Sympathetic determinants of resting blood pressure in males and females
Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H612-H622. doi: 10.1152/ajpheart.00497.2023. Epub 2024 Jan 12.ABSTRACTDischarge of postganglionic muscle sympathetic nerve activity (MSNA) is related poorly to blood pressure (BP) in adults. Whether neural measurements beyond the prevailing level of MSNA can account for interindividual differences in BP remains unclear. The current study sought to evaluate the relative contributions of sympathetic-BP transduction and sympathetic baroreflex gain on resting BP in young adults. Data were analyzed from 191 (77 females) young adults (18-39 years) who underwent continuous measur...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: Massimo Nardone Monique Foster Myles W O'Brien Yasmine Coovadia Shengkun Xie Charlotte W Usselman Derek S Kimmerly Chloe E Taylor Philip J Millar Source Type: research
Methods of Cough Assessment and Objectivization
Physiol Res. 2023 Dec 31;72(6):687-700. doi: 10.33549/physiolres.935062.ABSTRACTCough is one of the most important airway defensive reflexes aimed at removing foreign particles or endogenously produced materials from the airways and provides protection against aspiration. Generally considered, cough is a vital physiological defensive mechanism for lung health. However, in case of cough dysregulation this reflex can become pathological and leads to an adverse influence on daily life. Therefore, it is necessary to effectively evaluate the severity of cough for its diagnosis and treatment. There are subjective and objective m...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: J Jakusova M Brozmanova Source Type: research
Clinical Efficacy of Blood Ultrafiltration Therapy in Patients with Acute Decompensated Chronic Heart Failure Running Title: Blood Ultrafiltration Therapy for Heart Failure
In this study, we investigated the clinical effects of blood ultrafiltration therapy in patients with acute decompensated chronic heart failure. We enrolled 78 patients with acute decompensated chronic heart failure who were admitted to a hospital from September 2017 to December 2021, and divided them into two groups based on the digital randomization method. The FQ-16 heart failure ultrafiltration dehydrating device blood ultrafiltration therapy was administered to the observation group (39 patients) for 8-16 hours, while the control group (39 patients) received the stepped drug therapy. Echocardiography was used to asses...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: Yan-Wei He Feng-Qin Wang Fen-Fang Zhang Huan-Zhen Chen Source Type: research
Choline induced cardiac dysfunction by inhibiting the production of endogenous hydrogen sulfide in spontaneously hypertensive rats
In conclusion, choline aggravated cardiac dysfunction in HHD through inhibiting the production of endogenous H2S, which was reversed by supplementation of exogenous H2S donor.PMID:38215059 | PMC:PMC10805251 | DOI:10.33549/physiolres.935075 (Source: Physiological Research)
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: W Zhang Y Zhang Y Xia G Feng Y Wang C Wei A Tang K Song R Qiu Y Wu S Jin Source Type: research
Vagus nerve stimulation attenuates septic shock-induced cardiac injury in rats
This study suggests that VNS contributes to the reduction of myocardial apoptosis and improvement of left ventricular function to attenuate septic shock-induced cardiac injury in rats. The performance of VNS inhibits the inflammatory responses in heart tissues via the regulation of NF-kappa-B signal.PMID:38215060 | PMC:PMC10805250 | DOI:10.33549/physiolres.935136 (Source: Physiological Research)
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: Y Chen M Cui Y Cui Source Type: research
Comparison of Pulmonary and Extrapulmonary Models of Sepsis-Associated Acute Lung Injury
