Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Wen-Juan Yuan, Guo-Ping Yang, Jia-Hui Zhang, Yu Zhang, Duo-Zhi Chen, Shun-Lin Li, Ying-Tong Di, Xiao-Jiang Hao From the roots of Euphorbia ebracteolata Hayata, three new diterpenes, Ebracteolatas A–C, based on the rosane (1–2) and lathyrane (3) skeleton, were isolated together with four known ones (4–7). Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. Compounds 1, 6, and 7 exhibited moderate cytotoxic effects against five cancer cell lines. ...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Two new 3,4-secooleanane triterpenoids from Buddleja lindleyana Fort. fruits
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Ya-Shuo Ren, Feng-Qing Xu, Wei Zhang, Pei-Pei Li, Zheng Li, De-Ling Wu In the phytochemical investigation of the fruits of Buddleja lindleyana, two new rare 3,4-secooleanane triterpenoids, 4,23-dihydroxy-3,4-seco-olean-9,12-dien-3-oic acid (1) and 4,23,30-trihydroxy-3,4-seco-olean-9,12-dien-3-oic acid (2), together with nine known compounds (3–11) were isolated. The structures were elucidated primarily by means of extensive spectroscopic analysis. Compounds 1 and 2 have a neuroprotective effect against glutamate-induced neurotoxicity...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Ingenines C and D, new cytotoxic pyrimidine- β-carboline alkaloids from the Indonesian sponge Acanthostrongylophora ingens
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Sabrin R.M. Ibrahim, Gamal A. Mohamed Two new pyrimidine-β-carboline alkaloids, namely ingenines C (1) and D (2), along with three known compound: annomontine (3), acanthomine A (4), and 1-hydroxy-3,4-dihydronorharman (5) were isolated from the EtOAc fraction of the Indonesian sponge Acanthostrongylophora ingens. Their structures were unambiguously established on the basis of UV, IR, HRESIMS, 1D and 2D NMR experiments, in addition to comparison with literature data. β-Carboline alkaloids with a 2-aminopyrimidine moiety as found i...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Biosynthesis of ( −)-ent-kaurenoic acid in Smallanthus sonchifolius and its effect against microbial biofilms
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Adriana A. Lopes, Edieidia S. Pina, Talita T. Nader, Fernando B. Da Costa, Ana Maria S. Pereira, Mônica T. Pupo The biosynthetic pathway of (–)-ent-kaurenoic acid (1) was investigated by incorporation of 1-d-13C-glucose in Smallanthus sonchifolius (Asteraceae) plantlets. The 13C-enrichment pattern indicated that methylerythritol-4-phosphate (MEP) pathway is the biosynthetic pathway involved in diterpenoid biosynthesis. Our studies in S. sonchifolius reinforce that the biosynthesis of different classes of terpenes should not be ...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Two new compounds with antimicrobial activities from the seeds of Voacanga africana
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Yifeng Niu, Chen Yang, Jing Zhou, Shen Huang, Jiajia Liu Two new compounds, (R)-4-(2-methylpentyl)-4H-dithieno[2,3-b:3′,2′-e]pyran (1) and 4-(2-ethylbutyl)-4H-dithieno[2,3-b:3′,2′-e]pyran (2) were extracted from the seeds of Voacanga africana. The molecular structures of these compounds were measured with the help of broad spectroscopic (1D and 2D-NMR, IR, ESI-TOF-MS, HR-MS) analyses. The primary pharmacological operations of these compounds were brought to evaluation by applying the antibacterial extrasomatic test....
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using one strain-many compounds (OSMAC) method
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Wen-Cai Liu, Fan Yang, Ran Zhang, Xuan Shi, Xin-Hua Lu, Yu-Shi Luan, Zhi-Long Xiu, Yue-Sheng Dong Three new polyketides, wortmannilactones I1-I3, were purified from Talaromyces wortmannii using the One Strain Many Compounds (OSMAC) strategy. The polyketides’ structures were established using IR, 1D and 2D NMR, and HRESIMS analyses and the absolute configurations were identified by comparison of experimental and calculated ECDs. These polyketides exhibit selective inhibitory activity against NADH-fumarate reductase. Graphical abstract...
Source: Phytochemistry Letters - October 16, 2016 Category: Chemistry Source Type: research

Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Mariagrazia Roselli, Maria Maddalena Cavalluzzi, Claudio Bruno, Angelo Lovece, Alessia Carocci, Carlo Franchini, Solomon Habtemariam, Giovanni Lentini Two known berberine derivatives and novel N-benzyl phenethylamines as open models of berberine were synthesized and evaluated as acetylcholinesterase (AChE) inhibitors and antioxidant agents. While being less potent than the parent compound (IC50 =0.70±0.04μM), both berberine derivatives performed as good AChE inhibitors (IC50 =2.30±0.29μM and 7.8±0.8μM, respect...
Source: Phytochemistry Letters - October 15, 2016 Category: Chemistry Source Type: research

New flavonoids from the underground parts of Eriosema laurentii
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Sylvin Benjamin Ateba, Dieudonné Njamen, Katrin Ukowitz, Martin Zehl, Hanspeter Kählig, Stefanie Hobiger, Alois Jungbauer, Liselotte Krenn Pharmacological, toxicological and phytochemical investigations of aerial parts of Eriosema laurentii De Wild. (Leguminosae), a plant used in traditional African medicine, showed a complex pattern of very rare and several new exceptional phenolic compounds. In continuation of the phytochemical work and based on the activity of an extract from the underground parts, the presented study showed...
Source: Phytochemistry Letters - October 14, 2016 Category: Chemistry Source Type: research

Metabolites isolated from the rhizomes of Dorstenia contrajerva with anti-leishmanial activity
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Héctor A. Peniche-Pavía, Deisy Medrano-Nahuat, Luis W. Torres-Tapia, Mirza Mut-Martín, Rosario García-Miss, Sergio R. Peraza-Sánchez Two new 2-benzylbenzofurans, dorsjervin A (1) and dorsjervin B (2), were isolated together with other nine known compounds (3–11) from Dorstenia contrajerva. Structure elucidation of both compounds was done through UV, IR, 1D- and 2D-NMR experiments, and mass spectrometry. All of the isolated compounds were evaluated for an in vitro anti-leishmanial activity; compounds...
Source: Phytochemistry Letters - October 11, 2016 Category: Chemistry Source Type: research

Microbial transformation of bavachin by Absidia coerulea
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Fubo Han, Ik-Soo Lee Microbial transformation of bavachin (1), one of the major bioactive components of Psoralea corylifolia L., was performed by using Absidia coerulea. Three oxidized metabolites were obtained in the biotransformation of 1, and their structures were elucidated as bavachinone A (2), (2S)-4′-hydroxy-6,7-[(R)-2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanone (3), and (2S)-4′,7-dihydroxy-6-(2,3-dihydroxy-3-methylbutyl)flavanone (4) based on the spectroscopic analyses. Among them, metabolites 3 and 4 were new...
Source: Phytochemistry Letters - October 10, 2016 Category: Chemistry Source Type: research

Two new triterpenoid saponins from the roots of Albizia zygia (DC.) J.F. Macbr.
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Olivier Placide Noté, Line Simo, Joséphine Ngo Mbing, Dominique Guillaume, Sarah Ali Aouazou, Christian Dominique Muller, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein As part of our search of new apoptosis-inducing triterpenoid saponins from Cameroonian Albizia genus, phytochemical investigation of the roots of Albizia zygia led to the isolation of two new oleanane-type saponins, named zygiaosides A–B (1–2), together with two known saponins, coriarioside A (3) and lebbeckoside A (4). Their structures were...
Source: Phytochemistry Letters - October 2, 2016 Category: Chemistry Source Type: research

GSK-3 β inhibitory activities of novel dichroloresorcinol derivatives from Cosmospora vilior isolated from a mangrove plant
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Yoshihito Shiono, Nozomi Miyazaki, Tetsuya Murayama, Takuya Koseki, Harizon, Dewa Gede Katja, Unang Supratman, Juri Nakata, Yoshito Kakihara, Makio Saeki, Jun Yoshida, Shota Uesugi, Ken-ichi Kimura Cosmochlorins A (1), B (2), and C (3) were isolated from the endophytic fungus Cosmospora vilior IM2-155. The structures of 1, 2, and 3 were elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HRESITOFMS, and chemical reactions. Compounds 1, 2, and 3 were evaluated for their biological activity. Compounds...
Source: Phytochemistry Letters - October 1, 2016 Category: Chemistry Source Type: research

