Hydantoin and thioamide analogues from Lepidium meyenii
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): XiaoXue Tian, XingRong Peng, MuYuan Yu, YanJie Huang, Xia Wang, Lin Zhou, Minghua Qiu Four new compounds, including two hydantoin derivatives, macahydantoins C and D (1, 2), one urea derivative, macaurea A (3) and one thioamide analogue, macathioamide A (4), were isolated from the tube of Lepidium meyenii (Maca). Their chemical structures were determined by analyzing spectroscopic data, especially 1D and 2D NMR spectra, and comparing their specific rotation with data reported in literature. All of the isolates were obtained from plants for the...
Source: Phytochemistry Letters - March 27, 2018 Category: Chemistry Source Type: research

Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Hao-Wen Jiang, Jing Lin, Gui-Min Wang, Jing-Jing Zhang, Shan-Shan Gu, Lei Cao, Yan Chen, Ling Wang, He Jiao, Wei-Liang Zhu, Hai-Yan Zhang, Wei-Min Zhao, Jin-Long Li Seven new acetophenone derivatives, three couples of enantiomers (±)-cynwilforones D − F (1 − 3) together with cynwilforone G (4), were isolated form the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and X-ray crystallography. Each racemate was separated into individual enantiomers, and ele...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Zeapyranolactone − A novel strigolactone from maize
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Tatsiana V. Charnikhova, Katharina Gaus, Alexandre Lumbroso, Mark Sanders, Jean-Paul Vincken, Alain De Mesmaeker, Carolien P. Ruyter-Spira, Claudio Screpanti, Harro J. Bouwmeester The structure of a new strigolactone present in the root exudate and root extract of maize hybrid cv NK Falkone plants was elucidated and characterized as zeapyranolactone: Methyl .(E)-3-((4-methyl-5-oxo-2,5-dihydrofuran-2-yl)oxy)-2-(4,4,5-trimethyl-2-oxo-2,3,4,6,7,7a-hexahydrocyclopenta[b]pyran-7-yl)acrylate. Unlike any other strigolactone published so far, it cont...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Chemical constituents from the rhizomes of Gastrodia elata f. glauca and their potential neuroprotective effects
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Zhi-Wei Wang, Yun Li, Da-Hui Liu, Yan Mu, Hong-Jing Dong, Hong-Lei Zhou, Xiao Wang A phytochemical study on the rhizomes of Gastrodia elata f. glauca resulted in the isolation of three new parishin derivatives and one new adenosine derivative, together with six known compounds. Their structures were elucidated mainly by spectroscopic analysis and compared to published data. All these isolates were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and new compound 4 showed potent activity with an EC50 va...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Bicyclo[3.2.1]octanoid neolignans from Indonesian red betle leaves (Piper crocatum Ruiz & amp; Pav.)
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Dayar Arbain, Nofrizal, Nova Syafni, Friardi Ismed, Sammer Yousuf, M. Iqbal Choudhary Two new bicyclo[3.2.1]octanoid neolignans of guianin-type named as (1′R,2′R,3′S,7S,8R)-Δ5′,8′-2′-acetoxy-3,4,5,3′,5′-pentamethoxy-4′-oxo-8.1′,7.3′-neolignan (crocatin A, 1) and (1′R,2′R,3′S,7S,8R)-Δ5′,8′-2′-hydroxy-3,4,5,3′,5′-pentamethoxy-4′-oxo-8.1′,7.3′-neolignan (crocatin B, 2), along with known compounds pachypo...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Simple synthesis and anti-inflammatory activities of Spanrstolonin B derivatives
In this study, ten derivatives (A1–A6, B1–B2, and C1–C2) were synthesized by the structural modification of compounds 1 and 2, of which nine derivatives are new compounds. The n-octanol/water partition coefficients (K ow) of these derivatives were determined by high performance liquid chromatography method, and their anti-inflammatory activities were evaluated of inhibiting the secretion of TNF-α and IL-6 in LPS- or Pam3csk4- induced RAW264.7 cells. Preliminary structure-activity relationship study revealed that methylated, acetylated and butyrylated derivatives (A1–A6) exhibited weaker activi...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Bioactive dibenzofurans from the rattans of Bauhinia championii (Benth.) Benth.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Li-Ping Hua, Yu-Qin Zhang, Miao Ye, Wen Xu, Xiao-Ying Wang, Yan-Hui Fu, Wei Xu Two new dibenzofurans, bauhichamines A (1) and B (2), along with six known compounds (3-8), were isolated from the rattans of Bauhinia championii (Benth.) Benth. (Fabaceae). The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparison of their data with those reported in the literatures. All new compounds were evaluated for their anti-rheumatoid arthritis activities via examining their anti-proli...