Three terpenoid glycosides of Centipeda minima
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Nhi Y Thi Nguyen, Tien Huu Nguyen, Phu Hoang Dang, Quan Le Tran From the n-BuOH-soluble extract of the whole plant of Centipeda minima (Asteraceae), the investigation on chemical constituents led to the isolation of three new compounds including 3′-desulphatedatractyloside (1), 15-O-[α-l-rhamnosyl-(1→2)-β-d-glucosyl]grandiflorolic acid (2), and 2α-hydroxylemmonin C (3), along with five known compounds (4–8). Their structures were elucidated on the basis of the NMR spectroscopic analysis. Graphical abstrac...
Source: Phytochemistry Letters - May 25, 2017 Category: Chemistry Source Type: research

Phytochemical variation in the plant-part specific phenols of wild crowberry (Empetrum hermaphroditum Hagerup) populations
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Anu Lavola, Anneli Salonen, Virpi Virjamo, Riitta Julkunen-Tiitto The phytochemical content in plants can develop variably according to e.g. the microclimate and the soil conditions of the habitat. The evergreen dwarf shrub species Empetrum sp. occur widely in the northern hemisphere, where it is suggested to have its ecological contribution to the growth environment by a chemical interference with high constitutive levels of phenolic metabolites. We determined by HPLC and UHPLC-qtof-MS the individual phenolic compounds of fruits, leaves,...
Source: Phytochemistry Letters - May 24, 2017 Category: Chemistry Source Type: research

Chemical constituents of the bulbs of Haemanthus multiflorus
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Akihito Yokosuka, Natsumi Suzuki, Yoshihiro Mimaki Six new (1–6) and four known (7–10) phenolic glycosides were isolated from the bulbs of Haemanthus multiflorus (Amaryllidaceae). The structures of the new compounds were determined on the basis of spectroscopic analysis and of chromatographic analysis of the hydrolyzed products. Moreover, compound 1 showed moderate cytotoxicity against HL-60 human promyelocytic leukemia cells. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 23, 2017 Category: Chemistry Source Type: research

Stimulators of acylated ghrelin secretion from Moringa oleifera leaves
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Tomoe Ohta, Seikou Nakamura, Souichi Nakashima, Hiroyuki Shimakawa, Yuika Emi, Takahiro Matsumoto, Keiko Ogawa, Masashi Fukaya, Yoshimi Oda, Hisashi Matsuda A new nitrogen-containing phenolic glycoside, moringaside A (1), and a new megastigmane glycoside, moringamegastigmane A (2), were isolated from the leaves of Moringa oleifera together with 16 known compounds. The chemical structures of the isolated compounds were elucidated on the basis of chemical and physicochemical evidence. To the best of our knowledge, there are few reports of c...
Source: Phytochemistry Letters - May 23, 2017 Category: Chemistry Source Type: research

Antimicrobial activity of illudalane and alliacane sesquiterpenes from the mushroom Gloeostereum incarnatum BCC41461
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Nantiya Bunbamrung, Chakapong Intaraudom, Aibrohim Dramae, Nattawut Boonyuen, Sukitaya Veeranondha, Pranee Rachtawee, Pattama Pittayakhajonwut Eleven previously undescribed sesquiterpenes 1–4 (named incarnatins A − D) and 6–12 (named incarnolactones A − C, incarnatin E, incarnate methyl ester, incarnetic acid, and incarnatenin), together with two known compounds, chondrosterin B (13) and (E)-dictyochromenol (14), were isolated from the mushroom Gloeostereum incarnatum BCC41461. The chemical structures were determined on...
Source: Phytochemistry Letters - May 19, 2017 Category: Chemistry Source Type: research

Two new labdane diterpenoids from the foliar exudates of Blakiella bartsiifolia
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Diego Rodriguez-Hernandez, Alberto Oliveros-Bastidas, Miguel E. Alonso-Amelot, Maria Pia Calcagno-Pissarelli Two new labdane-type diterpenes, blakielloside (1) and bartsiifolicoside (2), have been isolated from the dichloromethane extract of the foliar exudates of Blakiella bartsiifolia (S.F. Blake), an endemic and rare high altitude plant of the northern Andes, Venezuela. The structures of the new compounds were elucidated through extensive spectroscopic methods (IR, HR-FIA-MS, 1D and 2D NMR). Both natural products showed phytotoxic activity ...
Source: Phytochemistry Letters - May 19, 2017 Category: Chemistry Source Type: research

