Is Heart Rate Variability the Spice of Life?*
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Editorials Source Type: research

Inequities in Pediatric Palliative Care: Where Are the Consults?*
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Editorials Source Type: research

My View From the Opposite Side of the Bed
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: PCCM Narrative Source Type: research

The Cardiovascular System in Severe Sepsis: Insight From a Cardiovascular Simulator
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: PCCM Concise Clinical Physiology Review Source Type: research

Association Between Digoxin Use and Cardiac Function in Infants With Single-Ventricle Congenital Heart Disease During the Interstage Period
CONCLUSIONS: Digoxin may partially mitigate the expected decrease in cardiac function during the interstage period through its positive inotropic effects. Prospective clinical trials are needed to establish the pharmacokinetics, safety, and efficacy of digoxin use in SV CHD. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Augmented Renal Clearance of Vancomycin in Suspected Sepsis: Single-Center, Retrospective Pediatric Cohort
CONCLUSIONS: Subtherapeutic VTL is associated with ARC in our single-center retrospective cohort of children with suspected sepsis. This problem may present a potential risk of treatment failure in Gram-positive sepsis or longer time to clinical response. Prospective studies to investigate the clinical significance and effect of optimizing vancomycin dose in patients with ARC are recommended. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Clinical Investigation Source Type: research

Impact of Blood Sampling on Anemia in the PICU: A Prospective Cohort Study
The objectives of this study were to describe blood sampling practice in a PICU, determine patient factors associated with increased sampling, and examine the association among blood sampling volume, anemia at PICU discharge, and change in hemoglobin from PICU entry to PICU discharge. DESIGN Prospective observational cohort study. SETTING: PICU of Sainte-Justine University Hospital. PATIENTS: All children consecutively admitted during a 4-month period. MEASUREMENTS AND MAIN RESULTS: Four hundred twenty-three children were enrolled. Mean blood volume sampled was 3.9 (±19) mL/kg/stay, of which 26...
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Feature Articles Source Type: research

Temporal and Spatial Changes in the Microbiome Following Pediatric Severe Traumatic Brain Injury
We report temporal and spatial alterations in the microbiome of previously healthy children with severe traumatic brain injury (TBI). DESIGN We collected oral, rectal, and skin swabs within 72 hours of admission and then twice weekly until ICU discharge. Samples were analyzed by 16S rRNA gene amplicon sequencing. Children undergoing elective outpatient surgery served as controls. Alpha and beta diversity comparisons were performed with Phyloseq, and differentially abundant taxa were predicted using Analysis of Composition of Microbiomes. SETTING: Five quaternary-care PICUs. PATIENTS: Patients less than...
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Feature Articles Source Type: research

Racial and Ethnic Differences in Inpatient Palliative Care for Pediatric Stem Cell Transplant Patients*
CONCLUSIONS: Racial and ethnic differences exist in the likelihood of receiving palliative care consultations among hospitalized pediatric stem cell transplant recipients. Evaluating the impact of systemic racism and social determinants on palliative care medicine as well as standardizing early integration of IPCC may potentially mitigate disparities in this population. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Feature Articles Source Type: research

In Memoriam: John J. “Jack” Downes, MD
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: In Memoriam Source Type: research

Editor’s Choice Articles for June
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Editor’s Choice Source Type: research

Hospital Charges Associated With Critical Bronchiolitis From 2009 to 2019: Erratum
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - May 1, 2022 Category: Pediatrics Tags: Online Erratum Source Type: research

Real-Time Ultrasound Guidance for Umbilical Venous Cannulation in Neonates With Congenital Heart Disease
CONCLUSIONS: Ultrasound guidance has become standard of care for percutaneous central venous access but is a new and emerging technique for umbilical vessel catheterization. In this early experience, we report that point-of-care ultrasound, together with liver pressure, can be used to markedly improve success of placement. This represents a significant advance in this core neonatal procedure. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - May 1, 2022 Category: Pediatrics Tags: Online Technical Note Source Type: research

Acute Kidney Injury After Pediatric Cardiac Surgery
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - May 1, 2022 Category: Pediatrics Tags: Online Concise Clinical Science Review Source Type: research

Outcome of Extracorporeal Membrane Oxygenation for Pediatric Patients With Neoplasm: An Extracorporeal Life Support Organization Database Study (2000–2019)
This study update in usage and outcomes of pediatric extracorporeal membrane oxygenation (ECMO) for patients with neoplasm analyzed according to demographics, clinical variables, and complications. DESIGN: Retrospective database review of the Extracorporeal Life Support Organization registry from the last 2 decades (2000–2019). The data were divided between two decades in order to compare patients’ backgrounds and outcomes over time. SETTING: ECMO centers reporting to Extracorporeal Life Support Organization. PATIENTS: Patients equal to or younger than 18 years old with International Classification...
Source: Pediatric Critical Care Medicine - May 1, 2022 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research