14-Noreudesmane sesquiterpenes from leaves of Nicotiana tabacum and their antiviral activity
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Shang Shan-Zhai, Zhao Wei, Tang Jian-Guo, Pu Jian-Xin, Zhu Dong-Lai, Yang Liu, Sun Han-Dong, Yang Guang-Yu, Chen Yong-Kuan Three new 14-noreudesmane sesquiterpenes (1–3) as well as four known ones (4–7) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1–7 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 1 exhibited moderate anti-T...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Alkaloids from Galanthus fosteri
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Ahmet Emir, Ceren Emir, Buket Bozkurt, Mustafa Ali Onur, Jaume Bastida, Nehir Unver Somer Three new alkaloids, oxoincartine, 3,11-O-diacetyl-9-O-demethylmaritidine and 11-O-acetyl-9-O-demethylmaritidine together with seven known compounds namely, incartine, galanthamine, galanthine, 9-O-methylpseudolycorine, N,O-dimethylnorbelladine, hordenine and vittatine were isolated from Galanthus fosteri Baker (Amaryllidaceae). Their structures were elucidated by spectroscopic analyses (UV, IR, MS, CD and 1D/2D NMR). Cholinesterase inhibitory...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Cytochalasins from mangrove endophytic fungi Phomopsis spp. xy21 and xy22
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Yan-Fang Luo, Min Zhang, Jun-Gui Dai, Patchara Pedpradab, Wen-Jing Wang, Jun Wu Chemical investigation of the mangrove fungal endophytes, Phomopsis spp. xy21 and xy22, afforded four new cytochalasins, named phomopsichalasins D-G, along with six known analogues. The structures of these cytochalasins were elucidated on the basis of HRESIMS and extensive NMR spectroscopic data. Phomopsichalasins D (1) and E (2) represent the first two 10-phenyl[11]-cytochalasans containing a 12-carboxyl function. All of the isolates were evaluated for...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Lepidiline C and D: Two new imidazole alkaloids from Lepidium meyenii Walpers (Brassicaceae) roots
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Wenwen Jin, Xuemin Chen, Pengfei Dai, Longjiang Yu Lepidium meyenii Walpers, a well-known crop with a long history in Peru, has been utilized in the Andean region as foodstuff and medical supply. In our study, ethanol extract was obtained from the dried root of this plant and then chemically investigated. Two new imidazole alkaloids, namely, lepidiline C (1) and D (2), along with two known imidazole alkaloids (lepidiline A and B), were isolated through semi-preparative high-performance liquid chromatography (HPLC). Their structures w...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Coixlachryside A: A new lignan glycoside from the roots of Coix lachryma-jobi L. var. ma-yuen Stapf.
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Seong Su Hong, Chun Whan Choi, Yun-Hyeok Choi, Joa Sub Oh A new lignan glycoside, 1-[3,6-(4,4′-dihydroxy-3,3′-dimethoxy-δ-truxinyl)-β-fructofuranosyl]-α-glucopyranoside (1), named coixlachryside A, together with nine known simple phenolic compounds (3–11) were isolated from the roots of Coix lachryma-jobi var. ma-yuen using various chromatographic methods. Their chemical structures were determined based on the spectroscopic data interpretation, particularly circular dichroism (CD), 1D and 2D NMR dat...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Two new P-coumaroyl flavonoid glycosides having Cytokine increasing activity from Centaurium spicatum L
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Ahmed E. Allam, Alaa M. Nafady, Ahmed M.M. Hassanein, Mahmoud A.H. Mostafa, Mohamed A. El-Shanawany, Fumide Takano, Tomihisa Ohta Two new P-coumaroyl flavonol glycosides, Kaempferol 3-O-[β-D-glucopyranosyl- (1→4)-α-l-rhamnopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-(4 trans- P-coumaroyl)]-β-D- galactopyranoside (1) and Quercetin 3-O-[β-D-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-(4 trans- P-coumaroyl)]-β-D-galactopyranoside (2) ...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Cytotoxic abietane-derivative diterpenoids of Salvia lachnostachys
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Cristhian S. Oliveira, Marcos J. Salvador, João E. de Carvalho, Élide P. Santos, Andersson Barison, Maria Élida A. Stefanello A bioassay-guided fractionation of Salvia lachnostachys Benth leaf extract led to the isolation of three known diterpenes, namely fruticuline A (1), fruticuline B (2) and 7,20-dihydrofruticuline A (3), together with two new compounds, 4 and 5. The structures were mainly elucidated by 1D and 2D NMR spectroscopy and HRESIMS. The cytotoxic activity of the crude ethanol extract, the semi-pur...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Two new sesterterpenoids, terretonins H and I, from the marine-derived fungus Aspergillus ustus
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Galina K. Oleinikova, Vladimir A. Denisenko, Dmitrii V. Berdyshev, Mikhail A. Pushilin, Natalia N. Kirichuk, Natalia I. Menzorova, Alexandra S. Kuzmich, Ekaterina A. Yurchenko, Olesya I. Zhuravleva, Shamil Sh. Afiyatullov Two new sesterterpenoids, terretonins H (1) and I (2), together with two known compounds, strobilactone A (3) and cerebroside D (4), were isolated from the lipophilic extract of the marine-derived fungus Aspergillus ustus KMM 4664. The structures of compounds 1 and 2 were determined based on spectroscopic meth...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Thiruventhan Karunakaran, Gwendoline C.L. Ee, Keng H. Tee, Intan S. Ismail, Nor H. Zamakshshari, Waziri M. Peter Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids, friedelin (6), stigmasterol (7), beta-sitosterol (8) and gamma-sitosterol (9). The structures of these compounds were elucida...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Sesquiterpenes with immunosuppressive effect from the stems of Solanum torvum
This article is the first to report on the immunosuppressive effects of spirovetiva-type sesquiterpenes. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Penicisimpins A –C, three new dihydroisocoumarins from Penicillium simplicissimum MA-332, a marine fungus derived from the rhizosphere of the mangrove plant Bruguiera sexangula var. rhynchopetala
