Zonal distribution of neutral aroma components in flue-cured tobacco leaves
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Jian-An Wang, Gai-He Yang, Chun-Xia Li To understand the regional distributions of neutral aroma components (NACs) of interest in flue-cured tobacco (Nicotiana tabacum L.), samples from a single cured leaf lamina were taken at 48 distinct points with the help of a thin transparent plastic board. We investigated 28 NACs belonging to five categories, namely aromatic amino acid cleavage substances (ACS), cembratriendid alkyl degrading products (CADP), carotenoid degradation products (CDP), chlorophyll degradation products (CDPS), and Maillard re...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

A new phenylpropane-pimarane heterodimer and a new ent-kaurene diterpene from the husks of Oryza sativa
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Qiang Zhang, Qiao-Lin Xu, Xiao-Mei Xia, Li-Mei Dong, Bi Luo, Wen-Bin Liu, Jian-Wen Tan A new phenylpropane-pimarane heterodimer, 2-[(E)-3-(4-hydroxy-3-methoxyphenyl) allylidene] momilactone A (1), and a new ent-kaurene diterpene, ent-3α,16α-dihydroxy-kauran-19-oic acid (2), were isolated from the rice husks of Oryza sative L., along with a known ent-kaurene diterpenoid ent-7-oxo-kaur-15-en-19-oic acid (3). Their structures were determined by spectroscopic means, including nuclear magnetic resonance (NMR) and mass spectrometry (MS)...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves
This study demonstrated that novel compounds isolated from C. zeylanica seem to be mediating potent cytotoxic effects in breast cancer cells through activation of caspase 3/7. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Furan fragment isomerized mexicanolide-type Limonoids from the stem barks of Khaya senegalensis
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Wen-Yan Zhang, Lu Qiu, Qin-Pei Lu, Miao-Miao Zhou, Jun Luo, Yi Li Four new mexicanolide-type limonoids with isomerized furan fragment khaysenelides G–J (1–4) were isolated from the stem barks of Khaya senegalensis. Their structures were elucidated on the basis of (1D and 2D) NMR and HRESIMS, and the normal furan rings in 1-4 were isomerized to hydroxybutenolide moieties. Bioactivities screening of new compounds indicated that 1 showed potent cytotoxicities against MDA-MB-231 and HepG2 human cancer cell lines with IC50 values of 6....
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Phytochemical constituents and chemosystematic significance of Pulicaria jaubertii E.Gamal-Eldin (Asteraceae)
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Abdelsamed I. Elshamy, Tarik A. Mohamed, Mona M. Marzouk, Taha A. Hussien, Akemi Umeyama, Mohamed Elamir F. Hegazy, Thomas Efferth The chemical characterization of methylene chloride/methanol (1:1) extract of the air-dried whole medicinal plant, Pulicaria jaubertii E. Gamal-Eldin, led to isolation and identification of two new hydroquinone compounds; 2-(2-acetoxy propyl), 5-methyl hydroquinone (1) and 2-(2-hydroxy propyl), 5-methyl hydroquinone-4-O-β-D-glucopyranoside (2), four known flavonols (3-6) and 7 known dihydroflavonols (7-13). T...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Novel macamides from maca (Lepidium meyenii Walpers) root and their cytotoxicity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Chen Xia, Jian Chen, Jun-Lin Deng, Yong-Qing Zhu, Wan-Yi Li, Bu Jie, Tian-Yuan Chen Maca, Lepidium meyenii Walpers (Brassicaceae), contains secondary metabolites, including macamides, which possess many bioactive properties. Two new macamides, namely, N-benzyl-9-oxo-10E,12E-octadecadienamide (3) and N-benzyl-9-oxo-10E,12Z-octadecadienamide (4), were isolated from maca root. In addition, two fatty acid derivatives, 9-oxo-10E,12E-octadecadienoic acid (1) and 9-oxo-10E,12Z-octadecadienoic acid (2), were found for the first time from maca. The str...
Source: Phytochemistry Letters - March 17, 2018 Category: Chemistry Source Type: research