C27-Nor lanostane triterpenoids of the fungus Ganoderma lucidum and their inhibitory effects on acetylcholinesteras
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Jiang-Chun Wei, Yu-Xin Wang, Rui Dai, Xiang-Ge Tian, Cheng-Peng Sun, Xiao-Chi Ma, Jing-Ming Jia, Bao-Jing Zhang, Xiao-Kui Huo, Chao Wang The lanostane nor-triterpenoids (ganoderic acids) of the functional food and folk medicine Ganoderma lucidum have been investigated by chromatographic techniques and spectroscopic data analysis. Nineteen nor-ganoderic acid analogues were obtained and identified, yielding five new lanostane analogues (1–4 and 11). All of the triterpenoids were systemically evaluated for their inhibitory effects against A...
Source: Phytochemistry Letters - May 18, 2017 Category: Chemistry Source Type: research

New lignan glycosides from the root barks of Litsea glutinosa
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Younan Wu, Yan Jin, Lin Dong, Yiying Li, Caiyun Zhang, Mei Gui, Xiaopo Zhang An investigation on the chemical constituents in the root barks of Litsea glutinosa was performed for the first time. Three new lignan glycosides named Litseasins A–C (1–3), together with a known one (4), were obtained. The structures of the new compounds were established through extensive spectroscopic analyses including HR-ESI–MS, NMR, and circluar dichroism (CD). The new compounds were evaluated for their anti-inflammatory activities on lipopolysa...
Source: Phytochemistry Letters - May 18, 2017 Category: Chemistry Source Type: research

A new δ-tocotrienolic acid derivative and other constituents from the cones of Cedrus atlantica and their in vitro antimicrobial activity
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Belhadj Mostefa Maya, Amin Abedini, Sophie C. Gangloff, Ahmed Kabouche, Zahia Kabouche, Laurence Voutquenne-Nazabadioko The phytochemical and antimicrobial properties of the cones of Cedrus atlantica (Endl) Manetti ex Carrière were investigated. Two new compounds (1,2) and nineteen known compounds (3–21) were isolated. Their structures were established by mass spectrometry (HRESIMS), 1D, 2D NMR and by comparison with literature data. Antimicrobial activity of hydromethanolic extract against a panel of 22 bacteria and yeasts showed...
Source: Phytochemistry Letters - May 18, 2017 Category: Chemistry Source Type: research

Spiroarthrinols a and B, two novel meroterpenoids isolated from the sponge- derived fungus Arthrinium sp
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Ahmed M. Elissawy, Sherif S. Ebada, Mohamed L. Ashour, Ferhat C. Özkaya, Weaam Ebrahim, AbelNasser B. Singab, Peter Proksch Chemical investigation of the sponge derived fungus Arthrinium sp. following fermentation on solid rice medium led to the isolation of two new meroterpenoidal alcohols spiroarthrinols A (1) and B (2) together with eighteen known compounds (3-20). The structures and relative configuration of the new compounds were unambiguously determined based on HRESIMS and extensive 1D and 2D NMR spectroscopic analyses. In addition...
Source: Phytochemistry Letters - May 15, 2017 Category: Chemistry Source Type: research

Diterpenoids from the needles and twigs of the cultivated endangered pine Pinus kwangtungensis and their PTP1B inhibitory effects
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Chang-Ling Hu, Juan Xiong, Pei-Pei Wang, Guang-Lei Ma, Yu Tang, Guo-Xun Yang, Jia Li, Jin-Feng Hu Pinus kwangtungensis is an endangered pine species native to China. In the present study, 15 diterpenoids including three new labdane-type analogs were isolated and characterized during a pioneer phytochemical investigation on a mass-limited sample of the needles and twigs of this plant, which is growing in a Cantonese garden. The new structures, (4S,5R,9S,10R)-6-oxo-labd-7,13-dien-16,15- olid-19-oic acid (1), 15(S)-n-butoxypinusolidic acid (2), a...
Source: Phytochemistry Letters - May 15, 2017 Category: Chemistry Source Type: research

Analysis of an immunoadjuvant saponin fraction from Quillaja brasiliensis leaves by electrospray ionization ion trap multiple-stage mass spectrometry
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Federico Wallace, Zohra Bennadji, Fernando Ferreira, Cristina Olivaro An immunoadjuvant saponin fraction from Quillaja brasiliensis leaves was investigated by direct infusion and liquid chromatography/electrospray ionization ion trap multiple-stage mass spectrometry in negative ion mode (DI-ESI-IT-MSn and LC-ESI-IT-MSn). The aglycone and the sequence of the oligosaccharide residues at C-3 and C-28 were characterized based on MS2 and MS3 experiments of the [MH]− ions. According to their [MH]− ions, characteristic product ions and re...
Source: Phytochemistry Letters - May 15, 2017 Category: Chemistry Source Type: research