New semi-synthetic scaffolds of isoalantolactone and their cytotoxic activity
In this study, a series of sixteen new isoalantolactone (IAL 1) amino derivatives (IAL 2 – IAL 17) had been synthesized. IAL 1 and synthesized analogs were evaluated for in vitro cytotoxicity against three human cancer cell lines including cervical cancer (SiHa), epidermoid carcinoma (KB) and colorectal carcinoma (HCT116). The compounds IAL 2, 8, 9, 10, 12 and 17 were found to be nearly active as IAL 1 against all the three tested cell lines, whereas IAL 4 and 16 against HCT116 cells. Findings of the cytotoxicity had provided a correlation on the structure activity relationship of IAL 1 and derivatized analogs agains...
Source: Phytochemistry Letters - September 30, 2016 Category: Chemistry Source Type: research

Four new compounds from edible algae Cladosiphon okamuranus and Chlorella sorokiniana and their bioactivities
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Kun-Ching Cheng, Ping-Chung Kuo, Hsin-Yi Hung, Ko-Hua Yu, Tsong-Long Hwang, Po-Chuen Shieh, Jo-Shu Chang, Tian-Shung Wu In the present work, two new compounds, known as mozukulins A (1) and B (2), together with three known compounds, including eicosapentaenoic acid (EPA), henicosahexaene and phytol, were characterized from edible brown alga Cladosiphon okamuranus. The anti-inflammatory activity results demonstrated that eicosapentaenoic acid (EPA) displayed significant bioactivity. We did not observe significant bioactivity for the two new...
Source: Phytochemistry Letters - September 30, 2016 Category: Chemistry Source Type: research

Cytotoxic 9,19-cycloartane triterpenoids from the roots of Cimicifuga foetida L.
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Guo-Lei Zhu, Yin Nian, Di-Fan Zhu, Luo-Sheng Wan, Ni-Man Bao, Wei-Hua Wang, Lin Zhou, Ming-Hua Qiu Eight new cycloartane triterpenoids (1–8), along with eight known analogues (9–16), were isolated from the roots of Cimicifuga foetida L. Their structures were elucidated by spectroscopic analysis and acidic hydrolysis. All of the new compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compound 2 showed inhibitory activities with IC50 values r...
Source: Phytochemistry Letters - September 30, 2016 Category: Chemistry Source Type: research

Synthesis and cytotoxic activity of boswellic acid analogues
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Peihong Fan, Tao Li, Yaqing Ye, Qian Luo, Huiqing Yuan, Hongxiang Lou Fifteen stereoisomers of boswellic acid analogues bearing 2-OH, 24-OH, 3-keto or 2-OH, 3-OH, 24-OH groups were synthesised and their structures were confirmed using 1H NMR, 13C NMR, 2D NMR and HRMS. The cytotoxic activities of these compounds toward three human tumor cell lines, K562, PC3 and A549, were evaluated. Preliminary biological evaluation indicated most of these compounds exhibited cytotoxic activity comparable to that of 3-O-acetyl-11-keto-β-boswellic acid...
Source: Phytochemistry Letters - September 30, 2016 Category: Chemistry Source Type: research

Pestalotiopamide E and pestalotiopin B from an endophytic fungus Aureobasidium pullulans isolated from Aloe vera leaves
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Mustapha El-Amrani, Sherif S. Ebada, Haidy A. Gad, Peter Proksch A detailed chemical investigation of the mycelial extract of the endophytic fungus Aureobasidium pullulans isolated from leaves of the Moroccan Aloe vera yielded one new amide pestalotiopamide E (1) and its corresponding new acid pestalotiopin B (2) together with two indole metabolites (3 and 4), isoochracinic acid (5) and two hydronaphthalene derivatives (6 and 7). All isolated compounds were tested for their antiproliferative activity against mouse lymphoma L5178Y cell line...
Source: Phytochemistry Letters - September 30, 2016 Category: Chemistry Source Type: research

Sesquiterpenoids from Ainsliaea spicata and their cytotoxic and NO production inhibitory activities
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Zhi-Ran Shi, Xian-Yuan Zhang, Ren-Tao Zeng, Zhi-Guo Zhuo, Feng Feng, Yun-Heng Shen, Wei-Dong Zhang Four new sesquiterpenes 8α-hydroxy-diaspanolide A (1) and spicatenes A–C (2–4), together with forty known ones (5–44), were isolated from Ainsliaea spicata. Their structures were established on the basis of spectroscopic analysis. All isolates were evaluated for cytotoxicity against three human tumor cell lines 95D, MDA-MB-231, HepG2. The dimeric sesquiterpene lactone 38 showed significant inhibitory activity against t...
Source: Phytochemistry Letters - September 22, 2016 Category: Chemistry Source Type: research

