Four new sesquiterpenoids from Dendranthema morifolium (Ramat.) kitam flowers
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Wenjing Chen, Mengnan Zeng, Meng Li, Fang Li, Xuan Zhao, Hui Fan, Xiaoke Zheng, Weisheng Feng Four new sesquiterpenoids, chrysanthguaianolactones C-F (1–4), together with four known sesquiterpenoids (5–8), including 3α,4α,10β-trihydroxy- 8α-acetoxyguai-1,11(13)-dien-6α,12-olide (5), 3α,4α,10β-trihydroxy-8α-acetoxy −11βH-guai-1-en-12,6α-olide (6), 8α-(angelyloxy)-3β,4β-dihydroxy-5αH,6βH,7αH, 11αH-guai-1(10)-en-12,6-olide (...
Source: Phytochemistry Letters - December 16, 2017 Category: Chemistry Source Type: research

Bioactive metabolites from marine-derived Streptomyces sp. A68 and its Rifampicin resistant mutant strain R-M1
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Le-Le Qin, Biao Zhou, Wanjing Ding, Zhongjun Ma Three new indolocabazole analogues (1-3), one eudesmane-type derivative (4), one bisphenol A propyl ether analogue (5), were purified from the fermentation of the marine- derived Streptomyces sp. A68 and its Rifampicin-resistant mutant strain R-M1. The structures were established through the interpretation of spectroscopic data combined with literature data review. The absolute stereochemistry of 1 was further confirmed by X-ray crystallography analysis. Bioactivity test showed that compounds...
Source: Phytochemistry Letters - December 16, 2017 Category: Chemistry Source Type: research

Two new nortriterpenoids from the fruiting bodies of Ganoderma daqingshanense
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Ning Ning Lan, Qing Yun Ma, Fan Dong Kong, Ning Ning Yang, Qing Yi Xie, Sheng Zhuo Huang, Li Man Zhou, You Gen Wu, You Xing Zhao Two new nortriterpenoids named daqingshones A (1) and B (2), along with two known ganderic acids (3 and 4), were isolated from the fruiting bodies of Ganoderma daqingshanense. Their structures were elucidated by spectroscopic data including MS, 1D and 2D NMR. Compound 2 exhibited weak anti-acetylcholinesterase (AChE) activity with IC50 value of 39.2μM. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Further chemical constituents from Sinningia canescens and S. leucotricha (Gesneriaceae)
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Maria Helena Verdan, Dilamara R. Scharf, Andersson Barison, Marcos J. Salvador, Maria Élida A. Stefanello Four new compounds were isolated from the tubers of Sinningia canescens and S. leucotricha: one naphthoquinone, 7-methoxy-8-hydroxy-α-dunnione (1); two arylbenzofurans, sinningial A (2) and B (3); and one sesquiterpene, 11-epi-subergorgiol (4). Seventeen additional known compounds were isolated and identified. The structures of all compounds were determined by spectroscopic and MS analysis. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Cytotoxic, antimicrobial activities, AChE and BChE inhibitory effects of compounds from Tanacetum chiliophyllum (Fisch. & amp; Mey.) Schultz Bip. var. oligocephalum (D.C.) Sosn. and T. chiliophyllum (Fisch. & amp; Mey.) Schultz Bip. var. monocephalum Grierson
In this study, cytotoxic, antimicrobial activities and acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory effects of pure compounds isolated from these plants were investigated. The tested compounds showed AChE and BChE inhibition which ranged between 7.20–80.37% and 9.19%–76.99% respectively. The highest AChE and BChE inhibition was observed for ulubelenolide which afforded 80.37% and 76.99% inhibition respectively. The cytotoxic effect of the compounds ranged between 22.34–49.77μg/mL IC50 values. Highest cytotoxic activity was observed against MCF-7 and HEK 293 cell line by 5–...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Bioactive lignans from the stems of Mappianthus iodoides
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Zhi-Hua Jiang, Ling Chai, Yan-Ping Liu, Hong-Cong Qiu, Ting-Ting Wang, Xing-Yang Feng, Yi-Tong Wang, Ze-Hao Huang, Bu-Ming Liu, Yan-Hui Fu Two new lignans, mappianthines A (1) and B (2), along with ten known analogues (3-12), were isolated from the stems of Mappianthus iodoides. The structures with the absolute configurations of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their anti-i...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Benzophenone derivatives from the plant endophytic fungus, Pestalotiopsis sp.
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Ren-Yu Song, Yi Liu, Rui-Huan Liu, Xiao-Bing Wang, Tian-Xiao Li, Ling-Yi Kong, Ming-Hua Yang Two new (1–2) and one known (3) benzophenone derivatives, along with five known ambuic acid analogues (4–8) were isolated from the solid cultures of a Pestalotiopsis sp. Compound 2 represented both enantiomeric and atropisomeric isomers, and the absolute configurations of enantiomers [(−)-2 and (+)-2] were determined by electronic circular dichroism (ECD) calculations. All the isolates were evaluated for their antimicrobial and cy...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Unusual 28, 29-nor-9, 19 cycloartane triterpenoids from Chinese medical plant Streptocaulon griffithii Hook
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Yi-Chao Ge, Yu-Chun Cheng, Kui-Wu Wang, Hong Wang Phytochemical investigation of the root of Streptocaulon griffithii Hook (Asclepiadaceae) led to the isolation of three unusual novel triterpenoids, 28, 29-nor-3β, 4β-dihydroxyl-9, 19-cycloartan-26-acid (1), 28, 29-nor-3β, 4β-dihydroxyl-9, 19-cycloartan- 26-acid methylester (2), a 30-nor-lupeol derivative 30-nor-3β -acetoxy-lupan-20-one (3) and five known compounds 4–8. Their structures were established on the basis of physical and spectroscopic analysis, incl...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Five new indole derivatives from the cyanobacterium Moorea producens
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Weina Jiang, Yingyue Bu, Mioko Kawaguchi, Hiroki Osada, Masayuki Fukuoka, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Hiroshi Nagai Chemical analysis of the hydrophilic fraction from marine cyanobacterium Moorea producens extracts led to the isolation of five new indole derivatives (1-5). So far, 2-formyl-4,5,6,7-tetrahydroindole has been reported only for 6 from the nature, consequently compounds 1-5 were the second representatives of this class. Cytotoxicity, diatom growth inhibition, and antibacterial activity tests for compounds...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