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Novel biflavonoids from Cephalotaxus oliveri Mast.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Dai Ren, Fan-Cheng Meng, Hui Liu, Tong Xiao, Jin-Jian Lu, Li-Gen Lin, Xiu-Ping Chen, Qing-Wen Zhang Three new biflavonoids, umcephabiflovin A (1), umcephabiflovin B (2), and S-taiwanhomoflavone-B (3), together with seven known flavonoids (4–10) and seven known alkaloids (11–17), were isolated from the twigs of Cephalotaxus oliveri Mast. The flavonoids were found to inhibit α-glucosidase activity. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Three new nortriterpenoids from the rattan stems of Schisandra chinensis
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Bing-You Yang, Zhang-Lin Chen, Yan Liu, Hai-Xue Kuang Three new nortriterpenoids, schindilactones L and M (1–2) and wuweizidilactone S (3), along with five known nortriterpenoids, schindilactone G (4), wuweizidilactone A (5), wuweizidilactone L (6), wuweizidilactone C (7) and pre-schisanartanin (8), were isolated from the rattan stems of Schisandra chinensis. The structure of the new compounds were elucidated by spectroscopic methods, including one and two-dimensional NMR as well as high-resolution mass spectrometry. All of the compound...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Cytotoxic and antimicrobial labdane and clerodane diterpenoids from Kaempferia elegans and Kaempferia pulchra
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Pornsuda Chawengrum, Jutatip Boonsombat, Prasat Kittakoop, Chulabhorn Mahidol, Somsak Ruchirawat, Sanit Thongnest Three previously undescribed diterpenoids, propadanes A-C (1-3), together with seventeen known compounds (4-20), were isolated from the rhizomes of Kaempferia elegans and Kaempferia pulchra. The structures of the isolated compounds were elucidated through extensive analysis of spectroscopic data. The absolute configuration (12R) of propadane A (1) was established by CD analysis. (−)-Kolavelool (15) and (−)-2β-hydr...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Oleanane triterpenoids from the Algerian Salvia phlomoides
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Lamia Benniou, Moses K. Langat, Dulcie A. Mulholland, Fadila Benayache, Samir Benayache Three previously unreported triterpenoids 2α,3β,11α-trihydroxyolean-18-ene 1, 3β-acetoxy,2α,11α- dihydroxyolean-18-ene 2 and 2α-acetoxy,3β,11α-dihydroxyolean-18-ene 3 were isolated from the chloroform extract of aerial parts (leaves and flowers) of Salvia phlomoides collected from the Constantine region in the east of Algeria. Structures were determined using NMR spectroscopy and HR-ESI mass spectrometry. ...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Two new naphthalenones from Diospyros undulata stem bark and their cytotoxic activity
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Natcha P. Suchaichit, Nattawut Suchaichit, Kwanjai Kanokmedhakul, Kitisak Poopasit, Panawan Moosophon, Somdej Kanokmedhakul Two new naphthalenones, cis-isoshinanolone-4-acetate (1) and 3,4-dihydro-4β-hydroxy-5,6-dimethoxy-2α-methyl-1(2H)-naphthalenone (2), were isolated together with three known naphthoquinone derivatives (3-5), four dimeric naphthoquinones (6-9), two coumarins (10-11) and four triterpenoids (12-15) from the stem bark of Diospyros undulata. Their structures were characterized by intensive spectroscopic data (1D and...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Zonal distribution of neutral aroma components in flue-cured tobacco leaves
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Jian-An Wang, Gai-He Yang, Chun-Xia Li To understand the regional distributions of neutral aroma components (NACs) of interest in flue-cured tobacco (Nicotiana tabacum L.), samples from a single cured leaf lamina were taken at 48 distinct points with the help of a thin transparent plastic board. We investigated 28 NACs belonging to five categories, namely aromatic amino acid cleavage substances (ACS), cembratriendid alkyl degrading products (CADP), carotenoid degradation products (CDP), chlorophyll degradation products (CDPS), and Maillard re...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

