Sickle Cell Disease: Past, Present, and Future
Pediatr Ann. 2024 Feb;53(2):e42. doi: 10.3928/19382359-20231205-01. Epub 2024 Feb 1.NO ABSTRACTPMID:38302119 | DOI:10.3928/19382359-20231205-01 (Source: Pediatric Annals)
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Radhika Peddinti Source Type: research
Comprehensive Care in Sickle Cell Disease
Pediatr Ann. 2024 Feb;53(2):e43-e46. doi: 10.3928/19382359-20231205-02. Epub 2024 Feb 1.ABSTRACTDespite advancements in sickle cell disease (SCD) management, individuals with SCD continue to face greater degrees of mortality, disability, and health care barriers compared with their healthy peers. Comprehensive care includes essential elements such as newborn screening, key immunizations, penicillin prophylaxis, and consistent health screening for common complications. Pediatricians should be familiar with treatment options for SCD to offer informed education to both patients and their families. By providing guided and comp...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Ananya Chandra Sabina Shamayeva Wendy Darlington Source Type: research
Disease-Modifying Therapies for Sickle Cell Disease-An Overview
Pediatr Ann. 2024 Feb;53(2):e52-e55. doi: 10.3928/19382359-20231205-05. Epub 2024 Feb 1.ABSTRACTSickle cell disease refers to a group of inherited blood disorders in which hemoglobin polymerization leads to hemolysis and vaso-occlusion. This causes a myriad of complications during a patient's life span, ranging from anemia, infections, and acute and chronic pain to stroke and multiorgan dysfunction. Although there have been dramatic improvements in childhood survival thanks to improved supportive care with penicillin prophylaxis, immunizations, and improved transfusion practices, there was a dearth of disease-modifying the...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Radhika Peddinti Source Type: research
Curative Therapies for Sickle Cell Disease
Pediatr Ann. 2024 Feb;53(2):e56-e61. doi: 10.3928/19382359-20231205-06. Epub 2024 Feb 1.ABSTRACTSickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that affects individuals worldwide. The mutation in the beta-globin gene leads to abnormal hemoglobin production, sickle hemoglobin, which polymerizes under stress leading to, among other end-organ manifestations, chronic hemolytic anemia, debilitating vaso-occlusive crises, and stroke. Unfortunately, chronic stress on end-organs impacts the life expectancy of patients with SCD, which in the United States averages 43 years, approximately 36 years less than peop...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Saara Kaviany Zhour Barnawi James LaBelle Source Type: research
Management of Acute Complications of Sickle Cell Disease
Pediatr Ann. 2024 Feb;53(2):e47-e51. doi: 10.3928/19382359-20231205-03. Epub 2024 Feb 1.ABSTRACTSickle cell disease (SCD) is a group of inherited autosomal recessive disorders that affect hemoglobin structure. The presence of this mutated form of hemoglobin, hemoglobin S, results in the abnormally ("sickle") shaped cells. These sickle-shaped red blood cells lead to the disruption of blood flow in small vessels and result in a myriad of complications. Pain, excruciating and unpredictable, is the hallmark of the disease. In addition, many organs are affected, including but not limited to brain, kidneys, bones, and lungs. Thi...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Sabina Shamayeva Perry Morocco Source Type: research
Concussion Care in Teenage Athletes
Pediatr Ann. 2024 Feb;53(2):e39-e41. doi: 10.3928/19382359-20240117-01. Epub 2024 Feb 1.ABSTRACTConcussion is a form of traumatic brain injury that occurs commonly in pediatric patients. One group at higher risk for concussion is adolescent and teenage athletes. Athletes may sustain one or more concussions throughout their athletic careers, and these injuries may lead to significant morbidities for children. Although most concussion symptoms will resolve in less than 1 month, there is a subset of patients for whom symptoms may persist. Given the increased interest in preventing long-term sequelae related to concussion, leg...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Molly M Diaz Kane Source Type: research
The Clinical Use of Artificial Intelligence and Machine Learning in Pediatrics
Pediatr Ann. 2024 Feb;53(2):e37-e38. doi: 10.3928/19382359-20240116-01. Epub 2024 Feb 1.NO ABSTRACTPMID:38302125 | DOI:10.3928/19382359-20240116-01 (Source: Pediatric Annals)
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Joseph R Hageman Lolita Alcocer Alkureishi Source Type: research
Multidisciplinary Treatment in Patients with Craniofacial, Neurocognitive, and Neuromuscular Disorders with Obstructive Sleep Apnea: A Systematic Review of the Literature