Identification of compounds with cytotoxic activity from Millettia dorwardi Coll. Et. Hemsl
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Kai Chen, Huan Tang, Li Zheng, Lun Wang, Linlin Xue, Ai-hua Peng, Ming-hai Tang, Chaofeng Long, Xiaoxin Chen, Hao-yu Ye, Li-juan Chen Two new lignan derivatives and nine known compounds were isolated from the EtOAc and n-BuOH extracts of Millettia dorwardi Coll. Et. Hemsl. The structures of the compounds were determined by 1D and 2D NMR, CD and HRMS. Then, cytotoxic effects of these compounds were evaluated against five cancer cell lines (HepG2, HCT116, MCF7, Raji and KG-1). Results showed the isolated compounds have no obvious cytotoxic activ...
Source: Phytochemistry Letters - March 17, 2018 Category: Chemistry Source Type: research

Scumoniliosides A and B, two new flavanone glucuronate esters from Scutellaria moniliorrhiza Komarov with anti-inflammatory activities
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Qing-Tong Han, Kai Xiao, Kang-Lin Xiang, Gui-Sheng Li, Sheng-Jun Dai Two new flavanone glucuronate esters, named scumoniliosides A and B (1-2), along with two known flavonoid glucuronate esters, 5,4′-dihydroxyflavonoid-7-O-β-d-glycuronate methyl ester (3) and 5,4′-dihydroxyflavonoid-7-O-β-d-glycuronate butyl ester (4), were isolated from the ethanolic extract of the whole plant of Scutellaria moniliorrhiza. Their chemical structures including absolute configurations were determined by means of integrated spectroscopic tec...
Source: Phytochemistry Letters - March 16, 2018 Category: Chemistry Source Type: research

Excoecarins L and O from the mangrove plant Excoecaria agallocha L.
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Nguyen Van Thanh, Lai Hop Hieu, Phan Thi Thanh Huong, Le Thi Vien, Tran My Linh, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam, Ngo Dai Quang, Chau Van Minh Two new beyerene-type diterpenoids (1 and 2), along with six known metabolites (3-8) were isolated from the twigs and leaves of the mangrove plant Excoecaria agallocha L. collected from coastal areas in Vietnam. The structures and relative configurations of new compounds were established on the basis of HR-ESI-MS, 1D and 2D NMR experiments. Two new metabolites were tested for cytoto...
Source: Phytochemistry Letters - March 16, 2018 Category: Chemistry Source Type: research

GC –MS detection of plant pigments and metabolites in Roman Julio-Claudian wall paintings
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Angelo Gismondi, Lorena Canuti, Giulia Rocco, Marcella Pisani, Alessandra Ghelli, Margherita Bonanno, Antonella Canini For the first time, plant pigments were detected in Roman frescoes. Indeed, only sporadic papers proved the application of natural hues in ancient paintings and none of them relative to Roman art. Therefore, eight differently coloured fragments of Julio-Claudian wall paintings, collected from Terme degli Stucchi Dipinti archaeological site (Rome, Italy), were subjected to GC–MS analysis, obtaining detailed chemical profi...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Rui Zhang, Chunping Tang, Yan Li, Chang-Qiang Ke, Ge Lin, Hua Xie, Sheng Yao, Yang Ye The first phytochemical investigation of the fruits of Rhododendron websterianum resulted in the isolation of two new triterpenoids, 11-dehydroxytrisnormogrol acid (1), 11-dehydroxytrisnormogrol (2), and 21 known analogues. Their structures were determined by extensive analysis of spectroscopic and mass data, as well as by comparison with those in literature. All isolates were assayed their cytotoxic activities on human hepatoma SMMC-7721 cells and human lung...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

Chemical constituents of root and stem bark of Erythrina brucei
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Getahun Tadesse Gurmessa, Souvik Kusari, Hartmut Laatsch, Gomotsang Bojase, Godiraone Tatolo, Ishmael B. Masesane, Michael Spiteller, Runner R.T. Majinda Two new isoflavanones, erybrucein A and B (1, 2), together with nineteen known compounds are reported herein from the stem and root bark of the Ethiopian medicinal plant, Erythrina brucei. All known compounds, except erythraline (19), have been isolated for the first time from E. brucei. Their structures were established on the basis of extensive spectroscopic and spectrometric analyses (1D a...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