New alkaloids with anti-inflammatory activities from Corydalis decumbens
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Qi Wang, Zhifeng Li, Zunhua Yang, Yuanying Fang, Hui Ouyang, Huiping Liao, Yulin Feng, Shilin Yang Phytochemical investigation of Corydalis decumbens has resulted in the isolation of one known Alkaloids named 1R,9S,7′S-O-methylegenine(1) and two new Alkaloids, 1S,9R,7′S-O-methyl egenine (2) and 1S,9S,7′S-O-methylegenine(3). Their structures were elucidated by various spectroscopic techniques. The absolute configurations of compounds 1–3 were determined by ECD calculations analysis.The anti-inflammatory activity of t...
Source: Phytochemistry Letters - September 16, 2016 Category: Chemistry Source Type: research

Diketopiperazine indole alkaloids from hemp seed
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Xiaoli Yan, Yuefang Zhou, Jiajing Tang, Mei Ji, Hongxiang Lou, Peihong Fan Hemp seeds from non-drug varieties of Cannabis sativa L. are an important source of food and medicine. In continuation of our ongoing study on hemp seed, two pairs of stereoisomers of diketopiperazine indole alkaloid (12S, 22R)-Dihydroxyisoechinulin A (1), (12S, 22S)-Dihydroxyisoechinulin A (2) and (12R/S)-Neoechinulin A (3) were isolated. Their structures were elucidated with UV, IR, NMR, MS, CD spectra, ECD and chiral HPLC analysis techniques. This type of alkaloi...
Source: Phytochemistry Letters - September 15, 2016 Category: Chemistry Source Type: research

Phytotoxicity evaluation of sesquiterpene lactones and diterpenes from species of the Decachaeta, Salvia and Podachaenium genera
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Carlos Rial, Rosa M. Varela, José M.G. Molinillo, Elihú Bautista, Alfredo Ortega Hernández, Francisco A. Macías Decachaeta, Salvia and Podachaenium genera are known for their wide variety of biological activities. Synthetic herbicides have caused a variety of environmental and resistance problems. Natural products represent an important alternative to combat such issues. Sesquiterpene lactones and diterpenes are families of bioactive natural products for which a range of activities have been described. The bioac...
Source: Phytochemistry Letters - September 14, 2016 Category: Chemistry Source Type: research

Two new phenanthrene glycosides from Liparis regnieri Finet and their antibacterial activities
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Jie Ren, Xiu-Ping Qian, Yi-Gong Guo, Tao Li, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang Two new phenanthrene glycosides, nudolglycosides A and B (1 and 2) and thirty known compounds (3–32) were isolated from the whole plant of Liparis regnieri Finet. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All the isolates were evaluated for their antibacterial activities against Bacillus subtilis, Enterococcus faecalis, Riemerella anatipestifer, Salmonella gallinarum, Staphylococcus aureus, Streptococcus ag...
Source: Phytochemistry Letters - September 14, 2016 Category: Chemistry Source Type: research

Neuroprotective constituent from the seeds of Alpinia katsumadai Hayata
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Dong-Yang Chen, Fan Yang, Yu-Qun Lin Two new compounds, named as rhamnocitrin-3-O-β-d-glucopyranosyl-4′-O-β-d-galactosyl-(1→3)-O-β-d-glucopyranoside (1), and (3R)-5,6,7-trihydroxy-3-isopropyl-3-methylisochroman-1-one (2), were isolated from the seeds of Alpinia katsumadai Hayata. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compounds 2 exhibited potent neuroprotective activity on 1-methyl-4-phenylpyridinium-induced oxidative damage in PC12 cells. Graphical abstract (Source...
Source: Phytochemistry Letters - September 7, 2016 Category: Chemistry Source Type: research

Label-free quantitative proteomic analysis of the inhibitory activities of juglone against translation and energy metabolism in Escherichia coli
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Jiayi Wang, Di Liu, Xiyun Sun, Bing Bai, Donghua Jiang, Zhaoxia Wu Plant-derived antimicrobial agents have received increasing attention owing to their potential to control pathogens and excellent efficacy despite the growing prevalence of antibiotic resistance. However, the antibacterial mechanism of juglone, a traditional medicine used to cure skin infections, is still unclear. Therefore, in this study, in order to elucidate the mechanisms underlying the antibacterial activity of juglone, label-free quantitative proteomic technology was ...
Source: Phytochemistry Letters - September 6, 2016 Category: Chemistry Source Type: research

