The joint action in the bioactivity studies of Antarctic lichen Umbilicaria antarctica: Synergic-biodirected isolation in a preliminary holistic ecological study
Publication date: Available online 28 December 2016 Source:Phytochemistry Letters Author(s): Jose L.G. Galindo, Benito F. García, Ascensión Torres, Juan C.G. Galindo, Joanne G. Romagni, Francisco A. Macías Antarctica is one of the world’s most inaccessible regions. This area is also unique in that it has a terrestrial biota dominated by non-vascular plants, of which lichens and mosses are typically the dominant life-forms. A phytochemical study of Antarctic lichen (Umbilicaria antarctica) collected from maritime Antarctica has been carried out. The hexane, acetone and butanol extracts have been ...
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research

Phytochemical variations of Rhodiola rosea L. wild-grown in Bulgaria
In this study, we report on the application of NMR-based metabolomics (1D and 2D) combined with multivariate data analysis and an HPLC method development for quantitative determination of the metabolic differences in R. rosea rhizomes, roots and aerial parts from its natural habitat in Bulgaria. In the rhizomes the content of salidroside, rosarin, rosavin and rosin was 2.67%, 0.37%, 1.97% and 0.04%, respectively, while their respective amounts in the roots were 0.31%, 0.06%, 0.39% and 0.01%. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research

Synthesis and cytotoxic effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 breast cancer cell lines
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Muhammad Nadeem Akhtar, Landa Zeenelabdin Ali Salim, Swee Keong Yeap, Nadiah Abu, Seema Zareen, Kong Mun Lo, Addila abu Bakar, Noorjahan Banu Alitheen A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68) and normal breast cell (MCF-10A). The structure of DMMF was determined by EI-MS, 1H NMR and single ...
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research

Bioactive flavonoid glycosides from Whole Plants of Iris japonica
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Guo-Ru Shi, Xin Wang, Yan-Fei Liu, Chun-Lei Zhang, Gang Ni, Ruo-Yun Chen, De-Quan Yu Phytochemical investigation of the ethanol extract of whole plants of Iris japonica led to the isolation of three new and eight known analogues of flavonoid glycosides. The newly isolated structures were determined by spectroscopic and chemical methods as tectorigenin-7-O-β-d-glucopyranosyl (1→3)-O-β-d-glucopyranoside (1), tectorigenin-7-O-β-d-deoxyallopyranoside (2), and tectorigenin-7-O-β-d-quinovopyranoside (3). In addition, all of...
Source: Phytochemistry Letters - December 28, 2016 Category: Chemistry Source Type: research

Early developmental onset of alkaloid biosynthesis in Mexican poppy (Argemone mexicana L) Papaveraceae
Publication date: Available online 26 December 2016 Source:Phytochemistry Letters Author(s): Jorge F. Xool-Tamayo, Miriam Monforte-González, Jorge Rubio-Piña, Gumersindo Mirón-López, Felipe Vázquez-Flota The distribution of berberine and sanguinarine, two benzylisoquinolinic alkaloids, was analysed at early developmental phases in Argemone mexicana, including hypocotyls, cotyledonary seedlings and plantlets (displaying the first pair of true meristematic leaflets). Transcripts corresponding to genes involved in the synthesis of each of these alkaloids were also analysed. Even though most...
Source: Phytochemistry Letters - December 27, 2016 Category: Chemistry Source Type: research

An ELISA method to identify the phytotoxic Pseudomonas syringae pv. actinidiae exopolysaccharides: A tool for rapid immunochemical detection of kiwifruit bacterial canker
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Alessio Cimmino, Marco Iannaccone, Milena Petriccione, Marco Masi, Marco Evidente, Rosanna Capparelli, Marco Scortichini, Antonio Evidente The phytotoxic exopolysaccharides produced by Pseudomonas syringae pv. actinidiae, the causal agent of bacterial canker of kiwifruit, were isolated and partially identified. Their phytotoxic activity was evaluated on host and non-host plants and their role in the complex mechanisms of host-pathogen interaction was also discussed. The phytotoxic exopolysaccharides, which are natural antigens, were used to a...
Source: Phytochemistry Letters - December 27, 2016 Category: Chemistry Source Type: research

Cytotoxic and anti-oxidant biphenyl derivatives from the leaves and twigs of Garcinia multiflora
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Dong-Song Tian, Wei Gu, Li-Ping Wang, Lie-Jun Huang, Qing Rao, Tao Huang, Yan-Hui Fu, Jian-Xin Zhang, Chun-Mao Yuan, Xiao-Jiang Hao Three new biphenyl derivatives (1–3), together with five known compounds, were isolated from the leaves and twigs of Garcinia multiflora. Their structures were determined by extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. All eight isolates showed weak cytotoxicity on five human tumor cell lines. In addition, the three biphenyl derivatives showed moderate anti-oxidant ac...
Source: Phytochemistry Letters - December 27, 2016 Category: Chemistry Source Type: research