New pterocarpon flavonoids from Wisteria sinensis tumor
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Guo-kai Wang, Bai-xiang Cai, Yun-peng Sun, Yang Yu, Pei-yun Wu, Zhong-yu Zhou, Hui Yang, Gang Wang, Jin-song Liu Three new pterocarpon flavonoids, wisterones B-D, together with nine isoflavone known compounds, were isolated from Wisteria sinensis Tumor. The structure of those compounds were elucidated on the basis of spectroscopic analyses, including UV, IR, MS and NMR experiments. These new compounds were investigated for their activities against anti-crop pathogenic fungi. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Cytotoxic drimane meroterpenoids from the Indonesian marine sponge Dactylospongia elegans
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Sherif S. Ebada, Nicole de Voogd, Rainer Kalscheuer, Werner E.G. Müller, Chaidir, Peter Proksch Chemical investigation of the methanol extract of an Indonesian marine sponge Dactylospongia elegans (family Thorectidae) afforded two undescribed drimane meroterpenoidal metabolites, dactylospongenones G and H (1 and 2) together with thirteen known compounds (3–15) including pelorol, 5-epi-ilimaquinone, 5-epi-smenospongine, 5-epi-smenospongidine, nakijiquinone D, smenospongine C, isospongiaquinone, isosmenospongine, nakijiquinones A-...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