A new phenylpropane-pimarane heterodimer and a new ent-kaurene diterpene from the husks of Oryza sativa
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Qiang Zhang, Qiao-Lin Xu, Xiao-Mei Xia, Li-Mei Dong, Bi Luo, Wen-Bin Liu, Jian-Wen Tan A new phenylpropane-pimarane heterodimer, 2-[(E)-3-(4-hydroxy-3-methoxyphenyl) allylidene] momilactone A (1), and a new ent-kaurene diterpene, ent-3α,16α-dihydroxy-kauran-19-oic acid (2), were isolated from the rice husks of Oryza sative L., along with a known ent-kaurene diterpenoid ent-7-oxo-kaur-15-en-19-oic acid (3). Their structures were determined by spectroscopic means, including nuclear magnetic resonance (NMR) and mass spectrometry (MS)...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves
This study demonstrated that novel compounds isolated from C. zeylanica seem to be mediating potent cytotoxic effects in breast cancer cells through activation of caspase 3/7. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Furan fragment isomerized mexicanolide-type Limonoids from the stem barks of Khaya senegalensis
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Wen-Yan Zhang, Lu Qiu, Qin-Pei Lu, Miao-Miao Zhou, Jun Luo, Yi Li Four new mexicanolide-type limonoids with isomerized furan fragment khaysenelides G–J (1–4) were isolated from the stem barks of Khaya senegalensis. Their structures were elucidated on the basis of (1D and 2D) NMR and HRESIMS, and the normal furan rings in 1-4 were isomerized to hydroxybutenolide moieties. Bioactivities screening of new compounds indicated that 1 showed potent cytotoxicities against MDA-MB-231 and HepG2 human cancer cell lines with IC50 values of 6....
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Phytochemical constituents and chemosystematic significance of Pulicaria jaubertii E.Gamal-Eldin (Asteraceae)
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Abdelsamed I. Elshamy, Tarik A. Mohamed, Mona M. Marzouk, Taha A. Hussien, Akemi Umeyama, Mohamed Elamir F. Hegazy, Thomas Efferth The chemical characterization of methylene chloride/methanol (1:1) extract of the air-dried whole medicinal plant, Pulicaria jaubertii E. Gamal-Eldin, led to isolation and identification of two new hydroquinone compounds; 2-(2-acetoxy propyl), 5-methyl hydroquinone (1) and 2-(2-hydroxy propyl), 5-methyl hydroquinone-4-O-β-D-glucopyranoside (2), four known flavonols (3-6) and 7 known dihydroflavonols (7-13). T...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Novel macamides from maca (Lepidium meyenii Walpers) root and their cytotoxicity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Chen Xia, Jian Chen, Jun-Lin Deng, Yong-Qing Zhu, Wan-Yi Li, Bu Jie, Tian-Yuan Chen Maca, Lepidium meyenii Walpers (Brassicaceae), contains secondary metabolites, including macamides, which possess many bioactive properties. Two new macamides, namely, N-benzyl-9-oxo-10E,12E-octadecadienamide (3) and N-benzyl-9-oxo-10E,12Z-octadecadienamide (4), were isolated from maca root. In addition, two fatty acid derivatives, 9-oxo-10E,12E-octadecadienoic acid (1) and 9-oxo-10E,12Z-octadecadienoic acid (2), were found for the first time from maca. The str...
Source: Phytochemistry Letters - March 17, 2018 Category: Chemistry Source Type: research

Identification of compounds with cytotoxic activity from Millettia dorwardi Coll. Et. Hemsl
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Kai Chen, Huan Tang, Li Zheng, Lun Wang, Linlin Xue, Ai-hua Peng, Ming-hai Tang, Chaofeng Long, Xiaoxin Chen, Hao-yu Ye, Li-juan Chen Two new lignan derivatives and nine known compounds were isolated from the EtOAc and n-BuOH extracts of Millettia dorwardi Coll. Et. Hemsl. The structures of the compounds were determined by 1D and 2D NMR, CD and HRMS. Then, cytotoxic effects of these compounds were evaluated against five cancer cell lines (HepG2, HCT116, MCF7, Raji and KG-1). Results showed the isolated compounds have no obvious cytotoxic activ...
Source: Phytochemistry Letters - March 17, 2018 Category: Chemistry Source Type: research

