Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity - A Pilot Study: Part 2 - Biliopancreatic Diversion
Physiol Res. 2023 Dec 17;72(S4):S405-S410.ABSTRACTObesity significantly increases the risk of developing metabolic and cardiovascular diseases. The most effective management tool for both obesity and type 2 diabetes (T2D) is bariatric/metabolic surgery. Delayed postprandial plasma triglyceride clearance contributes to the development of atherosclerosis in patients with T2D. Biliopancreatic diversion (BPD) was shown to be the most effective procedure in long-term T2D remission. However, the effect of BPD on postprandial metabolic profile has not been studied so far. In this pilot study, we therefore examined the changes in ...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: T Metelcov á V Hainer M Hill P Kalouskov á J Vrb íková P Šrámková M Fried R Taxov á Braunerová M Kune šová Source Type: research
Age-Related Changes in Proinsulin Processing in Normoglycemic Individuals
Physiol Res. 2023 Dec 17;72(S4):S389-S397.ABSTRACTIn order to understand the pathological changes associated with glucose homeostasis in old age, it is necessary to know the natural changes in the processing of proinsulin to mature insulin. While there is abundant information about insulin production and function in diabetics, the situation in healthy adults and the elderly has surprisingly rarely been investigated. The aim of the study was to determine how proinsulin secretion changes in individuals with normal glucose tolerance during the process of natural aging. A total of 761 individuals (539 women, 222 men) aged 18-9...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: M Va ňková D Vejra žková P Luk ášová J V čelák D Chocholov á B Bendlov á Source Type: research
The Endocannabinoid System - The Prediction of Spontaneous Preterm Birth in High-Risk Women: Protocol of a Study
We present the protocol for an open, non-randomized study to evaluate concentrations of AEA and other endocannabinoids: 2 linoleoylglycerol (2-AG), 2 linoleoylglycerol (2-LG), 2 oleoylglycerol (2-OG), and 2 arachidonoyldopamine (2-ADOPA or also NADA) in the blood of pregnant women as potential predictors of sPTB. In a total of 230 women with a history of sPTB or miscarriage, eCBs levels between 22 and 28 weeks of gestation will be assessed from maternal blood, in addition to the standard procedure. The aim of the study is to determine the relationship between blood concentrations of the endocannabinoids tested and the risk...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: A Pa řízek M Hill M Du šková L Kol átorová J Suchop ár P Šimják K Anderlov á E Kudov á V Rogalewicz J Vacek M Koudelkov á R Chloupkov á M Alblov á P Pa řízková Z La štůvka M Bart ák Source Type: research
Endocrine Disruptors and Estrogens in Human Prostatic Tissue
Physiol Res. 2023 Dec 17;72(S4):S411-S422.ABSTRACTEndocrine disruptors (EDs) are ubiquitous substances both in the environment and everyday products that interfere with the hormonal system. Growing evidence demonstrates their adverse effects on the organism, including the reproductive system and the prostate, owing to their (anti)estrogenic or antiandrogenic effects. Since EDs can interact with steroid hormone actions on-site, understanding the levels of intraprostatic EDs in conjunction with steroids may hold particular significance. The aim of this study was to develop and validate a method for determining estrogens, var...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: J Vitku T Skodova A Varausova L Gadus L Michnova L Horackova L Kolatorova M Simkova J Heracek Source Type: research
Recurrent Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 1 Syndrome
Physiol Res. 2023 Dec 17;72(S4):S423-S427.ABSTRACTPrimary hyperparathyroidism is a common endocrinopathy. Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominantly inherited endocrine tumor predisposition syndrome, with one of main manifestations being primary hyperparathyroidism. We retrospectively evaluated a set of 1011 patients who underwent surgery for primary hyperparathyroidism between the years 2018-2022, and found 78 (8 %) patients who underwent reoperations and 27 patients with MEN1 syndrome. In the group of patients with MEN1 syndrome, 7 (35 %) needed reoperations. Patients with multiple endocrin...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: P Lib ánský J Čarková I Kushnir M Mat ějková Běhanová K Procyklov á J Šedý M Vaculov á J V čelák V Zik án S Ad ámek Source Type: research