Protective effects of dammarane-type triterpenes from hydrolyzate of Gynostemma pentaphyllum against H2O2-induced injury and anti-hepatic fibrosis activities
In this study, phytochemical investigation of hydrolyzate of total G. pentaphyllum saponins led to the isolation of three previously undescribed triterpenes, Gypensapogenin R (1), Gypensapogenin S (2), and Gypensapogenin T (3). Their structures were mainly identified by 1D, 2D-NMR and HR-ESI–MS evidences. Anti-hepatic fibrosis activity was determined and the data showed that 2 and 3 exhibited more potent inhibitory effects (IC50 values 14.93 and 29.19, respectively) on the growth of t-HSC/Cl-6 cells than Silymarin (positive control), while having much weaker effect in the growth of normal cell. Additionally, all the ...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Corrigendum to “Investigation of chemical constituents from Spiraea prunifolia var. simpliciflora and their biological activities” [Phytochem. Lett. 22 (2017), 255–260]
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Chung Sub Kim, Joonseok Oh, Won Se Suh, Sung Wan Jang, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Monoterpene, benzyl and 3,4-dihydroxyphenethyl glycosides from Magnolia thailandica
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Tripetch Kanchanapoom, Poolsak Sahakitpichan, Nitirat Chimnoi, Chutima Srinroch, Wassapol Thamniyom, Somsak Ruchirawat A new monoterpene glucoside, (3S,6S)-6,7-dihydroxy-6,7-dihydrolinaloyl 6-O-β-d-glucopyranoside, along with two new aromatic glycosides, benzyl O-α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranoside and 3,4-dihydroxyphenethyl O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl−(1 → 3)]-β-d-glucopyranoside were isolated from Magnolia thailandica. Additionally, 29 known ...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Pahangine A and B, two new oxetane containing neolignans from the barks of Beilschmiedia glabra Kosterm (Lauraceae)
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Syazreen Nadia Sulaiman, Azeana Zahari, Sook Yee Liew, Marc Litaudon, A.M. Issam, Habibah A. Wahab, Khalijah Awang Phytochemical investigation on the barks of Beilschmiedia glabra Kosterm led to the isolation of two new oxetane containing neolignans, Pahangine A (1) and Pahangine B (2) together with eight known compounds. The structures of isolated compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR (1H–1H COSY, HSQC, and HMBC), DEPT-Q NMR, and by comparing with the published data. A possible biosyntheti...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Juan Xiong, Xi-Ying Wu, Pei-Pei Wang, Choiwan Lau, Hui Fan, Guang-Lei Ma, Yu Tang, Jia Li, Jin-Feng Hu Two new (1 and 2) and 10 known (3−12) acylated iridoid diglycosides were isolated from the twigs and leaves of the cultivated endangered ornamental plant Gmelina hainanensis. Based on spectroscopic data interpretation and chemical transformation, the new triacyl and the new diacyl iridoid diglycosides were established to be 6-O-α-L-(2″,3″-di-O-acetyl-4″-O-cis-cinnamoyl)rhamnopyranosylcatalpol (1) and 6-O-α-...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Garcixanthones B and C, new xanthones from the pericarps of Garcinia mangostana and their cytotoxic activity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Sabrin R.M. Ibrahim, Hossam M. Abdallah, Ali M. El-Halawany, Mohammed F. Radwan, Ibrahim A. Shehata, Essam M. Al-Harshany, Mohamed F. Zayed, Gamal A. Mohamed Two new prenylated xanthones, garcixanthones B (1) and C (2) and six known metabolites: gartanin (3), 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (4), rubraxanthone (5), 1,3,6,7-tetrahydroxy-8-prenylxanthone (6), garcinone C (7), and xanthone I (9-hydroxycalabaxanthone) (8) were separated from the EtOAc-soluble fraction of the air-dried pericarps of Gar...
Source: Phytochemistry Letters - March 10, 2018 Category: Chemistry Source Type: research

Bioactive triterpenoid glycosides from the twigs and leaves of Camellia reticulata
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Qi-Run Chen, Dan Li, Xu-Jie Qin, Hui Liu, Wei Ni, Huan Yan, Li He, Qing Zhao, Xiao Ma, Hai-Yang Liu Four previously undescribed oleanane-type triterpenoid glycosides (dianshanchaosides A–D) were isolated from the twigs and leaves of Camellia reticulata, together with seven known analogues. Their structures were established by comprehensive spectroscopic data and chemical methods The triterpenoid glycosides were evaluated their inhibitory effects on the LPS-induced NO production in RAW264.7 macrophages and cytotoxicities against five huma...
Source: Phytochemistry Letters - March 10, 2018 Category: Chemistry Source Type: research