Medicago sativa as a source of secondary metabolites for agriculture and pharmaceutical industry
Publication date: Available online 24 December 2016 Source:Phytochemistry Letters Author(s): Katarzyna Rafińska, Paweł Pomastowski, Olga Wrona, Ryszard Górecki, Bogusław Buszewski Medicago sativa L. (lucerne or alfalfa) is a species which is generally regarded as a cheap source of valuable protein not only for animal fodder but also for nourishment provided in the poorest and developing countries. Moreover, this plant has a long tradition of use in folk medicine. Numerous studies indicate that besides protein, M. sativa synthesizes a variety of secondary metabolites. Among secondary metabolite classes produced b...
Source: Phytochemistry Letters - December 25, 2016 Category: Chemistry Source Type: research

Thaixylogranins A –H: eight new limonoids from the Thai mangrove, Xylocarpus granatum
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Minghua Liao, Patchara Pedpradab, Jun Wu Eight new limonoids named thaixylogranins A–H (1–8), including seven mexicanolides (1–3 and 5–8), were isolated from the seeds of a Thai mangrove, Xylocarpus granatum. The structures of these limonoids were established on the basis of HRESIMS and NMR spectroscopic data. Compounds 1–4 possess an 8α, 30α-epoxy ring, whereas compounds 5−8 have a C8C30 bond. Compounds 1–8 exhibited weak cytotoxicities against the MDA-MB-231 cell with IC50 values of 49.4...
Source: Phytochemistry Letters - December 24, 2016 Category: Chemistry Source Type: research

A window on cyclitols: Characterization and analytics of inositols
Publication date: Available online 22 December 2016 Source:Phytochemistry Letters Author(s): Hossam Al-Suod, Magdalena Ligor, Ileana-Andreea Rațiu, Katarzyna Rafińska, Ryszard Górecki, Bogusław Buszewski Cyclitols are cycloalkanes with one hydroxyl group on each of three or more ring atoms, also called cycloalkane polyols or sugar alcohol which attract attention since they have numerous pharmaceutical properties and are widespread in the plants. Inositols are important cyclitols, which constitute a group of naturally occurring polyhydric alcohols and some isomers of this group can be commonly found in most plant...
Source: Phytochemistry Letters - December 23, 2016 Category: Chemistry Source Type: research

New metabolites with cytotoxic and antiproliferative activities isolated from Bonellia macrocarpa
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Sara E. Vila-Luna, Rosa E. Moo-Puc, Luis W. Torres-Tapia, Sergio R. Peraza-Sánchez Five compounds were isolated from Bonellia macrocarpa roots: 1,3,5,6-tetramethoxy-8-methylnaphthalene (1), 3,5-dihydroxy-1,2,2-trimethyl-benzocyclobutane (2), 3-methoxy-5-octylphenol (3), 3-methoxy-2-methyl-5-pentylphenol (4), and protoprimulagenin A (5), being 1–3 new. Compound 5 showed the best effect, exhibiting cytotoxic activity on three of the cancer cell lines (HeLa, SiHa, and MCF-7) and antiproliferative activity against two cell lines (SiH...
Source: Phytochemistry Letters - December 22, 2016 Category: Chemistry Source Type: research

Variation in polyphenolic profile and in vitro antioxidant activity of eastern teaberry (Gaultheria procumbens L.) leaves following foliar development
Publication date: Available online 20 December 2016 Source:Phytochemistry Letters Author(s): Piotr Michel, Aleksandra Owczarek, Martyna Kosno, Daniel Gontarek, Magdalena Matczak, Monika A. Olszewska Seasonal dynamics in the polyphenolic composition, antioxidant activity, and their relationships during plant development were evaluated for eastern teaberry (Gaultheria procumbens L.) leaves, a traditional herbal medicine of North American natives. With the complementary UHPLC-PDA-ESI-MS 3 , HPLC-PDA-fingerprint, Folin-Ciocalteau, and n-butanol/HCl assays of methanol-water (75:25, v/v) extracts, the dried leaf samples harvest...
Source: Phytochemistry Letters - December 21, 2016 Category: Chemistry Source Type: research

Floral scent: Regulation and role of MYB transcription factors
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Mummadireddy Ramya, Oh Keun Kwon, Hye Ryun An, Pil Man Park, Yun Su Baek, Pue Hee Park Floral scent plays a vital role in reproduction, including attracting pollinators to ensure that fertilization occurs in several plants. In addition, floral scents are widely applied in perfumes, flavors, cosmetics and medicinal substances. Floral scents mediate ecological interactions and have a primary function of attracting visitors and pollinators. Due to the importance of floral scents in plant biology, basic research on flora scent through breeding te...
Source: Phytochemistry Letters - December 17, 2016 Category: Chemistry Source Type: research

