Three new diterpenes from the seeds of Caesalpinia minax Hance and their anti-inflammatory activity
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Qin Liu, Bai Bai, Juan Shen, Sheng-qing Wu, Long-ping Zhu, De-po Yang, Zhi-min Zhao Three new diterpenes, caesalmin U (1), caesalmin V (2) and caesalmin W (3), were isolated from the EtOAc extract of the seeds of Caesalpinia minax Hance. Their structures were mainly characterized on the basis of extensive spectroscopic analyses and comparison with reported data. The inhibitory activities of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) of compounds 1-3 were evaluated, and compound 1 displayed ...
Source: Phytochemistry Letters - May 20, 2018 Category: Chemistry Source Type: research

Arylated gymnemic acids from Gymnema sylvestre R.Br. as potential α-glucosidase inhibitors
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Naila Hassan Alkefai, Javed Ahamad, Saima Amin, Manju Sharma, Showkat R. Mir A mixture of gymnemic acids was precipitated from the water extract of leaves of Gymnema sylvestre (Retz.) R.Br. ex Sm. (Asclepiadaceae) by acidification with mineral acid. The chromatographic separation of gymnemic acids mixture afforded four new arylated gymnemic acids (1–4) along with a gymnemasaponin (5). The compounds were characterized on the basis of extensive spectral data analysis. The arylated compounds (1–4) showed dose dependent inhibition of &...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

