Type 1 diabetes - What's new in prevention and therapeutic strategies?
Pediatr Endocrinol Diabetes Metab. 2023;29(3):196-201. doi: 10.5114/pedm.2023.132028.ABSTRACTType 1 diabetes (T1D) is an autoimmune disorder, and insulin deficiency is the result of b-cell dysfunction. Treatment of type 1 diabetes requires constant parenteral insulin administration, which can be very burdensome for the patient. Meticulous use of insulin therapy does not protect the patient against complications. Hence, the search for other methods of treatment as well as ways of preventing the onset of diabetes has been ongoing for a long time. The main obstacle in the implementation of the prevention task is the need to i...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Aleksandra Pil śniak Ewa Otto-Buczkowska Source Type: research

Adrenocortical carcinoma - 12-year observation period in a  single centre. Case report with literature review
CONCLUSIONS: A patient after ACC treatment requires regular check-ups and long-term observation. Constant supervision enables early diagnosis of disease recurrence, and the use of treatment improves the prognosis.PMID:38031835 | PMC:PMC10679906 | DOI:10.5114/pedm.2023.132131 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Patrycja Dasiewicz El żbieta Moszczyńska Danuta Perek Dariusz Polnik Maria Stepaniuk Joanna Trubicka Wies ława Grajkowska Source Type: research

Dietary guidelines in diabetes - why are they so difficult to follow?
Pediatr Endocrinol Diabetes Metab. 2023;29(3):125-127. doi: 10.5114/pedm.2023.132024.NO ABSTRACTPMID:38031827 | PMC:PMC10679908 | DOI:10.5114/pedm.2023.132024 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Beata Si ńska Alicja Kucharska Source Type: research

The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus -  a randomized clinical trial
CONCLUSIONS: According to the results of our study, consumption of oral probiotics has no significant effect on HbA1c levels in children with type 1 diabetes mellitus.PMID:38031828 | PMC:PMC10679923 | DOI:10.5114/pedm.2023.132025 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Hosein Shabani-Mirzaee Zahra Haghshenas Armen Malekiantaghi Mohsen Vigeh Fazeleh Mahdavi Kambiz Eftekhari Source Type: research

Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome - a  sibling-controlled study
CONCLUSIONS: The research results indicate differences in metabolic processes between the group of individuals with DS compared to the CG, despite shared environmental conditions. The presence of an additional copy of chromosome 21 may contribute to the occurrence of metabolic disorders. These findings emphasize the need for further research that will lead to a better understanding of these relationships and contribute to the development of effective therapeutic strategies.PMID:38031829 | PMC:PMC10679903 | DOI:10.5114/pedm.2023.131513 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Marta Hetman Ewa Barg Sylwia Placzkowska Source Type: research

Predisposition to atherosclerosis in children and adults with trisomy 21: biochemical and metabolomic studies
CONCLUSIONS: Down syndrome individuals show distinct cardiovascular risks, with decreased HDL and increased LDL levels. Combined with metabolomic disparities and higher BMI and TMI, this suggests an increased atherosclerosis risk compared to controls.PMID:38031830 | PMC:PMC10679913 | DOI:10.5114/pedm.2023.131162 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Marta Hetman Karolina Mielko Sylwia Placzkowska Aleksandra Bodetko Piotr M łynarz Ewa Barg Source Type: research

Nutrition analysis - with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market
Pediatr Endocrinol Diabetes Metab. 2023;29(3):166-174. doi: 10.5114/pedm.2023.132026.ABSTRACTThe aim of the study was to assess the nutrition of selected fermented dairy products available in Polish supermarkets and how many of them meet the criterion set by the European Parliament and Council Act (UE) no. 1924/2006 form 20 December 2006 on nutrition and health claims made on foods regarding low sugar content in a solid product. In the study 100 fermented products, widely available in Polish supermarkets, were selected, and their nutrition was analysed based on the information placed on the producer's label, and the carboh...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Irena Ma ńkiewicz-Żurawska Wanda Lutogniewska Eliza Ska ła-Zamorowska Przemys ława Jarosz-Chobot Source Type: research