Selective oxidation-reduction and esterification of asiatic acid by Pestalotiopsis microspora and anti-HCV activity
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Zhao-Hui Gao, Ran-Ran Gao, Xin-Ran Dong, Zhong-Mei Zou, Qi Wang, De-Min Zhou, Di-An Sun Microbial transformation of asiatic acid (AA) by an endophytic fungus, Pestalotiopsis microspora, yielded six metabolites: 2-oxo-3β,15α,23-trihydroxyurs-12-ene-28-oic acid (1); 2-oxo-3β,15α,22α,23-tetrahydroxyurs-12-ene-28-oic acid (2); 2-oxo-3β,15α,23,30-tetrahydroxyurs-12-ene-28-oic acid (3); 2α,3β,15α,23,30-pentahydroxyurs-12-ene-28-oic acid methyl ester (4); 2α,3α,15α,23-tetrahyd...
Source: Phytochemistry Letters - December 16, 2016 Category: Chemistry Source Type: research

Two new labdane diterpenoids and one new β-lactam from the aerial parts of Roylea cinerea
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Reena Sharma, Sona Mohammadi-Ostad-Kalayeh, Frank Stahl, Carsten Zeilinger, Gerald Dräger, Andreas Kirschning, P.C. Ravikumar Two new labdane diterpenoids cinereanoid C (1), cinereanoid D (2), a new β-lactam, cinerealactam E (3) as well as six known flavonoid glycosides (4–9) were isolated from the aerial parts of Roylea cinerea (Lamiaceae). The structures of (1–9) were all determined by MS, IR and NMR spectroscopy. The structure of cinereanoid D (2) was further proven by single crystal X-ray diffraction. Six known flavo...
Source: Phytochemistry Letters - December 15, 2016 Category: Chemistry Source Type: research

Diarylpropanes and lignans from Horsfieldia tetratepala
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Shou-Zhen Du, Zhi-Chong Wang, Ying Liu, Rui Zhan, Ye-Gao Chen Two new diarylpropanes (1–2), four known compounds, and a new artifact, were isolated from 70% aqueous acetone extract of the twigs of Horsfieldia tetratepala. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation against five cancer cell lines showed that none of these compounds was cytotoxic. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 15, 2016 Category: Chemistry Source Type: research

2-Carboxy-dihydrostilbene and flavan glycosides from Desmodium heterocarpon
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Poolsak Sahakitpichan, Piyawadee Chadmuk, Nitirat Chimnoi, Anucha Namsa-aid, Somsak Ruchirawat, Tripetch Kanchanapoom A new 2-carboxy-dihydrostilbene glucoside, 2-carboxy-3,5,4′-trihydroxydihydrostilbene 3-O-β-d-glucopyranoside (1) and a new flavan diglycoside, (2S)-5,7,4′-trihydroxyflavan 7-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside (3) were isolated from the aerial portion of Thai origin Desmodium heterocarpon together with five known compounds, lunularic acid 4′-O-β-d-glucopyranoside (2), vit...
Source: Phytochemistry Letters - December 15, 2016 Category: Chemistry Source Type: research

Biotransformation of 20(R)-panaxatriol by Aspergillus niger AS 3.739
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Yan Song, Jie Li, Sensen Yan, Haijun Lin, Jianlin Li, Juanjuan Wu, Xuguang Zhai, Guangtong Chen Microbial transformation of 20(R)-panaxatriol (PT) was performed by using the fungus Aspergillus niger AS 3.739. Six metabolites (1–6) including five new compounds were obtained. The chemical structures of these transformed products were elucidated based on various spectroscopic analyses, including 1D and 2D NMR and HRESI-MS. Metabolites 2–6 are new compounds. Furthermore, metabolites 2, 3, 5, and 6 exhibited significant anti-hepatic fi...
Source: Phytochemistry Letters - December 14, 2016 Category: Chemistry Source Type: research

Sesquiterpenes and triterpenoids from the rhizomes of Alisma orientalis and their pancreatic lipase inhibitory activities
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jian Cang, Chao Wang, Xiao-Kui Huo, Xiang-Ge Tian, Cheng-Peng Sun, Sa Deng, Bao-Jing Zhang, Hou-Li Zhang, Ke-Xin Liu, Xiao-Chi Ma Five new terpenoids, including three sesquiterpenes 11-hydroxy-8-ox-alismoxide (1), 11-oxo-13-nor-alismol (2), and 1β,11-dihydroxy-β-cyperone (3), and two protostane-type triterpenoids 16β-acetoxy alisol B (4) and 16α-acetoxy alisol B (5) were isolated from the rhizomes of Alisma orientalis together with 11 known compounds. Their structures were established using 1D and 2D NMR and HRESIMS spect...
Source: Phytochemistry Letters - December 14, 2016 Category: Chemistry Source Type: research