O-Glucoside of natural cleomiscosin-A: An attenuator of pro-inflammatory cytokine production
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Ahil Sajeli Begum, S. Santhosh Kumar, Suryanarayana Gottapu, Kirti Hira The study was aimed to improve the hydrophilic property and pro-inflammatory cytokine inhibitory effect of cleomiscosin-A (CA), a naturally occurring coumarinolignan in plants. In view of this, O-, N- and S-glucosides of cleomiscosin-A was designed and docking studies were performed for TNF-α protein. All derivatives showed considerable docking scores in the range of −8.433 to −9.401 kcal/mol compared to a standard TNF-α inhibitor. The O-glucosi...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Three novel 14-epiarborane triterpenoids from Imperata cylindrica Beauv. var. major
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Yuki Sakai, Junichi Shinozaki, Akihito Takano, Kazuo Masuda, Takahisa Nakane Three novel triterpenoids, 14-epiarbor-7-en-3β-ol (1), 14-epiarbor-7-en-3β-yl formate (2) and 14-epiarbor-7-en-3-one (3) were isolated from the rhizomes of Imperata cylindrica. Their structures were determined using spectroscopic methods including 2D NMR and using NMR shift reagents. These unique triterpenoid skeletons were isolated for the first time and the presence of these compounds suggests a novel biosynthetic route for triterpenoids. Graphical abstr...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Denis Kehdinga Sema, Alain Meli Lannang, Simplice J.N. Tatsimo, Mujeeb-ur-Rehman, Sammer Yousuf, Denis Zoufou, Urooj Iqbal, Jean Duplex Wansi, Norbert Sewald, M. Iqbal Choudhary Two new (1-2) and eight known (3-10) secondary metabolites were isolated from the rhizomes of Kniphofia reflexa Hutchinson ex Codd. Among them, an indane derivative kniphofiarindane (1), and naphthalene derivative kniphofiarexine (2), were identified as new natural products. 1D- and 2D-NMR spectroscopic studies together with single-crystal X-ray diffraction technique...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Neuroprotective effects of cryptotanshinone and 1,2-dihydrotanshinone I against MPTP induced mouse model of Parkinson ’s disease
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Gui-yun Cao, Xiao-hong Wang, Ke-ke Li, Ai-hong Zhao, Li Shen, Duo-nan Yu 1,2-dihydrotanshinone I (DTs1) and cryptotanshinone (CTs) are the two major compounds isolated from Salvia castanea f. tomentosa Stib., which possess diverse biological effects such as antioxidant, anticancer, anti-​atherogenic, anti-​hepatic fibrosis. However, there is no any report available on the neuroprotective effects of DTs1 and CTs against MPTP induced dopaminergic neurons damage. Therefore, in this study, we investigated the neuroprotective effects of DTs1 ...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Biosynthetic origin of alkylated decaline-type polyketides and induction of a new metabolite by addition of benzoate in cultured mycobionts of Pyrenula sp.
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Yukiko Takenaka, Takao Tanahashi The assembly pattern of acetate units and methyl groups in the biosynthesis of a polyketide, pyrenulic acid C (1), in cultured mycobionts of a Vietnamese Pyrenula sp. was verified by administration of sodium [1-13C]-acetate, sodium [1,2-13C2]-acetate, and L-[methyl-13C]-methionine. The cultured mycobionts were induced to produce a new polyketide, pyrenulic acid I (2), by addition of sodium benzoate to malt-yeast extract medium supplemented with 5% sucrose. Its structure was determined by spectroscopic methods...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Three new metabolites from the endophytic fungus Climacocystis montana isolated from the root bark of Paeonia ostia
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Pei-liang Zhang, Gang Wang, Jin-song Liu, Feng-qing Xu, Zhen-zhu Zhao, Wen-xiang Wang, Ju-tao Wang, Guo-kai Wang, Pei-yun Wu Two new pyridine derivatives climacomontaninates A–B (1–2), and a new sesquiterpenoid derivative climacomontanetate (3), together with twelve known compounds (4–15) were isolated from the culture extract of the fungal strain Climacocystis montana from the root bark of Paeonia ostii. The structures of these compounds were determined through spectroscopic methods such as NMR and HRMS. Moreover, we expou...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Two new cyclopropane monoterpene epimers from Varthemia iphionoides of Jordanian origin
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Mahmoud A. Al-Qudah, Musa H. Abu Zarga, Monther A. Khanfar, Hala I. Al-Jaber, Sultan T. Abu Orabi, Konrad Seppelt Two new monoterpenes, varthemic acid I (1) and varthemic acid II (2), in addition to 12 known compounds were isolated from the aerial parts of Varthemia iphionoides (Asteraceae family) growing wild in Jordan. Structural elucidation of all isolated compounds was performed utilizing extensive spectroscopic data including UV, IR, MS, and NMR (1 & 2D) spectroscopy. The absolute stereochemistry of compound 1 was determined by ...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Benzoxazinoid and indoxyl glycosides from Wrightia religiosa
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Poolsak Sahakitpichan, Nitirat Chimnoi, Chutima Srinroch, Somsak Ruchirawat, Tripetch Kanchanapoom A new class of secondary metabolites of the family Apocynaceae, benzoxazinoid, was reported for the first time from Wrightia religiosa. A new benzoxazinoid glycoside, (2S)-2-O-β-d-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one (2) and a new indole diglycoside, indoxyl 3-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (4) were isolated, together with twelve known compounds, including benzoxazinoid glycosides (1, 3), simple ar...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Flavonoids and saponins from two Bulgarian Astragalus species and their neuroprotective activity
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Aleksandar Shkondrov, Ilina Krasteva, Franz Bucar, Olaf Kunert, Magdalena Kondeva-Burdina, Iliana Ionkova Two novel compounds from A. glycyphylloides DC (1–2) and three rare flavonoids from A. spruneri Boiss. (3–5), alongside their neuroprotective activity and possible effects as human monoamine oxidase type B inhibitors were reported. The structural elucidation of the compounds was achieved by chemical, HRESIMS and NMR analyses. Their effects were investigated in vitro on isolated rat brain synaptosomes in 6-hydroxydopamine-indu...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Unveiling the fungal biotransformation of hydralazine using 13C-precursor