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Rui Xu, Xiao-Ming Li, Bin-Gui Wang Three new dihydroisocoumarin derivatives, penicisimpins A–C (1–3), were isolated and identified from Penicillium simplicissimum MA-332, a fungus derived from the rhizosphere of the marine mangrove plant Bruguiera sexangula var. rhynchopetala. Their structures and absolute configurations were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment. Compounds 1–3 exhibited brine shrimp (Artemia salina) lethality as well as broad-spectrum antimicr...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Cytotoxic and anti-inflammatory salicin glycosides from leaves of Salix acmophylla
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Zafar Ali Shah, Attiya Hameed, Aqeel Ahmed, Shabana U. Simjee, Almas Jabeen, Abid Ullah, Farzana Shaheen The species of genus Salix, commonly known as Willow, are well known worldwide as rich source of medicinally important salicin derivatives and phenolic glycosides. The current study focuses on Salix acmophylla Bioss with the aim of identifying new bioactive constituents of this plant. Two new salicin glycosides, acmophyllin A (1), acmophyllin B (2) and five reported phenolic glycosides 3–7, were identified from S. acmophy...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Antimicrobial and anti-oxidant activities of quinoline alkaloids from Pseudomonas aeruginosa BCC76810
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Khomsan Supong, Chitti Thawai, Sumalee Supothina, Patchanee Auncharoen, Pattama Pittayakhajonwut Twelve 4-hydroxyquinoline derivatives (1–12) and three phenazine alkaloids (13–15) have been isolated from Pseudomonas aeruginosa BCC76810. All these compounds, except compounds 6, 7, 9, and 11, are known. The new quinolines are 2-((Z)-undec-4′-enyl)-4-hydroxyquinoline (6), 2-(3′-(2′-hexylcyclopropyl)propyl)-4-hydroxyquinoline (7), 2-n-octyl-4-hydroxyquinoline N-oxide (9), and 2-((Z)-undec-4′-enyl)-4-h...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Jalapinoside II, a bisdesmoside resin glycoside, and related glycosidic acids from the officinal jalap root (Ipomoea purga)
This study also reports the complete NMR data assignment for purgic acid C and the structural elucidation of purgic acid D, both glycosidic acids were isolated, in conjunction with previously known purgic acids A and B, under saponification of the MeOH-soluble resin glycosides. HPLC and 13C NMR profiles were used as analytical tools for the authentication of the commercialized Mexican scammony resin. Reversal factor of multidrug resistance by the non-cytotoxic jalapinoside II was evaluated in vinblastine-resistant human breast carcinoma cells (RFMCF-7/Vin+ >1906). Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Anti-neuroinflammatory constituents from Sinomenium acutum rhizomes
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Seung Young Lee, Won Se Suh, Joon Min Cha, Eunjung Moon, Sang Keun Ha, Sun Yeou Kim, Kang Ro Lee In our continuing search for bioactive constituents from Korean medicinal sources, an investigation of the Sinomenium acutum Rehder et Wilson rhizome afforded three new lignan derivatives (1–3) together with nine known compounds (4–12). The identification and structural elucidation of these new compounds were based on 1D and 2D-NMR (COSY, HMQC, HMBC and NOESY) and MS data. The absolute configurations were established based ...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Two new hopane-type triterpenes from the aerial part of Chelidonium majus
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): An-Jun Deng, Zhi-Hui Zhang, Qian Li, Lin Ma, Hai-Lin Qin Two new hopane-type triterpenes, 1-oxo-3α-hydroxy-22(30)-hopen-29-oic acid (1) and 3α-hydroxy-22(30)-hopen-29-oic acid (2), and the known compounds dihydrosanguinarine (3), dl-stylopine (4), dihydrochelirubine (5), dihydromacarpine (6), dihydrochelerythrine (7), dihydrochelilutine (8), and norsanguinarine (9) were isolated from the aerial part of Chelidonium majus. The structures of the new compounds were elucidated based on extensive spectroscopic evidence, especi...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Anti-oxidant components from the aerial parts of Asterothamnus centrali-asiaticus
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Yan-Ming Wang, Jian-Qiang Zhao, Chun-Yan Yang, Yan-Duo Tao, Li-Juan Mei, Yan-Ping Shi Two new phenolic acids 2-hydroxy-5-[(6′-O-(E)-caffeoyl)-β-d-glucopyranosyl]-oxybenzoic acid (1) and 2-hydroxy-5-[(3′-O-(E)-caffeoyl)-β-d-glucopyranosyl]-oxybenzoic acid (2) were isolated from the aerial parts of Asterothamnus centrali-asiaticus, together with five known ones (3-7). Their structures were elucidated by extensive 1D and 2D NMR studies and HRESIMS investigations. The anti-oxidant activity of the isolates was eval...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Yhiya M. Amen, Qinchang Zhu, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu Further chemical investigation of the metabolites in the fruiting bodies of Ganoderma lingzhi resulted in isolation of eight triterpenes; two of them are new triterpene acid ethyl esters. Their structures were established based on spectroscopic studies and comparison with the known related compounds. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against five human cancer cell lines (MCF-7, HeLa, HCT...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Penicillars A –E from the marine animal endogenic fungus Penicillium sp. SCS-KFD08
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Fan Dong Kong, Li Man Zhou, Qing Yun Ma, Sheng Zhuo Huang, Pei Wang, Hao-Fu Dai, You-Xing Zhao Five new compounds named penicillars A–E were isolated from the fermentation broth of Penicillium sp. SCS-KFD08 associated with the marine animal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations were unambiguously elucidated by spectroscopic data, Mo2(OAc)4 induced CD spectrum analysis along with quantum ECD calculation. Among them, compounds 2 and 3, at a concentration of 50μg/m...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