Using MS-FINDER for identifying 19 natural products in the CASMI 2016 contest
Publication date: Available online 9 December 2016 Source:Phytochemistry Letters Author(s): Arpana Vaniya, Stephanie N. Samra, Mine Palazoglu, Hiroshi Tsugawa, Oliver Fiehn In its fourth year, the CASMI 2016 contest was organized to evaluate current chemical structure identification strategies for 19 natural products using high-resolution LC–MS and LC–MS/MS challenge datasets using automated methods with or without the combination of other tools. These natural products originate from plants, fungi, marine sponges, algae, or micro-algae. Every compound annotation workflow must start with determination of elemen...
Source: Phytochemistry Letters - December 10, 2016 Category: Chemistry Source Type: research

Phytochemical and cytotoxic investigations of pinguisanoids from liverwort Porella cordaeana
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Choon Yong Tan, Masanori Inagaki, Hee-Byung Chai, Merve Karadeniz Lambrechts, Alev Önder, Hatice Özenoğlu Kiremit, Liva Harinantenaina Rakotondraibe Four new pinguisane derivatives, namely porellacetals A-D (1–4), alongside with two known compounds, phytol (5) and stigmasterol (6), were isolated from an ether extract of Porella cordaeana, guided by cytotoxicity assays against MCF-7, a human breast cancer cell line, and HT-29, a human colorectal cancer cell line. The structures of the isolated compounds were elucidated with th...
Source: Phytochemistry Letters - December 8, 2016 Category: Chemistry Source Type: research

Flavonol glycosides from the leaves of Boldoa purpurascens and their anti-inflammatory properties
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Yannarys Hernández Ortega, Kenn Foubert, Wim Vanden Berghe, Chandra Sekhar Chirumamilla, Luc Pieters, Dulce María González Mosquera, Sandra Apers Boldoa purpurascens is used in Latin America and the Caribbean as a potent diurectic. Phytochemical analysis has shown the presence of flavonoids and other active compounds. In the present work, three flavonol glycosides were isolated from the leaves of the plant. Their structures have been determined by mass spectrometry and by 1D and 2D NMR analysis as 6-methoxykaempferol-3-O-...
Source: Phytochemistry Letters - December 8, 2016 Category: Chemistry Source Type: research

Chemical solution is an efficient method to induce the formation of 2-(2-phenylethyl) chromone derivatives in Aquilaria sinensis
In this study, mechanical wounds, fungal elicitors and salt solution were applied to induce the formation of 2-(2-phenylethyl) chromones, which are the principal compounds in agarwood. In this research, chemical solution was the best inducer that could induce Aquilaria sinensis calli to produce the highest amount of chromones E and M at 79.20 and 41.62μgg−1, respectively. Chemical solution was then applied on three-year-old saplings by transfusion to verify its induction effect. Chromones E and M were detected in treated saplings after 15 d and then increased with increasing pruning time; their contents reached 22...
Source: Phytochemistry Letters - December 8, 2016 Category: Chemistry Source Type: research

Determination of phenolic compounds and diterpenes in roots of Salvia miltiorrhiza and Salvia przewalskii by two LC –MS tools: Multi-stage and high resolution tandem mass spectrometry with assessment of antioxidant capacity
Publication date: Available online 6 December 2016 Source:Phytochemistry Letters Author(s): Marcin Ożarowski, Anna Piasecka, Agnieszka Gryszczyńska, Aneta Sawikowska, Aurelia Pietrowiak, Bogna Opala, Przemysław Ł. Mikołajczak, Radosław Kujawski, Piotr Kachlicki, Waldemar Buchwald, Agnieszka Seremak-Mrozikiewicz Comparative phytochemical analyses of hydroalcoholic (50% EtOH) extracts from roots of S. miltiorrhiza (SM) and S. przewalskii (SP) were performed using two complementary LC–MS systems: the first system HPLC-DAD-MSn an ion trap mass spectrometer and the second system consisted high resolution MS/MS Orbi...
Source: Phytochemistry Letters - December 7, 2016 Category: Chemistry Source Type: research

Three new arylbenzofurans from Lavandula angustifolia and their bioactivities
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Shiyun Tang, Jianlian Shi, Chunbo Liu, Fengmei Zhang, Nengjun Xiang, Xin Liu, Yongkuan Chen, Junheng You, Qinpeng Shen, Mingming Miao, Zhihua Liu, Guangyu Yang Three new arylbenzofurans, 2-(7-methoxy-2-(4-methoxyphenyl)-3-methylbenzofuran-5-yl)ethanol (1), 4-(5-(2-hydroxyethyl)-7-methoxy-3-methylbenzofuran-2-yl)phenol (2), and 2-(6-methoxy-2-(4- methoxyphenyl)-3-methylbenzofuran-5-yl)ethanol (3), together with three known ones (4–6) were isolated from the whole plant of Lavandula angustifolia. Their structures were determined by means o...
Source: Phytochemistry Letters - December 7, 2016 Category: Chemistry Source Type: research