New compounds with anti-inflammatory potential from Disporum cantoniense
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Zhifeng Li, Huiling Zhao, Hui Ouyang, Qi Wang, Jie Chen, Yulin Feng, Shilin Yang Phytochemical investigation of Disporum cantoniense has resulted in the isolation of two new compounds, namely (3S,4S,5S)-5-C-(4-hydroxy-3-methoxybenzyl)-γ-lactone-2-deoxy-pentonic acid(1) and (3R,4S,5R)-5-C-(4-hydroxy-3-methoxybenzyl) -γ-lactone-2-deoxy-pentonic acid(2). Their structures were elucidated by various spectroscopic techniques. The absolute configurations of compounds were determined by ECD calculations analysis. Compound 1 showed sign...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Aethusifolins A –D: Four new components from a traditional Mongolian medicinal herb Clematis aethusifolia Turcz
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Yanxi Chang, Ping Zhang, Jirimubatu Jurhiin, Xuan Zhang, Wuyahan Borgihiin, Hongmei Zhao, Sangho Koo, Wolf-Dieter Rausch, Agula B., Baoquan Bao Four new components named aethusifolins A–D (1–4), together with ten known (5–14) were isolated from the dried aerial parts of a traditional Mongolian medicinal herb Clematis aethusifolia Turcz. The planar structures were established based on extensive spectroscopic analysis (HRMS, 1D and 2D NMR), and the absolute configurations were determined by modified Mosher’s method, h...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Chemical constituents from the fungus Stereum sp. YMF1.04183
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Jun-Mei Yan, Xin Wang, Meng-Qing Tian, Cheng-Mang Liu, Ke-Qin Zhang, Guo-Hong Li The chemical constituents of the basidiomycete Stereum sp. YMF1.04183 were studied. Three new sesquiterpenes, stereumenes A–C (1–3), were isolated and identified from the EtOAc extract of Stereum sp. YMF1.04183 culture broth. Stereumene B showed weak nematicidal activity against Caenorhabditis elegans. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Tyrosinase inhibitory activity of three new glycosides from Breynia fruticosa
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Wei-Wen Peng, Zhu-Qiang Wang, Meng-Ying Ji, Zong-Lang Liao, Zhong-Qiu Liu, Peng Wu Two new flavanone glycoside derivatives and one new sulfur-containing spiroacetal glycoside, (2R, 3R)-3-acetyl-7-methoxy-(−)-epicatechin 5-O-(6-isobutanoyl)-β-d-glucopyranoside (1), (2R, 3R)-3-acetyl-7-methoxy-(−)-epicatechin 5-O-[6-(2-methylbutanoyl)]-β-d-glucopyranoside (2) and 4-[(carboxymethyl)thio]-5′-hydroxy-phyllaemblic acid O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside ester (3), along with twelve known fla...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Bioactive cassane diterpenoids from the seeds of Caesalpinia sappan
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Nai-Liang Zhu, Xu-Dong Xu, Mei-Geng Hu, Zhong-Hao Sun, Tong-Yu Wu, Jing-Quan Yuan, Hai-Feng Wu, Yu Tian, Peng-Fei Li, Jun-Shan Yang, Guo-Xu Ma Three new cassane-type diterpenoids named caesalppans G-I (1–3) together with three known ones (4–6), were isolated from the methanol extract of Caesalpinia sappan seeds. Their structures were determined based on spectroscopic data. Among the isolated compounds, compound 2 displayed a moderate antimalarial activity with an IC50 value of 2.4μM, and compound 4 showed mild anti-inflammat...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Pro-apoptotic activity of acylated triterpenoid saponins from the stem bark of Albizia chevalieri harms
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Olivier Placide Noté, Lin Marcellin Messi, Joséphine Ngo Mbing, Sarah Ali Azouaou, Mamadou Sarr, Dominique Guillaume, Christian Dominique Muller, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein As a continuation of our interest in apoptosis-inducing triterpenoid saponins from Albizia genus, phytochemical investigation of the stem bark of Albizia chevalieri led to the isolation of three new oleanane-type saponins, named chevalierosides A–C (1–3). Their structures were established on the basis of extensive ana...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

New sesquiterpenoids from Petasites japonicus and Petasites tricholobus
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Ping Hai, Yuan Gao, Chun-Gui Xiao, Xian-Jun Jiang, Xiang-Mei Li, Wan-Qiu Yang, Rong-Tao Li, Fei Wang Phytochemical investigation of the whole plants of Petasites japonicus and Petasites tricholobus led to the isolation of five new bakkenolide-type sesquiterpenoids, bakkenolide-Ib (1), bakkenolide-IIb (2), bakkenolide-IIIb (3), bakkenolide-IVb (4), and bakkenolide-Vb (5), and a new eremophilane-type norsesquiterpenoid, petasindiol (6). Their structures were elucidated by NMR and HRESIMS analyses. Petasindiol (6) represented the first exampl...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Pseudopulchellol: A unique sesquiterpene-monoterpene derived C-25 terpenoid from the leaves of Croton pseudopulchellus Pax (Euphorbiaceae)
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Moses K. Langat, Neil R. Crouch, Jean-Marc Nuzillard, Dulcie A. Mulholland A C-25 terpenoid, pseudopulchellol, a rare example of a compound formed by the combination of a monoterpenoid and a sesquiterpenoid unit, was isolated along with eudesm-4(15)-en-1β,6α-diol, its likely precursor, and nine known compounds, including six ent-kaurenoic acids, from the leaves of Croton pseudopulchellus. The Logic for Structure Determination (LSD) protocol was used to determine that pseudopelchellol consisted of the sesquiterpene, eudesm-4(15)-...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Thanika Promchai, Tongchai Saesong, Kornkanok Ingkaninan, Surat Laphookhieo, Stephen G. Pyne, Thunwadee Limtharakul (née Ritthiwigrom) Two new dihydrooxoprotoberberine alkaloids; miliusathorines A (1) and B (2), a new natural flavone, miliusathorone (3), together with twenty-two known compounds (4–25) were isolated from the combined stem and root extract and the leaf extract of Miliusa thorelii. The structures of all isolated compounds were elucidated by spectroscopic methods and mass spectrometry. All compounds were evaluated...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Six new steroidal glycosides from roots of Cynanchum bungei
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Shu-Juan Hao, Li-Juan Gao, Shi-Fang Xu, Yi-Ping Ye, Xiao-Yu LiGraphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