Structures of minor glucosides from the Far Eastern high-mountain endemic plant Ligularia alticola Worosch. Screening of bioactivity for some glycosides from L. alticola
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Alexandra S. Silchenko, Ludmila P. Ponomarenko, Anatoly I. Kalinovsky, Dmitrii V. Berdyshev, Sergey A. Avilov, Pelageya V. Andryjaschenko, Ekaterina G. Lyakhova, Alexandra S. Kuzmich, Natalia A. Terentieva, Peter G. Gorovoy Two new minor eremophilane-type sesquiterpene glucosides, alticolosides H (1) and I (2) along with known earlier lignan glucosides (−)-pinoresinol-4′-O-β-d-glucoside, plucheoside D1 and tortoside F were isolated from aerial parts of the endemic Far Eastern species Ligularia alticola Worosch. (Family Asterac...
Source: Phytochemistry Letters - May 15, 2017 Category: Chemistry Source Type: research

Three new terpenoids from the Eupatorium chinense
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Xiao-Qin Yu, Qing-Qing Zhang, Wei-Hong Yan, Lei Wang, Zhi-Yong Guo, Qing-Qing Yang, Cheng-Xiong Liu, Hai-Bo He, Kun Zou Three new terpenoids compounds (1–3) were obtained from ethyl acetate fraction, which was yielded from Eupatorium chinense’s ethanol extract. Their structures were determined on the basis of 1D and 2D NMR spectroscopy, including 1H-1H COSY, HMBC, HSQC and NOESY experiments. All of the isolated compounds were tested in vitro for their cytotoxic activities against the HepG2, HGC-27 and MDA-MB-231 cancer cell lines. ...
Source: Phytochemistry Letters - May 15, 2017 Category: Chemistry Source Type: research

C21 steroidal glycosides with cytotoxic activity from Cynanchum taihangense
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Yu-Bo Wang, Shan-Shan Su, Shao-Fei Chen, Ming-Xu Tang, Gang Chen, Dan Zhao, Xia-Nan Sang, Ying-Ying Si, Hai-Feng Wang, Yue-Hu Pei Four new C21 steroidal glycosides, cynataihosides A (1), B (2), C (5) and D (6), together with two known compounds, cynanoside J (3) and glaucoside H (4), were isolated from the 95% ethanol extract of Cynanchum taihangense. The aglycone of cynataihoside A (1) was also a new compound, and that of cynataihoside B (2) was unusual. Their structures were elucidated on the basis of 1D- and 2D- NMR spectroscopic data, HR-E...
Source: Phytochemistry Letters - May 13, 2017 Category: Chemistry Source Type: research

New pyranonaphthazarin and 2-naphthoic acid derivatives from the mangrove endophytic fungus Leptosphaerulina sp. SKS032
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Hui Cui, Yena Liu, Meng Ding, Zhengrui Zhang, Huiting Liu, Xishan Huang, Zhigang She Two new compounds, named leptospyranonaphthazarin A (1) and leptosnaphthoic acid A (2), together with four known compounds (3–6) were isolated from an endophytic fungus Leptosphaerulina sp. SKS032. Their structures were assigned using spectroscopic methods, computational methods, and single-crystal X-ray diffraction analysis. In the antibiotic assay, compounds 1, 2, and 6 exhibited antibacterial activities against Staphylococcus aureus with minimal inhib...
Source: Phytochemistry Letters - May 13, 2017 Category: Chemistry Source Type: research

Assessment of two centrifugal partition chromatography devices. Application to the purification of Centaurium erythraea methanolic extract
Publication date: Available online 11 May 2017 Source:Phytochemistry Letters Author(s): Tsvetelina Mandova, Grégoire Audo, Sylvie Michel, Raphaël Grougnet Two different centrifugal partition chromatography devices, Spot CPC and Quantum CPC, have been evaluated for the purification of swertiamarin from a methanolic extract of Centaurium erythraea. By using the same solvents system on isocratic and gradient mode, enriched fractions have been obtained and examined by HPLC–UV. The results are discussed, as well as various parameters such as rotation speed, flow rate and productivity. Graphical abstract (Sour...
Source: Phytochemistry Letters - May 12, 2017 Category: Chemistry Source Type: research

Caffeic acid derivatives as growth inhibitors of Setaria viridis: Structure-activity relationships and mechanisms
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Xiu-zhuang Li, Zhi-qiang Yan, Le Pan, Hui Jin, Xiao-yan Yang, Jun-de Liu, Xiao-feng He, Xia Ren, Min Xie, Kai Guo, Bo Qin Weeds bring severe threats to agricultural production and most traditional herbicides cause serious pollution to the environment. Caffeic acid is a potential allelochemical of many crops. To develop novel herbicides, a series of trans-caffeic acid analogues were prepared to evaluate their growth inhibition on S. viridis and investigate structure-activity relationships. Presence of hydroxyl groups on the benzene ring greatly...
Source: Phytochemistry Letters - May 12, 2017 Category: Chemistry Source Type: research