Three new labdane diterpenes from Loxocalyx urticifolius
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Min Zhao, Da-Le Guo, Lv-Yi Yuan, Yu-Cheng Gu, Lei Chen, Li-Sheng Ding, Yan Zhou Three new labdane diterpenes, namely loxocalyxin D (1), loxocalyxin E (2) and 13-epiloxocalyxin E (3), were isolated from the whole plants of Loxocalyx urticifolius Hemsl. Their structures were elucidated by extensive spectral analysis and chemical methods. The absolute configuration of loxocalyxin D (1) was confirmed by X-ray crystallographic analysis. The cytotoxic activities of the isolated labdane diterpenes were evaluated against the four human cancer cell li...
Source: Phytochemistry Letters - December 2, 2016 Category: Chemistry Source Type: research

Rhamnocitrin glycosides from Oxytropis chiliophylla
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jun Wang, Yang Liu, Norbo Kelsang, Kewu Zeng, Hong Liang, Qingying Zhang, Pengfei Tu Repeated chromatography of the n-BuOH soluble fraction from ethanol extract of the aerial part of Oxytropis chiliophylla led to the isolation of six new rhamnocitrin glycosides, named oxychilioflavonosides A−F (1–6), together with eight known rhamnocitrin glycosides (7–14) of which six were isolated from the genus Oxytropis for the first time. The structures of these compounds were elucidated by extensive spectroscopic techniques and chemica...
Source: Phytochemistry Letters - November 30, 2016 Category: Chemistry Source Type: research

Three new abietane-type diterpenes from the bark of Cryptomeria japonica
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Chi-I Chang, Chien-Chih Chen, Sheng-Yang Wang, Hsun-Shuo Chang, Louis Kuoping Chao, Jih-Jung Chen, Cheng-Chi Chen, Yueh-Hsiung Kuo Three new abietane-type diterpenoids, 7α-butoxyabieta-8,12-diene-11,14-dione (1), 6α,7α-dihydroxyabieta-8,12-dien-11,14-dione (2), and 6α,7β-dihydroxyabieta- 8,12-diene-11,14-dione (3) were isolated from the bark of Cryptomeria japonica D. Don. Their structures were established by means of 1D and 2D NMR, IR, UV, and HR-EI-MS spectra and comparison with the data of known analogues. Grap...
Source: Phytochemistry Letters - November 18, 2016 Category: Chemistry Source Type: research

Xanthine oxidase inhibitory effects of the constituents of Chrysanthemum morifolium stems
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Lu Qu, Jing-Ya Ruan, Li-Jun Jin, Wen-Zhong Shi, Xiao-Xia Li, Li-Feng Han, Yi Zhang, Tao Wang The flowers of Chrysanthemum morifolium Ramat. (family: Asteraceae) are used in Traditional Chinese Medicine to treat fever, cold and swelling. However the aerial part is considered as agriculture waste and the chemical and pharmacological information is scanty. From the stems of this plant, four new compounds named as morineoliganosides A (1), B (2), C (3) and heterophyllol-1-O-β-d-glucopyranoside A (4) together with 27 known isolates (5–3...
Source: Phytochemistry Letters - November 18, 2016 Category: Chemistry Source Type: research

On the probable composition of ‘Jamaican stone’ aphrodisiac
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Pablo Martín-Ramos, Paula Carrión-Prieto, Iosody Silva-Castro, Norlan M. Ruiz-Potosme, Salvador Hernández-Navarro, Jesús Martín-Gil A dangerous aphrodisiac, commonly known as ‘Jamaican stone’, banned by the U.S. Food and Drug Administration, has been studied by vibrational spectroscopy in order to solve the controversy on its composition. The results of the ATR-FTIR analysis revealed the presence of the α-pyrone ring, which is characteristic of bufadienolides from toad venom and bulbs of sq...
Source: Phytochemistry Letters - November 15, 2016 Category: Chemistry Source Type: research

Bioactive caffeic acid derivatives from Wedelia trilobata
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Hui Ren, Qiao-Lin Xu, Mei Zhang, Li-Mei Dong, Qiang Zhang, Bi Luo, Qin-Wen Luo, Jian-Wen Tan Two new caffeic acid derivatives, p-hydroxyphenyl caffeate (1) and methyl 3-(7-methoxy-dihydrocaffeoyl)-5-caffeoyl quinate (2), were isolated from the whole plant of Wedelia trilobata, along with four known ones, neochlorogenic acid methyl ester (3), methyl 4,5-di-O-caffeoyl quinate (4), methyl 3,5-di-O-caffeoyl quinate (5) and chlorogenic acid methyl ester (6). Their structures were elucidated on the basis of detailed spectroscopic analysis. They wer...
Source: Phytochemistry Letters - November 15, 2016 Category: Chemistry Source Type: research