New furanopyridine alkaloids from the leaves of Glycosmis pentaphylla
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Qiu-Bo Zhang, Gang Ding, Tao Zhang, Jin-Guang Si, Bo Song, Meng-Hua Wang, Jia-Huan Chen, Meng Yu, Yu-Cheng Gu, Zhong-Mei Zou Three new furanopyridine alkaloids, namely glypenfurans A–C (1–3), were isolated from the leaves of Glycosmis pentaphylla together with six known furoquinoline alkaloids. Their structures were determined by extensive spectral analysis (UV, IR, MS, 1D and 2D NMR). Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 6, 2016 Category: Chemistry Source Type: research

Antitrypanosomal activity of iridals from Iris domestica
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Anuradha Liyana Pathiranage, Jeannie Moore Stubblefield, Xiaolei Zhou, Jianhua Miao, Anthony L. Newsome, Norma Dunlap The petroleum ether extract of Iris domestica (Belamcanda chinensis) has been evaluated for activity against Trypanosoma brucei. Bioassay-guided fractionation led to the isolation of four known iridals as the active components. Chemical modification of these isolates afforded novel stable derivatives that maintained bioactivity. This is the first known report of the antitrypanosomal activity of these compounds. Graphical ab...
Source: Phytochemistry Letters - September 4, 2016 Category: Chemistry Source Type: research

Trichothecenes from the fungus Acremonium crotocinigenum BCC 20012
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Taridaporn Bunyapaiboonsri, Seangaroon Yoiprommarat, Sanisa Lapanun, Upin Balram, Rungtiwa Chanthaket, Anupong Klaysuban, Satinee Suetrong Two new trichothecenes (1 and 2) and a new chloroderivative of a trichothecene analogue (3) together with four known trichothecenes, crotocin, trichothecin, 8-deoxytrichothecinol B, and a trichothecene analogue, were isolated from the fungus Acremonium crotocinigenum BCC 20012. The structures of these compounds were elucidated by extensive spectroscopic analysis. Among the tested metabolites, trichothec...
Source: Phytochemistry Letters - September 3, 2016 Category: Chemistry Source Type: research

Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-induced nitric oxide release
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Guangming Xu, Zheming Wang, Biqing Zhao, Nianzheng Liu, Shenghui Yang, Yonghong Liu, Junfeng Wang, Xiaojiang Zhou Two new flavonoids, saniculamins A and B (1 and 2), together with three known flavonoid derivatives brosimacutin (3), 6-flavonol (4), and eucomol (5) were isolated from the whole plants of Sanicula lamelligera Hance collected in Mountain Emei, Sichuan Province, People’s Republic of China. The structures of all isolated compounds were determined on the basis of extensive spectroscopic analyses, including 1D/2D NMR, and HRM...
Source: Phytochemistry Letters - September 3, 2016 Category: Chemistry Source Type: research

Benzophenone derivatives from Garcinia livingstonei and their antioxidant activities
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Eva Muriithi, Gomotsang Bojase-Moleta, Runner R.T. Majinda Two new benzophenone derivatives 4,3′,4′-trihydroxy-2,6-dimethoxybenzophenone 1 and its glycoside 3′-β-d-glucosyloxy-4,4′-dihydroxy-2,6-dimethoxy-benzophenone 2 were isolated from the twigs and stem wood of Garcinia livingstonei together with twelve known compounds. The antioxidant activity of the isolates and extracts was evaluated. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research

Chemical composition, antibacterial, antioxidant and tyrosinase inhibitory activities of glycosides from aerial parts of Eryngium tricuspidatum L.
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Abbes Benmerache, Abdulmagid Alabdul Magid, Djemaa Berrehal, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Souhila Messaili, Amin Abedini, Dominique Harakat, Zahia Kabouche Two new phenolic glucosides, together with six known compounds, were isolated from the aerial part of Eryngium tricuspidatum L. (Apiaceae). The structures of the new compounds were established as 2-hydroxy- 3,5-dimethyl-acetophenon-4-O-β-d-glucopyranoside (1) and 2,3-dimethyl-4-hydroxymethylphenyl-1-hydroxymethyl-O-β-d-glucopyranoside (2) on the basis of de...
Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research

Two new lupane saponins from Schefflera kwangsiensis
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Yan Wang, Chun-Lei Zhang, Yan-Fei Liu, Ruo-Yun Chen, Feng-Zhong Wang, De-Quan Yu Two new lupane saponins, Schekwanglupasides A and B (1 and 2), together with three esters (3–5) of known lupane saponins were isolated from the aerial parts of Schefflera kwangsiensis. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 2 and 4 (10μM) exhibited moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell dam...
Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research