Steroid Conjugates and Their Physiological Role
Physiol Res. 2023 Dec 17;72(S4):S317-S322.ABSTRACTWhile there are hundreds of synthetic steroids conjugates with acids, sugars, proteins and other molecules, only two types of conjugates occur in living organisms, namely sulfates and glucuronides. Steroid glucuronidation in the human liver is the main mechanism controlling the levels and biological activity of unconjugated hormones, and glucuronides are their main excretion products. This process is generally irreversible. On the other hand, sulfates possess their own biological activity that differs from that of the unconjugated steroid, emphasizing the importance of ster...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: J V ítků R Hampl Source Type: research
The Effects of Different Types of Diets on Steroid Hormone Concentrations
Physiol Res. 2023 Dec 17;72(S4):S323-S337.ABSTRACTThe great popularity of various diets in recent years has led us to reflect on their suitability for our health. The aim of this communication is to review current knowledge on the influence of the most well-known diets on the concentrations of the main steroids and to consider possible mechanisms. The influence of diet on hormone concentrations is expected, but the literature data on this topic are inconsistent and yield conflicting results. The main problem in evaluating these influences is the change in weight that a change in diet induces. This effect needs to be filter...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: M Du šková Source Type: research
The Endocannabinoid System and Its Relationship to Human Reproduction
Physiol Res. 2023 Dec 17;72(S4):S365-S380.ABSTRACTThe endocannabinoid system is among the most important regulators of human reproduction. It already applies at the level of the sperm and the egg, plays an important role in the fertilization of the egg, its implantation, regulates the function of the placenta and participates in childbirth. The aim of this work is to summarize the knowledge accumulated so far and to show that the endocannabinoid system must be perfectly regulated in order to maintain a physiological pregnancy from implantation to delivery. Only an exceptional interplay of enzymes such as NAPE-PDL or FAAH, ...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: A Pa řízek J Suchop ár Z La štůvka M Alblov á M Hill M Du šková Source Type: research
Molecular Regulation of the CNS by Vitamin D
Physiol Res. 2023 Dec 17;72(S4):S339-S356.ABSTRACTVitamin D is a lipid-soluble vitamin that can be found in some foods. It is also produced endogenously (in the presence of ultraviolet light), transported through the blood to the targets organs and this is the reason to consider vitamin D as a hormone. It is known that vitamin D has genomic and non-genomic effects. This review is focused mainly on the vitamin D receptors, the importance of vitamin D as a neuromodulator, the role of vitamin D in the pathophysiology of devastating neurological disorders such as Alzheimer's disease, multiple sclerosis, amyotrophic lateral scl...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: L M áčová R Kancheva M Bi číková Source Type: research
Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism
Physiol Res. 2023 Dec 17;72(S4):S357-S363.ABSTRACTMultiglandular primary hyperparathyroidism (MGD) represents a rare form of primary hyperparathyroidism (PHPT). MGD is associated with hereditary PHPT, but the sporadic MGD is more common and affects a similar patient profile as single gland parathyroid disease (SGD). The distinction between SGD and MGD is of great clinical importance, especially for the strategy of parathyroidectomy. Based on the limited knowledge available, MGD is likely to be a genetically heterogeneous disease resulting from the interaction of germline and somatic DNA mutations together with epigenetic a...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: J V čelák Z Šerková K Zaj íčková Source Type: research
Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity - A Pilot Study: Part 1 - Laparoscopic Greater Curvature Plication