Two new compounds from Cryptoporus volvatus
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Ling-Yun Zhou, Pan-Pan Li, Jun-Ming Wang, Bin Lu, Yan Hua Two new compounds with the aldehyde group, cryptoporusal A (1) and 9-formyl-4-hydroxy-6, 9-dimethyl-1-O-β-D-xylosopyranosyl-8a,9-dihydro-ace-naphthylen-8-one (2), were isolated from the ethyl acetate extract of the fruiting bodies of Cryptoporus volvatus (Pk.) Hubbard. Their structures were elucidated by extensive spectroscopic studies, and comparison with literature data. Furthermore, they were evaluated for their in vivo cytotoxicity against five human cancer cell lines and antio...
Source: Phytochemistry Letters - May 12, 2017 Category: Chemistry Source Type: research

3,4-Dihydroisocoumarin derivatives from the marine-derived fungus Paraconiothyrium sporulosum YK-03
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Li-Hua Zhang, Sheng-Ge Li, Hong-Hua Wu, Gang Chen, Li Li, Jiao Bai, Hui-Ming Hua, Hai-Feng Wang, Yue-Hu Pei Two new 3,4-dihydroisocoumarin derivatives, (3S, 4S)-4,5-dihydroxymellein (1) and R-(−)-mellein-8-O-β-d-glucopyranoside (2), together with six known analogs (3–8) were isolated from the marine-derived fungus Paraconiothyrium sporulosum YK-03. Their structures including absolute configurations were elucidated by extensive spectroscopic methods in combination with computational electronic circular dichroism (ECD) method, o...
Source: Phytochemistry Letters - May 12, 2017 Category: Chemistry Source Type: research

Depsidones from Talaromyces stipitatus SK-4, an endophytic fungus of the mangrove plant Acanthus ilicifolius
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Runlin Cai, Senhua Chen, Yuhua Long, Chunyuan Li, Xishan Huang, Zhigang She An endophytic fungus (Talaromyces stipitatus SK-4) was isolated from the leaves of a mangrove plant Acanthus ilicifolius. Its crude extract exhibited significant antibacterial activity and was purified to afford two new depsidones, talaromyones A and B (1 and 2), along with five known depsidone analogs (3–7). Their structures, including absolute configuration, were elucidated through extensive spectroscopic data analysis and modified Mosher's method. Compound 2 s...
Source: Phytochemistry Letters - May 11, 2017 Category: Chemistry Source Type: research

Eudesmanolide sesquiterpenes and protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of Indonesian Wedelia prostata
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Delfly B. Abdjul, Hiroyuki Yamazaki, Wilmar Maarisit, Fitje Losung, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Michio Namikoshi Seven eudesmanolide sesquiterpenes (1–7) and two ent-kaurene diterpenes (8 and 9) including two new (9R)-eudesman-9,12-olides, named wedelolides I and J (1 and 2), were isolated from the aerial parts of Indonesian Wedelia prostata. The structures of 1 and 2 were assigned based on their spectroscopic data. Diterpenes 8 and 9 inhibited the activity of protein tyrosine phosphatase 1B (PTP1B) with IC50...
Source: Phytochemistry Letters - May 11, 2017 Category: Chemistry Source Type: research

Benzofuranylethanoid and phenylethanoid esters from Pteropyrum scoparium (Jaub. & amp; Spach)
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Zamzam Y.S. Al-I’shaqi, Majekodunmi O. Fatope, Maymoona S.M. Al-Badi, Ruwaya I. Al-Shueili, Badria Al-Habsi, John Husband Pteropyrum scoparium Jaub. & Spach (Polygonaceae) is a naturally growing shrub used as food crop in Oman. The chemical investigation of the ethyl acetate extracts of the leaf afforded phenylethanoid, benzofuranylethanoid and ethyl esters of caproic and lauric acids (1–3), proanthocyanidin trimer epicatechin-3-O-gallate-(4→8)-epicatechin-3-O-gallate-(4→8)-epicatechin-3-O-gallate (4) and epicatec...
Source: Phytochemistry Letters - May 8, 2017 Category: Chemistry Source Type: research

