Four new C-glycosylflavones from the leaves of Iris lactea Pall. var. chinensis (Fisch.) Koidz.
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Yu Meng, Minjian Qin, Bingxin Qi, Guoyong Xie Four new acylated C-glycosylflavones, termed embinins A–C and irislactin C, were isolated from the leaves of Iris lactea and their structures were elucidated by extensive NMR experiments and mass spectrometry studies. Embinin A and irislactin C showed weak cytotoxicity against A549 (human lung cancer) cells. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 13, 2017 Category: Chemistry Source Type: research

Two new iridoid glycosides from Odontonema cuspidatum and their bioactivities
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): M.S. Refaey, Ahmed M.M. Hassanein, Mahmoud A.H. Mostafa, Amira S. Wanas, A.A. Ali Two new iridoid glycosides, named 6β-O-methyl-unedoside (1) and 6β-O-methyl-5-deoxythunbergioside (2) along with two known phenyl propanoid glucoside compounds dolichandroside A (3) and verbascoside (4) were isolated from the aerial parts of Odontonema cuspidatum (Nees) Kuntze (Acanthaceae). Structure elucidation of the new compounds was established by interpretation of their 1D and 2D-NMR spectral data by comparing with literatures, HRESIMS and opt...
Source: Phytochemistry Letters - September 10, 2017 Category: Chemistry Source Type: research

Two new substituted polychiral 5, 6-dihydro- α-pyrones from Orthosiphon diffusus and molecular docking studies
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Harish Holla, Akanksha Sharma, Pritesh Bhat, Dhananjay Shinde, Biswanath Das Chemical investigation on Orthosiphon diffusus lead to isolation of two new substituted polychiral 5, 6-dihydro-α-pyrones, orthodiffenes E-F (5-6) which were characterized from the detailed studies of their 1D and 2D NMR spectra. Isolated molecules orthodiffenes E-F (5-6) along with previously isolated, reported orthodiffene A-D (1-4) molecules were subjected to in silico studies and analysed for anticancer target Topoisomerse I-B − DNA complex. Orthod...
Source: Phytochemistry Letters - September 10, 2017 Category: Chemistry Source Type: research

NMR study of age dependent metabolic adjustments in wild type and pp2a-b ’γ mutant Arabidopsis thaliana
In this study we set up the methodology of 1H NMR and principal component analysis (PCA) to address metabolic adjustments in Arabidopsis leaves. Wild type, together with a prematurely yellowing mutant deficient in a specific protein phosphatase 2A regulatory subunit PP2A-B’γ and a pp2a-b’γ 35S:PP2A-B’γ complementation line were analyzed at 4 and 6 weeks of age to reveal metabolic differences between vegetative and maturation phases of rosette growth. A PCA model revealed similar age-dependent metabolic adjustments in all genotypes. The contents of choline, sinapoyl malate, alanine and gl...
Source: Phytochemistry Letters - September 2, 2017 Category: Chemistry Source Type: research

Two pairs of new dihydrobenzophenanthridine alkaloid isolated from the root of Macleaya cordata
Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Kun Yu, Yi Peng, Zhixing Qing, Peng Yang, Zi Zuo, Pi Cheng, Xuefeng Mei, Jianguo Zeng Two pairs of dihydrobenzophenanthridine alkaloid, named (±)(S)-6-((R)-1-hydroxyethy) dihydrochelerythrine (1a, 1b) and (±)(S)-6-((R)-1-hydroxyethyl)dihydro-sangunarine (2a, 2b) were isolated from the root of Macleaya cordata. Their chemical structures were elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and were further confirmed by X-ray crystallographic analysis. Graphic...
Source: Phytochemistry Letters - September 2, 2017 Category: Chemistry Source Type: research

Anti-inflammatory abietane diterpenoids from the seeds of Podocarpus nagi
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Zhe-Ling Feng, Dan Li, Qian-Yu Liu, Jing-Xin Liu, Li Huang, Qing-Wen Zhang, Yi-Tao Wang, Li-Gen Lin In searching for naturally occurring anti-inflammatory agents, three new abietane-type diterpenoids, named 16-hydroxylambertic acid (1), 7-oxo-18-hydroxyferruginol (2), and 5α,12-dihydroxy-6-oxa-abieta-8,11,13-trien-7-one (3), were isolated from the seeds of Podocarpus nagi, together with three known compounds. The structures of the new compounds were elucidated by extensive analysis of NMR and HR-ESIMS data. All the new compounds wer...
Source: Phytochemistry Letters - July 24, 2017 Category: Chemistry Source Type: research

Lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma orbiforme
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Masahiko Isaka, Panida Chinthanom, Sermsiri Mayteeworakoon, Kobkul Laoteng, Rapheephat Suvannakad, Rattaket Choeyklin A new 3,4-seco-27-norlanostane triterpene, ganoboninketal D (1), a new lanostane, (24S)-3-oxo-7α,24,25-trihydroxylanosta-8-ene (2), together with six known lanostanes (3–8), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma orbiforme. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data, and the structures 1 and 2 were further confirmed by chemic...
Source: Phytochemistry Letters - July 21, 2017 Category: Chemistry Source Type: research

Antiproliferative constituents from Aphananthe aspera leaves
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Jia Sun, Quan Gao, Xia-Bing Li, Feng Tang, Cheng-Xiang Li Extensive screening for the antiproliferative activity of different compounds found in trees was performed by extracting the leaves of Aphananthe aspera (Thunb.) Planch and then using chromatographic separation to afford 2 new compounds, (2S,4R)-2-carboxy-4-(E)-p-caffeoyl-1-methyl-hydroxyproline (1) and 5-O-caffeoyl quinic acid-(7′R,8′S,7′′E)-3′,4′,3′′-dihydroxy-4′′,7′-epoxy-8′,5′′-neolign-7′-...
Source: Phytochemistry Letters - July 20, 2017 Category: Chemistry Source Type: research

Pancreatic lipase inhibitory and antioxidative constituents from the aerial parts of Paeonia lactiflora Pall. (Ranunculaceae)
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Odontuya Gendaram, Lai Daowan, Purevdorj Erdenetsogt, Proksch Peter To date, there have been reports mostly about research results of the peony root in comparison to the aerial parts. According to our study, the aerial parts of P.lactiflora showed superior anti-oxidative and pancreatic lipase inhibitory activities than its root. Especially, the water extract and the ethyl acetate fraction of the ethanol extract exhibited potent pancreatic lipase inhibitory activity by 53.11±1.22% and 46.16±1.55% at the same dose of orlistat ...
Source: Phytochemistry Letters - July 20, 2017 Category: Chemistry Source Type: research

Identification of new trace triterpenoids from the fungus Ganoderma duripora
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Chenlei Lian, Yaqing Wu, Tiqiang Chen, Xuqiang Liu, Hui Cong, Lei Xiao, Ying Xu, Jieqing Liu Ganoderma duripora is widely circulated in the Chinese herbal medicine market, although the chemical constituents of this fungus are remain poorly characterized. Phytochemical investigation of the EtOH extract of the fruiting body of G.duripora resulted in the isolation of two trace triterpenoids, named ganoduritriol A and B, and their structures were determined by a combination of 1D, 2D NMR and UPLC-TOF-MS. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 19, 2017 Category: Chemistry Source Type: research

Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Wan Nurul Nazneem Wan Othman, Yasodha Sivasothy, Sook Yee Liew, Jamaludin Mohamad, Mohd Azlan Nafiah, Kartini Ahmad, Marc Litaudon, Khalijah Awang (−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine ...
Source: Phytochemistry Letters - July 18, 2017 Category: Chemistry Source Type: research

Nitrophenyl dihydropyridine-derivatives from Seriphidium oliverianum
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Liaquat Ali, Muhammad Imran Tousif, Naheed Riaz, Mamona Nazir, Hidayat Hussain, Nusrat Shafiq, Abdul Jabbar, Rasool Bakhsh Tareen, Muhammad Saleem The chromatographic purification of the n-hexane soluble part of methanolic extract of Seriphidium oliverianum (J. Gay ex Besser) yielded six secondary metabolites that includes two new natural products; diethyl-2,6-diphenyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (1) and 2,6-diacetyl-3,5-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine (2) along with four known phytochemicals; te...
Source: Phytochemistry Letters - July 18, 2017 Category: Chemistry Source Type: research

New sesquiterpene lactones from Inula oculus-christi L.
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Antoaneta Trendafilova, Victoria Ivanova, Milka Todorova, Ina Aneva Investigation of the aerial parts of Inula oculus-christi L. led to the identification of four new sesquiterpene lactones: an eudesmanolide (4α,15α-epoxypulchellin E) and three guaianolides (2α-acetoxy-4α,9β-dihydroxy-1β-guaia-11(13),10(14)-dien-12,8α-olide, 9β,10β-epoxygaillardin, 9α,10α-epoxy-2-epi-gaillardin), in addition to the known gaillardin, pulchellin E, pulchellin C and 3-O-palmitates of 16β-hydr...
Source: Phytochemistry Letters - July 17, 2017 Category: Chemistry Source Type: research

Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Makungu Marco, Tsegaye Deyou, Amra Gruhonjic, John Holleran, Sandra Duffy, Matthias Heydenreich, Paul A. Firtzpatrick, Göran Landberg, Andreas Koch, Solomon Derese, Jerry Pelletier, Vicky M. Avery, Máté Erdélyi, Abiy Yenesew From the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia micans, a new pterocarpan, (6aR,11aR)-3-hydroxy-7,8,9-trimethoxypterocarpan (1), named micanspterocarpan, was isolated. Similar investigation of the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia dura gave a further n...
Source: Phytochemistry Letters - July 15, 2017 Category: Chemistry Source Type: research

New cytotoxic protolimonoids from the stem bark of Aglaia argentea (Meliaceae)
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Kindi Farabi, Desi Harneti, Nurlelasari, Rani Maharani, Ace Tatang Hidayat, Khalijah Awang, Unang Supratman, Yoshihito Shiono Two new protolimonoid compounds, namely, argentinin A (1) and B (2) along with five known triterpenoid compounds, dammar-24-en-3α-ol (3), 3-epi-cabraleahydroxy lactone (4), (E)-25-hydroperoxydammar-23-en-3β,20-diol (5), mixture of eichlerianic acid and shoreic acid (6a and 6b), and dammar-24-en-3α,20-diol (7), were isolated from the stem bark of Aglaia argentea. The structure of new compounds were ...
Source: Phytochemistry Letters - July 14, 2017 Category: Chemistry Source Type: research

Triterpenoid saponins from Clematis chinensis and their inhibitory activities on NO production
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Qiang Fu, Lu Qiu, Hai-Mei Yuan, Yu-Feng Du, Xiao-Ling Cheng, Ting-Ting Tang, Ping Wang, Ling Xu, Jun-Ming Liang, Long-Fei Yang, Liang Zou, Shu-Yun Xu Four new triterpenoid saponins, clematochinenoside H–K (1–4), and five known structures (5–9), were isolated from the roots and rhizomes of Clematis chinensis. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. All isolates were evaluated for inhibitory effects against nitric oxide (NO) production in LPS-induced RAW 246.7 macrop...
Source: Phytochemistry Letters - July 13, 2017 Category: Chemistry Source Type: research

Synthesis and cytotoxicity evaluation of A-ring derivatives of cycloartanone
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): E. Elisabeth Zambrano, Adriana G. Casas, Gabriela M. Di Venosa, María L. Uriburu, Fernando J. Duran, Jorge A. Palermo Sixteen derivatives, eight of which are new compounds, were prepared from cycloartenone (1) and cycloartanone (2), and the cytotoxic activity of 14 of these compounds, together with 1 and 2, was evaluated against a panel of four cell lines. Compound 1 was obtained from the epiphyte plant Tillandsia tenuifolia collected at Salta, Argentina. Due to chemoselectivity and regioselectivity problems observed in the reactio...
Source: Phytochemistry Letters - July 13, 2017 Category: Chemistry Source Type: research

New steroidal saponins with l-arabinose moiety from the rhizomes of Smilax scobinicaulis
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Jicheng Shu, Genhua Zhu, Guangyu Huang, Huilian Huang, Yonghong Liang, Xing Liu, Jiangli Yu, Meng Zhou, Linyu Li, Jiao Deng Phytochemical investigations of the rhizomes of Smilax scobinicaulis led to the isolation of seven steroidal saponins (1–7) of which four (1, 3, 4 and 6), nameed, Smilscobinosides C-F, respectively) are new. Five of these steroidal saponins with l-arabinose moiety are reported here for the first time in the genus Smilax. The structures were elucidated by spectroscopic analysis of the isolates and their hydrolys...
Source: Phytochemistry Letters - July 11, 2017 Category: Chemistry Source Type: research

Novel degraded polycyclic polyprenylated acylphloroglucinol and new polyprenylated benzophenone from Hypericum sampsonii
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Jun-Sheng Zhang, Jia-Luo Huang, Yi-Hong Zou, Xin Liu, Abrar Ahmed, Gui-Hua Tang, Sheng Yin Norhypersampsone A (1), a novel degraded polycyclic polyprenylated acylphloroglucinol (PPAP) derivative, 3-(2-hydroxy-7-methyl-3-methyleneoct-6-enyl)-5-isoprenyl-2,4,6-trihydroxybenzophenone (2), a new polyprenylated benzophenone derivative, and nine known compounds (3–11) were isolated from Hypericum sampsonii. Their structures were elucidated by comprehensive spectroscopic techniques. Compound 1 represents a novel cyclohexenone monocyclic-PP...
Source: Phytochemistry Letters - July 11, 2017 Category: Chemistry Source Type: research