NMR-based metabolomics study of Amphoricarpos species from Montenegro
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Mirjana Cvetković, Boban Anđelković, Vladimir Stevanović, Milka Jadranin, Iris Đorđević, Vele Tešević, Slobodan Milosavljević, Dejan Gođevac The genus Amphoricarpos Vis. is endemic of westpart of Balkan peninsula. In order to get more insight into the ambiguous taxonomy of the genus, the metabolomic study of the Amphoricarpos samples, has been undertaken. The1H NMR spectroscopy combined with multivariate data analysis has been applied. OPLS-DA has been shown to be the best method for clear discrimination of these samples based...
Source: Phytochemistry Letters - March 9, 2018 Category: Chemistry Source Type: research

Three eudesmanolide δ-lactones of Wedelia trilobata
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Shi-Fei Li, Jia-Yin Ding, Shun-Lin Li An ongoing phytochemical investigation of the whole plant of Wedelia trilobata, which is one of the 100 most invasive species in the world, led to the isolation of three new eudesmanolide δ-lactones wedelolides K-M (1-3). Their structures and relative configurations were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments (UV, IR, HRESIMS, 1D and 2D NMR). Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Non-destructive quality assessment of herbal tea blends using hyperspectral imaging
In this study, hyperspectral imaging is applied as a fast and non-destructive method for the quality control of herbal tea blends. The technique combines conventional spectroscopy and digital imaging to gather chemical information and visualise spatial distribution of chemical constituents within a matrix. Certified raw materials (Sceletium tortuosum and Cyclopia genistoides) and herbal tea blends were acquired from Parceval Pty (Ltd). Hyperspectral images of the raw material and tea blends were captured on a SisuChema® SWIR (short wave infrared) hyperspectral pushbroom imaging system using ChemaDAQ® software. The ...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Cytotoxic secondary metabolites from the endophytic fungus Aspergillus versicolor KU258497
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Sherif S. Ebada, Mona El-Neketi, Weaam Ebrahim, Attila Mándi, Tibor Kurtán, Rainer Kalscheuer, Werner E.G. Müller, Peter Proksch Two new isocoumarin dimers (1 and 2) and one new dihydroquinolone derivative (3) were isolated from Aspergillus versicolor, an endophyte derived from leaves of the Egyptian water hyacinth Eichhornia crassipes (Pontederiaceae), together with ten other known metabolites. Chemical structures of the isolated metabolites were determined based on HRESIMS, extensive 1D and 2D NMR spectroscopy. The relati...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Leucodine blocks mitotic clonal expansion during preadipoctye differentiation through cell cycle arrest
In this study, we investigated the effect of 11,13 dihydro-[11R]-dehydroleucodine (i.e., leucodine), a sesquiterpene lactone obtained from the reduction of dehydroleucodine, on adipogenesis of 3T3-L1 preadipocyte. 11,13 dihydro-[11R]-dehydroleucodine blocked the accumulation of lipid droplets stained with Oil Red O and inhibited the increase of triglycerides in the adipocytes (IC50: 71.0 ± 4.1 μM). Expressions of Glut-4, adiponectin and perilipin-2 were blocked in the presence of 11,13 dihydro-[11R]-dehydroleucodine. Furthermore, expression of PPARγ and C/EBPα was significantly inhibited by 11,1...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Daphnicyclidin M, a new alkaloid from Daphniphyllum paxianum Rosanth
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Li Zhang, GuoHu Zhao, CaiLing Yang, Lin Bai, HaiXia Liu A new daphniphyllum alkaloid daphnicyclidin M (1), containing one rare cyclopentadienyl anion, was isolated from the stems and leaves of Daphniphyllum paxianum Rosanth along with five known alkaloids, longistylumphylline A (2), caldaphnidine A (3), caldaphnidine E (4), daphnilongeranin A (5), and 2-hydroxyyunnandaphnine D (6). The structures were elucidated on the basis of spectroscopic data, and the absolute configuration of 1 was assigned by single-crystal X-ray diffraction crystallogr...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Protein tyrosine phosphatase 1B inhibitory components and a new unique N-alkylamide derivative with an endoperoxide bridge from aerial parts of Indonesian Spilanthes paniculata
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Delfly B. Abdjul, Hiroyuki Yamazaki, Wilmar Maarisit, Ryota Kirikoshi, Ohgi Takahashi, Fitje Losung, Magie M. Kapojos, Michio Namikoshi Research on protein tyrosine phosphatase (PTP) 1B inhibitors from terrestrial and marine natural resources identified N-isobutyl-2E-decenamide (1) and 3,4,5-tri-O-caffeoylquinic acid (2) as PTP1B inhibitory substances together with a new N-alkylamide (3) and two known congeners (4 and 5) from the aerial parts of Indonesian Spilanthes paniculata. The structure of 3 was elucidated as (2E, 7Z)-6,9-endoperoxy-N-2...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