New Triterpene saponins from the stem of Acacia kamerunensis (Mimosaceae)
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Abdou Tchoukoua, Turibio Kuiate Tabopda, Narandulam Usukhbayar, Ken-ichi Kimura, Eunsang Kwon, Hiroyuki Momma, Takuya Koseki, Yoshihito Shiono, Bonaventure Tchaleu Ngadjui Three previously undescribed oleanane-type saponins acylated with monoterpenic acid, kamerunosides A, B, and C were isolated from the stem liana of Acacia kamerunensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR data and HRESIMS analyses. Their cytotoxicities were evaluated against HL60 cells. Kamerunoside B was the most cytotoxic. Graphical...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Marine fungi: An untapped bioresource for future cosmeceuticals
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Shivankar Agrawal, Alok Adholeya, Colin J. Barrow, Sunil Kumar Deshmukh A number of useful metabolites with cosmeceutical potential have been reported from marine sources over the last several years. Marine life, particularly sponge, algae, tunicates, bacteria and fungi, produces a wide variety of bioactive metabolites whose diversity is enhanced by the varied environmental conditions present in the oceans. The marine environment has a large biological and chemical diversity and serves as a source of novel chemical entities with potential ...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Enzymatic biosynthesis of novel bavachin glucosides via Bacillus UDP-glycosyltransferase
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Yiqun Dai, Songsong Zhang, Da-Chuan Liu, Hong-Mei Li, Tao Ma, Qiang Huo, Cheng-Zhu Wu A UDP-glycosyltransferase (YjiC) from Bacillus licheniformis was exploited for the glycosylation of bavachin. The in vitro glycosylation reaction generated three novel bavachin glucosides, which were structurally characterized as bavachin-4′-O-β-d-glucopyranoside (1), bavachin-7-O-β-d-glucopyranoside (2), and bavachin-4′,7-di-O-β-d-glucopyranoside (3) based on spectroscopic techniques. To enhance product yield, the reaction time...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Chemical Constituents of the Leaves of Caloncoba welwitschii Gilg.
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Pascal D. Douanla, Marguerite Hortence K. Tchuendem, Alembert T. Tchinda, Turibio Kuiate Tabopda, Denis Zofou, Ewa Cieckiewicz, Michel Frédérich, Augustin E. Nkengfack Two new compounds namely acetylcaloncobaside (1) and friedocaloncobic acid (2) were isolated from the leaves of Caloncoba welwitschii together with six known compounds. Their structures were determined by standard spectroscopic methods including one- and two-dimensional NMR, EI-MS, and HRESIMS. The new compounds were established as kaempferol 4′,7-dimetho...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Three new indole alkaloids from Mappianthus iodoides
Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Jiao-Jiao Wei, Wen-Qiong Wang, Wei-Bin Song, Jun Li, Li-jiang Xuan Quite recently, our laboratory reported the isolation and analysis of terpenoid indole alkaloids from Mappianthus iodoides Hand.-Mazz. (Cong et al., 2014). As part of our ongoing chemical investigation of M. iodoides, three new indole alkaloids, mappiodosides H-J (1–3), were isolated from the stems of M. iodoides. Their structures were determined by comprehensive analysis of spectroscopic data including 1D and 2D NMR and HRMS data. All new compounds were evaluated for...
Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research

Secondary metabolites produced by an endophytic fungus Cordyceps ninchukispora from the seeds of Beilschmiedia erythrophloia Hayata
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Hsun-Shuo Chang, Ming-Jen Cheng, Ming-Der Wu, Hing-Yuen Chan, Sung-Yuan Hsieh, Chu-Hung Lin, Yi-Jen Yech, Ih-Sheng Chen Four new amide derivatives, designated as cordycepiamides A–D (1–4), together with 14 known compounds (5–18), were isolated from the EtOAc-soluble fraction of the 95% EtOH extract of long-grain rice fermented with the endophytic fungus C. ninchukispora BCRC 31900, derived from the seeds of medicinal plant Beilschmiedia erythrophloia Hayata. Their structures were elucidated by means of spectroscopic and m...
Source: Phytochemistry Letters - October 12, 2017 Category: Chemistry Source Type: research