Pediatr Ann. 2024 Feb;53(2):e62-e69. doi: 10.3928/19382359-20231205-04. Epub 2024 Feb 1.ABSTRACTObstructive sleep apnea (OSA) is a respiratory disorder that has a high prevalence in patients with craniofacial, neurocognitive, and neuromuscular disorders. Currently, the treatments for this population are diverse and depend on the individual conditions of the patient and the severity of the case. However, there are no multidisciplinary dental treatment guidelines. The aim of the present study was to determine the multidisciplinary dental treatment alternatives in patients with craniofacial, neurocognitive, and neuromuscular ...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Julian F Beltran Oscar E Ramirez Angela Carrillo Eneida L ópez Angela Su árez Lucas Guimar ães-Abreu Sonia M Restrepo-Gualteros Carlos E Rodriguez-Martinez Liliana Otero Source Type: research
Sickle Cell Disease: Past, Present, and Future
Pediatr Ann. 2024 Feb;53(2):e42. doi: 10.3928/19382359-20231205-01. Epub 2024 Feb 1.NO ABSTRACTPMID:38302119 | DOI:10.3928/19382359-20231205-01 (Source: Pediatric Annals)
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Radhika Peddinti Source Type: research
Comprehensive Care in Sickle Cell Disease
Pediatr Ann. 2024 Feb;53(2):e43-e46. doi: 10.3928/19382359-20231205-02. Epub 2024 Feb 1.ABSTRACTDespite advancements in sickle cell disease (SCD) management, individuals with SCD continue to face greater degrees of mortality, disability, and health care barriers compared with their healthy peers. Comprehensive care includes essential elements such as newborn screening, key immunizations, penicillin prophylaxis, and consistent health screening for common complications. Pediatricians should be familiar with treatment options for SCD to offer informed education to both patients and their families. By providing guided and comp...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Ananya Chandra Sabina Shamayeva Wendy Darlington Source Type: research
Disease-Modifying Therapies for Sickle Cell Disease-An Overview
Pediatr Ann. 2024 Feb;53(2):e52-e55. doi: 10.3928/19382359-20231205-05. Epub 2024 Feb 1.ABSTRACTSickle cell disease refers to a group of inherited blood disorders in which hemoglobin polymerization leads to hemolysis and vaso-occlusion. This causes a myriad of complications during a patient's life span, ranging from anemia, infections, and acute and chronic pain to stroke and multiorgan dysfunction. Although there have been dramatic improvements in childhood survival thanks to improved supportive care with penicillin prophylaxis, immunizations, and improved transfusion practices, there was a dearth of disease-modifying the...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Radhika Peddinti Source Type: research
Curative Therapies for Sickle Cell Disease
Pediatr Ann. 2024 Feb;53(2):e56-e61. doi: 10.3928/19382359-20231205-06. Epub 2024 Feb 1.ABSTRACTSickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that affects individuals worldwide. The mutation in the beta-globin gene leads to abnormal hemoglobin production, sickle hemoglobin, which polymerizes under stress leading to, among other end-organ manifestations, chronic hemolytic anemia, debilitating vaso-occlusive crises, and stroke. Unfortunately, chronic stress on end-organs impacts the life expectancy of patients with SCD, which in the United States averages 43 years, approximately 36 years less than peop...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Saara Kaviany Zhour Barnawi James LaBelle Source Type: research
Management of Acute Complications of Sickle Cell Disease
Pediatr Ann. 2024 Feb;53(2):e47-e51. doi: 10.3928/19382359-20231205-03. Epub 2024 Feb 1.ABSTRACTSickle cell disease (SCD) is a group of inherited autosomal recessive disorders that affect hemoglobin structure. The presence of this mutated form of hemoglobin, hemoglobin S, results in the abnormally ("sickle") shaped cells. These sickle-shaped red blood cells lead to the disruption of blood flow in small vessels and result in a myriad of complications. Pain, excruciating and unpredictable, is the hallmark of the disease. In addition, many organs are affected, including but not limited to brain, kidneys, bones, and lungs. Thi...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Sabina Shamayeva Perry Morocco Source Type: research
Concussion Care in Teenage Athletes
Pediatr Ann. 2024 Feb;53(2):e39-e41. doi: 10.3928/19382359-20240117-01. Epub 2024 Feb 1.ABSTRACTConcussion is a form of traumatic brain injury that occurs commonly in pediatric patients. One group at higher risk for concussion is adolescent and teenage athletes. Athletes may sustain one or more concussions throughout their athletic careers, and these injuries may lead to significant morbidities for children. Although most concussion symptoms will resolve in less than 1 month, there is a subset of patients for whom symptoms may persist. Given the increased interest in preventing long-term sequelae related to concussion, leg...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Molly M Diaz Kane Source Type: research
The Clinical Use of Artificial Intelligence and Machine Learning in Pediatrics
Pediatr Ann. 2024 Feb;53(2):e37-e38. doi: 10.3928/19382359-20240116-01. Epub 2024 Feb 1.NO ABSTRACTPMID:38302125 | DOI:10.3928/19382359-20240116-01 (Source: Pediatric Annals)
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Joseph R Hageman Lolita Alcocer Alkureishi Source Type: research