New saikosaponins from the roots of Bupleurum chinense
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Yanyan Wang, Qiang Guo, Zhongbin Cheng, Kewu Zeng, Hong Liang, Pengfei Tu, Shizhong Chen, Qingying Zhang Seven new saikosaponins (1 − 7), together with four known ones (8 − 11), were isolated from the roots of Bupleurum chinense. Their structures were elucidated by comprehensive spectroscopic analysis and chemical methods. All obtained saikosaponins were oleanane-type, except for compound 11, which was the first lupane–type saikosaponin isolated from the genus Bupleurum. Compound 1 represented the first example of saikos...
Source: Phytochemistry Letters - July 11, 2017 Category: Chemistry Source Type: research

Melohenryines A and B, two new indole alkaloids from Melodinus henryi
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Ling-Li Guo, Yu-Xi Yuan, Hong-Ping He, Shun-Lin Li, Yu Zhang, Xiao-Jiang Hao Two new monoterpenoid indole alkaloids, melohenryines A and B (1 and 2), along with six known indole alkaloids, were isolated from the twigs and leaves of Melodinus henryi. Structures of the new alkaloids were established by extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. Melohenryine A (1) represents the first example of monoterpenoid indole alkaloids characterized an ester carbonyl group at C-19 position. All of the new comp...
Source: Phytochemistry Letters - July 10, 2017 Category: Chemistry Source Type: research

Marasmane and normarasumane sesquiterpenenoids from the edible mushroom Russula nigricans
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Masahiko Isaka, Arunrat Yangchum, Sarunyou Wongkanoun, Surisa Kongthong Three new marasmane sesquiterpenes, russulanigrins A–C (1–3), and a new normarasmane, russulanigrin D (4), together with six known sesquiterpenes, 5, 6, isolactarorufin (7), 8, lactarorufin A (9), and 10, were isolated from fruiting bodies of the edible mushroom Russula nigricans. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Compounds 4, 5, and 7 were inactive in several biological assays: anti-bacterial (Bac...
Source: Phytochemistry Letters - July 10, 2017 Category: Chemistry Source Type: research

New antioxidant C-geranylated flavonoids from the fruit peels of Paulownia catalpifolia T. Gong ex D.Y. Hong
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Ying-ai Wang, Jing Xue, Xian-hui Jia, Cheng-lin Du, Wen-zhao Tang, Xiao-jing Wang Three new geranylated flavonoids, including two geranylflavones (1, 2) and one geranylflavonol (3), named as paucatalinone C–E, were isolated from the fruit peel of P. catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, MS, and NMR techniques. To our known, geranylflavone or geranylflavonol was the first isolation from the genus Paulownia. These isolated geranylated flavonoids displayed good antioxidant effects on DP...
Source: Phytochemistry Letters - July 10, 2017 Category: Chemistry Source Type: research

Pseudo-disesquiterpenoids from seeds of Vernonia anthelmintica and their biological activities
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Ablajan Turak, Zulipiya Maimaiti, HaiRong Ma, Haji Akber Aisa Three new pseudo-disesquiterpenoids, vernodalidimer F – H (1 – 3), which are formed by esterification of two sesquiterpenoids, along with a new sesquiterpenoid (4) and two known sesquiterpeonids (5, 6) were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by NMR data. The absolute configurations of 1–3 and 5 were determined by comparison of the experimental and calculated electronic circular dichroism spectra. Cytotoxicity of...
Source: Phytochemistry Letters - July 7, 2017 Category: Chemistry Source Type: research

Three new alkaloids and a new iridoid glycoside from the roots of Rehmannia glutinosa
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Meng Li, Xiaolan Wang, Zhiguang Zhang, Jingke Zhang, Xuan Zhao, Xiaoke Zheng, Weisheng Feng Three new alkaloids, rehmanalkaloid A-C (1-3), and a new iridoid glycoside, rehmaglutoside L (4), together with nine known compounds, including (8S)-7,8-dihydrogeniposid (5), diglycoside (6), monomelittoside (7), mussaenoside (8), darendoside A (9), syringing (10), phenyl-6-O-β-d-xylopyranosyl-O-β-d-glucopyranoside (11), (7R, 8S)-4,9-dihydroxy-3,3′-dimethoxy-7,8-dihydrobenzofuran-1′-propanalneolignan (12), and trans-liovil (13...
Source: Phytochemistry Letters - July 6, 2017 Category: Chemistry Source Type: research

Stachaegyptin A-C: Neo-clerodane diterpenes from Stachys aegyptiaca
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): M-E.F. Hegazy, Ahmed R. Hamed, El-Sayeda A. El-Kashoury, Alaa M. Shaheen, Wafaa A. Tawfik, Paul W. Paré, Essam Abdel-Sattar Phytochemical investigation of Stachys aegyptiaca resulted in the characterization of three new diterpenes (1-3) together with eleven known compounds including four neo-clerodane diterpenes and seven flavonoid aglycones. Structure elucidation was performed by spectroscopic analysis by HRFABMS, 1D and 2D NMR and X-ray. Isolated compounds were screened for anti-inflammatory activity using a lipopolysaccharide-in...
Source: Phytochemistry Letters - July 5, 2017 Category: Chemistry Source Type: research