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Marilia O. Almeida, Adriana A. Lopes, Patricia G. Roberto, Bianca W. Bertoni, Mônica T. Pupo The fermentation of the endophyte Fusarium oxysporum SS46 and Fusarium oxysporum ATCC MYA 4623 with epigenetic modulator hydralazine in Czapek medium led to the isolation of 3-methyl-1,2,4-triazolo[3,4-a]phthalazine (1). The mechanism of biotransformation involves reaction with acetyl-CoA and further cyclization, and was unveiled using 13C-precursor. Additionally, AFLP technique for genomic DNA and differential gene expression (cDNA) analyses w...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Melantheraside A –E, five original triterpenes with natural chloride or oxime group from the aerial parts of Melanthera elliptica O. Hoffm.
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Cyrille Ngoufack Tagousop, David Ngnokam, Dominique Harakat, Laurence Voutquenne-Nazabadioko Five new pentacyclic triterpenoids, Melantheraside A–E (1–5) together with eleven known compounds (6-16) were isolated from the methanol extract of the aerial parts of Melanthera elliptica O. Hoffm. Their structures were established by extensive analysis of 1D- (1H, 13C), 2D- (COSY, ROESY, HSQC and HMBC) NMR data experiments in conjunction with mass spectrometry (TOFESIMS and HR-TOFESIMS) and by comparison with data reported in the litera...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Understanding health-related properties of bushmint (Hyptis) by pharmacokinetic modelling of intestinal absorption
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Jamie Selby-Pham, Sophie N.B. Selby-Pham, Kimber Wise, Louise E. Bennett Hyptis species including H. pectinata and H. verticillata are widely used in ethnopharmacology, wherein plant-extracts are ingested to treat a range of ailments including gastro-intestinal afflictions. However, the intestinal pharmacokinetics of these extracts are poorly understood. Recently, a Phytochemical Absorption Prediction (PCAP) model was reported, allowing prediction of the time for ingested phytochemicals to reach maximal plasma concentration (Tmax) in humans ...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Antagonistic metabolites produced by the fungus Curvularia sp. BCC52426 against Aspergillus sp. BCC51998
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Nantiya Bunbamrung, Chakapong Intaraudom, Aibrohim Dramae, Nattawut Boonyuen, Rungtiwa Chanthaket, Pranee Rachtawee, Pattama Pittayakhajonwut Four previously undescribed compounds, including (Z)-chloromonilinic acid B (1), (E)-chloromonilinic acid C (2), 4-chlorocurvularin (5), and 4-chlorocurvularinic acid (6), together with four known compounds, (E)-chloromonilinic acids A and B, pinselin, and anhydromevalonolactone, were isolated from the fungus Curvularia sp. BCC52426. The chemical structures were determined by comparing their NMR spectr...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Identification of antioxidant constituents of the aerial part of Plantago asiatica using LC –MS/MS coupled DPPH assay
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Jong Hoon Ahn, Yang Hee Jo, Seon Beom Kim, Ayman Turk, Kyung-Eon Oh, Bang Yeon Hwang, Ki Yong Lee, Mi Kyeong Lee Screening of EtOAc soluble fraction of Plantago asiatica (Plantaginaceae) using HPLC–MS/MS coupled DPPH online assay suggested the presence of antioxidant compounds, which characterized as phenylethanoid glycosides. Twenty-nine compounds including three new compounds, plantalides A–C, a phenylethanoid (1), a phenolic compound (9) and an iridoid (10), were isolated from P. asiatica. Consistent with HPLC–MS/MS anal...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Three new chlorophenolic glucosides from Curculigo orchioides Gaertn
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Zhen-Hui Wang, Xue-Yun Gong, De-Jun Zhou, Peng-Fei Xu, Mei Huang, Qing-Ling Zhang, Yue-Li Meng, Chao Niu, Yan-Ru Zhang Three new chlorophenolic glucosides, Curculigine M (1), Curculigine N (2) and Curculigine O (3) were isolated from the dried rhizomes of Curculigo orchioides Gaertn. Their structures were identified by means of spectroscopic methods such as 1D, 2D NMR and MS. These chlorophenolic glycosides were evaluated for effect on osteoblast proliferation against MC3T3-E1 cell line by using MTT assays. Compounds 1, 2 and 3 showed modera...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Chemical constituents of the stems of Neolitsea kedahensis Gamble
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Nor Akmalazura Jani, Hasnah Mohd Sirat, Farediah Ahmad, Salam Ahmed Abed, Nurul Iman Aminudin Two new β-carboline alkaloids, daibucarbolines D (1) and E (2) and one new sesquiterpene dilactone, pseudovillosine (3), together with five known compounds, taraxerone, taraxerol, pseudoneoliacine, daibucarboline A and linderaggrine A were isolated from the stems of Neolitsea kedahensis (Lauraceae). The structures were confirmed through extensive spectroscopic analysis, while the relative configuration of compound (3) was determined by a single...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Sesquiterpenoids from Ainsliaea yunnanensis and their cytotoxic activities
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Xin Fang, Ren-Tao Zeng, Zhi-Guo Zhuo, Yun-Heng Shen, Wei-Dong Zhang Three new sesquiterpenoids, named yunnanolides J-K and yunnanol A (1-3), together with ten known sesquiterpenoids (4-13), have been isolated from the dried whole plants of Ainsliaea yunnanensis Franch. The chemical structures of compounds 1-3 were elucidated by NMR and HRESIMS analysis. All the compounds were tested for in vitro cytotoxicity against three human tumor cell lines (95D, MDA-MB-231, and HepG2). Compound 13 showed moderate cytotoxicity against human cancer cell l...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Three new iridolactone derivatives from the whole plant of Brillantaisia owariensis P. Beauv
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Perrin Lanversin Foning Tebou, David Ngnokam, Dominique Harakat, Laurence Voutquenne-Nazabadioko Owariensisone B-D, three new lactone iridoids, identified as lactone of α-(3-acetoxymethyl-2-hydromethylcyclopent-3-en-yl) ethanoic acid (1), lactone of α-(4-β-acetoxy-3-β-acetoxymethyl-2-hydromethyl-3-hydroxycyclopentyl) ethanoic acid (2) and lactone of α-(4-β-acetoxy-3-α-acetoxymethyl-2-hydromethyl-3-hydroxycyclopentyl) ethanoic acid (3) were isolated from the n-hexane extract of the whole plant of Brillanta...
Source: Phytochemistry Letters - April 15, 2018 Category: Chemistry Source Type: research