Petchiethers A and B, novel meroterpenoids with a 14- or 15-membered ring from Ganoderma petchii
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Cheng-Gang Li, Qi Luo, Ping-Xia Guo, Li-Li Chen, Yong-Xian Cheng Petchiethers A (1) and B (2), two novel meroterpenoids respectively with a 14- or 15-membered ring were isolated from the fruiting bodies of Ganoderma petchii. Their structures were identified by spectroscopic data. The absolute configurations of compounds 1 and 2 were assigned by computational methods. In particular, the stereochemistry of 1 was further confirmed by the Mosher’s method. The inhibitory effects of compounds 1 and 2 on fibronectin secretion were evaluated...
Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research

Two new flavonol glycosides from the leaves of Cleome viscosa L.
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Nhat Minh Phan, Tan Phat Nguyen, Tien Dung Le, Thanh Chi Mai, Mai Thanh Phong, Dinh Tri Mai From the leaves of Cleome viscosa L., two new flavonol glycosides, named visconoside A (1) and visconoside B (2), together with six known flavonol glycosides, vincetoxicoside A (3), vincetoxicoside B (4), kaempferitrin (5), kaempferide 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (6), kaempferol 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (7), and isorhamnetin 3-O-β-d-glucopyranoside (8) were isolated by various c...
Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research

Bioactive cucurbitane triterpenoids from the tubers of Hemsleya penxianensis
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Ye-Dan Li, Si-Rong Yi, Xiao-Bo Sun, Xing-Yang Zhou, Hong-Yang Zhang, Yun-Qing Wang, Jun-Shan Yang, Xu-Dong Xu, Guo-Xu Ma Four new cucurbitacins, jinfushanencins C-F (1–4) and three known analogues (5–7) were isolated from the tubers of Hemsleya penxianensis by Silica gel column, ODS column, pre-HPLC techniques. The structures of 1–7 were establishhed on the basis of extensive spectroscopic. The isolated compounds were tested for their cytotoxic activity against Hela human cancer cell line and compounds 1, 5, and 7 showed ...
Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research

New monoterpenes from stalks and infructescence of Sibiraea leavigata
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Jian-Qiang Zhao, Yan-Ming Wang, Jun-Jiang Lv, Shuo Wang, Li-Juan Mei, Yan-Duo Tao Chemical investigation of the ethanol extract of the stalks and infructescence of Sibiraea leavigata led to the isolation of two new monoterpenes named (4R)-2-(2-hydroxy-4-methyl-3-pentenyl)furan-2(5H)-one (1) and (2R,4R)-2-(2-hydroxyethyl)-4-(2-methyl-1-propenyl)furan-5H-2-one (2) along with eight known phenylpropanoids (3–10). Their structures were established on the basis of the interpretation of spectroscopic data and electronic circular dichroism (...
Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research

Cytotoxic and antimalarial constituents from aerial parts of Sphaeranthus indicus
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Watchara Sangsopha, Ratsami Lekphrom, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul Two new eudesmanolide type sesquiterpenes, indicusalactone (1) and (−)​-​oxyfrullanolide (2), along with twelve known compounds (3–14), were isolated from the aerial parts of Sphaeranthus indicus. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data. Compounds 1–4 and 12–14 showed antimalarial activity against Plasmodium falciparum with IC50 values ranging from 2.32 to 6.47μg...
Source: Phytochemistry Letters - August 19, 2016 Category: Chemistry Source Type: research

Potential role of metabolomics in the improvement of research on traditional African medicine
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Emmanuel Quansah, Thomas K. Karikari The global market for herbal medicine is growing steadily. The usage of herbal medicine is particularly common in many parts of Africa; the World Health Organization estimates that approximately 80% of Africans rely on traditional African medicines (TAMs) for treating various diseases. TAMs hold promise in preventive treatment, early disease intervention and personalized medicine. However, clinical integration of TAMs is restricted due to limited information concerning their characterization. Presently...
Source: Phytochemistry Letters - August 18, 2016 Category: Chemistry Source Type: research

Six new dihydrobenzofuran lignans from the branches and leaves of Illicium wardii and their cytotoxic activities
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Feng-mei Ye, Yang-guo Xie, Jie Ren, Ji Ye, Yi-gong Guo, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang Six new dihydrobenzofuran lignans, named illiciumlignans A–F (compounds 1–6), along with 15 known compounds (7–21) were isolated from the branches and leaves of Illicium wardii. The structures of 1–6 were determined using a combination of 1D and 2D NMR, HR-ESI–-MS, and CD spectroscopic data. Illiciumlignan D (4) is the first reported dihydrobenzofuran lignan arabinofuranoside that is derivatized with the arabinofur...
Source: Phytochemistry Letters - August 17, 2016 Category: Chemistry Source Type: research