A new monoterpene and a new sesquiterpene from the roots of Ageratina adenophora
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Bi Luo, Li-Mei Dong, Qiao-Lin Xu, Xu Xhang, Qiang Zhang, Wen-Bin Liu, Jian-Wen Tan A new thymol type monoterpene, 2α-methoxyl-3β-methyl-6-(acetyl-O-methyl)-2,3-dihydrobenzofuran (1), and a new cadinane-type sesquiterpenoid, 1,6-dihydroxy-1-isopropyl-4,7-dimethyl-3,4-dihydronaphthalen-2(1H)-one (2), were isolated from the roots of Ageratina adenophora, along with four known compounds, eupatorenone (3), 3-hydroxymuurola-4,7(11)-dien-8-one (4), 9-oxoageraphorone (5) and (4R,5S)-4-Hydroxy-5-isopropyl-2-methyl-2-cyclohexehone (6). Their...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Triterpenoid saponins and phenylpropanoid glycosides from the roots of Polygala japonica Houtt. with anti-inflammatory activity
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Tran Hong Quang, Pham Thanh Cong, Duong Thi Hai Yen, Nguyen Xuan Nhiem, Bui Huu Tai, Pham Hai Yen, Nguyen Thi Thanh Ngan, Dong Cheol Kim, Youn-Chul Kim, Hyuncheol Oh, Chau Van Minh, Phan Van Kiem Phytochemical study of the roots of Polygala japonica resulted in the isolation of a new triterpenoid saponin, polyjaposide A (1), a new phenylpropanoid glycoside, japonicaside A (6), and 10 known compounds: tenuifolin (2), polygalasaponin XXVIII (3), polygalasaponin XLVII (4), fallaxsaponin A (5), β-d-[(1-O-cinnamoyl)-(3-O-benzoyl)]-fructofuran...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Sesquiterpenoids from the aerial parts of Pogostemon cablin
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Ou Dai, Xiao-Hong Li, Qin-Mei Zhou, Cheng Peng, Li Guo, Liang Xiong Six sesquiterpenoids including three previously undescribed ones (1–3) were isolated from the essential oil of the aerial parts of Pogostemon cablin. Their structures were determined to be (+)-(1S,4R,6S,7R,10S)-1-hydroxycadinan-12-ene-5-one (1), 11-dehydroxy-cinnamosin A (2), and 1-methoxy-senecrassidiol (3) by extensive spectroscopic analyses. This is the first report of cadinane-, cyperane-, and caryolane-type sesquiterpenoids from the genus Pogostemon. Particularly, ...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Nurulfazlina Edayah Rasol, Fasihuddin Badruddin Ahmad, Xiang-Yin Lim, Felicia Fei-Lei Chung, Chee-Onn Leong, Chun-Wai Mai, Nur Vicky Bihud, Hamizah Mohd Zaki, Nor Hadiani Ismail Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along with two known naphthoquinone alkaloids, 2-acetyl-3-amino-5-hydroxy-1,4-naphthoquinone (3) and cleistopholine (4) were isolated from the cytotoxic, dichloromethane root extract of Goniothalamus lanceolatus (Annonaceae). The structures were elucidated by spectroscopic ...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Bioactive hydroanthraquinones from endophytic fungus Nigrospora sp. BCC 47789
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Jittra Kornsakulkarn, Wilunda Choowong, Pranee Rachtawee, Nattawut Boonyuen, Surisa Kongthong, Masahiko Isaka, Chawanee Thongpanchang A new hydroanthraquinone, nigrosporone A (1), and a new naturally occurring nigrosporone B (2), together with eleven known compounds, were isolated from an endophytic fungus, Nigrospora sp. BCC 47789. The structure of nigrosporone A was confirmed by X-ray crystallographic analysis. The absolute configurations of nigrosporone B were determined by the modified Mosher’s method. Nigrosporone B exhibited a bro...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Metabolic response of Aspergillus sydowii to OSMAC modulation produces acetylcholinesterase inhibitors