New isoflavans from the root bark of Erythrina livingstoniana
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Kibrom Gebreheiwot Bedane, Ishmael B. Masesane, Runner R.T. Majinda The phytochemical study on the root bark of Erythrina livingstoniana has led to the isolation of two new isoflavans namely 7-hydroxy-2′-methoxy-[6′′,6′′-dimethylpyrano (2′′,3′′:4′,5′)]isoflavan (1) and 7,2′-dihydroxy-[6′′,6′′-dimethyl pyrano (2′′,3′′:4′,5′)]isoflavan (2) together with eight known flavonoids (3-10). Their structures were e...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Two new sulfur-containing iridoid glucosides from Saprosma merrillii
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Xue-Ming Zhou, Cai-Juan Zheng, Gao-Nan Li, Xiao-Ping Song, Guang-Ying Chen, Rui-Jie Liu, Li-Lian Ren, Jing-Yu Yang, Wen-Xing Chen Two new sulfur-containing iridoid glucosides saprosmosides J and K (1 and 2) together with seven known iridoid glucosides (3–9) were isolated from the stems of Saprosma merrillii. The structures of these compounds were elucidated using comprehensive spectroscopic methods. The absolute configuration of 3 was determined by X-ray crystallographic analysis for the first time. The absolute configurat...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Two new quinic acid derivatives and one new lignan glycoside from Erycibe obtusifolia
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Zi-ming Feng, Zhao-zhen Liu, Peng-fei Yang, Ya-nan Yang, Jian-shuang Jiang, Pei-cheng Zhang Three new compounds, 4-{erythro-2-[3-(4-hydroxyl-3-methoxyphenyl)-3-O-β-d-glucopyranosyl-propan-1-ol]}-O-medioresinol (1), (7″E,9″E,1″R*,3″S*,5″R*,6″S*)-5-O-caffeoyl-3-O-dihydrophaseicoylquinic acid (2), and (7″E,9″E,1″R*,3″S*,5″R*,6″S*)-5-O-caffeoyl-4-O-dihydrophaseicoylquinic acid (3), were isolated from Chinese folk herb Erycibe obtusifolia together with six know...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