Labdane and norlabdane diterpenoids from the aerial parts of Leonurus japonicus
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Ly T.T. Nguyen, Huong K.T. Vo, Son V. Dang, Tho H. Le, Ly D. Ha, Le-Thu T. Nguyen, Lien-Hoa D. Nguyen A new labdane diterpenoid, leojaponicin (1), a novel norlabdane, methyl 15,16-dinor-7-oxolabda-8-ene-14-oate (2), along with four known labdanes, hispanone (3), leoheteronins A (4) and B (5), 15-methoxyleoheteronin B (6), and three norlabdanes, 14,15,16-trinor-7-oxolabda-8-ene-13-oic acid (7), methyl 14,15,16-trinor-7-oxolabda-8-ene-13-oate (8), 14,15-dinor-8-labdene-7,13-dione (9), and a steroid, stigmast-4-ene-3-one (10), were isolated f...
Source: Phytochemistry Letters - October 10, 2017 Category: Chemistry Source Type: research

Welwitschianalol A and B, two cyclohexene derivatives and other insecticidal constituents of Caesalpinia welwitschiana (Oliv.) Brenan
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Flaure Rosette Ehawa Essoung, Brice Mittérant Mba’ning, Samira Abuelgasim Mohamed, Wilber Lwande, Silvère Augustin Ngouela, Etienne Tsamo, Sumesh Chander Chhabra, Ahmed Hassanali, Russell John Cox Crude methanol extract of the leaves of Caesalpinia welwitschiana was found to possess moderate larvicidal activity against second-instar larvae of Tuta absoluta Meyrick. Bioassay-guided fractionation of this extract led to the isolation of two oxygenated cyclohexene derivatives, welwitschianalol A (1, (1α,2β)-2-ace...
Source: Phytochemistry Letters - October 7, 2017 Category: Chemistry Source Type: research

New cytotoxic steroidal saponins from Cestrum parqui
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Radwa R. Mosad, Mohamed H. Ali, Magda T. Ibrahim, Hala M. Shaaban, Marwan Emara, Amir E. Wahba Two new steroidal saponins, 25(R)-3β [(O-β-d-glucopyranosyl-(1→3)-β-d-glucopyranosyl-(1→2)-O-[β-d-xylopyranosyl-(1→3)-O-β-d-glucopyranosyl-(1→4)-β-d-galactopyranosyl)oxy]-5α, 15β, 22R, 25R-spirostan-3,15-diol (1, named parquispiroside) and 25R-26-[(β-d-glucopyranosyl)Oxy]-(3β [(O-β-d-glucopyranosyl-(1→3)-β-d-glucopyranosyl-(1→2)-O-[β-d-xylopyranosyl-(1...
Source: Phytochemistry Letters - October 6, 2017 Category: Chemistry Source Type: research

A constituent of Alpinia katsumadai suppresses allergic airway inflammation
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Chun-Yuan Wang, Zhen-Ming Song, Cheng-Long He, Ling-Yu Zhang Two new compounds, named as (3R)-5,7-dihydroxy-3-isopropyl-3-methylisochroman-1-one (1), and (1R,3R,4S)-1-(4′-methyl-phenyl)-3,4-dihydro-3,4-dimethyl-1H-2-benzopyran-5,6,8-triol (2), were isolated from seeds of Alpinia katsumadai Hayata. Structures of compounds 1 and 2 were elucidated and determined on the basis of spectroscopic analysis. Additionally, compound 1 significantly suppressed allergic airway inflammation induced by OVA through reducing airway hyperresponsiveness...
Source: Phytochemistry Letters - October 4, 2017 Category: Chemistry Source Type: research

Two new lactones from whole herbs of Patrinia villosa Juss
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Ming Bai, Si-Fan Liu, Wei Wang, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song Chemical investigation of 70% EtOH exact of Patrinia villosa Juss. led to the isolation, purification and identification of two new lactones (1-2) along with twelve known compounds (3-14). Their structures were established by comprehensive spectroscopic analyses. All compounds were evaluated for their cytotoxic activities against A549, HepG2, Hep3B and MCF-7 cancer cell lines. Compounds 1, 8, 10, 11 and 12 displayed weak cytotoxic activities against MCF-7 cell l...
Source: Phytochemistry Letters - October 3, 2017 Category: Chemistry Source Type: research

