The chloroplast genome of < em > Scutellaria franchetiana < /em > H.L év. 1911 and its implications for phylogenetic relationships in the < em > Scutellaria < /em > genus
Mitochondrial DNA B Resour. 2023 Oct 30;8(11):1154-1157. doi: 10.1080/23802359.2023.2275829. eCollection 2023.ABSTRACTScutellaria franchetiana H.Lév. 1911 is an important medicinal plant distributed on hillside wetlands at an altitude of 830-2300 m. The total length of complete chloroplast genome of S. franchetiana 151,852 bp of 38.37% GC content. It is a typical quadratic structure with four subregions consisting of a large single-copy region (83,894 bp), a small single-copy region (17,520 bp), and a pair of inverted repeats (25,219 bp). In the chloroplast genome of S. franchetiana, 130 genes were detected, comprising 86...
Source: Physiological Research - January 8, 2024 Category: Physiology Authors: Jiabin Yu Ning Huang Chuliang Wang Weikai Gao Jutao Sun Source Type: research
Sports activities and cardiovascular system change
Physiol Res. 2023 Dec 29;72(S5):S429-S444.ABSTRACTSports activity is generally considered to be beneficial to health. The World Health Organization (WHO) recommends physical activity as part of a healthy lifestyle. Sports activities significantly affect the cardiovascular system. A number of studies show that they significantly reduce the risk of cardiovascular disease as well as decrease cardiovascular mortality. This review discusses changes in various cardiovascular parameters in athletes - vagotonia/bradycardia, hypertrophy of heart, ECG changes, blood pressure, and variability of cardiovascular parameters. Because of ...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: P Štursová X Budinsk á Z Nov áková P Dob šák P Babula Source Type: research
An overview of the methamphetamine effect on male sexual behavior and reproductive system
Physiol Res. 2023 Dec 29;72(S5):S445-S459.ABSTRACTDrug addiction and its effect on the behavior and development of children has become a serious problem in our society. Methamphetamine (MA) is one of the most abused psychostimulants in the Czech Republic, and its abuse is rising worldwide. Previous studies have demonstrated the adverse long-term effects of maternal drug abuse on rat offspring. However, the father's contribution as a parent and donor of half of the genetic information is unclear. Previous studies of other psychostimulant drugs indicate that long-term application of MA to adult male rats may induce changes i...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: L Mihal číková R Šlamberová Source Type: research
Serum biomarkers of hypoxic-ischemic brain injury
Physiol Res. 2023 Dec 29;72(S5):S461-S474.ABSTRACTBrain injury is a multifaceted condition arising from nonspecific damage to nervous tissue. The resulting cognitive developmental impairments reverberate through patients' lives, affecting their families, and even the broader economic landscape. The significance of early brain injury detection lies in its potential to stave off severe consequences and enhance the effectiveness of tailored therapeutic interventions. While established methods like neuroimaging and neurophysiology serve as valuable diagnostic tools, their demanding nature restricts their accessibility, particu...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: A Tefr Faridov á H He řman Š Danačíková J Svoboda J Ot áhal Source Type: research
Unusual functions of insect vitellogenins: minireview
Physiol Res. 2023 Dec 29;72(S5):S475-S487.ABSTRACTInsect vitellogenins are an intriguing class of complex proteins. They primarily serve as a source of energy for the developing embryo in insect eggs. Vitellogenesis is a complex hormonally and neurally controlled process that command synthesis of vitellogenin molecules and ensures their transport from the female fat bodies or ovarial cells into eggs. The representatives of all insect hormones such as juvenile hormones, ecdysteroids, and neurohormones participate in vitellogenesis, but juvenile hormones (most insect species) and ecdysteroids (mostly Diptera) play the most i...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: D Kodr ík R Čapková Frydrychová D Hl ávková O Skokov á Habuštová H Štěrbová Source Type: research
High "fitness age" as a risk factor for morbidity and premature mortality