Phenylpropanoid glycosides from the roots of Jasminum giraldii
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Zhenggang Yue, Pei Xie, Hui Qin, Yalei Pan, Xiupeng Zhang, Mingfei Zhang, Xiaomei Song, Feng Feng, Zhishu Tang, Jinao Duan As part of our ongoing research in medicinal herbs of Qinba Mountains in China, the plant Jasminum giraldii was chemically investigated. Four new phenylpropanoid glycosides, 9-O-(E-cinnamoyl)-coniferin (1), 6′-O-(E-cinnamoyl)-coniferin (2), 6′-O-(E-cinnamoyl)-syringin (3) and 2′-O-(E-cinnamoyl)-syringin (4), together with two known phenylpropanoid glucosides, coniferin (5) and ethylsyringin (6) were ...
Source: Phytochemistry Letters - July 5, 2017 Category: Chemistry Source Type: research

Phytochemical profile of Schiekia orinocensis (Haemodoraceae)
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Fernanda M.M. Ocampos, Christian Paetz, Guilherme M. Antar, Riya C. Menezes, Obdulio G. Miguel, Bernd Schneider Phytochemical investigation of different plant parts of Schiekia orinocensis, a neotropical member of the Haemodoraceae, resulted in the structure elucidation of thirteen phenylphenalenone-type compounds, five known flavonoids and one new 1,3-disubstituted glycerol derivative. Six of the phenylphenalenones are reported for the first time, among them five minor compounds derived from the reaction with acetone used for extraction....
Source: Phytochemistry Letters - June 30, 2017 Category: Chemistry Source Type: research

Monoterpene derivatives from the flowers of the Hemerocallis minor Mill.
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Xincai Zhao, Yigong Guo, Yu Zhang, Yangguo Xie, Shikai Yan, Huizi Jin, Weidong Zhang Three new monoterpene derivatives, named hemerolides A–C (1–3), one new phenol derivative hemeratrol A (4), along with thirteen known compounds (5–17) were isolated from the flowers of Hemerocallis minor Mill. The structures of the isolated compounds were determined by a combination of 1D and 2D NMR, HRESIMS, and CD spectroscopic data. All the isolates were evaluated their inhibitory activity against NF-κB activation in HeLa cells....
Source: Phytochemistry Letters - June 30, 2017 Category: Chemistry Source Type: research

Novel saponins from Nigella arvensis var. involucrata
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Kenan Bıçak, Derya Gülcemal, İbrahim Demirtaş, Özgen Alankuş Four new oleanane-type triterpene glycosides namely 3-O-[β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl-(1→2)-α-l-arabinopyranosyl] oleanolic acid, 3-O-[β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl-(1→2)-α-l-arabinopyranosyl]-28-O-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] oleanolic acid, 3-O-[β-d-quinovopyranosyl-(1→3)-α-l-rhamnopyranosyl-(...
Source: Phytochemistry Letters - June 28, 2017 Category: Chemistry Source Type: research

New flavone and eudesmane derivatives from Lawsonia inermis and their inhibitory activity against NO production
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Chang-Syun Yang, Jih-Jung Chen, Hui-Chi Huang, Guan-Jhong Huang, Sheng-Yang Wang, Louise-Kuoping Chao, Chin Hsu, Yueh-Hsiung Kuo A new flavone derivative, 7-hydroxy-3,5-dimethoxy-6,8-dimethylflavone (1) and a new eudesmane derivative, eudesmane-4β,7α-diol (2), have been isolated from the aerial part of Lawsonia inermis, together with ten known compounds (3–12). The structures of two new compounds were determined through spectroscopic and MS analyses. All compounds were evaluated for their inhibitory effects on Nitric Oxid...
Source: Phytochemistry Letters - June 27, 2017 Category: Chemistry Source Type: research

Three new monoterpene glucosides and one new sorbitol ester identified from Sibiraea angustata with hypolipidemic activities in HepG2 cells
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Zheng-Zheng Yao, Hong-Dong Liu, Xiao-Tian Chen, Dong-Ming Zhang, Xue-Wen Lai, Peng Xu, Bin Li Three new monoterpene glycosides, sibiraglycoside L (1), M (2), N (3) and one new sorbitol ester, resibirate (4), together with four known compounds including caffeic acid glucitol ester (5), sibiscolacton C (6), geraniol-1-O-[α-l-rhamnopyranosyl-(1→6)-1-β-d-glucopyranoside] (7), and sibiraglycoside K (8), respectively, were isolated from an aqueous extract of the aerial portion of Sibiraea angustata. Their structures were elucida...
Source: Phytochemistry Letters - June 27, 2017 Category: Chemistry Source Type: research

