Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis
Publication date: Available online 22 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Anita A. Pinar, Tara E. Scott, Brooke M. Huuskes, Felipe E. Tapia Cáceres, Barbara K. Kemp-Harper, Chrishan S. SamuelAbstractCardiovascular fibrosis refers to the scar tissue that develops in the injured heart and blood vessels from an aberrant wound healing response to organ injury or insult. Established fibrosis becomes a hallmark of chronic disease progression and a key contributor to tissue stiffness and dysfunction, which ultimately leads to heart failure. As wound healing and fibrotic responses to myocardial injury are m...
Source: Pharmacology and Therapeutics - February 24, 2020 Category: Drugs & Pharmacology Source Type: research
Targeting prostaglandin receptor EP2 for adjunctive treatment of status epilepticus
Publication date: Available online 21 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Marwa M. Nagib, Ying Yu, Jianxiong JiangAbstractStatus epilepticus (SE) is an emergency condition that can cause permanent brain damage or even death when generalized convulsive seizures last longer than 30 min. Controlling the escalation and propagation of seizures quickly and properly is crucial to the prevention of irreversible neuronal death and the associated morbidity. However, SE often becomes refractory to current anticonvulsant medications, which primarily act on ion channels and commonly impose undesired effects. Id...
Source: Pharmacology and Therapeutics - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: March 2020Source: Pharmacology & Therapeutics, Volume 207Author(s): (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation
Publication date: Available online 15 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Boris Manoury, Sarah Idres, Véronique Leblais, Rodolphe FischmeisterAbstractNumerous mediators and drugs regulate blood flow or arterial pressure by acting on vascular tone, involving cyclic nucleotide intracellular pathways. These signals lead to regulation of several cellular effectors, including ion channels that tune cell membrane potential, Ca2+ influx and vascular tone. The characterization of these vasocontrictive or vasodilating mechanisms has grown in complexity due to i) the variety of ion channels that are expressed...
Source: Pharmacology and Therapeutics - February 16, 2020 Category: Drugs & Pharmacology Source Type: research
TSH/IGF1 receptor crosstalk: Mechanism and clinical implications
Publication date: Available online 13 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Christine C. Krieger, Susanne Neumann, Marvin C. GershengornAbstractIncreasing evidence of interdependence between G protein-coupled receptors and receptor tyrosine kinase signaling pathways has prompted reevaluation of crosstalk between these receptors in disease and therapy. Investigations into thyroid-stimulating hormone (TSH) and insulin-like growth factor 1 (IGF1) receptor crosstalk, and its application to the clinic have in particular shown recent progress. In this review, we summarize current insights into the mechanism ...
Source: Pharmacology and Therapeutics - February 15, 2020 Category: Drugs & Pharmacology Source Type: research