Chromatographic profiling of Pancharishta at different stages of its development using HPTLC, HPLC, GC –MS and UPLC–MS
Publication date: Available online 5 May 2017 Source:Phytochemistry Letters Author(s): Washim Khan, Karishma Chester, Varisha Anjum, Wasim Ahmad, Sayeed Ahmad, Avinash Narwaria, Das Prasanta Kumar, C.K. Katiyar Pancharishta is the traditional Ayurvedic polyherbal formulation prepared by decoction of plant materials followed by fermentation for preservation and facilitation of extraction due to the production of alcohol. Since the preparation of pancharishta involves various steps. The aim of the current investigation was to carry out comparative metabolomics profiling at different stages of preparation for the understandi...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Inhibition of nitric oxide production by natural oxyprenylated coumarins and alkaloids in RAW 264.7 cells
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Salvatore Genovese, Vito Alessandro Taddeo, Serena Fiorito, Francesco Epifano, Mariangela Marrelli, Filomena Conforti A series of naturally occurring 3,3-dimethylallyloxy- and geranyloxycoumarins and alkaloids were chemically synthesized and tested as anti-inflammatory agents for their inhibitory effects on nitric oxide production in LPS-stimulated RAW 264.7 cells. Results indicated that the alkaloid of fungal origin 3-methylbut-2-enyl-4-methoxy-8-[(3-methylbut-2-enyl)oxy]quinoline-2-carboxylate, commonly known as Ppc-1, and coumarins having a...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Cytotoxic sesquiterpene lactones from Artemisia anomala
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Lu Li, Hongchun Liu, Chunping Tang, Sheng Yao, Changqiang Ke, Chenghui Xu, Yang Ye Two new sesquiterpene lactones, 8α-acetoxy-1,10α-epoxy-2-oxo-guaia-3,11(13)-dien-12,6α-olide (1) and 13-acetoxy-1-oxo-4α-hydroxy-eudesman-2(11)-dien-12,6α-olide (2), along with six known analogs (3-8), were isolated from the whole plant of Artemisia anomala S. Moore. Their structures were elucidated by extensive analysis of spectroscopic data. Compounds 6 and 7 exhibited in vitro moderate cytotoxicity against A549 cells with IC50 va...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Cancer chemopreventive constituents from Melicope lunu-ankenda
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Chihiro Ito, Takuya Matsui, Harukuni Tokuda, Hugh T.W. Tan, Masataka Itoigawa A study of the chemical constituents obtained from twigs of Melicope lunu-ankenda (Gaertn.) T.G. Hartley (Rutaceae) led to the isolation and structure elucidation of two new coumarins, 7-(4-hydroxy-3-methylbutanoxy) coumarin and 7-(3-methyl-4-carboxybutanoxy) coumarin methyl ester, named melilunumarin A (1) and melilunumarin B (2), respectively. A new benzaldehyde derivative, 3,4-dihydro-3,4-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde, named melilunumane ...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Three new chlorinated phenolic glycosides from Przewalskia tangutica
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Min Zhao, Zhuo-Ma Da-Wa, Yu-Cheng Gu, Da-Le Guo, Ye Ye, Li-Sheng Ding, Yan Zhou Three new chlorinated phenolic glycosides, namely przewatangosides A-C (1-3), along with one known compound, globosumoside A (4), were isolated from the whole plants of Przewalskia tangutica. Their structures were unequivocally determined by extensive spectroscopic analysis and chemical method. The cytotoxic activities of the isolated phenolic glycosides (1-4) were evaluated against the five human cancer cell lines A549, MCF-7, SMMC-7721, HepG2 and HL-60. Przewatan...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Prenylated flavonol glycosides from Epimedium grandiflorum: Cytotoxicity and evaluation against inflammation and metabolic disorder
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Fazila Zulfiqar, Shabana I. Khan, Samir A. Ross, Zulfiqar Ali, Ikhlas A. Khan Two new prenylated flavonol glycosides, epimedigrandiosides A and B (1 and 2), and 28 previously known compounds including prenylated flavonol derivatives, flavonol glycoside, megastigmanes, phenyl alkanoids, sesquiterpenoid glycoside, lignan, and hexene glucoside were isolated from the methanol extract of Epimedium grandiflorum. Structure elucidation was achieved by means of spectroscopic and spectrometric techniques including 1D and 2D NMR and HRESIMS. The absolute...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Four new ent-kaurene diterpene glucosides from Mikania micrantha
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Li-Mei Dong, Xu-Chao Jia, Qing-Wen Luo, Yi-Ming Peng, Qiang Zhang, Bi Luo, Jian-Wen Tan Phytochemical study on the aerial parts of Mikania micrantha led to the isolation of four new ent-kaurene diterpene glucosides, β-d-glucopyranosyl-15α-(3-hydroxy-3-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (1), β-d-glucopyranosyl-15α-(3-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (2), β-d-glucopyranosyl-15α-(2-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (3), β-d-glucopyranosyl-15...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Identification, characterization and in vitro neuroprotection of N6-(4-hydroxybenzyl) adenine riboside and its metabolites