Flavonol triglycosides of leaves from Maytenus robusta with acetylcholinesterase inhibition
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Grasiely F. de Sousa, Mariana G. de Aguilar, Jacqueline A. Takahashi, Tânia M.A. Alves, Markus Kohlhoff, Sidney A. Vieira Filho, Grácia D.F. Silva, Lucienir P. Duarte Although Maytenus robusta aqueous infusions of leaves are used in Brazilian traditional medicine for stomach disease treatment, only a few chemical studies of this species are found in literature. The phytochemical investigation of methanol extract from M. robusta leaves yielded the known compound kaempferol (3) and two new flavonol glycosides: kaempferol-3-O-β...
Source: Phytochemistry Letters - November 15, 2016 Category: Chemistry Source Type: research

Triterpenoids from seeds of Tapinanthus bangwensis
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Hermine Maza, Pierre Mkounga, Sandra Larissa Fenkam, Sylvain Kamdem Sado, Hayato Hishikawa, Hiroshi Nishino, Ephrem Augustin Nkengfack Seven new pentacyclic triterpenoids, including five oleanane-types designated bangwaoleanenes A–E (1)–(5), and two ursane-types, named bangwaursenes A (6) and B (7) together with eight known compounds: 3β-acetoxy-urs-12,13-ene-11-one (8), 3β-acetoxy-11α-hydroxyurs-12,13-ene (9), 11α,12α-oxidotaraxeryl acetate (10), β-amyrin acetate (11), (1R,5S,7S)-7-[2-(4-hydroxyph...
Source: Phytochemistry Letters - November 15, 2016 Category: Chemistry Source Type: research

Four new limonoids from the seeds of Chukrasia tabularis A. Juss.
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Li Yi, Hongjian Zhang, Xiaomeng Tian, Jie Luo, Jun Luo, Lingyi Kong Two new C-15 enolic acyl phragmalin-type limonoid orthoesters (1-2) which possessed a C-15-propionyl phragmalin skeleton and two new mexicanolide-type limonoids (3-4) were isolated from the ethanol extract of seeds of Chukrasia tabularis A. Juss. Their structures were established on the basis of spectroscopic analyses and electronic circular dichroism (ECD) exciton chirality method. Additionally, all of the compounds were screened against three human tumor cell lines MCF-7, S...
Source: Phytochemistry Letters - November 13, 2016 Category: Chemistry Source Type: research

Bioactive phenolics from in vitro cultures of Lactuca aculeata Boiss. et Kotschy
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Anna Stojakowska, Janusz Malarz A callus culture of Lactuca aculeata, except for commonly distributed caffeic acid derivatives typically found in the Asteraceae family (chlorogenic acid, methyl caffeate, 1,5- dicaffeoylquinic acid), yielded bioactive lignans: (+)-5-methoxybalanophonin, syringaresinol, (+)-balanophonin-9-O-β-glucopyranoside, (+) buddlenol A, (−)-dihydrodehydrodiconiferyl alcohol-4-O-β-glucopyranoside and (−)-dihydrodehydrodiconiferyl alcohol-9-O-β-glucopyranoside. Sesquiterpene lactones characteristi...
Source: Phytochemistry Letters - November 12, 2016 Category: Chemistry Source Type: research

Neoclerodane diterpenoids from aerial parts of Scutellaria barbata
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Guo-Chun Yang, Chen Liang, Sheng-Ge Li, Min Liu, Ming-Jing Jia, Xiao-Nan Xu, Xiao-Bo Wang, Hui-Ming Hua, Li-Xin Sun Three new neoclerodane diterpenoids, scutebatas U-W (1–3), along with nine known ones (4–12) were obtained via the phytochemical investigation of the aerial parts of Scutellaria barbata. The structure of these compounds was established by spectroscopic analysis. The absolute configurations of 1 and 2 were elucidated based on CD exciton chirality and electronic circular dichroism (ECD) calculation. Moreover, compounds...
Source: Phytochemistry Letters - November 12, 2016 Category: Chemistry Source Type: research

Fruit extracts of 10 varieties of elderberry (Sambucus nigra L.) interact differently with iron and copper
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Přemysl Mladěnka, Michal Říha, Jan Martin, Barbora Gorová, Aleš Matějíček, Jiřina Spilková The fruits of elderberry, Sambucus nigra L. (Adoxaceae), are a rich source of cyanidin-based anthocyanins. However, despite the plethora of research on their potential health benefits, information on possible interactions with metals, in particular the two essential trace elements, iron and copper, is lacking. We tested the interaction of elderberry fruit extracts with these metals under different (patho)physi...
Source: Phytochemistry Letters - November 10, 2016 Category: Chemistry Source Type: research