Sesquiterpenoids from cultures of the edible mushroom Craterellus cornucopioides
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Hua Guo, Quan-Ping Diao, Dong-Yan Hou, Zheng-Hui Li, Zhong-Yu Zhou, Tao Feng, Ji-Kai Liu Three illudin sesquiterpenoids, craterellins A–C, and one gymnomitrane sesquiterpenoids, gymnomitr-3-en-10β,15-diol, were isolated from cultures of the basidiomycete Craterellus cornucopioides, along with four previously reported compounds: illudin F, illudin M, illudin T and illudalenol. Structures of new compounds were elucidated on the basis of extensive spectroscopic analysis and their cytotoxic activities on five tumor cell lines were ...
Source: Phytochemistry Letters - June 27, 2017 Category: Chemistry Source Type: research

New coumestan and coumaronochromone derivatives from Dalbergia boehmii Taub. (Fabaceae)
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Jean Pierre Abdou, Jean Momeni, Achyut Adhikari, Nole Tsabang, Alembert T. Tchinda, Muhammad I. Choudhary, Augustin E. Nkengfack Chemical investigation of leaves and heartwood of Dalbergia boehmii resulted in the isolation of two new phenolic compounds, designated dalbergestan (1) and dalbergichromone (2), along with eleven known compounds, carpachromene (3), proanthocyanidin A-2 (4); piceatannol (5); biochanin A (6); macckiain (7); homopterocarpin (8); angolensin (9); medicarpin (10); 2′,7-dihydroxy-4′,5′-dimethoxyisofl...
Source: Phytochemistry Letters - June 24, 2017 Category: Chemistry Source Type: research

New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Wael M. Abdel-Mageed, Lamya H. Al-Wahaibi, Enaam Y. Backheet, Ali A. El-Gamal, Yaser G. Gouda, Omer A. Basudan, Maged S. Abdel-Kader, Azza A. Khalifa Three new phenolic glycosides (1–3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. ...
Source: Phytochemistry Letters - June 23, 2017 Category: Chemistry Source Type: research

Ent-kaurene diterpenoids and lignan from Leontopodium leontopodioides and their inhibitory activities against cyclooxygenases-1 and 2
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Chu-Lu Qi, En Wang, Li-Qin Jin, Ming Yan, Xiao-Qi Zhang, Hao Wang, Wen-Cai Ye Two new ent-kaurene diterpenoids, 13α,15α-dihydroxy-18-carboxy-19-nor-ent-kaur-16-ene-2β-O-(2′-angelate)-β-d-glucopyranoside (leontocin A, 1), 13α,15α-dihydroxy-18-carboxy-19-nor-ent-kaur-16-ene-2β-O-(2′-angelate-6′-acetyl)-β-d-glucopyranoside (leontocin B, 2), and one new lignan, 2,3-bis[(3,4-di-hydroxyphenyl)methylene]-monoethyl ester-butanedioic acid (leontolignan A, 3), together with three known p...
Source: Phytochemistry Letters - June 23, 2017 Category: Chemistry Source Type: research

Phenylphenalenone glycosides: Occurrence, structure revision, and substituent effects on the steric orientation
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Bernd Schneider Glycosides and acyl glycosides of phenylphenalenones, phenylbenzoisochromenones, and structurally related natural products from plants are compiled. With the exception of one naphthalic anhydride glucoside from the Musaceae, all glycosides are chemotaxonomic markers of the Haemodoraceae, subfamily Haemodoroideae. NMR spectroscopic data indicate that in 6-O-glycosides of phenylphenalenones and phenylbenzoisochromenones, the substituents at C-5 and C-7 impede rotation of the interjacent sugar moiety at C-6. Furthermore, the ...
Source: Phytochemistry Letters - June 23, 2017 Category: Chemistry Source Type: research

A furan-2-carbonyl C-glucoside and an alkyl glucoside from the parasitic plant, Dendrophthoe pentandra
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Poolsak Sahakitpichan, Wannaporn Disadee, Rada Buntawong, Nitirat Chimnoi, Somsak Ruchirawat, Tripetch Kanchanapoom A new furan-2-carbonyl C-(6′-O-galloyl)-β-glucopyranoside (scleropentaside F, 1) and a new alkyl glucoside [butane-2,3-diol 2-(6′-O-galloyl)-O-β-glucopyranoside, 2] were isolated from the entire hemi-parasitic plant, Dendrophthoe pentandra growing on Tectona grandis together with ten known compounds including, benzyl-O-β-d-glucopyranoside (3), benzyl-O-α-l-rhamnopyranosyl-(1→6)-β-d-...
Source: Phytochemistry Letters - June 19, 2017 Category: Chemistry Source Type: research