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Gesiane da Silva Lima, Aline Mendes da Rocha, Gabriel Franco dos Santos, Alice Ferreira D’Silva, Ivanildo Evódio Marriel, Jacqueline Aparecida Takahashi Fungi are an extraordinary source of bioactive metabolites especially because their metabolic profile can be modulated according to the conditions under which they are grown, a strategy known as OSMAC. Aspergillus sydowii has been showing to be a fungal species with a series of interesting biosynthetic pathways, but production of acethylcholinesterase inhibitors was still not suf...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Anti-oxidant and anti-inflammatory effects of new bibenzyl derivatives from Dendrobium parishii in hydrogen peroxide and lipopolysaccharide treated RAW264.7 cells
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Virunh Kongkatitham, Chawanphat Muangnoi, Napat Kyokong, Wuttinont Thaweesest, Kittisak Likhitwitayawuid, Pornchai Rojsitthisak, Boonchoo Sritularak Oxidative stress and inflammatory responses are the main causes of various diseases and disorders. To prevent these incidents, antioxidant and anti-inflammatory agents are needed. Dendrobium parishii, known in Thai as “Ueang Khrang Sai San” was studied for chemical constituents by solvent extraction, followed by column chromatography. Seven compounds including two new (1–2) and ...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Crinane, augustamine, and β-carboline alkaloids from Crinum latifolium
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Tran Thi Hong Hanh, Do Hoang Anh, Phan Thi Thanh Huong, Nguyen Van Thanh, Nguyen Quang Trung, Tran Van Cuong, Nguyen Thi Mai, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh Three new crinane-type alkaloids, namely, 6-methoxyundulatine (1), 6-methoxycrinamidine (2), and undulatine N-oxide (3), along with the known compounds 6-hydroxyundulatine (4), 6-hydroxybuphanidrine (5), undulatine (6), crinamidine (7), ambelline (8), filifoline (9), augustamine (10), and perlolyrine (11), were isolated from the leaves of Crinum latifo...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Three novel epoxy-clerodanes bearing a furan ring from Croton hypoleucus
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): René Velázquez-Jiménez, Diego Vargas-Mendoza, Juan A. Gayosso-de-Lucio, Simplicio González-Montiel, José Roberto Villagómez-Ibarra Three new epoxy-clerodanes bearing a furan ring hypoleins A–C, were isolated from the aerial parts of Croton hypoleucus, along with the known compounds crotonpenes A and B. The structure of all compounds was elucidated on the basis of extensive ID and 2D NMR and mass (HR-ESIMS) spectroscopic data analyses. All of them possess an epoxy ring at C-3/C-4, and one furan r...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Coumarins from Juglans Mandshurica Maxim and their apoptosis-inducing activities in hepatocarcinoma cells
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Li-Li Lou, Rui Guo, Zhuo-Yang Cheng, Peng Zhao, Guo-Dong Yao, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song Phytochemical investigation of the bark of Juglans mandshurica led to the isolation of two new coumarins, juglansoside A–B (1–2), along with five known compounds (3–7). The structures of new compounds were elucidated by comprehensive spectroscopic analyses. All compounds were evaluated for their cytotoxicity in vitro using two human hepatocellular carcinoma cell lines (Hep3B and HepG2). Among them, compounds 1 and 2 d...
Source: Phytochemistry Letters - January 23, 2018 Category: Chemistry Source Type: research

