14β)-2,5,14-trihydroxy-bufa-20,22-dienolide (1), (3α,16β)-3,16-dihydroxy-bufa-14,20,22-trienolide (2) and (3β,5β,16α)-3,5,16-trihydroxy-bufa-14,20,22-trienolide (3), together with three known analogs (4-6), were isolated from the aqueous extracts of the skins of Bufo melanosticus. Their structures were determined by spectroscopic studies, in...
Source: Phytochemistry Letters - March 25, 2019 Category: Chemistry Source Type: research

One new 2-(2-Phenylethyl)chromone Derivative from Agarwood of Aquilaria crassna in Cambodia
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Lu-Lu Xia, Wei Li, Hao Wang, Wen-Hua Dong, Cai-Hong Cai, Cui-Juan Gai, Li Yang, Wen-Li Mei, Hao-Fu DaiAbstractOne new 2-(2-phenylethyl)chromone (1), three new naturally occurring 2-(2-phenylethenyl)chromones (3–5), together with a known 2-(2-phenylethyl)chromone (2) were isolated from the EtOH extract of agarwood originating from Aquilaria crassna in Cambodia. Their structures were unambiguously elucidated by detailed spectroscopic (NMR, UV, IR, MS) analyses. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity...
Source: Phytochemistry Letters - March 24, 2019 Category: Chemistry Source Type: research

Postharvest UV-A and UV-B treatments may cause a transient decrease in grape berry skin flavonol-glycoside contents and total antioxidant capacities
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Kristóf Csepregi, László Kőrösi, Péter Teszlák, Éva HidegAbstractControlled postharvest abiotic stresses have already been shown to affect the secondary metabolism of fresh produce. We applied broad band ultraviolet (either 312 nm centred UV-B or 355 nm centred UV-A) radiation on harvested berry clusters of the red table grape Emperor, and measured berry skin antioxidant capacities and phenolic profiles 2, 24 and 48 h after these treatments. There was no significant change in t...
Source: Phytochemistry Letters - March 22, 2019 Category: Chemistry Source Type: research

New lignan glycosides from the stems of Securidaca inappendiculata Hassk
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Junyang Ji, Qiwen Wang, Maolin Wang, Jianwei Chen, Xiang LiAbstractThree new lignan glycosides, (7R,8S)-4-hydroxy-3,5′-dimethoxy-4′,7-epoxy-8,3′-neoligna-9,9′-diol-4-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (1), (7S,8R)-4-hydroxy-3,5,5′-trimethoxy-4′,7-epoxy-8,3′-neoligna-9,9′-diol-4-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (2) and (7S,7′S,8R,8′R)-4,4′-dihydroxy-3,5,3′,5′-tetramethoxy-7,9′:7′,9-diepoxylignane-4-O-&b...
Source: Phytochemistry Letters - March 22, 2019 Category: Chemistry Source Type: research

Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Chu Chu, Tuo Li, Hans Albert Pedersen, Kenneth T. Kongstad, Jizhong Yan, Dan StaerkAbstractType 2 diabetes is a chronic metabolic disorder affecting millions of people worldwide, and new drug leads are urgently needed. The dried stem of Dendrobium officinale is used in China to alleviate the symptoms of diabetes, but investigations of its bioactive components have been limited. We have applied a simple, fast, and effective method, combining triple high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibit...
Source: Phytochemistry Letters - March 21, 2019 Category: Chemistry Source Type: research

Prenyl bibenzyls isolated from Chinese liverwort Radula amoena and their cytotoxic activities
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Shenghua Fan, Rongxiu Zhu, Jinchuan Zhou, Yi Li, Yanan Qiao, Chunyang Zhang, Jiaozhen Zhang, Yun Gao, Wang Chen, Hongxiang LouAbstractSix previously undescribed prenyl bibenzyls Radulamoenins A–F (1–6) and eleven known analogues (7–17) were isolated from the Chinese liverwort Radula amoena Herzog. Their structures were determined based on the analysis of their spectroscopic data and electronic circular dichroism (ECD) calculations. Cytotoxicity tests of all the isolated compounds showed that 2-carbomethoxy-3,5dihydroxystilbene ...
Source: Phytochemistry Letters - March 21, 2019 Category: Chemistry Source Type: research