Protective effect of hexahydrobenzo[c]phenanthridine alkaloids isolated from Corydalis ambigua var. amurensis on myocardial ischemia-hypoxia cells
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Zhi-Hui Liu, Qiao Li, Sheng Chang, Zhi-You Yang, Na Han, Jun Yin Two new hexahydrobenzo[c] phenanthridine alkaloids, ambiguanine H (1) and ambiguanine I (2) together with six known hexahydrobenzo[c] phenanthridine alkaloids (3–8), were isolated and purified from the Corydais ambigua var. amurensis leaves. Their structures were elucidated by extensive spectroscopic methods and all the compounds except comp. 6 showed the remarkable protective effect on myocardium ischemia-hypoxia cells and comp. 4 was the most active compound with cel...
Source: Phytochemistry Letters - August 17, 2016 Category: Chemistry Source Type: research

Rearranged Sesquiterpenes and Branched Polyketides Produced by the Endophyte Camarops sp.
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Juliana R. Gubiani, Cláudio R. Nogueira, Marcos D.P. Pereira, Maria C.M. Young, Paulo M.P. Ferreira, Manoel O. de Moraes, Cláudia Pessoa, Vanderlan S. Bolzani, Angela R. Araujo Two rearranged sesquiterpenes, 3,5,9-trihydroxy presilphiperfolane (1) and 4-deoxy-10-oxodihydrobotrydial (2), and two branched polyketides, 4-((E)-pent-1-enyl)-3-((1'S,2'S)-1',2'-dihydroxybut-3-enyl)-5H-furan-2-one (3) and (2E,4R)-2,4-dimethylnon-2-enoic acid (4), along with three known compounds (2E,4S)-2,4-dimethyloct-2-enoic acid (5), xylarenone C...
Source: Phytochemistry Letters - August 13, 2016 Category: Chemistry Source Type: research

Acyl flavone and lignan glucosides from Leontopodium leontopodioides
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Yangyang Xiao, Haihui Xie, Li Zhao, Ping Gou Two new acyl flavone glucosides, luteolin-4′-O-(6-p-hydroxybenzoyl)-β-d-glucopyranoside (leontopodioside A, 1) and luteolin-4′-O-[6-(2-methylbutyryl)]-β-d-glucopyranoside (leontopodioside B, 2), and a new acyl lignan glucoside, lariciresinol-9-angeloyl-4-O-β-d-glucopyranoside (leontopodiosideC, 3) were isolated from the whole plants of Leontopodium leontopodioides (Asteraceae). Their structures were determined by spectroscopic and chemical methods. Compounds 1–3...
Source: Phytochemistry Letters - August 13, 2016 Category: Chemistry Source Type: research

Cytotoxic and antimalarial constituents from the roots of Toddalia asiatica
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Chayanis Hirunwong, Sanwat Sukieum, Ratchanee Phatchana, Chavi Yenjai A rare isoprene coumarin, toddayanin (1), and a new dihydrochelerythrine-cadinane derivative, toddayanis (2), along with 16 known compounds were isolated from the root of Toddalia asiatica Lam. Compound 12 showed strong antimalarial activity against Plasmodium falciparum with an IC50 value of 5.4μg/mL and was inactive against normal, Vero cells. Compound 13 showed cytotoxicity against the MCF-7 cell line with an IC50 value of 8.7μg/mL and was inactive against Vero...
Source: Phytochemistry Letters - August 12, 2016 Category: Chemistry Source Type: research

Alkaloids and phenolic glycosides from Clematis mandshurica and their inhibitory effects against NO production in LPS-induced RAW 246.7 macrophages
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Qiang Fu, Jiang Chen, Hai-Mei Yuan, Yu Ma, Tian Yu, Liang Zou Two new alkaloids (1 and 2), one new phenolic glycoside (3), and five known structures (4–8) were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. All isolates were evaluated for inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 246.7 macrophages. Feruloyl and isoferuloyl derivates showed moderate inhibitory effects with the inhibition ra...
Source: Phytochemistry Letters - August 11, 2016 Category: Chemistry Source Type: research