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Chunlan Tang, Jialing Wang, Jie Yu, Li Wang, Mengchun Cheng, Wei Cui, Jinshun Zhao, Hongbin Xiao N6-(4-hydroxybenzyl) adenine riboside (NHBA), isolated from Gastrodia elata Blume, has been demonstrated to show great pharmacological effects. The present study aimed to synthesize and identify the metabolites of NHBA, and to determine their neuroprotective potentials in vitro. After incubation with rat liver microsomes in the presence of NADPH, two metabolites were detected, which were further semisynthesized and identified as N6-(4-hydroxylbenzy...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Intra-specific diversity of the chemical composition of Ligularia lamarum in the Hengduan Mountains, China: The structures of four new eremophilanes and a new seco-eremophilane
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Yoshinori Saito, Motoki Hidaka, Akané Fukuda, Yasuko Okamoto, Katsuyuki Nakashima, Motoo Tori, Ryo Hanai, Xun Gong, Eiji Watanabe, Chiaki Kuroda Chemical compositions and internal transcribed spacer (ITS) sequences of five samples of Ligularia lamarum collected in Sichuan Province, China, were analyzed. Fourteen compounds, including four new eremophilanes and one new seco-eremophilane, were isolated and their structures were elucidated by spectroscopic methods. Intra-specific diversity in the chemical composition was found to be higher ...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Two new sesquiterpenoids and a new lindenane sesquiterpenoid dimer from Chloranthus japonicus
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Zhi-Guo Zhuo, Zi-Ying Cheng, Ji Ye, Hui-Liang Li, Xi-Ke Xu, Ning Xie, Wei-Dong Zhang, Yun-Heng Shen A structurally novel 8,9-seco-eudesma-9,4:8,12-dilactone sesquiterpenoid, chlorajapodiolide (1), a new eudesmane sesquiterpenoid, chlorajapotriol (2), a new lindenane-type sesquiterpenoid dimer, chlorajaponilide I (3), and four known lindenane-type sesquiterpenoid dimers were isolated from the whole plant of Chloranthus japonicus. Their structures were established through extensive analysis of NMR spectroscopic data in combination with mass spec...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Chemical constituents from Oncocalyx glabratus and their biological activities
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Sarfaraz Ahmed, Adnan J. Al-Rehaily, Mohammad S. Ahmad, Muhammad Yousaf, Mohammad Nur-e-Alam, Mohammad K. Parvez, Mohammed S. Al-Dosari, Omar M. Noman, Shabana I. Khan, Ikhlas A. Khan Chemical investigation of the aerial parts of Oncocalyx glabratus resulted in the isolation of three new flavan derivatives, 5,3′,4′-trihydroxyflavan 7-O-gallate (1), 5,4′-dihydroxyflavan 7-3′-O-digallate (2) and 5,3′-dihydroxyflavan 7-4′-O-digallate (3), named oncoglabrinol A, B and C, respectively, together with four known fl...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Three new compounds isolated from Eleutherococcus senticosus (Rupt. & amp; Maxim.) Maxim
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Ban-Ban Li, Jia-Lin Li, Na Li, Hyun-Sun Lee, Xi-Bin Wang, Long Cui Three new compounds, 3α, 2β-2-(3′-Hydroxy-4′-methoxy-phenyl)-1-(4″-hydroxy-5″-methoxyphenyl)-1-oxo-3-propanol (1), 1,6-Bis-(3,5-dimethoxy-4-hydroxyphenyl) hexane-1,6-dione (2) and 1-(3-Methoxy-4-hydroxyphenyl)-6-(3,5-dimethoxy-4-hydroxyphenyl) hexane-1,6-dione (3) along with six known compounds (4–9) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus (Rupt. & Maxim.) Maxim. Their structures were elucidated...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Two new compounds and α-glucosidase inhibitors from the leaves of Bidens pilosa L.
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Truong Van Nguyen Thien, Vi Ha Thi Huynh, Loan Kieu Thi Vo, Nhan Trong Tran, Thuat My Luong, Tho Huu Le, Toan Phan Duc, Quang Ton That From the leaves of Bidens pilosa L., the n-hexane, chloroform, and aqueous extracts exhibited in vitro α-glucosidase inhibitory activity, with IC50 values of 235.8, 125.6, and 100.3μg/mL, respectively. Two new compounds, methyl 4-O-caffeoyl-2-C-methyl-d-erythronate (1) and 4-O-methylokanin (2), and seven known compounds were isolated from these extracts. The chemical structures of 1–9 were elucid...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Cytotoxic, anti-HIV –1 and anti-inflammatory activities of lanostanes from fruits of Garcinia speciosa
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Phanruethai Pailee, Thongchai Kruahong, Sakchai Hongthong, Chutima Kuhakarn, Thaworn Jaipetch, Manat Pohmakotr, Surawat Jariyawat, Kanoknetr Suksen, Radeekorn Akkarawongsapat, Jitra Limthongkul, Ampai Panthong, Palangpon Kongsaeree, Samran Prabpai, Patoomratana Tuchinda, Vichai Reutrakul Bioassays-guided isolation of the hexanes and ethyl acetate extracts of the fruits of Garcinia speciosa led to the isolation of three new lanostane triterpenes 1–3 together with three related known derivatives 4–6. The new structures elucidated on ...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Two new flavanone glycosides from Scutellaria galericulata with anti-inflammatory activities
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Kai Xiao, Qing-Tong Han, Lei Zhang, Sheng-Jun Dai Two new flavanone glycosides, named scugalerosides A and B (1-2), were isolated from the whole plant of Scutellaria galericulata. Their chemical structures including absolute configurations were established on the basis of detailed physical data analyses. In vitro, two new compounds showed anti-inflammatory activities, with the inhibition rates of release of β-glucuronidase from polymorphonuclear leukocytes of rats being 43.7% and 45.1% at concentrations of 10 μM. Graphical abstract (So...
Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research