Endocyclic double bond isomers and by-products from rebaudioside A and stevioside formed under acid conditions
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Wilmer H. Perera, Maite L. Docampo, Frank T. Wiggers, Charles D. Hufford, Frank R. Fronczek, Bharathi Avula, Ikhlas A. Khan, James D. McChesney The hydrolysis reaction of rebaudioside A and stevioside was studied under mild and strong acidic conditions at different temperatures and times. Exposure of rebaudioside A to vigorous acid conditions yielded three different aglycone cores which were purified by silica gel chromatography: compound 1 (isosteviol), 2 (steviol) and 3 (endocyclic isomer of steviol). Four new glucoside degradation products ...
Source: Phytochemistry Letters - April 14, 2018 Category: Chemistry Source Type: research

Acylated flavone 8-C-glucosides from the flowers of Trollius chinensis
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Jin-Xia Wei, Dan-Yi Li, Zhan-Lin Li Ten new flavone 8-C-glucosides, trollichinensides A–J, with the substitution of various acyls at C-2″, C-3″, or C-6″ of the glucose moiety, together with thirteen known ones were isolated from the flowers of Trollius chinensis. Spectroscopic analyses including NMR and HRESIMS resulted in the establishment of the structures of these constituents and electronic circular dichroism (ECD) experiment was employed for the determination of the absolute configuration of the glucose residue in ...
Source: Phytochemistry Letters - April 14, 2018 Category: Chemistry Source Type: research

Four new diterpenoid alkaloids with anti-inflammatory activities from Aconitum taronense Fletcher et Lauener
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Tianpeng Yin, Xiaofang Hu, Ruifeng Mei, Yan Shu, Dong Gan, Le Cai, Zhongtao Ding Four new C19-diterpenoid alkaloids, named taronenines A-D (1-4), have been isolated from the roots of Aconitum taronense Fletcher et Lauener (Ranunculaceae), which has long been used as a folk medicine to treat rheumatism and arthritis in China. Their structures were established on the basis of extensive spectroscopic analyses. The isolated compounds were evaluated for their potential anti-inflammatory effects using LPS-stimulated RAW 264.7 macrophages. Compounds ...
Source: Phytochemistry Letters - April 13, 2018 Category: Chemistry Source Type: research

Five new triterpenoids from Syzygium samarangense (Bl.) Merr. et Perry
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Yi-Kao Hu, Li Wang, Yuan-Yuan Li, Meng-Jia Li, Wen Xu, Yan Zhao, Feng Li, Yong Zhao Four undescribed ursane triterpenoids, sysamarins A–D, along with an undescribed oleanane triterpenoid, sysamarin E, were isolated from the ethyl acetate extract of the leaves of Syzygium samarangense. Their structures were elucidated on the basis of extensive spectroscopic analysis including HR-ESI–MS, 1D- and 2D-NMR techniques, and comparison with the data reported in the literatures. This is the first example of ursane and oleanane triterpenoids ...
Source: Phytochemistry Letters - April 13, 2018 Category: Chemistry Source Type: research

An unprecedented spiro [furan-2,1 ’-indene]-3-one derivative and other nematicidal and antimicrobial metabolites from Sanghuangporus sp. (Hymenochaetaceae, Basidiomycota) collected in Kenya
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Clara Chepkirui, Tian Cheng, Josphat Matasyoh, Cony Decock, Marc Stadler Bioassay guided fractionation of extracts derived from submerged cultures of a Sanghuangporus sp. (i.e., the genus that was until recently referred to as the “Inonotus linteus complex” of medicinal mushrooms) originating from Kenya led to the isolation of a new spiro [furan-2,1’-indine]-3-one derivative, for which we propose the trivial name phelligridin L (1) together with the known compounds 3,14′-bihispidinyl (2), hispidin (3), ionylideneacetic ...
Source: Phytochemistry Letters - April 12, 2018 Category: Chemistry Source Type: research