Physiol Res. 2023 Dec 31;72(6):741-752. doi: 10.33549/physiolres.935123.ABSTRACTTo compare different rat models of sepsis at different time points, based on pulmonary or extrapulmonary injury mechanisms, to identify a model which is more stable and reproducible to cause sepsis-associated acute lung injury (ALI). Adult male Sprague-Dawley rats were subjected to (1) cecal ligation and puncture (CLP) with single (CLP1 group) or two repeated through-and-through punctures (CLP2 group); (2) tail vein injection with lipopolysaccharide (LPS) of 10mg/kg (IV-LPS10 group) or 20 mg/kg (IV-LPS20 group); (3) intratracheal instillation w...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: G Zhou D Xie R Fan Z Yang J Du S Mai L Xie Q Wang T Mai Y Han F Lai Source Type: research
Role of Cisplatin in Inducing Acute Kidney Injury and Pyroptosis in Mice via the Exosome miR-122/ELAVL1 Regulatory Axis
Physiol Res. 2023 Dec 31;72(6):753-765. doi: 10.33549/physiolres.935129.ABSTRACTAlthough cisplatin is an effective chemotherapy drug for the treatment of various cancers, its clinical use is limited due to its side effects, especially nephrotoxicity. Unfortunately, acute kidney injury (AKI) caused by cisplatin remains one of the main challenges in effective cancer treatment. Evidence increasingly suggests that renal inflammation and pyroptotic inflammatory cell death of renal tubular epithelial cells (RTECs) mainly determine the progression and outcome of cisplatin-induced AKI. However, it is not clear how cisplatin regula...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: B Zhu J He X Ye X Pei Y Bai F Gao L Guo H Yong W Zhao Source Type: research
Analysis of Efficacy and Safety of Small-Volume-Plasma Artificial Liver Model in the Treatment of Acute-On-Chronic Liver Failure
Physiol Res. 2023 Dec 31;72(6):767-782. doi: 10.33549/physiolres.935158.ABSTRACTTo explore the efficacy and safety of a small-volume-plasma artificial liver support system (ALSS) in the treatment of acute-on-chronic liver failure (ACLF). A retrospective analysis was performed. All ACLF patients received ALSS of plasma exchange & double plasma molecular absorb system (PE+DPMAS) treatment, and successfully completed this treatment. Patients were divided into small-volume and half-volume plasma groups. We compared the changes of the indicators on liver function, kidney function, blood coagulation function, and blood ammon...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: D Li X Wang J Zhou Z Duan R Yang Y Liu Y Chen L Zhang H Liu W Li J You Source Type: research
Ginsenoside Rg1 attenuates dextran sodium sulfate-induced ulcerative colitis in mice
Physiol Res. 2023 Dec 31;72(6):783-792. doi: 10.33549/physiolres.935182.ABSTRACTUlceration colitis (UC) is a chronic and recurrent inflammatory disorder in the gastro-intestinal tract. The purpose of our study is to explore the potential mechanisms of ginsenoside Rg1 (GS Rg1) on dextran sulfate sodium (DSS)-induced colitis in mice and lipopolysaccharide (LPS)-induced RAW 264.7 cells. Acute colitis was induced in male C57BL/6 mice. In vitro model of LPS-induced RAW 264.7 cells to simulate enteritis model. The disease activity index (DAI), colon length, body weight and histopathological analysis were performed in vivo. Pro-i...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: Y Chen Q Zhang L Sun H Liu J Feng J Li Z Wang Source Type: research
Modulation of Melatonin Receptors Regulates Reproductive Physiology: The Impact of Agomelatine on the Estrus Cycle, Gestation, Offspring, and Uterine Contractions in Rats
Physiol Res. 2023 Dec 31;72(6):793-807. doi: 10.33549/physiolres.935064.ABSTRACTAgomelatine is a pharmaceutical compound that functions as an agonist for melatonin receptors, with a particular affinity for the MT1 and MT2 receptor subtypes. Its mode of action is integral to the regulation of diverse physiological processes, encompassing the orchestration of circadian rhythms, sleep-wake cycles, and mood modulation. In the present study, we delve into the intricate interplay between agomelatine and the modulation of estrus cycles, gestation periods, offspring numbers, and uterine contractions, shedding light on their collec...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: E Kacar F Tan S Sahinturk G Zorlu I Serhatlioglu O Bulmus Z Ercan H Kelestimur Source Type: research
Hydrolat of Helichrysum italicum promotes tissue regeneration during wound healing