Fractionation of UV-B absorbing molecules and of free radical scavenging compounds from Solieria chordalis by using centrifugal partition chromatography
Publication date: Available online 22 March 2017 Source:Phytochemistry Letters Author(s): R. Boulho, J. Le Roux, C. Le Quémener, G. Audo, N. Bourgougnon, G. Bedoux Liquid-liquid chromatography can lead to the isolation of compounds or enrichment of fractions. To investigate the structural characteristics of antioxidants and UV-B absorbing molecules, a preparative centrifugal partition chromatography (CPC) method was developed to prepare enriched bioactive fractions from the red seaweed Solieria chordalis (Gigartinales, Solieriaceae). After a methanolic extraction of dried Solieria chordalis and liquid-liquid separa...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Could multivariate statistics exploit HPTLC and NMR data to reveal bioactive compounds? The case of Paeonia mascula
Publication date: Available online 23 March 2017 Source:Phytochemistry Letters Author(s): Vasiliki-Ioanna Boka, Konstantina Stathopoulou, Dimitra Benaki, Evangelos Gikas, Nektarios Aligiannis, Emmanuel Mikros, Alexios-Leandros Skaltsounis Bioassay screening or pharmacological evaluation is a common approach to guide the isolation process towards the pure bioactive component. Nevertheless, plenteous time is wasted on isolation, purification and structural elucidation of already known compounds. The tendency over the last years for implementation of high-throughput screening (HTS) technologies leads to the prior identificat...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Comparative determination of the essential oil composition in Bulgarian endemic plant Achillea thracica Velen. during the process of ex situ conservation
Publication date: Available online 23 March 2017 Source:Phytochemistry Letters Author(s): Zhenya P. Yordanova, Maria A. Rogova, Miroslava K. Zhiponova, Milen I. Georgiev, Veneta M. Kapchina-Toteva Ex situ conservation of Bulgarian endemic plant Achillea thracica Velen. was achieved by successful in vitro cultivation of mono-nodal segments on MS-B5 medium supplemented with 1.0mg/L BA for 20days and subsequent transferring of regenerated plants on hormone free basal MS-B5 medium for root development and accumulation of leaf biomass. In vitro multiplicated plants were successfully acclimated in a growth chamber with 100% sur...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Two cytotoxic triterpenes from cultures of a Kenyan Laetiporus sp. (Basidiomycota)
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Clara Chepkirui, Josphat Clement Matasyoh, Cony Decock, Marc Stadler HPLC profiling of the mycelial culture of a poroid basidomycete collected in Mount Elgon, Kenya, which probably represents a new species of the genus Laetiporus, led to isolation of two previously undescribed lanostane type triterpenes.We propose the trivial names laetiporins A (1) and B (2). In addition, five known ones: dehydrosulphurenic acid (3), sulphurenic acid (4), eburicoic acid (5), 15α-hydroxytrametenolic acid (6) and trametenolic acid (7) were also isolated. ...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Steroidal saponins with cytotoxic activities from the rhizomes of Anemarrhena asphodeloids Bge.
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Yu-Wei Zhang, Yun-Fang Zhao, Yin-Ru Wang, Ting-Ting Shang, Lei-Min Yang, Xue-Feng Huang Two new steroidal saponins, named timosaponin R (1) and S (2), together with seven known compounds (3-9) were isolated from the rhizomes of Anemarrhena asphodeloides Bge. Their structures were elucidated on the basis of NMR spectroscopy and mass spectrometry. All the compounds were evaluated for cytotoxic activities against the four human cancer cell lines MCF7, SW480, HepG2 and SGC7901 in vitro. Compounds 7-9 showed moderate activities against all the cell...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Neolignan and monoterpene glycoside from the seeds of Pharbitis nil
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Seoung Rak Lee, Eunjung Moon, Ki Hyun Kim Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z,7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-β-d-glucopyranoside (2), together with a known compound, ethyl α-l-arabinofuranoside (3). The chemical structures of these compounds were unambiguously determined using physical data, HR-ESI–MS and spectros...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Excavasides A and B, two new flavonoid glycosides from Clausena excavata Burm. f. (Rutaceae)