New metabolites produced by Fusarium solani T-13 isolated from a dead branch
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Yoshihito Shiono, Nanang Rudianto Ariefta, Chairil Anwar, Sabirin Matsjeh, Ruengrit Sappapan, Tetsuya Murayama, Takuya Koseki, Tetsuaki Kawamura, Shota Uesugi, Ken-ichi Kimura Three novel benzenediol lactone derivatives, 7-hydroxy-14-de-O-methyl-lasiodiplodin (2), ethyl-3,5-dihydroxy-7-(6,8-dihydroxynonyl)benzoate (4), and 7-ethylbenzoate-7-heptanoic acid (5), together with known compounds, 14-de-O-methyl-lasiodiplodin (1) and ethyl-3,5-dihydroxy-7-(8-hydroxynonyl)benzoate (3), were isolated from the culture of Fusarium solani T-13, a fun...
Source: Phytochemistry Letters - August 10, 2016 Category: Chemistry Source Type: research

Notolutesin K −P, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus collenchymatosus
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Jing-Yi Wu, Xiao Wang, Jiao-Zhen Zhang, Jin-Chuan Zhou, Lin Li, Hong-Xiang Lou Six new dolabrane-type diterpenoids, notolutesin K–P (1–6), were isolated from the Chinese liverwort Notoscyphus collenchymatosus, along with five known dolabrane derivatives and a known pimarane derivative. Their structures were elucidated on the basis of extensive analysis of spectroscopic data. Cytotoxicity test against a panel of human cancer cell lines demonstrated that compound 6 showed cytotoxic activity with IC50 values range from 3.50 to 5....
Source: Phytochemistry Letters - August 8, 2016 Category: Chemistry Source Type: research

Antimicrobial fungal endophytes from the botanical medicine goldenseal (Hydrastis canadensis)
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Joseph M. Egan, Amninder Kaur, Huzefa A. Raja, Joshua J. Kellogg, Nicholas H. Oberlies, Nadja B. Cech The potential of fungal endophytes to alter or contribute to plant chemistry and biology has been the topic of a great deal of recent interest. For plants that are used medicinally, it has been proposed that endophytes might play an important role in biological activity. With this study, we sought to identify antimicrobial fungal endophytes from the medicinal plant goldenseal (Hydrastis canadensis L., Ranunculaceae), a plant used in tradi...
Source: Phytochemistry Letters - August 8, 2016 Category: Chemistry Source Type: research

New triterpenoidal saponins from Koelreuteria paniculata
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Ahmad E. Mostafa, Atef A. El-Hela, Abd-Elsalam I. Mohammad, Stephen J. Cutler, Samir A. Ross Bioassay guided fractionation and chemical investigation of the ethanolic extract of the aerial parts of Koelreuteria paniculata Laxm. (Sapindaceae), resulted in the isolation and identification of three new triterpenoid saponins 1–3 named Paniculatosoid A–C, along with eleven known compounds. The structures of the isolated compounds were elucidated using 1D and 2D NMR experiments, HRESIMS, and comparison with literature data. The occu...
Source: Phytochemistry Letters - August 4, 2016 Category: Chemistry Source Type: research

Three new acylated prenylflavonol glycosides from Epimedium koreanum
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Jin-Yu Li, Hong-Mei Li, Dan Liu, Xuan-Qin Chen, Chi-Ho Chen, Rong-Tao Li Phytochemical investigation on the EtOAc extract of the aerial parts of Epimedium koreanum led to the isolation of three new acylated prenylflavonol glycosides, korepimeosides A-C (1–3), together with twenty known ones (4–23). The structures of three new compounds (1–3) were established on the basis of chemical and spectroscopic methods as icaritin 3-O-[2,6-O-diacetyl-β-d-glucopyranosyl(1→3)-4-O-acetyl-α-l-rhamnopyranoside] (1...
Source: Phytochemistry Letters - July 29, 2016 Category: Chemistry Source Type: research

Unusual new phenylethanoid and phenylpropanoid diglycosides from the leaves of Chloranthus spicatus (Thunb.) Makino
This study represents the first report of glycoside from C. spicatus. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 29, 2016 Category: Chemistry Source Type: research

SNPs of dammarenediol synthase gene were associated with the accumulation of ginsenosides in DAMAYA ginseng, a cultivar of Panax ginseng C. A. Mey.
Discussion and conclusion Our findings suggest that specific SNPs of DS gene might be associated with the accumulation of some ginsenosides in DAMAYA ginseng and thus can be used for varietal characterization, molecular identification, qualitative evaluation of ginseng-type medicinal materials, or gene engineering and ginseng breeding. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 26, 2016 Category: Chemistry Source Type: research