Alkenylphenols from Piper dilatatum and P. diospyrifolium
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Nídia C. Yoshida, Aline M. Benedetti, Ruilan A. dos Santos, Clécio S. Ramos, Ronan Batista, Lydia F. Yamaguchi, Massuo J. Kato As part of our continuing phytochemical survey on Piper species, three previously undescribed alkenylphenols were isolated and characterized, including 4-[(3′E)-tetradec-3′-en-1-yl] phenol (1) and 4-[(2′E,4′E)-heptadeca-2′,4′-dien-1-yl] phenol (3) from P. diospyrifolium and 4-[(3′E)-hexadec-3′-en-1-yl] phenol (2) from P. dilatatum. The structures of the comp...
Source: Phytochemistry Letters - April 12, 2018 Category: Chemistry Source Type: research

Bioactive aromatic metabolites from the sea urchin-derived actinomycete Streptomyces spectabilis strain HDa1
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Zhi Kai Guo, Rong Wang, Fu Xiao Chen, Tian Mi Liu, Ming Qiu Yang An actinomycete strain HDa1, capable of producing new acetylcholinesterase (AchE) inhibitors, was isolated from the gut of sea urchin Anthocidaris crassispina and identified as Streptomyces spectabilis by morphology and 16S rRNA gene sequence. Chemical investigation of the fermentation broth of Streptomyces spectabilis HDa1 by bioactivity-guided fractionation led to the isolation of 3,4-dimethoxy-1-naphthamide (1), p-O-(3,3-dimethylallyl)-benzamide (2), cyclo-(L-Val-l-Pro) (3), c...
Source: Phytochemistry Letters - April 12, 2018 Category: Chemistry Source Type: research

Aspidsaponins A –D, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their cytotoxicity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Sheng-Qi Zuo, Ying-Nan Liu, Yang Yang, Zhi-Qiang Guo, Cheng-Xiong Liu, Zhi-Yong Guo, Hai-Bo He, Xuan Tu, Kun Zou Four new furostanol saponins, named aspidsaponins A–D (2–5), together with one known steroidal saponin (1) were isolated from the rhizomes of Aspidistra elatior Blume. Their structures were determined on the basis of chemical methods and spectral data. Compounds 1 and 2, 4 and 5 were two pairs of diastereoisomeric furostanol saponins, and 3-5 were rarely steroidal glycosides of the C4-linked sugar and possessed highly ox...
Source: Phytochemistry Letters - April 12, 2018 Category: Chemistry Source Type: research

Three new eudesmane sesquiterpenoids and a new dimer from the aerial part of Salvia plebeia R. Br.
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Lie-Feng Ma, Hong Xu, Ji-Dong Wang, Xiang-Min Tong, Zha-Jun Zhan, You-Min Ying, Jian-Wei Wang, Hui Zhang, Wei-Guang Shan Four new compounds, including three eudesmane sesquiterpenoids (1–3) and a dimeric sesquiterpenoid lactone (4), were isolated from the aerial part of Salvia plebeia R. Br., together with two known eudesmanolides (5–6). Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI–MS spectra. Antiproliferative activities of isolates against six human myeloid leukemia ce...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Chemical structures and antimutagenic effects of unusual oximes from the peels of Citrus limon
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Takahiro Matsumoto, Maoko Koike, Chika Arai, Takahiro Kitagawa, Eriko Inoue, Daisuke Imahori, Tetsushi WatanabeGraphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Nantiya Bunbamrung, Khomsan Supong, Chakapong Intaraudom, Aibrohim Dramae, Patchanee Auncharoen, Pattama Pittayakhajonwut Eight new anthrone derivatives, which are (+)-oxanthromicins E (1), F (4), and G (5), (±)-hemi-oxanthromicin D (2), azanthromicin A (7), adxanthromicin A2 (10), 3-methoxy oxanthromicin (11), and (±)-oxanthromicin G (13), along with eight previously described compounds (6, 8, 9, 12, 14–17) have been isolated from the terrestrial actinomycete, Actinomodura sp. BCC47066. The chemical structures have been de...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Bioactive aporphine alkaloids from Fissistigma tungfangense
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Qi Zhou, Yan-Hui Fu, Yu-Qin Zhang, Shou-Yuan Wu, Xiao-Ping Song, Wei Xu, Guang-Ying Chen Three new aporphine alkaloids, fissitungfines C–E (1–3), together with five known analogues (4–8) were isolated from the stems of Fissistigma tungfangense. Their structures were elucidated by extensive spectroscopic methods Among them, fissitungfines C (1) and D (2) are two unusual aporphine alkaloids with a carboxyl group as a substituent at N-6. All isolated compounds were evaluated for their anti-rheumatoid arthritis activities via exa...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Polyoxygenated ergosteroids from the macrofungus Omphalia lapidescens and the structure-cytotoxicity relationship in a human gastric cancer cell line
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Yue Wang, Ou Dai, Cheng Peng, Hai-Guo Su, Lu-Lin Miao, Lu-Si Liu, Liang Xiong Seventeen polyoxygenated Δ22-ergosteroids (1–17), including two new compounds (1 and 15), were isolated from the ethyl acetate soluble fraction of a 95% ethanol extract of Omphalia lapidescens Schroet. According to the oxidation degree and the oxidation positions of A and B rings, the isolates could be divided into three subtypes: 3,5,6-trioxygenated Δ7-ergosteroids (1–9), 3,5,6,7-tetraoxygenated ergosteroids (10–14), and conjugated &Del...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