Scumoniliosides A and B, two new flavanone glucuronate esters from Scutellaria moniliorrhiza Komarov with anti-inflammatory activities
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Qing-Tong Han, Kai Xiao, Kang-Lin Xiang, Gui-Sheng Li, Sheng-Jun Dai Two new flavanone glucuronate esters, named scumoniliosides A and B (1-2), along with two known flavonoid glucuronate esters, 5,4′-dihydroxyflavonoid-7-O-β-d-glycuronate methyl ester (3) and 5,4′-dihydroxyflavonoid-7-O-β-d-glycuronate butyl ester (4), were isolated from the ethanolic extract of the whole plant of Scutellaria moniliorrhiza. Their chemical structures including absolute configurations were determined by means of integrated spectroscopic tec...
Source: Phytochemistry Letters - March 16, 2018 Category: Chemistry Source Type: research

Excoecarins L and O from the mangrove plant Excoecaria agallocha L.
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Nguyen Van Thanh, Lai Hop Hieu, Phan Thi Thanh Huong, Le Thi Vien, Tran My Linh, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam, Ngo Dai Quang, Chau Van Minh Two new beyerene-type diterpenoids (1 and 2), along with six known metabolites (3-8) were isolated from the twigs and leaves of the mangrove plant Excoecaria agallocha L. collected from coastal areas in Vietnam. The structures and relative configurations of new compounds were established on the basis of HR-ESI-MS, 1D and 2D NMR experiments. Two new metabolites were tested for cytoto...
Source: Phytochemistry Letters - March 16, 2018 Category: Chemistry Source Type: research

GC –MS detection of plant pigments and metabolites in Roman Julio-Claudian wall paintings
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Angelo Gismondi, Lorena Canuti, Giulia Rocco, Marcella Pisani, Alessandra Ghelli, Margherita Bonanno, Antonella Canini For the first time, plant pigments were detected in Roman frescoes. Indeed, only sporadic papers proved the application of natural hues in ancient paintings and none of them relative to Roman art. Therefore, eight differently coloured fragments of Julio-Claudian wall paintings, collected from Terme degli Stucchi Dipinti archaeological site (Rome, Italy), were subjected to GC–MS analysis, obtaining detailed chemical profi...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Rui Zhang, Chunping Tang, Yan Li, Chang-Qiang Ke, Ge Lin, Hua Xie, Sheng Yao, Yang Ye The first phytochemical investigation of the fruits of Rhododendron websterianum resulted in the isolation of two new triterpenoids, 11-dehydroxytrisnormogrol acid (1), 11-dehydroxytrisnormogrol (2), and 21 known analogues. Their structures were determined by extensive analysis of spectroscopic and mass data, as well as by comparison with those in literature. All isolates were assayed their cytotoxic activities on human hepatoma SMMC-7721 cells and human lung...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

Chemical constituents of root and stem bark of Erythrina brucei
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Getahun Tadesse Gurmessa, Souvik Kusari, Hartmut Laatsch, Gomotsang Bojase, Godiraone Tatolo, Ishmael B. Masesane, Michael Spiteller, Runner R.T. Majinda Two new isoflavanones, erybrucein A and B (1, 2), together with nineteen known compounds are reported herein from the stem and root bark of the Ethiopian medicinal plant, Erythrina brucei. All known compounds, except erythraline (19), have been isolated for the first time from E. brucei. Their structures were established on the basis of extensive spectroscopic and spectrometric analyses (1D a...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