Physiol Res. 2023 Dec 29;72(S5):S489-S497.ABSTRACTThe level of cardiorespiratory capacity, as measured by maximum VO(2)max oxygen consumption, is a significant factor related to the risk of metabolic syndrome, coronary heart disease and other health disorders. A total cohort of 2901 examinations was divided into 5 groups according to the nature of physical activity: group A - endurance athletes, group B - team sports players, group C - other competitive athletes, group D - recreational leisure-time athletes, group E - people with health problems. Cardiorespiratory fitness was assessed according to the VO(2)max and METmax p...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: J Nov ák M Štork Source Type: research
Sex differences in plasma metabolites in a guinea pig model of allergic asthma
This study aimed to find sex-related differences in metabolome measured by hydrogen-1 nuclear magnetic resonance ((1)H NMR) spectroscopy in healthy and ovalbumin (OVA)-sensitized guinea pigs. Adult male and female animals were divided into controls and OVA-sensitized groups. OVA-sensitization was performed by OVA systemic and inhalational administration within 14 days; on day 15, animals were killed by anesthetic overdose followed by exsanguination. Blood was taken and differential white blood cell count was measured. Left lung was saline-lavaged and differential cell count in the bronchoalveolar lavage fluid (BALF) was me...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: R Barosova E Baranovicova J Adamcakova K Prso J Hanusrichterova D Mokra Source Type: research
The effect of budesonide delivered by high-frequency oscillatory ventilation on acute inflammatory response in severe lung injury in adult rabbits
This study aimed to investigate the effect of budesonide therapy delivered intratracheally by high-frequency oscillatory ventilation (HFOV) on lung function and inflammation in severe ARDS. Adult New Zealand rabbits with respiratory failure (P/F<13.3 kPa) induced by intratracheal instillation of hydrochloric acid (HCl, 3 ml/kg, pH 1.5) followed by high tidal ventilation (VT 20 ml/kg) to mimic ventilator-induced lung injury (VILI) were treated with intratracheal bolus of budesonide (0.25 mg/kg, Pulmicort) delivered by HFOV (frequency 8 Hz, MAP 1 kPa, deltaP 0.9 kPa). Saline instead of HCl without VILI with HFOV delivered...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: N Nemcova P Kosutova M Kolomaznik S Mateffy Z Turianikova A Calkovska P Mikolka Source Type: research
The effect of bariatric-metabolic surgery on selected components of metabolic syndrome and visceral adipose tissue - the pilot study
Physiol Res. 2023 Dec 29;72(S5):S523-S534.ABSTRACTThe aim of this study was to monitor changes in the components of the metabolic syndrome defined by Adult Treatment Panel III and the risk of adipose tissue. The study population consisted of 45 patients (30 women, 15 men) who underwent one bariatric procedure - partial jejuno-ileal derivation (n=17), sleeve resection (n=14) or laparoscopic gastric - plication (n=14). Components of metabolic syndrome such as waist circumference, morning glycemia/antihypertension, TAG, HDL cholesterol and blood pressure (BP)/antihypertension were monitored in probands. In addition, Dual Ener...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: V Hork á M Bu žýga J Mach áčková P Hol éczy Z Švagera Source Type: research
Changes in gene expression in pressure ulcers debrided by different approaches - a pilot study
Physiol Res. 2023 Dec 29;72(S5):S535-S542.ABSTRACTPressure ulcers (PUs), also known as pressure injuries, are chronic wounds that represent potential lifelong complications. Pressure ulcers of a deep category (III and IV) are often indicated for surgical treatment - debridement and surgical reconstruction. Sharp surgical debridement is widely used in the debridement of PUs; however, the Versajet® hydrosurgery system is becoming an increasingly popular tool for tangential excision in surgery due to its numerous advantages. This work focused on the expression of selected genes, especially those associated with oxidative str...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: A Samadian M Kratochv ílová A Hokynkov á P Šín M Nov áková P Štěpka A Pokorn á P Babula Source Type: research
Cerebral perfusion pressure and behavior monitoring in freely moving rats