Tyroscherin and tyroscherin analogs from Pseudallescheria boydii SNB-CN85 isolated from termite Termes cf. hispaniolae
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Jonathan Sorres, Charlotte Nirma, Morgane Barthélemy, Véronique Eparvier, Didier Stien Two new tyroscherin derivatives: N-methyl-tyroscherone (2) and tyroscherin N,O-acetonide (3), as well as two known secondary metabolites tyroscherin (1) and pseurotin A (4), were isolated from a solid culture of the termite-borne fungus Pseudallescheria boydii SNB-CN85. The structures were elucidated by spectroscopic analysis and chemical modification. Compound 3 was synthesized from tyroscherin (1) in the free amine form by heating in deut...
Source: Phytochemistry Letters - October 3, 2017 Category: Chemistry Source Type: research

Four new phenylpropanoid glycosides from Clausena dunniana var. robustaand their antiinflammatory activities
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Yigong Guo, Shenglan Zhu, Guojing Wu, Mengling Huang, Shikai Yan, Huizi Jin, Weidong Zhang Four new phenylpropanoid glycosides, clausenaglycosides A–D (1–4), along with fourteen known compounds (5–18) were isolated from the leaves and twigs of Clausena dunniana var. robusta. The structures of the isolated compounds were determined by a combination of 1D and 2D NMR, MS, and CD spectroscopic data. The NF-κB inhibitory activity was evaluated in HeLa cells. Compound 17 displayed a moderate inhibition against NF-κB...
Source: Phytochemistry Letters - October 3, 2017 Category: Chemistry Source Type: research

Three new triterpenoid saponins from the aerial parts of Lysimachia foenum-graecum
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Lu-Mei Dai, Ri-Zhen Huang, Bin Zhang, Jing Hua, Hai-Bing Liao, Heng-Shan Wang, Dong Liang A further phytochemical investigation of the aerial parts of Lysimachia foenum-graecum Hance led to the isolation of three new oleanane-type triterpenoid saponins, foegraecumosides L–N (1–3), along with one known saponin, 3-O-β-d-glucopyranosyl-(1→2)-α-l-arabinopyranosyl-cyclamiretin A (4). Their structures were elucidated by spectroscopic data analyses and chemical methods Compounds 1−4 were evaluated for their cytot...
Source: Phytochemistry Letters - October 3, 2017 Category: Chemistry Source Type: research

Synthesis and cytotoxicity against KB and NCI-H187 cell lines of sporogen AO-1 analogues
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Chittreeya Tansakul, Vatcharin Rukachaisirikul, Thidarat Chalothorn, Souwalak Phongpaichit, Jariya Sakayaroj 20 Analogues of sporogen AO-1 were synthesized by chemical modification at α,β-unsaturated carbonyl, 3-hydroxyl and vinylic methyl groups of sporogen AO-1 precursor, and were evaluated for their cytotoxic activities against human oral epidermoid carcinoma (KB) and human small cell lung (NCI-H187) cancer cell lines. Structure-activity relationship study indicated the importance of α,β-unsaturated carbonyl moiety...
Source: Phytochemistry Letters - October 3, 2017 Category: Chemistry Source Type: research

Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Jutatip Choochuay, Xin Xu, Vatcharin Rukachaisirikul, Piyada Guedduaythong, Souwalak Phongpaichit, Jariya Sakayaroj, Jing Chen, Xu Shen Two new curvularin derivatives, curvulopyran (1) and ent-curvulone A (2), along with ten known compounds including five cytochalasins and five curvularins, were isolated from a culture broth of the soil-derived fungus Aspergillus polyporicola PSU-RSPG187. Their structures were determined by spectroscopic methods. Known aspochalasin D displayed moderate antifungal activity against flucytosine–resistan...
Source: Phytochemistry Letters - October 2, 2017 Category: Chemistry Source Type: research

Benzoate esters and flavonoids from Desmos pedunculosus
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Jason A. Clement, John G. Ondeyka, Michael A. Goetz The genus Desmos (Annonaceae) is comprised of about thirty-three species of trees and shrubs found in southern Asia, Indonesia, and northern Australia. The chemistry of many of these species is largely unreported. Phytochemical investigation of a methanol extract of the aerial parts of D. pedunculosus led to the isolation of two flavonoids and eight benzoate ester derivatives. Three of these benzoate esters are new compounds, while two others are known synthetic compounds reported here as...
Source: Phytochemistry Letters - September 29, 2017 Category: Chemistry Source Type: research