Protective effects of dammarane-type triterpenes from hydrolyzate of Gynostemma pentaphyllum against H2O2-induced injury and anti-hepatic fibrosis activities
In this study, phytochemical investigation of hydrolyzate of total G. pentaphyllum saponins led to the isolation of three previously undescribed triterpenes, Gypensapogenin R (1), Gypensapogenin S (2), and Gypensapogenin T (3). Their structures were mainly identified by 1D, 2D-NMR and HR-ESI–MS evidences. Anti-hepatic fibrosis activity was determined and the data showed that 2 and 3 exhibited more potent inhibitory effects (IC50 values 14.93 and 29.19, respectively) on the growth of t-HSC/Cl-6 cells than Silymarin (positive control), while having much weaker effect in the growth of normal cell. Additionally, all the ...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Corrigendum to “Investigation of chemical constituents from Spiraea prunifolia var. simpliciflora and their biological activities” [Phytochem. Lett. 22 (2017), 255–260]
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Chung Sub Kim, Joonseok Oh, Won Se Suh, Sung Wan Jang, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Monoterpene, benzyl and 3,4-dihydroxyphenethyl glycosides from Magnolia thailandica
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Tripetch Kanchanapoom, Poolsak Sahakitpichan, Nitirat Chimnoi, Chutima Srinroch, Wassapol Thamniyom, Somsak Ruchirawat A new monoterpene glucoside, (3S,6S)-6,7-dihydroxy-6,7-dihydrolinaloyl 6-O-β-d-glucopyranoside, along with two new aromatic glycosides, benzyl O-α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranoside and 3,4-dihydroxyphenethyl O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl−(1 → 3)]-β-d-glucopyranoside were isolated from Magnolia thailandica. Additionally, 29 known ...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Pahangine A and B, two new oxetane containing neolignans from the barks of Beilschmiedia glabra Kosterm (Lauraceae)
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Syazreen Nadia Sulaiman, Azeana Zahari, Sook Yee Liew, Marc Litaudon, A.M. Issam, Habibah A. Wahab, Khalijah Awang Phytochemical investigation on the barks of Beilschmiedia glabra Kosterm led to the isolation of two new oxetane containing neolignans, Pahangine A (1) and Pahangine B (2) together with eight known compounds. The structures of isolated compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR (1H–1H COSY, HSQC, and HMBC), DEPT-Q NMR, and by comparing with the published data. A possible biosyntheti...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Juan Xiong, Xi-Ying Wu, Pei-Pei Wang, Choiwan Lau, Hui Fan, Guang-Lei Ma, Yu Tang, Jia Li, Jin-Feng Hu Two new (1 and 2) and 10 known (3−12) acylated iridoid diglycosides were isolated from the twigs and leaves of the cultivated endangered ornamental plant Gmelina hainanensis. Based on spectroscopic data interpretation and chemical transformation, the new triacyl and the new diacyl iridoid diglycosides were established to be 6-O-α-L-(2″,3″-di-O-acetyl-4″-O-cis-cinnamoyl)rhamnopyranosylcatalpol (1) and 6-O-α-...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Garcixanthones B and C, new xanthones from the pericarps of Garcinia mangostana and their cytotoxic activity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Sabrin R.M. Ibrahim, Hossam M. Abdallah, Ali M. El-Halawany, Mohammed F. Radwan, Ibrahim A. Shehata, Essam M. Al-Harshany, Mohamed F. Zayed, Gamal A. Mohamed Two new prenylated xanthones, garcixanthones B (1) and C (2) and six known metabolites: gartanin (3), 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (4), rubraxanthone (5), 1,3,6,7-tetrahydroxy-8-prenylxanthone (6), garcinone C (7), and xanthone I (9-hydroxycalabaxanthone) (8) were separated from the EtOAc-soluble fraction of the air-dried pericarps of Gar...
Source: Phytochemistry Letters - March 10, 2018 Category: Chemistry Source Type: research

Bioactive triterpenoid glycosides from the twigs and leaves of Camellia reticulata
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Qi-Run Chen, Dan Li, Xu-Jie Qin, Hui Liu, Wei Ni, Huan Yan, Li He, Qing Zhao, Xiao Ma, Hai-Yang Liu Four previously undescribed oleanane-type triterpenoid glycosides (dianshanchaosides A–D) were isolated from the twigs and leaves of Camellia reticulata, together with seven known analogues. Their structures were established by comprehensive spectroscopic data and chemical methods The triterpenoid glycosides were evaluated their inhibitory effects on the LPS-induced NO production in RAW264.7 macrophages and cytotoxicities against five huma...
Source: Phytochemistry Letters - March 10, 2018 Category: Chemistry Source Type: research

NMR-based metabolomics study of Amphoricarpos species from Montenegro
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Mirjana Cvetković, Boban Anđelković, Vladimir Stevanović, Milka Jadranin, Iris Đorđević, Vele Tešević, Slobodan Milosavljević, Dejan Gođevac The genus Amphoricarpos Vis. is endemic of westpart of Balkan peninsula. In order to get more insight into the ambiguous taxonomy of the genus, the metabolomic study of the Amphoricarpos samples, has been undertaken. The1H NMR spectroscopy combined with multivariate data analysis has been applied. OPLS-DA has been shown to be the best method for clear discrimination of these samples based...
Source: Phytochemistry Letters - March 9, 2018 Category: Chemistry Source Type: research