New aromatic lactone derivatives with inhibitory activities on nitric oxide production from Homalium stenophyllum
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Shou-Yuan Wu, Yan-Hui Fu, Qi Zhou, Meng Bai, Guang-Ying Chen, Si-Yu Zhao, Xiao-Ping Song, Chang-Ri Han Two new aromatic lactone derivatives, homastenones A (1) and B (2), together with six known compounds (3–8), were isolated from the stems of Homalium stenophyllum. Their structures were established on the basis of extensive spectroscopic analyses. Among them, homastenones A (1) and B (2) are two novel aromatic lactone derivatives containing 12 carbon atoms on the carbon skeleton, and the known compounds (3–8) were isolated from th...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Fingerprinting metabolomics in tropical mistletoes: A case study with facultative aluminum-accumulating species
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Marcelo Claro de Souza, Annylory Lima Rosa, Charlotte Poschenrieder, Roser Tolrà, Fernando Batista Da Costa Aluminum (Al) toxicity is a hot topic due to the high sensitivity of cultivated plants. Despite the large investment in the last century in understanding the mechanisms used by sensitive and Al-excluding species to avoid Al uptake from soil, little attention has been devoted to understanding the mechanisms used by native Al-accumulating species to deal with Al-toxicity. Passovia ovata (Pohl ex DC.) Kuijt and Struthanthus polyanthu...
Source: Phytochemistry Letters - April 10, 2018 Category: Chemistry Source Type: research

Fusidic acid ring B hydroxylation by Cunninghamella elegans
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Abdel-Rahim S. Ibrahim, Amany E. Ragab Fusidic acid (1) biotransformation using the fungus Cunninghamella elegans NRRL 1392 was studied. Two hydroxylated derivatives of fusidic acid (2, 3) were isolated, and their structures were fully elucidated using various spectroscopic techniques including 1D, 2D NMR and HRESI-FTMS. Cunninghamella elegans NRRL 1392 mediated the hydroxylation of ring B to yield 7-β-hydroxy (compound 2) and 6-β-hydroxyfusidic acid (compound 3). The antimicrobial activity of compounds 2 and 3 was evaluated against ...
Source: Phytochemistry Letters - April 10, 2018 Category: Chemistry Source Type: research

New iridoids from the flowers of Plumeria rubra “Acutifolia”
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Yu-Ying Xia, Chao-Zhan Lin, Xian-Jin Lu, Fang-Le Liu, Ai-ZHi Wu, Lei Zhang, Chen-Chen Zhu Four new iridoids, 1α-protoplumericin B-C (1-2), 13-O-caffeoyl-15-demethy-plumieride (3), 15-demethy-plumieride p-E-coumarate (4), together with six known iridoids (5-10) were isolated from the flowers of Plumeria rubra “Acutifolia”. Their structures and relative configurations were established by extensive spectroscopic methods, including IR, HRESIMS, HSQC, HMBC, 1H-1H COSY and NOESY analysis. All compounds were evaluated for cytotoxic ...
Source: Phytochemistry Letters - April 10, 2018 Category: Chemistry Source Type: research