UVC-priming mediated modulation of forskolin biosynthesis key genes against Macrophomina root rot of Coleus forskohlii —A tissue culture based sustainable approach
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Moumita Gangopadhyay, Saikat Gantait, Shouroseni Palchoudhury, Md. Nasim Ali, Chhanda Mondal, Arun Kumar Pal Coleus forskohlii is susceptible to root rot disease that reduces yield of root specific metabolite forskolin. In this communication, we first time reported sustainable management of Macrophomina phaseolina root rot in C. forskohlii via Ultraviolet-C (UVC)-hormesis using tissue culture. Compact calli were developed using 2,4-dichlorophenoxy acetic acid (2.0mgl−1) and tolerance level of UVC exposure was optimized. Calli...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis
In this study, the fungus Aspergillus felis (strain UFMGCB 8030) was isolated from rocks in the Atacama Desert, Chile. Its CH2Cl2 extract exhibited antifungal activity (MIC of 1.9μg/mL) against Paracoccidioides brasiliensis (Pb18), which is the etiological agent for paracoccidioidomycosis. The crude extract was purified, and a new cytochalasin derivative, cytochalasin Z15E (1), and one ardeemin derivative, 5-N-acetyl-8-β-isopropyl-ardeemin (4), in addition to five known secondary metabolites, rosellichalasin (2), cytochalasin E (3), gancidin (5), pseurotin A1 (6), and 2,4-dihydroxyacetophenone (7), were isolated. T...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Caesalmins N-Q, new cassane diterpenes from the seeds of Caesalpinia minax
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Qing Li, Ying-Na He, Bei Niu, Xin-Guo Wang, Li-Ying Niu, Wei Feng Four new cassane diterpenes, named caesalmins N-Q together with six known compounds (1–10) were isolated from the MeOH extract of seeds of Caesalpinia minax Hance. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and HRESIMS data. All the new compounds were evaluated for their antiproliferative activities in vitro against three human cancer cell lines, and they showed weak cytotoxic activity with the IC50 values ranging fr...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Proliferative constituents from Selaginella moellendorffii Hieron
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Tian-Tian Wang, Hang Yin, Yong-Quan Zhang, Li Zhang Two new compounds, 7,3′-di-O-methylquercetin-4′-O-[β-galactosyl-(1→3)-β-glucoypranactosyl]-3-O-β- glucopyranoside (1) and (3R)-5,6,7-trihydroxy-3-isopropyl-3-methylisochroman-1-one (2), were isolated from Selaginella moellendorffii Hieron. Their structures were determined by spectroscopic methods. Compound 1 stimulated the growth of NIH3T3 cells and promoted the cell migration through increasing the gene and protein expression of connective tissue gro...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Three new phthalide glycosides from the rhizomes of Ligusticum chuanxiong
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Le-Jie Li, Yan-Fang Su, Shi-Li Yan Three new phthalide glycosides, named chuanxiongoside A (1), chuanxiongoside B (2) and ligusticoside B (3) together with two known glycosides, celephthalide A (4) and icariside F2 (5), were isolated from the rhizomes of Ligusticum chuanxiong. This is the first report of compounds 4–5 from the title plant. The structures of compounds 1–3 were identified using various spectroscopic methods. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Phytochemical investigation and antimicrobial assessment of Bellis sylvestris leaves
This study led to the isolation of 28 secondary metabolites belonging to different classes. The structures of these compounds have been elucidated on the basis of extensive 2D-NMR spectroscopic analyses, including COSY, TOCSY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY, along with Q-TOF HRMS2 analysis. Three of them, two megastimane derivatives and a glycoside of 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone, were reported for the first time. The compounds isolated from Bellis sylvestris were tested for their antimicrobial activity against some microorganisms associated with urinary tract infections (Proteus mirabilis...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