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Changon Seo, Eun-Kyung Ahn, Jae-Shin Kang, Jae-Ho Lee, Joa Sub Oh, Seong Su Hong Two new flavonoid glycosides, excavaside A (1) and B (2), together with 14 known compounds, myricetin 3-O-β-d-rutinoside (3), myricetin 3,3′-di-α-l-rhamnopyranoside (4), myricetin 3′-α-l-rhamnopyranoside (5), myricitrin (6), myricetin (7), quercitrin (8), clauslactone B (9), clauslactone A (10), murrayacoumarin C (11), clauslactone E (12), triphasiol (13), clauslactone P (14), seseline (15), and 5-geranyloxy-7-hydroxycoumarin (16) have...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Two new 2,5-diketopiperazines produced by Streptomyces sp. SC0581
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Li Yang, Ahmed Mahal, Youhua Liu, Hanxiang Li, Ping Wu, Jinghua Xue, Liangxiong Xu, Xiaoyi Wei Two new diketopiperazines, cyclo(l-Phe-l-NMe-DOPA) (2) and cyclo[l-Phe-l-(NMe-3-(NMe-3-O-α-l-rhamnopyranosyl)-DOPA] (3), along with a known diketopiperazine (1), were isolated from the cultures of Streptomyces sp. SC0581. Their structures were elucidated by extensive spectroscopic analysis, single-crystal X-ray crystallographic analysis, and chemical correlation. Compounds 1 − 3 exhibited more potent ABTS radical cation scavenging activit...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Chemical constituents of the root bark of Erythrina droogmansiana
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Kibrom Gebreheiwot Bedane, Souvik Kusari, Anke Bullach, Ishmael B. Masesane, Shetonde O. Mihigo, Michael Spiteller, Runner R.T. Majinda Two new compounds namely 7,4′-dihydroxy-2′-methoxy-3′-(3-methylbut-2-enyl)isoflavanone (1) and 5,7,3′-trihydroxy-8-(3-methylbut-2-enyl)-[6′′,6′′-dimethylpyrano(2′′,3′′:4′,5′)]isoflavone (4) were isolated from the root bark of Erythrina droogmansiana together with eight known compounds. Their structures were elucidated on the ba...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Secondary metabolites from the leaves of the medicinal plant goldenseal (Hydrastis canadensis)
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Martha Leyte-Lugo, Emily R. Britton, Daniel H. Foil, Adam R. Brown, Daniel A. Todd, José Rivera-Chávez, Nicholas H. Oberlies, Nadja B. Cech The study presented herein constitutes an extensive investigation of constituents in Hydrastis canadensis L. (Ranunculaceae) leaves. It describes the isolation and identification of two previously unknown compounds, 3,4-dimethoxy-2-(methoxycarbonyl)benzoic acid (1) and 3,5,3′-trihydroxy-7,4′-dimethoxy-6,8-C-dimethyl-flavone (2), along with the known compounds (±)-chilenine ...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Direct analysis of Peucedanum palustre samples by desorption atmospheric pressure photoionization-mass spectrometry
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Teijo Yrjönen, Heikki Vuorela, Tiina J. Kauppila Desorption atmospheric pressure photoionization (DAPPI) is an ambient mass spectrometry (MS) technique that can be used for the analysis of polar and nonpolar compounds directly from surfaces. Here, the feasibility of DAPPI-MS in the screening of plant metabolites from dried Peucedanum palustre leaves and umbels was studied. DAPPI-MS requires no prior sample preparation or chromatographic separation, and the analysis can therefore be performed directly from the untreated plant material. P. ...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Novel labdane diterpenoids from the aerial parts of Leonurus japonicus
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Yao Peng, Chuan Zheng, Ya-Nan Wang, Ou Dai Three new labdane diterpenoids, leojapones A–C (1–3), along with a new artifactual analogue (4) and four known terpenoids, were isolated from the EtOAc extract of the aerial parts of Leonurus japonicus Houtt. Their structures were elucidated by spectroscopic analyses and physicochemical evidences. The effects of new compounds against the abnormal increase in platelet aggregation induced by adenosine diphosphate were examined. But instead of inhibiting the abnormal platelet aggregation, com...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research