Tetrahydro- β-Carboline alkaloids from Carthamus tinctorius L. with tyrosinase inhibitory activity
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Li-Li Lou, Sen Liu, Zhi-Yang Yan, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song Phytochemical research on the dry flower of Carthamus tinctorius L. led to the isolation of two new epimeric tetrahydro-β-carboline alkaloids (1 and 2), together with three known analogues (3–5). Their planar structures were determined by comprehensive 1D, 2D-NMR, and HR-ESI–MS spectroscopic data analyses. The absolute configurations of alkaloids 1 and 2 were assigned by comparing their experimental electronic circular dichroism (ECD)...
Source: Phytochemistry Letters - September 29, 2017 Category: Chemistry Source Type: research

Lanostane triterpenes isolated from epidermis of Poria cocos
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Hong-Jing Dong, Zhen-Zhen Xue, Yan-Ling Geng, Xiao Wang, Bin Yang Four new lanostane triterpenes together with twenty-two known lanostane triterpenes were isolated from the epidermis of Poria cocos. The chemical structures of all compounds were determined mainly by 1D and 2D-NMR spectrometry. Three of the new compounds (5, 10 and 24) were evaluated for cytotoxic activities against human gastric carcinoma MGC-803, human hepatocellular carcinoma HepG2, and African green monkey kidney (VERO) cell lines in vitro. The results showed that only c...
Source: Phytochemistry Letters - September 29, 2017 Category: Chemistry Source Type: research

Alpha-glucosidase and alpha-amylase inhibiting thiodiketopiperazines from the endophytic fungus Setosphaeria rostrata isolated from the medicinal plant Costus speciosus in Sri Lanka
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Ryan M. Centko, Pamoda B. Ratnaweera, Christina Tysoe, Stephen G. Withers, E. Dilip de Silva, Raymond J. Andersen Three new thiodiketopiperazine derivatives, rostratazine A (1), rostratazine B (2) and rostratazine C (3) along with exserohilone (4) and boydine A (5) were isolated and identified from the laboratory culture of Setosphaeria rostrata, an endophytic fungus obtained from the fresh asymptomatic leaf tissues of the medicinal plant Costus speciosus from Sri Lanka. The structures of compounds 1–3 were elucidated on the basis of...
Source: Phytochemistry Letters - September 23, 2017 Category: Chemistry Source Type: research

Microbial metabolism of senegenic acid and senegenin by Mucor polymorphosporus
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Hang Liu, Pei Guo, Jizhong Shen, Haixia Zhang, Pengyu Zhuang, Xiufang Duan, Jian Zhou Biotransformation of senegenic acid (1) and senegenin (2) mediated by Mucor polymorphosporus AS 3.3443 produced the corresponding C-21 hydroxylated and oxidized derivatives. These four metabolites were identified as 21β-hydroxyl senegenic acid (3), 21-keto senegenic acid (4), 21α-hydroxyl senegenin (5), and 21-keto senegenin (6), respectively. Among them, compounds 3, 5, and 6 displayed selective neuroprotective effects at a concentration of 10...
Source: Phytochemistry Letters - September 23, 2017 Category: Chemistry Source Type: research

Isolation and structure elucidation of flavonoids from Amburana cearensis resin and identification of human DNA topoisomerase II- α inhibitors
In this study, we isolated 15 principal phenolics and established their structures by different spectroscopic methods, including 1D and 2D NMR experiments, as well HR-ESI–MS analysis. The isolated reference compounds were used to explore fragmentation pathways. Compound identification was based on the exact mass, general fragmentation behaviors, retention times and UV absorption. The activity of the principal compounds against human DNA topoisomerase II-α was evaluated. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 21, 2017 Category: Chemistry Source Type: research

Two new sesquarterpenoids from the bark of Cryptomeria japonica
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Chi-I Chang, Sheng-Yang Wang, Ming-Der Wu, Ming-Jen Cheng, Horng-Huey Ko, Hsun-Shuo Chang, Jih-Jung Chen, Cheng-Chi Chen, Yueh-Hsiung Kuo Two new sesquarterpenoids, i.e. ferrugicadinol A (1) and ferrugicryptomeridiol (3), and one known sesquarterpenoid, ferrugicadinol (2) were isolated from the bark of Cryptomeria japonica D. Don. Their structures were identified by extensive spectral analysis and comparison with the data of known analogues. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 21, 2017 Category: Chemistry Source Type: research