Flavonol glycosides and lignans from the leaves of Opilia amentacea
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Abdulmagid Alabdul Magid, Anaëlle Abdellah, Virginie Pecher, Laure Pasquier, Dominique Harakat, Laurence Voutquenne-Nazabadioko Two previously undescribed flavonol tetraglycosides, isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (1) and isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside (2), along with nine known compounds inclu...
Source: Phytochemistry Letters - June 16, 2017 Category: Chemistry Source Type: research

Lanostane triterpenoids, spiro-astraodoric acid, and astraodoric acids E and F, from the edible mushroom Astraeus odoratus
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Suphongphan Srisurichan, Jittra Piapukiew, Songchan Puthong, Surachai Pornpakakul Three lanostane-type triterpenoids, spiro-astraodoric acid (1), and astraodoric acids E and F (2 and 3), together with 6 known compounds (4–9) were isolated from fruit bodies of an edible mushroom, Astraeus odoratus. Compound 1 possessed an unusual spirocyclic lanostane triterpenoid structure. Their structures were determined by spectroscopic analysis and the absolute configuration of spiro-astraodoric acid and astraodoric acids was described herein. C...
Source: Phytochemistry Letters - June 16, 2017 Category: Chemistry Source Type: research

Two new hemiterpene glycosides and one new phenolic glycoside from the roots of Securidaca inappendiculata Hassk
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Zhi Wang, Haiyan Zha, Xuedong Yang, Licui Hu, Wenfeng Zheng, Lizhen Xu Two new hemiterpene glycosides, named as securiterpenoside B (1), and securiterpenoside C (2), and one new phenolic glycoside, named as securiphenoside A (3) were isolated from the roots of Securidaca inappendiculata Hassk. Their structures were elucidated on the basis of 1D and 2D NMR data and HRESIMS and comparisons with published data. Moreover, compounds 1–3 were evaluated for cytotoxicities against A549 (Lewis lung cancer), Hela (human cervical cancer) and M...
Source: Phytochemistry Letters - June 16, 2017 Category: Chemistry Source Type: research

Cycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysis
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Behnaz Aslanipour, Derya Gülcemal, Ayşe Nalbantsoy, Hasan Yusufoglu, Erdal Bedir Two new tridesmosidic cycloartane-type triterpene glycosides (1 and 2) were isolated from the methanolic extract of the roots of Astragalus brachycalyx FISCHER (A. brachycalyx) along with ten (3–12) known cycloartane-type triterpene glycosides. Structures of the new compounds were established as 3-O-β-d-xylopyranosyl-6-O-β-d-glucopyranosyl-16-O-β-d-glucopyranosyl-3β,6α,16β,24(S)-25-pentahydroxycycloartane (1), 3-O-[&...
Source: Phytochemistry Letters - June 14, 2017 Category: Chemistry Source Type: research

Anti-inflammatory, antimicrobial and acetylcholinesterase inhibitory activities of friedelanes from Maytenus robusta branches and isolation of further triterpenoids
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Grasiely F. de Sousa, Mariana G. de Aguilar, Danielle F. Dias, Jacqueline A. Takahashi, Maria Eliza C. Moreira, Sidney A. Vieira Filho, Grácia D.F. Silva, Salomão B.V. Rodrigues, Maria Cristina T. Braga Messias, Lucienir P. Duarte The new pentacyclic triterpenoids friedel-1-en-3,16-dione (1), 1α,29-dihydroxyfriedelan-3-one (2) and 16β,28,29-trihydroxyfriedelan-3-one (3) were isolated from Maytenus robusta branches in addition to the known, but new for this species, triterpenoid 12α,29-dihydroxyfriedelan-3-on...
Source: Phytochemistry Letters - June 14, 2017 Category: Chemistry Source Type: research

New aromatic compounds from the rhizomes of Homalomena occulta
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Jing Ye, Peng Yin, Mei-Tian Xiao Three new aromatic compounds, identified as 1-(3′,4′-methylenedioxy-phenyl)-10-(3″-hydroxyphenyl)-decane (1), 1-(3′,4′-methylenedioxy-phenyl)-12-(3″-hydroxyphenyl)-dodecane (2), and 1-(3′,4′-methylenedioxy-phenyl)-12-(3″-hydroxyphenyl)-6Z-dodecylene (3), along with six known compounds (4–9) were isolated from the 95% EtOH extract of Homalomena occulta. Their structures were elucidated by chemical and spectral methods Compounds 4–9 were isola...
Source: Phytochemistry Letters - June 14, 2017 Category: Chemistry Source Type: research