Studies on the accumulation of phenolic acids and flavonoids in different in vitro culture systems of Schisandra chinensis (Turcz.) Baill. using a DAD-HPLC method
Publication date: Available online 4 November 2016 Source:Phytochemistry Letters Author(s): Agnieszka Szopa, Adam Kokotkiewicz, Marcelina Bednarz, Maria Luczkiewicz, Halina Ekiert Different in vitro culture systems of the East-Asian origin medicinal plant species − Schisandra chinensis, were tested in order to investigate their potential for the accumulation of two groups of phenolic compounds. In vitro cultures were maintained on the Murashige and Skoog (MS) medium supplemented with 3mg/l BA and 1mg/l NAA in an agar system (30- and 60-day growth cycles), and also in two different liquid systems: stationary and agit...
Source: Phytochemistry Letters - November 5, 2016 Category: Chemistry Source Type: research

Sesquiterpenoids from roots of Lactuca sativa var. angustana cv. “Grüner Stern”
Publication date: Available online 4 November 2016 Source:Phytochemistry Letters Author(s): Klaudia Michalska, Oskar Michalski, Anna Stojakowska From the roots of Lactuca sativa var. angustana cv. “Grüner Stern” 21 known sesquiterpene lactones, both aglycones and glycosides, together with four phenolic compounds were isolated from ethanol extracts using extensive chromatographic methods (CC, TLC, HPLC/DAD). The compounds were identified by spectroscopic methods (1D- and 2D-NMR) and ESI mass spectrometry. This is the first report on the occurrence of 11β-hydroxyleucodin-11-O-β-glucopyranoside and...
Source: Phytochemistry Letters - November 5, 2016 Category: Chemistry Source Type: research

Antimicrobial lignans derived from the roots of Streblus asper
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Hui Nie, Xin-Lan Guan, Jian Li, Yan-Jun Zhang, Rui-Jie He, Yan Huang, Bu-Ming Liu, De-Xiong Zhou, Sheng-Ping Deng, Huang-Can Chen, Rui-Yun Yang, Jun Li Four new lignans, (7′R,8′S)-4,4'-Dimethoxy-strebluslignanol (1), 3'-Hydroxy-isostrebluslignaldehyde (2), 3,3'-Methylene-bis(4-hydroxybenzaldehyde) (3), and 4-Methoxy-isomagnaldehyde (4), and six known lignans (5–10), were isolated from the roots of Streblus asper. The structures of these molecules were elucidated through various spectroscopic methods of analysis, including...
Source: Phytochemistry Letters - November 5, 2016 Category: Chemistry Source Type: research

Alternative approach to species identification of Actaea racemosa L. (syn. Cimicifuga racemosa (L.) Nutt., black cohosh) herbal starting material: UV spectroscopy coupled with LDA
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Marian Bittner, Regina Schenk, Matthias F. Melzig The North American Actaea racemosa L. (syn. Cimicifuga racemosa (L.) Nutt., commonly known as black cohosh), considered to be a more “natural” alternative to conventional therapies, is used to relieve menopausal symptoms. The high demand for plant material has led to problems with substitution/adulteration of raw material of wholesale origin. The authenticity of the starting material is crucial for the herbal product’s efficacy and safety, and tests on identity and substit...
Source: Phytochemistry Letters - November 3, 2016 Category: Chemistry Source Type: research