In conclusion our results are en-couraging, highlighting novel regenerative properties of hydrolat of H. italicum and paving the way for future application of this wasting product in accelerating wound healing.PMID:38215066 | PMC:PMC10805257 | DOI:10.33549/physiolres.935101 (Source: Physiological Research)
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: D Serra E Bellu G Garroni S Cruciani G Sarais D Dessi A Pashchenko R Satta M A Montesu E Amler M Floris M Maioli Source Type: research
Results of flow cytometric detection of gamma-deltaT cells in peripheral blood of patients with ankylosing spondylitis: a pilot study
Physiol Res. 2023 Dec 31;72(6):819-832. doi: 10.33549/physiolres.935140.ABSTRACTPrevious studies have suggested that gamma-delta T cells play an important role in the pathogenesis of ankylosing spondylitis (AS). In this pilot study, the peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and healthy volunteers were stained and analyzed by flow cytometry to distinguish gamma-delta T cells and its subtypes, and then to report the distribution of gamma-delta T cells and iyts subtypes and their correlation with ankylosing spondylitis. A total of 17 patients with active AS and 10 age- and gen...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: Si-Liang Man Peng Dong Wei Liu Hong-Chao Li Liang Zhang Xiao-Jian Ji Li-Dong Hu Hui Song Source Type: research
miR-29c-3p Attenuates beta-Amyloid-Induced Neurotoxicity in Alzheimer's Disease Through Regulating beta-Site Amyloid Precursor Protein-Cleaving Enzyme 1
Physiol Res. 2023 Dec 31;72(6):833-841. doi: 10.33549/physiolres.935084.ABSTRACTThe aberrantly expressed microRNAs (miRNAs) including miR-29c-3p have been reported in the brains of Alzheimer's disease (AD) patients in recent researches. Nevertheless, the functional role and underlying molecular mechanism of miR-29c-3p in AD pathogenesis are still not well elucidated. The purpose of this study was to examine whether miR-29c-3p regulated beta-Ameyloid (Abeta)-induced neurotoxicity by targeting beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). The expressions of miR 29c 3p and BACE1 mRNA and protein levels in Abe...
Source: Physiological Research - January 12, 2024 Category: Physiology Authors: X Wang M Li Y Hu Source Type: research
The chloroplast genome of < em > Scutellaria franchetiana < /em > H.L év. 1911 and its implications for phylogenetic relationships in the < em > Scutellaria < /em > genus
Mitochondrial DNA B Resour. 2023 Oct 30;8(11):1154-1157. doi: 10.1080/23802359.2023.2275829. eCollection 2023.ABSTRACTScutellaria franchetiana H.Lév. 1911 is an important medicinal plant distributed on hillside wetlands at an altitude of 830-2300 m. The total length of complete chloroplast genome of S. franchetiana 151,852 bp of 38.37% GC content. It is a typical quadratic structure with four subregions consisting of a large single-copy region (83,894 bp), a small single-copy region (17,520 bp), and a pair of inverted repeats (25,219 bp). In the chloroplast genome of S. franchetiana, 130 genes were detected, comprising 86...
Source: Physiological Research - January 8, 2024 Category: Physiology Authors: Jiabin Yu Ning Huang Chuliang Wang Weikai Gao Jutao Sun Source Type: research
The chloroplast genome of < em > Scutellaria franchetiana < /em > H.L év. 1911 and its implications for phylogenetic relationships in the < em > Scutellaria < /em > genus
Mitochondrial DNA B Resour. 2023 Oct 30;8(11):1154-1157. doi: 10.1080/23802359.2023.2275829. eCollection 2023.ABSTRACTScutellaria franchetiana H.Lév. 1911 is an important medicinal plant distributed on hillside wetlands at an altitude of 830-2300 m. The total length of complete chloroplast genome of S. franchetiana 151,852 bp of 38.37% GC content. It is a typical quadratic structure with four subregions consisting of a large single-copy region (83,894 bp), a small single-copy region (17,520 bp), and a pair of inverted repeats (25,219 bp). In the chloroplast genome of S. franchetiana, 130 genes were detected, comprising 86...
Source: Physiological Research - January 8, 2024 Category: Physiology Authors: Jiabin Yu Ning Huang Chuliang Wang Weikai Gao Jutao Sun Source Type: research