Physiol Res. 2023 Dec 29;72(S5):S543-S549.ABSTRACTCerebral perfusion pressure (CPP) is the net pressure gradient that drives oxygen delivery to cerebral tissue. It is the difference between the mean arterial pressure (MAP) and the intracranial pressure (ICP). As CPP is a calculated value, MAP and ICP must be measured simultaneously. In research models, anesthetized and acute monitoring is incapable of providing a realistic picture of the relationship between ICP and MAP under physiological and/or pathophysiological conditions. For long-term monitoring of both pressures, the principle of telemetry can be used. The aim of th...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: P Kozler D Mare šová M Hrachovina J Pokorn ý Source Type: research
Methylphenidate attenuates signs of evoked neuropathic pain in animal model
Physiol Res. 2023 Dec 29;72(S5):S551-S558.ABSTRACTMethylphenidate is a psychostimulant that increases dopamine and noradrenaline levels. Recent studies have shown that methylphenidate potentiates the effect of morphine and together suppress acute and chronic pain. In clinical practice, methylphenidate has been used as a treatment for ADHD and changes of pain threshold have been noted in these patients. The aim of this study was to determine the effect of methylphenidate in an animal model of peripheral neuropathic pain. Neuropathic pain was modeled by the chronic constriction of the sciatic nerve (CCI) in Wistar rats. We e...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: K Panu šková L Vod ěrová Š Vaculín Source Type: research
Levels of BDNF and NGF in adolescent rat hippocampus neonatally exposed to methamphetamine along with environmental alterations
We examined if all these three factors had impact on BDNF and NGF levels during three phases of adolescence - postnatal days (PDs) 28, 35 and 45. Our results show that EE did not increase BDNF levels neither in control or MA exposed animals and these results are similar for both direct and indirect exposure. On the other side, social separation after weaning did reduce BDNF levels in comparison to standard housing animals but this effect was reversed by direct MA exposure. In terms of NGF, EE environment increased its levels only in indirectly exposed controls and MA animals during late adolescence. On the other hand, soci...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: B Čechová L Mihal číková Š Vaculin Š Šandera R Šlamberová Source Type: research
Magnetic resonance imaging techniques for indirect assessment of myelin content in the brain using standard T1w and T2w MRI sequences and postprocessing analysis
In this study, we focused on techniques utilizing standard MRI T1-weighted (T1w) and T2 weighted (T2w) sequences commonly used in brain imaging protocols. We evaluated the applicability of the T1w/T2w ratio in assessing myelin content by comparing it to quantitative T1 mapping (qT1). Our study included 1 healthy adult control and 7 neurologic patients (comprising both pediatric and adult populations) with epilepsy originating from focal epileptogenic lesions visible on MRI structural scans. Following image acquisition on a 3T Siemens Vida scanner, datasets were co registered, and segmented into anatomical regions using the...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: P Poko šová D Kala J Šanda P Je ždík Y Prysiazhniuk A Faridov á A Jahodov á A B ělohlávková A Kalina Z Holubov á B Jur ášek M Kyn čl J Ot áhal Source Type: research
Hypoxia-inducible factors activator, roxadustat, increases pulmonary vascular resistance in rats
Physiol Res. 2023 Dec 29;72(S5):S587-S592.ABSTRACTActivators of hypoxia inducible factors (HIFs), such as roxadustat, are promising agents for anemia treatment. However, since HIFs are also involved in the regulation of the pulmonary circulation, we hypothesized that roxadustat increases pulmonary vascular resistance and vasoconstrictor reactivity. Using isolated, cell-free solution perfused rat lungs, we found perfusion pressure-flow curves to be shifted to higher pressures by 2 weeks of roxadustat treatment (10 mg/kg every other day), although not as much as by chronic hypoxic exposure. Vasoconstrictor reactivity to angi...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: T Nov ák M Žaloudíková P Smolkov á B Kaftanov á J Edlmanov K Kr ása V Hampl Source Type: research