The incidence of insulin resistance based on indices calculated using the HOMA and Belfiore methods and its impact on the occurrence of metabolic complications in prepubertal children born small for gestational age
CONCLUSIONS: It seems worth recommending IRIBelfiore derived from OGTT as a valuable diagnostic tool for identifying IR in SGA prepubertal children. Abnormal IRIBelfiore is related to higher blood pressure and lower HDL-cholesterol concentration in this group.PMID:38031832 | PMC:PMC10679911 | DOI:10.5114/pedm.2023.130027 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Anna Łupińska Renata Stawerska Ma łgorzata Szałapska Marzena Kolasa-Kici ńska Krzysztof Jeziorny Wojciech Stawerski Sara Aszkie łowicz Andrzej Lewi ński Source Type: research

Dietary treatment of type 1 diabetes - once upon a  time versus today
Pediatr Endocrinol Diabetes Metab. 2023;29(3):184-189. doi: 10.5114/pedm.2023.132027.ABSTRACTType 1 diabetes is a disease in which nutrition is an integral part of treatment. The type of recommended diets for therapeutic purposes has changed over the years. Proper metabolic equalization of the disease is an enormous challenge and problem for patients at the same time. This review paper discusses the history of dietary treatment of type 1 diabetes and refers to current dietary recommendations and their impact on the patient's health. The important roles of glycaemic index and glycaemic load are pointed out for proper treatm...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Monika Soczewka Andrzej K ędzia Bogda Skowro ńska El żbieta Niechciał Source Type: research

Type 1 diabetes - What's new in prevention and therapeutic strategies?
Pediatr Endocrinol Diabetes Metab. 2023;29(3):196-201. doi: 10.5114/pedm.2023.132028.ABSTRACTType 1 diabetes (T1D) is an autoimmune disorder, and insulin deficiency is the result of b-cell dysfunction. Treatment of type 1 diabetes requires constant parenteral insulin administration, which can be very burdensome for the patient. Meticulous use of insulin therapy does not protect the patient against complications. Hence, the search for other methods of treatment as well as ways of preventing the onset of diabetes has been ongoing for a long time. The main obstacle in the implementation of the prevention task is the need to i...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Aleksandra Pil śniak Ewa Otto-Buczkowska Source Type: research

Adrenocortical carcinoma - 12-year observation period in a  single centre. Case report with literature review
CONCLUSIONS: A patient after ACC treatment requires regular check-ups and long-term observation. Constant supervision enables early diagnosis of disease recurrence, and the use of treatment improves the prognosis.PMID:38031835 | PMC:PMC10679906 | DOI:10.5114/pedm.2023.132131 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Patrycja Dasiewicz El żbieta Moszczyńska Danuta Perek Dariusz Polnik Maria Stepaniuk Joanna Trubicka Wies ława Grajkowska Source Type: research

Dietary guidelines in diabetes - why are they so difficult to follow?
Pediatr Endocrinol Diabetes Metab. 2023;29(3):125-127. doi: 10.5114/pedm.2023.132024.NO ABSTRACTPMID:38031827 | PMC:PMC10679908 | DOI:10.5114/pedm.2023.132024 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Beata Si ńska Alicja Kucharska Source Type: research

The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus -  a randomized clinical trial
CONCLUSIONS: According to the results of our study, consumption of oral probiotics has no significant effect on HbA1c levels in children with type 1 diabetes mellitus.PMID:38031828 | PMC:PMC10679923 | DOI:10.5114/pedm.2023.132025 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Hosein Shabani-Mirzaee Zahra Haghshenas Armen Malekiantaghi Mohsen Vigeh Fazeleh Mahdavi Kambiz Eftekhari Source Type: research

Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome - a  sibling-controlled study
CONCLUSIONS: The research results indicate differences in metabolic processes between the group of individuals with DS compared to the CG, despite shared environmental conditions. The presence of an additional copy of chromosome 21 may contribute to the occurrence of metabolic disorders. These findings emphasize the need for further research that will lead to a better understanding of these relationships and contribute to the development of effective therapeutic strategies.PMID:38031829 | PMC:PMC10679903 | DOI:10.5114/pedm.2023.131513 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Marta Hetman Ewa Barg Sylwia Placzkowska Source Type: research

Predisposition to atherosclerosis in children and adults with trisomy 21: biochemical and metabolomic studies
CONCLUSIONS: Down syndrome individuals show distinct cardiovascular risks, with decreased HDL and increased LDL levels. Combined with metabolomic disparities and higher BMI and TMI, this suggests an increased atherosclerosis risk compared to controls.PMID:38031830 | PMC:PMC10679913 | DOI:10.5114/pedm.2023.131162 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Marta Hetman Karolina Mielko Sylwia Placzkowska Aleksandra Bodetko Piotr M łynarz Ewa Barg Source Type: research