Protein tyrosine phosphatase 1B inhibitory polybromobiphenyl ethers and monocyclofarnesol-type sesquiterpenes from the Indonesian marine sponge Lamellodysidea cf. herbacea
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Magie M. Kapojos, Delfly B. Abdjul, Hiroyuki Yamazaki, Ryota Kirikoshi, Ohgi Takahashi, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Kazuyo Ukai, Michio Namikoshi Three known polybromobiphenyl ether derivatives, 2-(2′,4′-dibromophenoxy)-3,5-dibromophenol (1), 2-(2′,4′-dibromophenoxy)-4,6-dibromophenol (2), and 2-(2′-dibromophenoxy)-3,4,5,6-tetrabromophenol (3), were identified as PTP1B inhibitors from the Indonesian marine sponge Lamellodysidea sp. (cf. L. herbacea) together with two new monocy...
Source: Phytochemistry Letters - January 23, 2018 Category: Chemistry Source Type: research

Four new C19-diterpenoid alkaloids from Delphinium elatum
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Hiroshi Yamashita, Megumi Katoh, Akane Kokubun, Ayano Uchimura, Sakina Mikami, Ayana Takeuchi, Kyousuke Kaneda, Yuji Suzuki, Megumi Mizukami, Masuo Goto, Kuo-Hsiung Lee, Koji Wada Diterpenoid alkaloids with remarkable chemical properties and biological activities are frequently found in plants of the genera Aconitum, Delphinium, and Garrya. Accordingly, several C19-diterpenoid alkaloid components from Delphinium elatum cv. Pacific Giant, as well as their derivatives, exhibited cytotoxic activity against lung, prostate, nasopharyngeal, and vin...
Source: Phytochemistry Letters - January 6, 2018 Category: Chemistry Source Type: research

NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Clinton G.L. Veale, Weiyang Chen, Sushil Chaudhary, Sarah N. Kituyi, Michelle Isaacs, Heinrich Hoppe, Adrienne L. Edkins, Sandra Combrinck, Bewketu Mehari, Alvaro Viljoen Chemical interrogation of the Sceletium genus and Amaryllidaceae family of plants has yielded a diverse array of aryl-hydroindole containing alkaloids. Included in this class is channaine, which was tentatively identified, without comprehensive structural elucidation from Sceletium tortuosum in 1957. Following its isolation from S. strictum, the structure of channaine was...
Source: Phytochemistry Letters - January 4, 2018 Category: Chemistry Source Type: research

Secondary metabolites from the aerial parts of Cytisus villosus Pourr.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Farida Larit, Manal A. Nael, Samira Benyahia, Mohamed M. Radwan, Francisco León, Izabela Jasicka-Misiak, Anna Poliwoda, Dorota Wieczorek, Fadila Benayache, Samir Benayache, Piotr P Wieczorek, Stephen J. Cutler Phytochemical investigation of the aerial parts of Cytisus villosus Pourr. resulted in the isolation and characterization of a new isoflavan, (3S, 4S)-2ʹ,4ʹ-dihydroxy-3ʹ-methoxy-6,7-methylenedioxyisoflavan-4-ol (1), and a new monoterpene, (4R,6S )-4-hydroxy-2,2,6-trimethyl-9-oxabicyclo [4.2.1] non-1(8)-en-7-one (2), together w...
Source: Phytochemistry Letters - December 27, 2017 Category: Chemistry Source Type: research

Two new tricycloalternarene acids from the marine-derived fungus Alternaria alternata ICD5-11
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Sheng-Tao Fang, Feng-Ping Miao, Xiang-Hong Liu, Yin-Ping Song, Nai-Yun Ji Two new meroterpenoids, named tricycloalternarenes K (1) and L (2), together with one known analog (3) were isolated from the marine-derived fungus Alternaria alternata ICD5-11, which was obtained from marine isopod Ligia exotica. Their structures and relative/absolute configurations were elucidated by extensive spectroscopic methods, including 1D/2D NMR, CD, and mass spectra and by comparison with literature data. The antimicrobial activities of two new compounds we...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

Foliar flavonol concentration in Sclerocarya birrea saplings responds to nutrient fertilisation according to growth-differentiation balance hypothesis
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Peter F. Scogings The growth-differentiation balance hypothesis (GDBH) postulates a nonlinear, ‘hump-shaped’ response of plant secondary metabolites (PSMs), such as flavonoids, in relation to nitrogen (N) availability. The response is most easily detected when there are at least five levels of N availability, but very few studies that directly or indirectly tested the GDBH have used three or more levels. Fifty Sclerocarya birrea (marula) saplings (mean basal diameter = 35.5 mm, SEM = 0.52; mean height = 80.9 cm,...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

Prenylated biflavonoids from the green branches of Garcinia dulcis
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Ilham Abdullah, Souwalak Phongpaichit, Supayang Piyawan Voravuthikunchai, Wilawan Mahabusarakam The green branches extract of Garcinia dulcis was studied in the search for biflavonoids. Two new prenylated biflavonoids, named dulcisbiflavonoid B (1) and dulcisbiflavonoid C (2), along with 6 previously reported biflavonoids and flavonoids were isolated from the acetone extract of the green branches of G. dulcis. The structures of the isolates were determined on the basis of spectroscopic analysis and the data was compared with those previous...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