New sesquiterpene polyol esters from the root bark of Pseudolarix kaempferi
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Hai-Long Jiang, Wei Ha, Jun-Li Yang, Yan-Ping Shi A series of sesquiterpene polyol esters, including two new β-dihydroagarofuran sesquiterpenes (1-2) and 14 known compounds (3-16), were isolated from the root bark of Pseudolarix kaempferi. The esters’ structures were elucidated by employing extensive spectroscopic analyses and by comparison to literature compounds. The absolute configurations of the two new compounds were determined by the CD exciton chirality method. The known compounds 3-16 were isolated from the Pseudol...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities
This report describes the first time that compounds 4-8 have been isolated from this plant, while 8 has never been identified in the genus Ochna. Some of the isolated compounds were evaluated for their antiplasmodial activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7 and antioxidant activity using DPPH radical scavenging and Ferric reducing-antioxidant power (FRAP) assays. Compound 5 exhibited prominent radical scavenging and FRAP activities, while 7 had weak activity. Compound 1 showed good in vitro anti-plasmodial activity. The structures of the isolated compounds were elucidated by spectroscopic...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

New guaiane and acorane sesquiterpenes in high quality agarwood “Qi-Nan” from Aquilaria sinensis
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Delan Yang, Jun Wang, Wei Li, Wenhua Dong, Wenli Mei, Haofu Dai Two new guaiane sesquiterpenes (1–2), one new acorane sesquiterpene (3), along with two known sesquiterpenes (4–5) were isolated from high quality agarwood ‘Qi-Nan’ originating from Aquilaria sinensis. Their structures were established based on spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR. Compound 1 was a guaiane sesquiterpene lactone, and compound 2 was a guaiane sesquiterpene with a 5/6/7 ring carbon skeleton. Compounds 3 and 4...
Source: Phytochemistry Letters - July 24, 2016 Category: Chemistry Source Type: research

Prenylflavone derivatives from the seeds of Psoralea corylifolia exhibited PPAR- γ agonist activity
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Shunan Ma, Youwu Huang, Yuanyuan Zhao, Guoxin Du, Li Feng, Cheng Huang, Yiming Li, Fujiang Guo Three new prenylflavones 2(R,S)-4′-hydroxy-6,7-[2-(1-methoxy-1-methylethyl)-furano]-flavanone (1), 4′,7-dihydroxy-3′,5′-diprenyl-isoflavone (2) and 3,4′,7-trihydroxy-2-methoxy-3′-geranyl-isoflavanone (3), as well as 19 known ones were isolated and identified from the seeds of Psoralea corylifolia. In total, 22 prenylated molecules, including flavanones, isoflavones and chalcones analogues, were screened on...
Source: Phytochemistry Letters - June 18, 2016 Category: Chemistry Source Type: research

Dammarane-type saponins from Ziziphus jujube and their inhibitory effects against TNF- α release in LPS-induced RAW 246.7 macrophages
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Qiang Fu, Hai-Mei Yuan, Jiang Chen, Jian-You Shi Four new dammarane-type saponins jujubosides F–J, together with six known compounds were isolated from the seeds of Ziziphus jujube. Their structures were elucidated on the basis of chemical and spectroscopic evidences. Compounds 1–10 showed moderate inhibitory effects against pro-inflammatory cytokine TNF-α release in LPS-induced RAW 246.7 macrophages. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - June 18, 2016 Category: Chemistry Source Type: research

Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Nurul Iman Aminudin, Farediah Ahmad, Muhammad Taher, Razauden Mohamed Zulkifli Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5-hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Calophyllum incrassatum (Guttiferae). The compounds were isolated and purified by size-exclusion recycling HPLC and column chromatographic techniques. The struct...
Source: Phytochemistry Letters - May 29, 2016 Category: Chemistry Source Type: research

Novel metabolites from the roots of Cadaba natalensis
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): J.A. Monjane, A. Uamusse, O. Sterner From an extract of the roots of Cadaba natalensis Sond. the novel macrocyclic dibenzo-diazacyclododecanedione 1 was isolated together with (S)-2-ethyl-2-methyloxazolidin-5-one (2a). In addition, the five known compounds were obtained. Of these, (R)-5-ethyl-5-methyloxazolidin-2-one (3) is reported as a natural product for the first time. The structures of the isolated compounds were elucidated by analysis of the spectral data, 1D NMR (1H, 13C, and DEPT), 2D NMR (COSY, HMQC, HMBC, and NOESY), and HRESIMS,...
Source: Phytochemistry Letters - May 29, 2016 Category: Chemistry Source Type: research

Three new sesquiterpene lactone dimers from Carpesium faberi
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Xi-ke Xu, Ji Ye, Li-ping Chen, Wei-dong Zhang, Yong-xun Yang, Hui-liang Li Three new 2,4-linked sesquiterpene lactone dimers (SLDs), faberidilactones F-H (1–3), have been isolated from Carpesium faberi. Unlike 1 and 2, 3 was a modified Diels-Alder adduct, characteristic by a 1′-OH and a Δ5′(6′) double bond. Furthermore, the relative configuration of 1′-OH in 3 was assigned as β-configuration by comparison the experimental NOESY data with those of its two possible epimers. The exo/endo stereochemi...
Source: Phytochemistry Letters - May 29, 2016 Category: Chemistry Source Type: research

Pyrrolidine alkaloids and their glycosylated derivatives from the root bark of Dichrostachys cinerea (L) Wight & Arn. (Fabaceae)
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Joël M.E. Dade, Genéviève Irie-N’Guessan, Gustav Komlaga, Martial Say, Timothée A. Okpekon, Jean B. Boti, Brou Jérôme Kablan, El Hadji Sawaliho Bamba Phytochemical investigation of the methanol extract of the root bark of Dichostachys cinerea (Fabaceae) led to the isolation and characterization of 3 new pyrrolidine-derived compounds with 12 carbon side chain and their glycosides. The structures of these compounds (1–3) were established using spectroscopic analytical methods comprising...
Source: Phytochemistry Letters - May 22, 2016 Category: Chemistry Source Type: research

Four new dimeric spiro-azaplilone derivatives cochliodones E-H from the entophytic fungus Chaetomium sp. M336
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Fei-Xue Yu, Yao Chen, Yin-He Yang, Pei-Ji Zhao Chaetomium sp. M336 was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation based on its special environment. To understand the secondary metabolites of strain Chaetomium sp. M336, four new dimeric spiro-azaplilone derivatives cochliodones E-H (1–4) were isolated from solid fermentation products of the fungus, which were elucidated by extensive spectroscopic analyses, including 1D- and 2D NMR, and HR-ESI–MS experiments. The antibact...
Source: Phytochemistry Letters - May 20, 2016 Category: Chemistry Source Type: research

New punctaporonins from two fungicolous isolates of Pestalotiopsis sp.
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): In Hyun Hwang, Donald T. Wicklow, James B. Gloer Seven new caryophyllene sesquiterpenoids (5–11) were isolated during investigation of two fungicolous isolates of Pestalotiopsis sp. and identified as punctaporonin analogues. The structures of these compounds were mainly assigned by analysis of NMR and HRMS data. Compounds 5–7 are 13-hydroxy analogues of 6-hydroxypunctaporonins A, B, and E, respectively, and compound 8 is a 6-hydroxy analogue of punctaporonin D. Compounds 9 and 11 are ketone–containing analogues of 6-hydro...
Source: Phytochemistry Letters - May 20, 2016 Category: Chemistry Source Type: research