Three eudesmanolide δ-lactones of Wedelia trilobata
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Shi-Fei Li, Jia-Yin Ding, Shun-Lin Li An ongoing phytochemical investigation of the whole plant of Wedelia trilobata, which is one of the 100 most invasive species in the world, led to the isolation of three new eudesmanolide δ-lactones wedelolides K-M (1-3). Their structures and relative configurations were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments (UV, IR, HRESIMS, 1D and 2D NMR). Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Non-destructive quality assessment of herbal tea blends using hyperspectral imaging
In this study, hyperspectral imaging is applied as a fast and non-destructive method for the quality control of herbal tea blends. The technique combines conventional spectroscopy and digital imaging to gather chemical information and visualise spatial distribution of chemical constituents within a matrix. Certified raw materials (Sceletium tortuosum and Cyclopia genistoides) and herbal tea blends were acquired from Parceval Pty (Ltd). Hyperspectral images of the raw material and tea blends were captured on a SisuChema® SWIR (short wave infrared) hyperspectral pushbroom imaging system using ChemaDAQ® software. The ...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Cytotoxic secondary metabolites from the endophytic fungus Aspergillus versicolor KU258497
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Sherif S. Ebada, Mona El-Neketi, Weaam Ebrahim, Attila Mándi, Tibor Kurtán, Rainer Kalscheuer, Werner E.G. Müller, Peter Proksch Two new isocoumarin dimers (1 and 2) and one new dihydroquinolone derivative (3) were isolated from Aspergillus versicolor, an endophyte derived from leaves of the Egyptian water hyacinth Eichhornia crassipes (Pontederiaceae), together with ten other known metabolites. Chemical structures of the isolated metabolites were determined based on HRESIMS, extensive 1D and 2D NMR spectroscopy. The relati...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Leucodine blocks mitotic clonal expansion during preadipoctye differentiation through cell cycle arrest
In this study, we investigated the effect of 11,13 dihydro-[11R]-dehydroleucodine (i.e., leucodine), a sesquiterpene lactone obtained from the reduction of dehydroleucodine, on adipogenesis of 3T3-L1 preadipocyte. 11,13 dihydro-[11R]-dehydroleucodine blocked the accumulation of lipid droplets stained with Oil Red O and inhibited the increase of triglycerides in the adipocytes (IC50: 71.0 ± 4.1 μM). Expressions of Glut-4, adiponectin and perilipin-2 were blocked in the presence of 11,13 dihydro-[11R]-dehydroleucodine. Furthermore, expression of PPARγ and C/EBPα was significantly inhibited by 11,1...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Daphnicyclidin M, a new alkaloid from Daphniphyllum paxianum Rosanth
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Li Zhang, GuoHu Zhao, CaiLing Yang, Lin Bai, HaiXia Liu A new daphniphyllum alkaloid daphnicyclidin M (1), containing one rare cyclopentadienyl anion, was isolated from the stems and leaves of Daphniphyllum paxianum Rosanth along with five known alkaloids, longistylumphylline A (2), caldaphnidine A (3), caldaphnidine E (4), daphnilongeranin A (5), and 2-hydroxyyunnandaphnine D (6). The structures were elucidated on the basis of spectroscopic data, and the absolute configuration of 1 was assigned by single-crystal X-ray diffraction crystallogr...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Protein tyrosine phosphatase 1B inhibitory components and a new unique N-alkylamide derivative with an endoperoxide bridge from aerial parts of Indonesian Spilanthes paniculata
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Delfly B. Abdjul, Hiroyuki Yamazaki, Wilmar Maarisit, Ryota Kirikoshi, Ohgi Takahashi, Fitje Losung, Magie M. Kapojos, Michio Namikoshi Research on protein tyrosine phosphatase (PTP) 1B inhibitors from terrestrial and marine natural resources identified N-isobutyl-2E-decenamide (1) and 3,4,5-tri-O-caffeoylquinic acid (2) as PTP1B inhibitory substances together with a new N-alkylamide (3) and two known congeners (4 and 5) from the aerial parts of Indonesian Spilanthes paniculata. The structure of 3 was elucidated as (2E, 7Z)-6,9-endoperoxy-N-2...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