Physiol Res. 2023 Dec 17;72(S4):S399-S403.ABSTRACTThe long-term effects of bariatric surgery on postprandial profiles in patients with obesity and type 2 diabetes (T2D) have not yet been investigated. Therefore, this study examined postprandial profiles before laparoscopic greater curvature plication (LGCP), and then at 2 and 10 years after surgery.The studied cohort included 10 women (mean age= 54.4±5 years) with obesity (mean BMI= 42.5±7.8 kg/m?) and T2D who underwent LGCP. All subjects underwent a standardized liquid mixed-meal test. For statistical evaluation, ANOVA with Bonferroni multiple comparison was used. Mean ...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: T Metelcov á V Hainer M Hill P Kalouskov á J Vrb íková P Šrámková M Fried R Taxov á Braunerová M Kune šová Source Type: research
Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity - A Pilot Study: Part 2 - Biliopancreatic Diversion
Physiol Res. 2023 Dec 17;72(S4):S405-S410.ABSTRACTObesity significantly increases the risk of developing metabolic and cardiovascular diseases. The most effective management tool for both obesity and type 2 diabetes (T2D) is bariatric/metabolic surgery. Delayed postprandial plasma triglyceride clearance contributes to the development of atherosclerosis in patients with T2D. Biliopancreatic diversion (BPD) was shown to be the most effective procedure in long-term T2D remission. However, the effect of BPD on postprandial metabolic profile has not been studied so far. In this pilot study, we therefore examined the changes in ...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: T Metelcov á V Hainer M Hill P Kalouskov á J Vrb íková P Šrámková M Fried R Taxov á Braunerová M Kune šová Source Type: research
Age-Related Changes in Proinsulin Processing in Normoglycemic Individuals
Physiol Res. 2023 Dec 17;72(S4):S389-S397.ABSTRACTIn order to understand the pathological changes associated with glucose homeostasis in old age, it is necessary to know the natural changes in the processing of proinsulin to mature insulin. While there is abundant information about insulin production and function in diabetics, the situation in healthy adults and the elderly has surprisingly rarely been investigated. The aim of the study was to determine how proinsulin secretion changes in individuals with normal glucose tolerance during the process of natural aging. A total of 761 individuals (539 women, 222 men) aged 18-9...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: M Va ňková D Vejra žková P Luk ášová J V čelák D Chocholov á B Bendlov á Source Type: research
The Endocannabinoid System - The Prediction of Spontaneous Preterm Birth in High-Risk Women: Protocol of a Study
We present the protocol for an open, non-randomized study to evaluate concentrations of AEA and other endocannabinoids: 2 linoleoylglycerol (2-AG), 2 linoleoylglycerol (2-LG), 2 oleoylglycerol (2-OG), and 2 arachidonoyldopamine (2-ADOPA or also NADA) in the blood of pregnant women as potential predictors of sPTB. In a total of 230 women with a history of sPTB or miscarriage, eCBs levels between 22 and 28 weeks of gestation will be assessed from maternal blood, in addition to the standard procedure. The aim of the study is to determine the relationship between blood concentrations of the endocannabinoids tested and the risk...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: A Pa řízek M Hill M Du šková L Kol átorová J Suchop ár P Šimják K Anderlov á E Kudov á V Rogalewicz J Vacek M Koudelkov á R Chloupkov á M Alblov á P Pa řízková Z La štůvka M Bart ák Source Type: research
Endocrine Disruptors and Estrogens in Human Prostatic Tissue
Physiol Res. 2023 Dec 17;72(S4):S411-S422.ABSTRACTEndocrine disruptors (EDs) are ubiquitous substances both in the environment and everyday products that interfere with the hormonal system. Growing evidence demonstrates their adverse effects on the organism, including the reproductive system and the prostate, owing to their (anti)estrogenic or antiandrogenic effects. Since EDs can interact with steroid hormone actions on-site, understanding the levels of intraprostatic EDs in conjunction with steroids may hold particular significance. The aim of this study was to develop and validate a method for determining estrogens, var...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: J Vitku T Skodova A Varausova L Gadus L Michnova L Horackova L Kolatorova M Simkova J Heracek Source Type: research