An actomyosin-like cytoskeleton in the cyanobiont (Nosctoc sp.) of Peltigera canina
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Eva-María Diaz, Christophe Ampe, Maleen van Troys, Miguel Vicente-Manzanares, María-Estrella Legaz, Carlos Vicente Lichenized Nostoc cells isolated from the lichen Peltigera canina develop chemotaxis towards a lectin purified from the lichen thallus. Similar movements in unicellular eukaryotes require actin and myosin to generate contraction and relaxation along the chemotactic axis. We provide evidences for prokaryotic actin-like and myosin-like proteins in the cyanobiont Nostoc sp using cross-reacting antibodies against ...
Source: Phytochemistry Letters - May 20, 2016 Category: Chemistry Source Type: research

Two new highly-oxygenated flavonoid glycosides from Eupatorium adenophorum Spreng
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Caifang Wang, Ru Yang, Ling Song, Baoming Ning, Canbin Ou-yang, Aocheng Cao, Lan He Two new highly-oxygenated flavonoid glycosides, gossypetin-5-O-(6″-(E)-caffeoyl)-β-d-glucoside (1) and herbacetin-5-O-(6″-(E)-caffeoyl)-β-d-glucoside (2) were isolated from the leaves of Eupatorium adenophorum Spreng. Their structures were determined by spectroscopic methods including one- and two-dimensional NMR, and HR-ESI–MS. Compounds have potent DPPH radical scavenging activity with IC50 12.0μM (1) and 22.9μM (2) (...
Source: Phytochemistry Letters - May 20, 2016 Category: Chemistry Source Type: research

Three new diterpenoids from Marrubium aschersonii
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Jun-Sheng Zhang, Yi-Hong Zou, Jing-Jun Zhao, Ye Chen, Jing-Mei Bao, Gui-Hua Tang One new halimane diterpenoid, marrubasch C (1), two new labdane diterpenoids, marrubaschs D and E (2 and 3), and three known labdane diterpenoids, marrubasch F (4), marrubiin (5), and marrubenol (6), were isolated from the ethanol extract of Marrubium aschersonii Magnus (Lamiaceae). Structures of these compounds were elucidated on the basis of spectroscopic analysis. The inhibitory effects of compounds 1–6 on nitric oxide (NO) production in RAW 264.7 ...
Source: Phytochemistry Letters - May 19, 2016 Category: Chemistry Source Type: research

Cytotoxic sesquiterpenoids from Senecio densiserratus
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Mei-Li Yang, Jian-Jun Chen, Hong-Bo Wei, Kun Gao Two new highly oxygenated guaiane-type sesquiterpenoids (1 and 2), along with nine known compounds (3–11) were isolated from the methanol extract of Senecio densiserratus Chang by cytotoxicity-guidance. Their structures were elucidated through spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) as well as by comparison with literature data. The two new compounds represent a rare type of guaiane sesquiterpenoid glucosides with angeloyloxy groups directly connected to the glycosyl moiet...
Source: Phytochemistry Letters - May 18, 2016 Category: Chemistry Source Type: research

Desflavasides A-D: Four new tetrasaccharide pregnane glycosides from Desmidorchis flava
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Muhammad Adil Raees, Hidayat Hussain, Ahmed Al-Rawahi, René Csuk, Ahmed Al-Ghafri, Najeeb Ur Rehman, Ali Elyassi, Ivan R. Green, Talat Mahmood, Ahmed Al-Harrasi Four new pregnane glycosides named desflavasides A-D (1–4) were isolated from the sap of Desmidorchis flava (N.E.Br) Meve & Liede. The structures of all new compounds were elucidated based on 1D and 2D NMR spectroscopic techniques coupled with mass spectromentry (ESIMS and HRESIMS). Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 13, 2016 Category: Chemistry Source Type: research

Two new pyranoanthraquinones from the root of Rennellia elliptica Korth. (Rubiaceae)
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Che Puteh Osman, Nor Hadiani Ismail, Agustono Wibowo, Rohaya Ahmad Two new pyranoanthraquinones, rennellianone A (1) and rennelianone B (2) along with four known compounds, alizarin-1-methyl ether (3), scopoletin (4), 4-hydroxy-3,5-dimethoxybenzaldehyde (5) and 3b-acetateoleanan-13b, 28-lactone (6) were isolated and characterized from the root extract of Rennellia elliptica. The structures were established based on spectroscopic data including HR-ESI–MS, 1D and 2D NMR. Triterpenoid lactone (6) is reported for the first time from fam...
Source: Phytochemistry Letters - May 10, 2016 Category: Chemistry Source Type: research