A new monoterpene and a new sesquiterpene from the roots of Ageratina adenophora
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Bi Luo, Li-Mei Dong, Qiao-Lin Xu, Xu Xhang, Qiang Zhang, Wen-Bin Liu, Jian-Wen Tan A new thymol type monoterpene, 2α-methoxyl-3β-methyl-6-(acetyl-O-methyl)-2,3-dihydrobenzofuran (1), and a new cadinane-type sesquiterpenoid, 1,6-dihydroxy-1-isopropyl-4,7-dimethyl-3,4-dihydronaphthalen-2(1H)-one (2), were isolated from the roots of Ageratina adenophora, along with four known compounds, eupatorenone (3), 3-hydroxymuurola-4,7(11)-dien-8-one (4), 9-oxoageraphorone (5) and (4R,5S)-4-Hydroxy-5-isopropyl-2-methyl-2-cyclohexehone (6). Their...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Triterpenoid saponins and phenylpropanoid glycosides from the roots of Polygala japonica Houtt. with anti-inflammatory activity
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Tran Hong Quang, Pham Thanh Cong, Duong Thi Hai Yen, Nguyen Xuan Nhiem, Bui Huu Tai, Pham Hai Yen, Nguyen Thi Thanh Ngan, Dong Cheol Kim, Youn-Chul Kim, Hyuncheol Oh, Chau Van Minh, Phan Van Kiem Phytochemical study of the roots of Polygala japonica resulted in the isolation of a new triterpenoid saponin, polyjaposide A (1), a new phenylpropanoid glycoside, japonicaside A (6), and 10 known compounds: tenuifolin (2), polygalasaponin XXVIII (3), polygalasaponin XLVII (4), fallaxsaponin A (5), β-d-[(1-O-cinnamoyl)-(3-O-benzoyl)]-fructofuran...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Sesquiterpenoids from the aerial parts of Pogostemon cablin
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Ou Dai, Xiao-Hong Li, Qin-Mei Zhou, Cheng Peng, Li Guo, Liang Xiong Six sesquiterpenoids including three previously undescribed ones (1–3) were isolated from the essential oil of the aerial parts of Pogostemon cablin. Their structures were determined to be (+)-(1S,4R,6S,7R,10S)-1-hydroxycadinan-12-ene-5-one (1), 11-dehydroxy-cinnamosin A (2), and 1-methoxy-senecrassidiol (3) by extensive spectroscopic analyses. This is the first report of cadinane-, cyperane-, and caryolane-type sesquiterpenoids from the genus Pogostemon. Particularly, ...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Nurulfazlina Edayah Rasol, Fasihuddin Badruddin Ahmad, Xiang-Yin Lim, Felicia Fei-Lei Chung, Chee-Onn Leong, Chun-Wai Mai, Nur Vicky Bihud, Hamizah Mohd Zaki, Nor Hadiani Ismail Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along with two known naphthoquinone alkaloids, 2-acetyl-3-amino-5-hydroxy-1,4-naphthoquinone (3) and cleistopholine (4) were isolated from the cytotoxic, dichloromethane root extract of Goniothalamus lanceolatus (Annonaceae). The structures were elucidated by spectroscopic ...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Bioactive hydroanthraquinones from endophytic fungus Nigrospora sp. BCC 47789
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Jittra Kornsakulkarn, Wilunda Choowong, Pranee Rachtawee, Nattawut Boonyuen, Surisa Kongthong, Masahiko Isaka, Chawanee Thongpanchang A new hydroanthraquinone, nigrosporone A (1), and a new naturally occurring nigrosporone B (2), together with eleven known compounds, were isolated from an endophytic fungus, Nigrospora sp. BCC 47789. The structure of nigrosporone A was confirmed by X-ray crystallographic analysis. The absolute configurations of nigrosporone B were determined by the modified Mosher’s method. Nigrosporone B exhibited a bro...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Metabolic response of Aspergillus sydowii to OSMAC modulation produces acetylcholinesterase inhibitors
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Gesiane da Silva Lima, Aline Mendes da Rocha, Gabriel Franco dos Santos, Alice Ferreira D’Silva, Ivanildo Evódio Marriel, Jacqueline Aparecida Takahashi Fungi are an extraordinary source of bioactive metabolites especially because their metabolic profile can be modulated according to the conditions under which they are grown, a strategy known as OSMAC. Aspergillus sydowii has been showing to be a fungal species with a series of interesting biosynthetic pathways, but production of acethylcholinesterase inhibitors was still not suf...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Anti-oxidant and anti-inflammatory effects of new bibenzyl derivatives from Dendrobium parishii in hydrogen peroxide and lipopolysaccharide treated RAW264.7 cells
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Virunh Kongkatitham, Chawanphat Muangnoi, Napat Kyokong, Wuttinont Thaweesest, Kittisak Likhitwitayawuid, Pornchai Rojsitthisak, Boonchoo Sritularak Oxidative stress and inflammatory responses are the main causes of various diseases and disorders. To prevent these incidents, antioxidant and anti-inflammatory agents are needed. Dendrobium parishii, known in Thai as “Ueang Khrang Sai San” was studied for chemical constituents by solvent extraction, followed by column chromatography. Seven compounds including two new (1–2) and ...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Crinane, augustamine, and β-carboline alkaloids from Crinum latifolium
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Tran Thi Hong Hanh, Do Hoang Anh, Phan Thi Thanh Huong, Nguyen Van Thanh, Nguyen Quang Trung, Tran Van Cuong, Nguyen Thi Mai, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh Three new crinane-type alkaloids, namely, 6-methoxyundulatine (1), 6-methoxycrinamidine (2), and undulatine N-oxide (3), along with the known compounds 6-hydroxyundulatine (4), 6-hydroxybuphanidrine (5), undulatine (6), crinamidine (7), ambelline (8), filifoline (9), augustamine (10), and perlolyrine (11), were isolated from the leaves of Crinum latifo...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Three novel epoxy-clerodanes bearing a furan ring from Croton hypoleucus
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): René Velázquez-Jiménez, Diego Vargas-Mendoza, Juan A. Gayosso-de-Lucio, Simplicio González-Montiel, José Roberto Villagómez-Ibarra Three new epoxy-clerodanes bearing a furan ring hypoleins A–C, were isolated from the aerial parts of Croton hypoleucus, along with the known compounds crotonpenes A and B. The structure of all compounds was elucidated on the basis of extensive ID and 2D NMR and mass (HR-ESIMS) spectroscopic data analyses. All of them possess an epoxy ring at C-3/C-4, and one furan r...
Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research