Inhibitory effects of phloroglucinols from the roots of Dryopteris crassirhizoma on melanogenesis
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Van Cong Pham, Okhwa Kim, Jeong-Hyung Lee, Byung Sun Min, Jeong Ah Kim Two new phloroglucinols (7 and 10), along with 12 known derivatives (1-6, 8-9, and 11-14), were isolated from the roots of Dryopteris crassirhizoma (Aspiadaceae). Their chemical structures were elucidated by various spectroscopic methods (1H NMR, 13C NMR, COSY, HMQC, and HMBC) and high-resolution mass spectrometry. All isolates (1-14) were tested for their inhibitory effects on melanin production in B16F10 murine melanoma cells. Norflavaspidic acid AB (8), norflavaspid...
Source: Phytochemistry Letters - June 10, 2017 Category: Chemistry Source Type: research

Phenylpropanoid amides from Alisma orientalis and their protective effects against H2O2-induced damage in SH-SY5Y cells
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Xiu-Lan Xin, Zhen-Long Yu, Xiang-Ge Tian, Jiang-Chun Wei, Chao Wang, Xiao-Kui Huo, Jing Ning, Lei Feng, Cheng-Peng Sun, Sa Deng, Bao-Jing Zhang, Hou-Li Zhang, Xin-Yu Zhao, Guang-Jun Fan Five new phenylpropanoid amides, including N-trans-feruloyl-N′-cis-feruloyl-cadaverine (1), N,N′-trans-diferuloyl-3-oxo-cadaverine (2), N-trans-feruloyl-N′-cis-feruloyl-3-hydroxy-cadaverine (3), N,N′-cis-diferuloyl-3-hydroxy-cadaverine (4), N-trans-p-coumaroyl-N′-trans-feruloyl-3-hydroxy-cadaverine (5), were isolated from Alis...
Source: Phytochemistry Letters - June 10, 2017 Category: Chemistry Source Type: research

Stilbeno-phenylpropanoids from Gnetum montanum Markgr.
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Ya-Qian Ma, Yi-Ming Zhai, Yi Deng, Lan Guo, Yi-Qun Wan, Chang-Heng Tan Four new stilbeno-phenylpropanoids, gnetumonins A−C (1−3) and (−)-gnetucleistol F (4), together with two known compounds, gnetupendin A and (+)-gnetofuran A, were isolated from the caulis of Gnetum montanum Markgr. (Gnetaceae). The structures of those new compounds were established by extensive analysis of MS, 1D and 2D NMR spectroscopic data. The relative configurations of 1−3 were elucidated by means of the analysis of shielded effect correlat...
Source: Phytochemistry Letters - June 8, 2017 Category: Chemistry Source Type: research

Three new dolabrane diterpenes from the Chinese mangrove plant of Ceriops tagal
Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Yuan Peng, Shu-Jun Ni, Jun Li, Min-Yi Li Three new dolabranes, tagalenes G − I (1 − 3), together with five known analogues (4 − 8), were isolated from the twigs of the Chinese mangrove, Ceriops tagal. Their structures were determined on the basis of extensive spectroscopic analysis and the comparison with the previous data. Tagalene G (1) is a 16-nordolabrane with a 15-hydroxymethyl scaffold, tagalene H (2) possesses an 18-hydroxymethyl moiety, whereas tagalene I (3) is a further addition to the small group of dolabranes...
Source: Phytochemistry Letters - June 8, 2017 Category: Chemistry Source Type: research

Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Xiu-Hong Zhong, Mei-Fen Bao, Chun-Xia Zeng, Bing-Jie Zhang, Jing Wu, Yu Zhang, Xiang-Hai Cai Five new alkaloids together with 20 known ones were isolated from Alstonia rostrata, and identified on the base of NMR, MS, UV and IR spectroscopic data. Additionally, alstrostine G (1) possessed an unprecedented 6/5/6/6/5/6-ring system. The analysis of those alkaloids’ biosynthetic pathway partly indicated their reticulate metabolic relationship. The research result disclosed diverse biogenesis of monoterpenoid indole alkaloids from Alstonia ros...
Source: Phytochemistry Letters - June 7, 2017 Category: Chemistry Source Type: research

Arvoredol —An unusual chlorinated and biofilm inhibiting polyketide from a marine Penicillium sp. of the Brazilian coast
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Marina Scopel, Beatriz Mothes, Clea B. Lerner, Amélia T. Henriques, Alexandre J. Macedo, Wolf-Rainer Abraham Penicillium sp. F37 has been isolated from the marine sponge Axinella corrugata and shown to be closely related to Penicillium maximae. From the culture of Penicillium sp. F37 arvoredol, a novel chlorinated polyketide with 6,7-dihydro-4(5H)-benzofuranone moiety has been isolated and characterized by spectroscopic methods Arvoredol prevented biofilm formation of the human pathogen Staphylococcus epidermidis at a concentration of 1...
Source: Phytochemistry Letters - June 7, 2017 Category: Chemistry Source Type: research