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Orthobiologics
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - November 19, 2022 Category: Rehabilitation Authors: MICHAEL KHADAVI, LUGA PODESTA Source Type: research

Copyright
ELSEVIER (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - November 19, 2022 Category: Rehabilitation Source Type: research

Contributors
SANTOS F. MARTINEZ, MD, MS (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - November 19, 2022 Category: Rehabilitation Source Type: research

Contents
Santos F. Martinez (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - November 19, 2022 Category: Rehabilitation Source Type: research

Forthcoming Issues
Shoulder Rehabilitation (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - November 19, 2022 Category: Rehabilitation Source Type: research

Basic Science of Autologous Orthobiologics
In recent years, autologous biological preparations have emerged as a growing area of medical innovation in interventional orthopedical procedures and surgical interventions. These cellular therapies are often referred to as orthobiologics and are derived from patient ’s own tissues, such as blood, bone marrow, and adipose tissue to prepare platelet-rich plasma (PRP), bone marrow concentrate, and adipose tissue concentrate, respectively. In this article, we will emphasize and discuss the physiological variability of autologous PRP bioformulations regarding thei r effectivity in tissue repair. Furthermore, recent developm...
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Peter A. Everts, Payman Sadeghi, David R. Smith Source Type: research

Insights with Friends
Orthobiologics has progressively permeated diverse subspecialties in medicine. Just a few years ago, this was considered a fringe topic with a very select following. Now Orthobiologics is considered a mainstream modality for musculoskeletal and sports medicine practitioners. National and international researchers and practitioners congregate to discuss their latest findings and protocols. There are very few top academic facilities, Sports Medicine meccas, or national Orthopedic conferences that do not offer or include some form of regenerative or Orthobiologic leaning modality training. (Source: Physical Medicine and Rehab...
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Santos F. Martinez Tags: Foreword Source Type: research

Basic Science of Autologous Orthobiologics Part 1. Platelet-Rich Plasma
In recent years, autologous biological preparations have emerged as a growing area of medical innovation in interventional orthopedical procedures and surgical interventions. These cellular therapies are often referred to as orthobiologics and are derived from patient ’s own tissues, such as blood, bone marrow, and adipose tissue to prepare platelet-rich plasma (PRP), bone marrow concentrate, and adipose tissue concentrate, respectively. In this article, we will emphasize and discuss the physiological variability of autologous PRP bioformulations regarding thei r effectivity in tissue repair. Furthermore, recent developm...
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Peter A. Everts, Payman Sadeghi, David Smith Source Type: research

Basic Science of Autologous Orthobiologics
In recent years, autologous biological preparations have emerged as a growing area of medical innovation in interventional orthopedical procedures and surgical interventions. These cellular therapies are often referred to as orthobiologics and are derived from patient ’s own tissues, like blood, bone marrow, and adipose tissue to prepare platelet-rich plasma (PRP), bone marrow concentrate (BMC), and adipose tissue concentrate (ATC), respectively. In this article, we emphasize and discuss the physiologic variability of autologous prepared BMC and ATC for the del ivery of mesenchymal stem cells to support tissue repair pro...
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Peter A. Everts, Alberto Panero Source Type: research

Medical Concerns in Orthobiologics Procedures
Orthobiologics have shown immense treatment potential in many medical fields including sports medicine, musculoskeletal disorders, and pain management. As with the case of any medical procedures and treatments, there are potential side effects or caveats that physicians and patients should be cognizant of. Nevertheless, the use of orthobiologics does not seem to have consistent severe side effects and do not have increased risks with transmissible disease, immune-modulated reactions, or oncologic processes. (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Peter C. Yeh, Prathap Jayaram Source Type: research

An Evidence-Based Approach to Orthobiologics for Tendon Disorders
Tendinopathy is a chronic injury that affects both the athletic and general population. Recalcitrant tendinopathy is both frustrating for patients and providers once typical conservative treatments have been exhausted. Current research in orthobiologics shows that they are safe and could improve pain and function in recalcitrant cases. Unfortunately, many studies show inconsistency in the content of the orthobiologic injectate and approach in treatment protocols. There are robust data to support the use of platelet-rich plasma for the treatment of recalcitrant common extensor tendinopathy and plantar fasciopathy, but high-...
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Andre Armando Abadin, Jordan Pearl Orr, Alexander Raphael Lloyd, Phillip Troy Henning, Adam Pourcho Source Type: research

Intradiscal Leukocyte Rich Platelet Rich Plasma for Degenerative Disc Disease
If we could choose a single non-fatal medical condition to find a better solution that would make the greatest impact on global health it would be a solution for degenerative disc disease (DDD) - the number one cause of chronic low back pain (CLBP). (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Gregory E. Lutz Source Type: research

Prolotherapy
is a nonsurgical regenerative technique that allows small amounts of irritant solution to be injected into the site of painful tendon and ligament insertions to promote the growth of healthy cells and tissues. The goal of prolotherapy is to stimulate growth factors that may strengthen attachments and reduce pain. Prolotherapy injection technique is centered around a focused physical examination and strong anatomic knowledge for maximized results. Prolotherapy is beneficial in a variety of different musculoskeletal conditions, including, but not limited to, lateral epicondylosis, rotator cuff tendinopathy, plantar fasciiti...
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Connie Hsu, Kevin Vu, Joanne Borg-Stein Source Type: research

Special Populations in Orthobiologics
This section is devoted to a review of the literature regarding the usage of orthobiologics in the special populations of elite athletes, the elderly, and pediatrics. The prospect of these regenerative options is encouraging to help provide alternative options that may enhance recovery and healing of acute and degenerative pathologic conditions. The goal is to provide the readers an overview of the existing literature highlighting areas with growing research and others that are still lacking. (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Arthur Jason De Luigi, Stephanie Tow, Ryan Flowers, Andrew H. Gordon Source Type: research

Orthobiologic Techniques for Surgical Augmentation
General awareness and clinical utilization of orthobiologic therapy has increased sharply in the recent years. Orthobiologics can be defined as “biological materials and substrates that promote bone, ligament, muscle, and tendon healing.” There are 3 major strategies by which orthobiologics are thought to augment tissue repair or native biologic potential: factor-based, cell-based, and biomechanical augmentation. The purpose of this rev iew is to synthesize the recent literature on orthobiologic techniques for surgical augmentation, with focus on several key areas including meniscus repair, osteochondral grafting, and ...
Source: Physical Medicine and Rehabilitation Clinics of North America - October 17, 2022 Category: Rehabilitation Authors: Kenneth M. Lin, Christopher S. Frey, Ran Atzmon, Kinsley Pierre, Monica S. Vel, Seth L. Sherman Source Type: research