Three new 3,4-seco-cycloartane triterpenoids from the flower of Gardenia jasminoides
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Li-Sha Zhang, Yan-Lan Wang, Qian Liu, Chang-Xin Zhou, Jian-Xia Mo, Li-Gen Lin, Li-She Gan Three new 3,4-seco-cycloartane triterpenoids (1-3), including an unusual C-1 oxygenated 3,4-seco-cycloartane triterpenoid lactone (3), along with six known triterpenoids, were isolated from 95% ethanol extract of the flower of Gardenia jasminoides. Their structures were determined by spectroscopic methods, especially 2D NMR and HRESIMS techniques. Compounds 3, 4 (dikamaliartane D), and 7 (ursolic acid) showed promising cytotoxic activity against HepG2...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Yushuang Liu, Jingjing Xue, Jianxin Han, Huiming Hua, Tao Yuan Two new polyacetylenes, (2R,11S,12S)-(3E)-tridecene-5,7,9-triyne-1,2,11,12-tetraol (1) and (8S)-deca-4,6-diyne-1,8-diol-8-O-β-d-glucopyranoside (2), together with six known polyacetylenes (3–8), were isolated from the florets of Carthamus tinctorius. Their structures were elucidated on the basis of spectroscopic data (NMR and HRMS) and Mo2(OAc)4-induced circular dichroism. Compounds 4 and 5 were cytotoxic to the human cancer cell lines HL-60 (IC50 = 6.40, 3.66 ...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

Cyclopurpuracin, a cyclopeptide from Annona purpurea seeds
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): María Rosa González-Tepale, Lino Reyes, Marlen Mayorga-Flores, Benito Reyes-Trejo, David Gómez-Zepeda, Federico del Rio-Portilla, José Juan Ordaz-Ortiz, José Enrique Herbert-Pucheta From a 60% hydroalcoholic extract of the seeds of Annona purpurea, a novel cyclooctapeptide, cyclopurpuracin (1), or cyclo(-Pro1-Gly2-Phe3-ILe4-Gly5-Ser6-Pro7-Val8-), has been isolated. The structure of cyclopurpuracin (1) was determined by de novo sequencing based on MS/MS spectra and 1D and 2D NMR techniques (1H, 13C, HSQC, ...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome
Conclusion The anabolic steroid 1,4-androstadiene-3,17-dione was not detectable in the Rhodiola rosea roots and rhizomes, at least not present in amounts which may be a concern for athletes who want to avoid the consumption of this anabolic agent with Rhodiola dietary supplementation. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

Seven new phenolic compounds from Lavandula angustifolia
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Nigary Yadikar, Khayrulla Bobakulov, Gen Li, Haji Akber Aisa Seven new phenolic compounds: lavandunat (1), lavandufurandiol (2), lavandufluoren (3), lavandupyrones A (4) and B (5), and lavandudiphenyls A (6) and B (7), along with five known compounds, 4-(1-hydroxy-1-methylethyl) benzoic acid (8), methyl 3-(3,4-dihydroxyphenyl)propanoate (9), 3,4,α-trihydroxyl-ethyl phenylpropionate (10), rosmarinic acid (11), and isosalvianolic acid C (12), were isolated from the ethyl acetate extract of the remaining material, which was obtained fro...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

Alkenyl cyclohexanone derivatives from Lannea rivae and Lannea schweinfurthii
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Souaibou Yaouba, Andreas Koch, Eric M. Guantai, Solomon Derese, Beatrice Irungu, Matthias Heydenreich, Abiy Yenesew Phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Lannea rivae (Chiov) Sacleux (Anacardiaceae) led to the isolation of a new alkenyl cyclohexenone derivative: (4R,6S)-4,6-dihydroxy-6-((Z)-nonadec-14′-en-1-yl)cyclohex-2-en-1-one (1), and a new alkenyl cyclohexanol derivative: (2S*,4R*,5S*)-2,4,5-trihydroxy-2-((Z)-nonadec-14′-en-1-yl)cyclohexanone (2) along with four known compounds, namel...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research

Three new pyrrole alkaloids from the roots of Lepidium meyenii
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Min Zhou, Rui-Qi Zhang, Yan-Jun Chen, Ling-Min Liao, Yan-Qi Sun, Zu-Hong Ma, Qiao-Fen Yang, Ping Li, Yan-Qing Ye, Qiu-Fen Hu Three new pyrrole alkaloids macapyrrolins A–C (1–3) were isolated from the roots of Lepidium meyenii collected from Lijiang, Yunnan province in China. Their structures were elucidated by extensive NMR and MS spectroscopic analyses. Interestingly, macapyrrolins A–C represent the first examples of pyrrole alkaloids found in Lepidium meyenii with a benzyl substituent attached to the pyrrole nucleus. Al...
Source: Phytochemistry Letters - December 23, 2017 Category: Chemistry Source Type: research