Two unprecedented nor-iridal esters from Iris wattii Baker and their bioactivities
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Gang Ni, Jia-Yuan Li, De-Quan YuAbstractTwo unprecedented C16 nor-iridal esters (1―2), named iriwattin A (1) and iriwattin B (2), along with one known iridal ester and two known iridal-type triterpenoids were isolated from Iris wattii Baker by comprehensive chromatographic methods. The structures of 1―2 were elucidated by interpretation of extensive spectroscopic analyses (1D and 2D NMR, ESI- and HRESI-MS). The two new compounds have interesting nor-iridal skeleton that are previously undescribed, and therefore constitute a new class of C16 ...
Source: Phytochemistry Letters - March 18, 2019 Category: Chemistry Source Type: research

Inside Front Cover (Editorial Board)
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 16, 2019 Category: Chemistry Source Type: research

Contents (graphical abstracts and research highlights)
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 16, 2019 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 16, 2019 Category: Chemistry Source Type: research

A phenanthroindolizidine glycoside with HIF-1 inhibitory activity from Tylophora atrofolliculata
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Cheng-Yu Chen, Guo-Yuan Zhu, Tang-Gui Xie, Ping-Chuan Jiang, Jing-Rong Wang, Zhi-Hong JiangAbstractA phenanthroindolizidine glycoside 6-O-β-D-glucopyranosyl-tylophorinidine (1), the first glycoside of phenanthroindolizidine alkaloid in nature, was isolated from whole plants of Tylophora atrofolliculata (Asclepiadaceae). Its structure was elucidated by means of spectral and chemical evidences. Compound 1 showed potent inhibitory effect (IC50: 69 ± 13 nM) on hypoxia induced factor-1 (HIF-1) activation. It was disco...
Source: Phytochemistry Letters - March 16, 2019 Category: Chemistry Source Type: research

Metabolites and biological activities of Phoenix dactylifera L. pulp and seeds: A comparative MS and NMR based metabolomics approach
This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the ...
Source: Phytochemistry Letters - March 15, 2019 Category: Chemistry Source Type: research

Antimicrobial gastrodin derivatives isolated from Bacopa procumbens
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Manasés González-Cortazar, Valentín López-Gayou, Jaime Tortoriello, Blanca E. Domínguez-Mendoza, Ada M. Ríos-Cortes, Raúl Delgado-Macuil, Elías E. Hernández-Beteta, Ever A. Blé-González, Alejandro ZamilpaAbstractThe bioassay-guided fractionation of the hydroalcoholic extract from aerial parts of Bacopa procumbens (Mill.) Greenm., allowed to isolate the known phenolic compound arbutin (1) as well as three new gastrodin derivatives which were denominated procumgastrodin A...
Source: Phytochemistry Letters - March 15, 2019 Category: Chemistry Source Type: research

Effect of LED illumination and amino acid supplementation on phenolic compounds profile in Agastache rugosa in vitro cultures
In conclusion, the production of phenolic compounds in A. rugosa in vitro shoots was influenced by the age of the shoot cultures, illumination regime and amino acids supplementation.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 15, 2019 Category: Chemistry Source Type: research

Effect of jasmonic acid and chitosan on triterpenoid production in Calendula officinalis hairy root cultures
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Abdulwadood Shakir Mahmood Alsoufi, Cezary Pączkowski, Anna Szakiel, Marek DługoszAbstractTwo lines of Calendula officinalis in vitro hairy root culture, obtained as a result of transformation with the wild type Agrobacterium rhizogenes strain ATCC 15834, were subjected to elicitation by jasmonic acid and chitosan in the context of possible stimulation of biosynthesis, accumulation and secretion of triterpenoids. Jasmonic acid was found to be a very effective elicitor, increasing both the accumulation of oleanolic acid saponins in the hairy ro...
Source: Phytochemistry Letters - March 11, 2019 Category: Chemistry Source Type: research

Four meroterpenoids from Alternaria alternata isolated from Paeonia lactiflora
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Ju-Tao Wang, Zong-Hui Ma, Guo-Kai Wang, Feng-Qing Xu, Lin Chen, Yang Yu, Gang Wang, Jin-Song LiuAbstractFour new natural meroterpenoids, tricycloalternarenes (TCAs)15b‒18b (1‒4) along with four known TCAs (5‒8) have been isolated from the fermentation broth of Alternaria alternata derived from Paeonia lactiflora. The structures of compounds 1‒4 were elucidated by in-depth analyses of NMR spectra, HRESIMS and optical rotation experiments. Cytotoxic activities of 1‒4 against five selected tumor cell lines were evaluated.Graphical abstrac...
Source: Phytochemistry Letters - March 9, 2019 Category: Chemistry Source Type: research