The chemical constituents from twigs of Lindera glauca (Siebold & amp; Zucc.) Blume and their antiviral activities
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): SeonJu Park, Jae-Hyoung Song, Nguyen Xuan Nhiem, Hyun-Jeong Ko, Seung Hyun Kim Four new compounds (1–3 and 5), along with 17 known compounds, were isolated from the twigs of Lindera glauca (Siebold & Zucc.) Blume. The absolute configuration of compound 4 was determined for the first time in the present study. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their antiviral activities against HRV1B-...
Source: Phytochemistry Letters - April 8, 2018 Category: Chemistry Source Type: research

Hydantoin and thioamide analogues from Lepidium meyenii
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): XiaoXue Tian, XingRong Peng, MuYuan Yu, YanJie Huang, Xia Wang, Lin Zhou, Minghua Qiu Four new compounds, including two hydantoin derivatives, macahydantoins C and D (1, 2), one urea derivative, macaurea A (3) and one thioamide analogue, macathioamide A (4), were isolated from the tube of Lepidium meyenii (Maca). Their chemical structures were determined by analyzing spectroscopic data, especially 1D and 2D NMR spectra, and comparing their specific rotation with data reported in literature. All of the isolates were obtained from plants for the...
Source: Phytochemistry Letters - March 27, 2018 Category: Chemistry Source Type: research

Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Hao-Wen Jiang, Jing Lin, Gui-Min Wang, Jing-Jing Zhang, Shan-Shan Gu, Lei Cao, Yan Chen, Ling Wang, He Jiao, Wei-Liang Zhu, Hai-Yan Zhang, Wei-Min Zhao, Jin-Long Li Seven new acetophenone derivatives, three couples of enantiomers (±)-cynwilforones D − F (1 − 3) together with cynwilforone G (4), were isolated form the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and X-ray crystallography. Each racemate was separated into individual enantiomers, and ele...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Zeapyranolactone − A novel strigolactone from maize
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Tatsiana V. Charnikhova, Katharina Gaus, Alexandre Lumbroso, Mark Sanders, Jean-Paul Vincken, Alain De Mesmaeker, Carolien P. Ruyter-Spira, Claudio Screpanti, Harro J. Bouwmeester The structure of a new strigolactone present in the root exudate and root extract of maize hybrid cv NK Falkone plants was elucidated and characterized as zeapyranolactone: Methyl .(E)-3-((4-methyl-5-oxo-2,5-dihydrofuran-2-yl)oxy)-2-(4,4,5-trimethyl-2-oxo-2,3,4,6,7,7a-hexahydrocyclopenta[b]pyran-7-yl)acrylate. Unlike any other strigolactone published so far, it cont...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Chemical constituents from the rhizomes of Gastrodia elata f. glauca and their potential neuroprotective effects
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Zhi-Wei Wang, Yun Li, Da-Hui Liu, Yan Mu, Hong-Jing Dong, Hong-Lei Zhou, Xiao Wang A phytochemical study on the rhizomes of Gastrodia elata f. glauca resulted in the isolation of three new parishin derivatives and one new adenosine derivative, together with six known compounds. Their structures were elucidated mainly by spectroscopic analysis and compared to published data. All these isolates were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and new compound 4 showed potent activity with an EC50 va...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Bicyclo[3.2.1]octanoid neolignans from Indonesian red betle leaves (Piper crocatum Ruiz & amp; Pav.)
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Dayar Arbain, Nofrizal, Nova Syafni, Friardi Ismed, Sammer Yousuf, M. Iqbal Choudhary Two new bicyclo[3.2.1]octanoid neolignans of guianin-type named as (1′R,2′R,3′S,7S,8R)-Δ5′,8′-2′-acetoxy-3,4,5,3′,5′-pentamethoxy-4′-oxo-8.1′,7.3′-neolignan (crocatin A, 1) and (1′R,2′R,3′S,7S,8R)-Δ5′,8′-2′-hydroxy-3,4,5,3′,5′-pentamethoxy-4′-oxo-8.1′,7.3′-neolignan (crocatin B, 2), along with known compounds pachypo...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Simple synthesis and anti-inflammatory activities of Spanrstolonin B derivatives
In this study, ten derivatives (A1–A6, B1–B2, and C1–C2) were synthesized by the structural modification of compounds 1 and 2, of which nine derivatives are new compounds. The n-octanol/water partition coefficients (K ow) of these derivatives were determined by high performance liquid chromatography method, and their anti-inflammatory activities were evaluated of inhibiting the secretion of TNF-α and IL-6 in LPS- or Pam3csk4- induced RAW264.7 cells. Preliminary structure-activity relationship study revealed that methylated, acetylated and butyrylated derivatives (A1–A6) exhibited weaker activi...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Bioactive dibenzofurans from the rattans of Bauhinia championii (Benth.) Benth.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Li-Ping Hua, Yu-Qin Zhang, Miao Ye, Wen Xu, Xiao-Ying Wang, Yan-Hui Fu, Wei Xu Two new dibenzofurans, bauhichamines A (1) and B (2), along with six known compounds (3-8), were isolated from the rattans of Bauhinia championii (Benth.) Benth. (Fabaceae). The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparison of their data with those reported in the literatures. All new compounds were evaluated for their anti-rheumatoid arthritis activities via examining their anti-proli...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Novel biflavonoids from Cephalotaxus oliveri Mast.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Dai Ren, Fan-Cheng Meng, Hui Liu, Tong Xiao, Jin-Jian Lu, Li-Gen Lin, Xiu-Ping Chen, Qing-Wen Zhang Three new biflavonoids, umcephabiflovin A (1), umcephabiflovin B (2), and S-taiwanhomoflavone-B (3), together with seven known flavonoids (4–10) and seven known alkaloids (11–17), were isolated from the twigs of Cephalotaxus oliveri Mast. The flavonoids were found to inhibit α-glucosidase activity. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Three new nortriterpenoids from the rattan stems of Schisandra chinensis
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Bing-You Yang, Zhang-Lin Chen, Yan Liu, Hai-Xue Kuang Three new nortriterpenoids, schindilactones L and M (1–2) and wuweizidilactone S (3), along with five known nortriterpenoids, schindilactone G (4), wuweizidilactone A (5), wuweizidilactone L (6), wuweizidilactone C (7) and pre-schisanartanin (8), were isolated from the rattan stems of Schisandra chinensis. The structure of the new compounds were elucidated by spectroscopic methods, including one and two-dimensional NMR as well as high-resolution mass spectrometry. All of the compound...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Cytotoxic and antimicrobial labdane and clerodane diterpenoids from Kaempferia elegans and Kaempferia pulchra
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Pornsuda Chawengrum, Jutatip Boonsombat, Prasat Kittakoop, Chulabhorn Mahidol, Somsak Ruchirawat, Sanit Thongnest Three previously undescribed diterpenoids, propadanes A-C (1-3), together with seventeen known compounds (4-20), were isolated from the rhizomes of Kaempferia elegans and Kaempferia pulchra. The structures of the isolated compounds were elucidated through extensive analysis of spectroscopic data. The absolute configuration (12R) of propadane A (1) was established by CD analysis. (−)-Kolavelool (15) and (−)-2β-hydr...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Oleanane triterpenoids from the Algerian Salvia phlomoides
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Lamia Benniou, Moses K. Langat, Dulcie A. Mulholland, Fadila Benayache, Samir Benayache Three previously unreported triterpenoids 2α,3β,11α-trihydroxyolean-18-ene 1, 3β-acetoxy,2α,11α- dihydroxyolean-18-ene 2 and 2α-acetoxy,3β,11α-dihydroxyolean-18-ene 3 were isolated from the chloroform extract of aerial parts (leaves and flowers) of Salvia phlomoides collected from the Constantine region in the east of Algeria. Structures were determined using NMR spectroscopy and HR-ESI mass spectrometry. ...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Two new naphthalenones from Diospyros undulata stem bark and their cytotoxic activity
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Natcha P. Suchaichit, Nattawut Suchaichit, Kwanjai Kanokmedhakul, Kitisak Poopasit, Panawan Moosophon, Somdej Kanokmedhakul Two new naphthalenones, cis-isoshinanolone-4-acetate (1) and 3,4-dihydro-4β-hydroxy-5,6-dimethoxy-2α-methyl-1(2H)-naphthalenone (2), were isolated together with three known naphthoquinone derivatives (3-5), four dimeric naphthoquinones (6-9), two coumarins (10-11) and four triterpenoids (12-15) from the stem bark of Diospyros undulata. Their structures were characterized by intensive spectroscopic data (1D and...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research