Prenylflavone derivatives from the seeds of Psoralea corylifolia exhibited PPAR-γ agonist activity
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Shunan Ma, Youwu Huang, Yuanyuan Zhao, Guoxin Du, Li Feng, Cheng Huang, Yiming Li, Fujiang Guo Three new prenylflavones 2(R,S)-4′-hydroxy-6,7-[2-(1-methoxy-1-methylethyl)-furano]-flavanone (1), 4′,7-dihydroxy-3′,5′-diprenyl-isoflavone (2) and 3,4′,7-trihydroxy-2-methoxy-3′-geranyl-isoflavanone (3), as well as 19 known ones were isolated and identified from the seeds of Psoralea corylifolia. In total, 22 prenylated molecules, including flavanones, isoflavones and chalcones analogues, were screened on...
Source: Phytochemistry Letters - May 8, 2016 Category: Chemistry Source Type: research

Six new cassane diterpenoids from the seeds of Caesalpinia sappan
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Zhen-Tao Deng, Jia Su, Lin-Fen Ding, Wen-Chao Tu, Hui Yang, Li-Yan Peng, Qin-Shi Zhao, Liu-Dong Song, Xing-De Wu Six new cassane diterpenoids (1–6) and 15 known compounds were isolated and identified from the seeds of Caesalpinia sappan. The structures of the new compounds were determined based on the spectroscopic methods, including 1D and 2D NMR techniques. Compound 1 is a rare cassane diterpenoid featuring a nitrogen containing bridge between C-19 and C-20. Compounds 1 and 2 exhibited moderate cytotoxicity against HCT116, AG...
Source: Phytochemistry Letters - May 8, 2016 Category: Chemistry Source Type: research

Dianthus erinaceus var. erinaceus: Extraction, isolation, characterization and antimicrobial activity investigation of novel saponins
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Kiymet Mutlu, Nazli Boke Sarikahya, Ihsan Yasa, Suheyla Kirmizigul A phytochemical analysis of Dianthus erinaceus Boiss. var. erinaceus (Caryophyllaceae) has led to the isolation of two novel triterpenoid saponins, containing an oleane type skeleton, named dianosides K and L (1, 2), along with six known triterpenoid saponins (3–8). On the basis of chemical and spectrometric data, the structures of the new compounds were elucidated as 3-O-[β-d-glucopyranosyl (1→3)]–[β-d-glucopyranosyl (1→6)]-β-d-glucopy...
Source: Phytochemistry Letters - May 8, 2016 Category: Chemistry Source Type: research

Four new coumarins from the leaves of Calophyllum inophyllum
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Zhan-lin Li, Yuan Li, Ning-bo Qin, Da-hong Li, Zhi-guo Liu, Qian Liu, Hui-ming Hua Four new coumarins, namely (−)-12-methoxyinophyllum A, (+)-12-methoxyinophyllum H-1, (-)-12-methoxyinophyllum H-2, and inophyllum J, along with two known compounds, 12-ethoxyinophyllum D and isoinophynone were isolated from the leaves of Calophyllum inophyllum. Their structures were elucidated by spectroscopic analyses, and complete assignments of 1H and 13C NMR spectroscopic data were achieved by 1D and 2D NMR experiments. Graphical abstract (Sour...
Source: Phytochemistry Letters - May 7, 2016 Category: Chemistry Source Type: research

Microbial metabolism of prenylated apigenin derivatives by Mucor hiemalis
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Yina Xiao, Ik-Soo Lee 6-Prenylapigenin (1) and 8-prenylapegenin (2) were semi-synthesized from apigenin by nuclear prenylation. Morusin (3) was isolated from the root bark of Morus alba L. The microbial transformation studies of these three bioactive prenylated apigenin derivatives were performed using eighteen cell cultures in order to select microorganisms capable of transforming them. It was identified that Mucor hiemalis (KCTC 26779) showed the ability to metabolize the parent compounds (1–3) into three new (4–6) and one kno...
Source: Phytochemistry Letters - May 7, 2016 Category: Chemistry Source Type: research