Biological activity of Aesculus hippocastanum flower extracts on vascular endothelial cells cultured in vitro
In conclusion, HF extract exhibits anti-hyaluronidase activity, antimicrobial properties, and reduces ROS production. These observations may partly justify the use of HF in supporting wound healing.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 6, 2019 Category: Chemistry Source Type: research

Inhibition of cytokine secretion by scrophuloside A3 and gmelinoside L isolated from Verbascum blattaria L. by high-performance countercurrent chromatography
Publication date: Available online 6 March 2019Source: Phytochemistry LettersAuthor(s): Simon-Vlad Luca, Monika Ewa Czerwińska, Laurent Marcourt, Anca Miron, Ana Clara Aprotosoaie, Nina Ciocarlan, Jean-Luc Wolfender, Sebastian Granica, Krystyna Skalicka-WoźniakAbstractThe purpose of this study was to analyze the HPLC-DAD-ESI-Q-TOF-MS/MS profile of the methanolic extract obtained from the aerial parts of Verbascum blattaria L. and develop efficient high-performance countercurrent chromatography (HPCCC) methods for isolation of its major iridoid glycosides. Additionally, the potential anti-inflammatory activities of the ex...
Source: Phytochemistry Letters - March 6, 2019 Category: Chemistry Source Type: research

Polyphenolic profile, antioxidant activity, and pro-inflammatory enzymes inhibition of leaves, flowers, bark and fruits of Cotoneaster integerrimus: A comparative study
Publication date: Available online 5 March 2019Source: Phytochemistry LettersAuthor(s): Agnieszka Kicel, Aleksandra Owczarek, Paulina Gralak, Pawel Ciszewski, Monika A. OlszewskaAbstractComplementary UHPLC-PDA-ESI-MS3, HPLC-PDA-fingerprint, Folin-Ciocalteau, n-butanol/HCl and hide powder assays were employed to study the qualitative and quantitative differences in phenolic composition between different organs (leaves, flowers, bark and fruits) of Cotoneaster integerrimus. The bark and flowers were the richest source of polyphenols (107.0–113.6 mg GAE/g dw of plant material), with the dominating proanthocyanidi...
Source: Phytochemistry Letters - March 6, 2019 Category: Chemistry Source Type: research

Triterpenoid profiles of the leaves of wild and domesticated grapevines
Publication date: Available online 2 March 2019Source: Phytochemistry LettersAuthor(s): Aleksandra Burdziej, Cezary Pączkowski, Agnès Destrac-Irvine, Tristan Richard, Stéphanie Cluzet, Anna SzakielAbstractThe composition of steroids and triterpenoids in the leaves of eight grapevine species was analyzed in order to assess phenotypic differences. Four wild species (Vitis aestivalis Michx., Vitis labrusca L., Vitis riparia Michx., and Vitis vinifera subsp. sylvestris (Gmelin) Hegi) and four domesticated (Vitis vinifera cultivars: Cabernet Sauvignon, Gamay, Marselan, and Merlot) were studied. Although the main ...
Source: Phytochemistry Letters - March 4, 2019 Category: Chemistry Source Type: research

New triterpenoid saponins with cytotoxic activities from Ligularia przewalskii
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Zhuan-Ning Shi, Yu-Dong Wang, Yuan Gong, Hong-Fang Li, Ying ZhuAbstractTwo new triterpenoid saponins, a cycloartane-type triterpenoid saponin (1) and a oleanane-type triterpenoid saponin (2), were isolated from the whole plant of Ligularia przewalskii. Their structures were elucidated based on extensive spectroscopic studies, including IR, UV, HR-ESI-MS, 1D and 2D NMR experiments. (1H-NMR, 13C-NMR, DEPT, 1H-1H COSY, HMBC, HSQC, and NOESY). Their cytotoxic activities were evaluated against six human cancer (HeLa, HepG2, SGC7901, MDA231, HL60, an...
Source: Phytochemistry Letters - March 1, 2019 Category: Chemistry Source Type: research

Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Zheng-Hong Pan, Ling Cheng, De-Sheng Ning, Li-Yan Peng, Yu-Xia Fu, Lian-Chun LiAbstractAs part of our ongoing search for novel and bioactive natural products in Karst plants, two new sesqui-neolignans, difengpienol A (1) and difengpienol B (2), together with two known analogues (3 and 4), were isolated from the stem bark of Illicium difengpi. Their structures were elucidated by analysis of spectroscopic data. Difengpienol A (1) possessed a unique 1, 4-dibenzodioxocine moiety. All isolates were evaluated for inhibitory effects against lipopolysa...
Source: Phytochemistry Letters - March 1, 2019 Category: Chemistry Source Type: research

2,4,6-Trihydroxyphenanthrene, a trans-resveratrol photoreaction byproduct: First evidences of genotoxic risk
In this study we investigated the cytotoxicity and genotoxicity of 2,4,6-trihydroxyphenanthrene (THP), derived from trans-resveratrol photochemical isomerization and electrocyclization. To achieve this goal, we used Caulobacter crescentus as the experimental model for evaluating the colony-forming ability and the SOS response induction of cells exposed to THP. DNA-strand breaks and oxidative damage were assessed by the cell-free pCMut plasmid.The obtained data demonstrated that THP induces a cytotoxic and genotoxic effect of THP even at sub-micromolar concentrations, through a pro-oxidant mechanism leading to DNA damage.Gr...
Source: Phytochemistry Letters - February 26, 2019 Category: Chemistry Source Type: research

Benzyl and phenylethanoid glycosides from the leaves of Magnolia sirindhorniae
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Chutima Srinroch, Poolsak Sahakitpichan, Supanna Techasakul, Nitirat Chimnoi, Somsak Ruchirawat, Tripetch KanchanapoomAbstractA new benzyl triglycoside, benzyl O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-glucopyranoside (1) together with two diastereomer phenylethanoid glycosides, (7R) and (7S)-campneoside I (10, 11) were isolated from the leaves of Magnolia sirindhorniae in addition to 20 known compounds. The structure elucidation of these compounds was based on analyses of physical and spectroscopic da...
Source: Phytochemistry Letters - February 26, 2019 Category: Chemistry Source Type: research

Phytochemical analysis and biological activity of Lupinus luteus seeds extracts obtained by supercritical fluid extraction
Publication date: Available online 23 February 2019Source: Phytochemistry LettersAuthor(s): Bogusław Buszewski, Katarzyna Rafińska, Aleksandra Cvetanović, Justyna Walczak, Aneta Krakowska, Joanna Rudnicka, Zoran ZekovićAbstractThe article describes a possible application of Sc-CO2 extraction for isolation of polyphenols from germinated lupin seeds. Efficiency of germination duration was valorized, and the obtained results suggest that six-day-long germination process provides samples with the highest polyphenolic yield. Optimization of extraction parameters was done by using response surface methodology (RSM). Extracts...
Source: Phytochemistry Letters - February 25, 2019 Category: Chemistry Source Type: research

Phosphodiesterase-1 inhibitory potential of several natural products by molecular docking approach
Publication date: Available online 23 February 2019Source: Phytochemistry LettersAuthor(s): Abdur Rauf, Muslim Raza, Muhammad Saleem, Ilkay Erdogan Orhan, Ufuk Ozgen, Esen Sezen Karaoglan, Gulin Renda, Erhan PalaskaAbstractNatural products of herbal origin are well-known to exhibit diverse biological activities. In the present study, a number of natural compounds of plant origin; luteolin 5-O-β-glucoside (1), methyl rosmarinate (2), apigenin (3), vicenin 2 (4), lithospermic acid (5), soyasaponin II (6), and rubiadin 3-O-β-primeveroside (7) were tested at 0.5 mM using ELISA microtiter assay against phosphod...
Source: Phytochemistry Letters - February 25, 2019 Category: Chemistry Source Type: research

MS/MS and UPLC-MS profiling of triterpenoid saponins from leaves and roots of four red beet (Beta vulgaris L.) cultivars
Publication date: Available online 21 February 2019Source: Phytochemistry LettersAuthor(s): Agnieszka Mroczek, Ireneusz Kapusta, Anna Stochmal, Wirginia JaniszowskaAbstractTriterpene saponins from the leaves of red beet (Beta vulgaris L.) were qualitatively profiled using electrospray ionization tandem mass spectrometry (ESI-MS/MS). Results indicated that red beet leaves contain 11 saponins, including oleanolic acid aglycone and a varying number of sugars plus acetyl or methyl groups. We identified and studied two additional saponins other than the nine reported previously from red beets. Relative quantification was undert...
Source: Phytochemistry Letters - February 23, 2019 Category: Chemistry Source Type: research