Floral volatile profile in Pleurothallidinae, an orchid subtribe pollinated by flies: ecological and phylogenetic considerations
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Poliana Cardoso-Gustavson, Silvia Ribeiro de Souza, Fábio de Barros The Pleurothallidinae are recognized as the largest orchid group pollinated by Diptera. This subtribe has been focus of ongoing phylogenetic studies, in which the floral biology and mating systems of their representatives have been recently assessed and some synapomorphies pointed out, all of them regarding features or processes occurring in flowers. Data about the flower volatiles are still scarce, although it may offer valuable information about the floral biology...
Source: Phytochemistry Letters - September 20, 2017 Category: Chemistry Source Type: research

Temporal lag between gene expression and metabolite accumulation in flavonol biosynthesis of Arabidopsis roots
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Ryo Nakabayashi, Tetsuya Mori, Tomoko Nishizawa, Kazuki Saito The temporal lag between gene expression and metabolite accumulation has been estimated in flavonol biosynthesis, but the time difference between these events is unclear. In the present study, we investigated the expression of flavonol biosynthetic genes ELONGATED HYPOCOTYL5, MYELOBLASTOSIS PROYEIN12/PRODUCTION OF FLAVONOL GLYCOSYDES1, CHALCONE SYNTHASE, CHALCONE ISOMERASE, FLAVANONE 3-HYDROXYLASE, and FLAVONOL SYNTHASE1, and the accumulation of flavonol glycosides (kaempferol a...
Source: Phytochemistry Letters - September 19, 2017 Category: Chemistry Source Type: research

New cytotoxic dihydrochalcone and steroidal saponins from the aerial parts of Sansevieria cylindrica Bojer ex Hook
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Mona A. Raslan, Farouk R. Melek, Ataa A. Said, Abdelsamed I. Elshamy, Akemi Umeyama, Marwa M. Mounier A new dihydrochalcone, 2‘,4‘-dihydroxy-3‘-methoxy-3,4-methylenedioxy-8-hydroxymethylene dihydrochalcone 1 and two new steroidal saponins, (25S)-ruscogenin-1-O-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside 2, (25S)-ruscogenin-3-O-α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranoside 3, together with three known steroidal saponins (25S)-ruscogenin-3-O-β-d-glucopyranoside 4, (25S)-ruscogenin-1-O-...
Source: Phytochemistry Letters - September 14, 2017 Category: Chemistry Source Type: research

Four new C-glycosylflavones from the leaves of Iris lactea Pall. var. chinensis (Fisch.) Koidz.
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Yu Meng, Minjian Qin, Bingxin Qi, Guoyong Xie Four new acylated C-glycosylflavones, termed embinins A–C and irislactin C, were isolated from the leaves of Iris lactea and their structures were elucidated by extensive NMR experiments and mass spectrometry studies. Embinin A and irislactin C showed weak cytotoxicity against A549 (human lung cancer) cells. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 13, 2017 Category: Chemistry Source Type: research

Two new iridoid glycosides from Odontonema cuspidatum and their bioactivities
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): M.S. Refaey, Ahmed M.M. Hassanein, Mahmoud A.H. Mostafa, Amira S. Wanas, A.A. Ali Two new iridoid glycosides, named 6β-O-methyl-unedoside (1) and 6β-O-methyl-5-deoxythunbergioside (2) along with two known phenyl propanoid glucoside compounds dolichandroside A (3) and verbascoside (4) were isolated from the aerial parts of Odontonema cuspidatum (Nees) Kuntze (Acanthaceae). Structure elucidation of the new compounds was established by interpretation of their 1D and 2D-NMR spectral data by comparing with literatures, HRESIMS and opt...
Source: Phytochemistry Letters - September 10, 2017 Category: Chemistry Source Type: research

Two new substituted polychiral 5, 6-dihydro- α-pyrones from Orthosiphon diffusus and molecular docking studies
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Harish Holla, Akanksha Sharma, Pritesh Bhat, Dhananjay Shinde, Biswanath Das Chemical investigation on Orthosiphon diffusus lead to isolation of two new substituted polychiral 5, 6-dihydro-α-pyrones, orthodiffenes E-F (5-6) which were characterized from the detailed studies of their 1D and 2D NMR spectra. Isolated molecules orthodiffenes E-F (5-6) along with previously isolated, reported orthodiffene A-D (1-4) molecules were subjected to in silico studies and analysed for anticancer target Topoisomerse I-B − DNA complex. Orthod...
Source: Phytochemistry Letters - September 10, 2017 Category: Chemistry Source Type: research