Coumarins from Juglans Mandshurica Maxim and their apoptosis-inducing activities in hepatocarcinoma cells
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Li-Li Lou, Rui Guo, Zhuo-Yang Cheng, Peng Zhao, Guo-Dong Yao, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song Phytochemical investigation of the bark of Juglans mandshurica led to the isolation of two new coumarins, juglansoside A–B (1–2), along with five known compounds (3–7). The structures of new compounds were elucidated by comprehensive spectroscopic analyses. All compounds were evaluated for their cytotoxicity in vitro using two human hepatocellular carcinoma cell lines (Hep3B and HepG2). Among them, compounds 1 and 2 d...
Source: Phytochemistry Letters - January 23, 2018 Category: Chemistry Source Type: research

Protein tyrosine phosphatase 1B inhibitory polybromobiphenyl ethers and monocyclofarnesol-type sesquiterpenes from the Indonesian marine sponge Lamellodysidea cf. herbacea
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Magie M. Kapojos, Delfly B. Abdjul, Hiroyuki Yamazaki, Ryota Kirikoshi, Ohgi Takahashi, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Kazuyo Ukai, Michio Namikoshi Three known polybromobiphenyl ether derivatives, 2-(2′,4′-dibromophenoxy)-3,5-dibromophenol (1), 2-(2′,4′-dibromophenoxy)-4,6-dibromophenol (2), and 2-(2′-dibromophenoxy)-3,4,5,6-tetrabromophenol (3), were identified as PTP1B inhibitors from the Indonesian marine sponge Lamellodysidea sp. (cf. L. herbacea) together with two new monocy...
Source: Phytochemistry Letters - January 23, 2018 Category: Chemistry Source Type: research

Four new C19-diterpenoid alkaloids from Delphinium elatum
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Hiroshi Yamashita, Megumi Katoh, Akane Kokubun, Ayano Uchimura, Sakina Mikami, Ayana Takeuchi, Kyousuke Kaneda, Yuji Suzuki, Megumi Mizukami, Masuo Goto, Kuo-Hsiung Lee, Koji Wada Diterpenoid alkaloids with remarkable chemical properties and biological activities are frequently found in plants of the genera Aconitum, Delphinium, and Garrya. Accordingly, several C19-diterpenoid alkaloid components from Delphinium elatum cv. Pacific Giant, as well as their derivatives, exhibited cytotoxic activity against lung, prostate, nasopharyngeal, and vin...
Source: Phytochemistry Letters - January 6, 2018 Category: Chemistry Source Type: research