New guaiane and acorane sesquiterpenes in high quality agarwood ⿿Qi-Nan⿿ from Aquilaria sinensis
Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Delan Yang, Jun Wang, Wei Li, Wenhua Dong, Wenli Mei, Haofu Dai Two new guaiane sesquiterpenes (1⿿2), one new acorane sesquiterpene (3), along with two known sesquiterpenes (4⿿5) were isolated from high quality agarwood ⿿Qi-Nan⿿ originating from Aquilaria sinensis. Their structures were established based on spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR. Compound 1 was a guaiane sesquiterpene lactone, and compound 2 was a guaiane sesquiterpene with a 5/6/7 ring carbon skeleton. Compounds 3 and 4 were acorane-type sesq...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Cognate and cognitive ecopharmacognosy — in an anthropogenic era
Publication date: Available online 17 October 2016 Source:Phytochemistry Letters Author(s): Geoffrey A. Cordell The vibrant future of pharmacognosy is discussed in terms of sustainable development. The future role of biologically active natural products is presented with respect to the time and consciousness required to contemplate the continuing future strategies for ecopharmacognosy to be impactful. Integration of allied sciences and technologies through regulatory harmonization, international collaboration, and translation of holistic quality control techniques to manufacturers, is essential to achieve higher levels of...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Acetylcholinesterase inhibitory assessment of isolated constituents from Salsola grandis Freitag, Vural & amp; Ad ıgüzel and molecular modeling studies on N-acetyltryptophan
Publication date: Available online 27 October 2016 Source:Phytochemistry Letters Author(s): Ilkay Erdogan Orhan, Nurgun Kucukboyaci, Ihsan Calis, José P. Cerón-Carrasco, Helena den-Haan, Jorge Peña-García, Horacio Pérez-Sánchez S. grandis Freitag, Vural & N. Adıgüzel is an endemic plant species to Turkey. Since some other Salsola species have been reported to exert cholinesterase inhibitory effect, we aimed to investigate its inhibitory potential against AChE. The EtOH extract and thirteen constituents [ten flavonol derivatives; e.g. isorhamnetin-3-O-rutinoside (1), ...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Four new minor spirostanol glycosides from Helleborus thibetanus
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Hui Zhang, Yan-Fang Su, Feng-Ying Yang Four new minor spirostanol glycosides (1–4) were isolated from the dried roots and rhizomes of Helleborus thibetanus. Structures of the compounds were established by means of a combination of 1D and 2D NMR experiments, together with HRESIMS and IR measurements as well as the results of acid hydrolysis. The spirostanol glycosides with both a double bond at C-25 and glycosidation at 1-OH have seldom been reported. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Sesquiterpenoids from the Chinese endangered plant Manglietia aromatica
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Li-Jun Wang, Juan Xiong, Yike Zou, Qi-Bing Mei, Wen-Xuan Wang, Jin-Feng Hu One new bourbonane-type (1) and one new cadinane-type (2) sesquiterpenoids, along with one known aromodendrane-type (3) and five known megastigmane-type (4–8) compounds, were isolated from the leaves and twigs of Manglietia aromatica, a Chinese endangered plant that has not been previously phytochemically investigated. The structures and absolute configurations of the new isolates, (1R,4S,5S,6S,7S,10S)-4-hydroxy-bourbon-8-one (1) and (1R,6S,7S)-1-hydroxy- cadi...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Antimicrobial meroterpenoids from the endophytic fungus Penicillium sp. T2-8 associated with Gastrodia elata
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Rongting Duan, Hao Zhou, Yabin Yang, Hongtao Li, Jianwei Dong, Xiaozhan Li, Guangyi Chen, Lixing Zhao, Zhongtao Ding A new meroterpenoid preaustinoid D (1) and a new neogrifolin derivative dihydroxyneogrifolic acid (2), together with other five previously reported meroterpenoids (3-7) were isolated from the endophytic fungus Penicillium sp. T2-8 associated with Gastrodia elata. The structures were elucidated on the basis of spectroscopic data analyses. It was the first time that neogrifolin and its derivatives were isolated from microorgan...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Rearranged ent-kauranoid glycosides from the fruits of Xanthium strumarium and their antiproliferative activity
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Hai Jiang, Guo-Xu Ma, Liu Yang, Xu-Dong Xing, Mei-Ling Yan, Yan-Yan Zhang, Qiu-Hong Wang, Hai-Xue Kuang, Xu-Dong Xu Three new ent-kauranoid glycosides, fructusnoids A-C (1-3) were isolated from the fruits of Xanthium strumarium. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and HRESIMS data. Compounds 1-2 are novel examples of rearranged ent-kauranoid diterpenes with missing C-18/19 carbons. All the compounds were evaluated for their antiproliferative activity in vitro against three human cancer ce...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Phenolic bisabolanes from the sponge-derived fungus Aspergillus sp.
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Shuai Liu, Haofu Dai, Belma Konuklugil, Raha S. Orfali, Wenhan Lin, Rainer Kalscheuer, Zhen Liu, Peter Proksch Two new phenolic bisabolane sesquiterpenes, asperchondols A (1) and B (2), together with seven known analogues (3–9) and four known diphenyl ethers (10–13) were obtained from Aspergillus sp., that had been isolated from the marine sponge Chondrilla nucula. Their structures were elucidated through NMR and MS analysis, and by comparison with literature data. All isolated compounds were evaluated for their antibacterial a...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research

Azaphilones isolated from an alga-derived fungus Penicillium sp. ZJ-27
Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Liu-hong Zhang, Yi Long, Xiao-ling Lei, Jia-yi Xu, Zhi-jian Huang, Zhi-gang She, Yong-cheng Lin, Jing Li, Lan Liu Four new azaphilones, peniazaphilones A–D (1–4), together with four analogues (5–8), were isolated from the alga-derived fungus Penicillium sp. ZJ-27. The structures of 1–8 were elucidated by 1D and 2D NMR analysis. The absolute configurations of 1–4 were determined by electronic circular dichroism (ECD). The isolated compounds were evaluated for cytotoxic activity against two tumor cell lines and ...
Source: Phytochemistry Letters - October 29, 2016 Category: Chemistry Source Type: research