Image analysis is an excellent tool for quantifying Ki ‐67 to predict the prognosis of gastrointestinal stromal tumor patients
We examined 92 patients, focusing on the correlation between age, sex, primary tumor site, tumor size, predominant histologic type, mitotic index, modified NIH classification (low/intermediate vs high), Ki‐67 quantitation, and recurrence‐free survival (RFS). We compared two IA processes for whole slide imaging (WSI) and manually captured image (MCI) methods. A Ki‐67 quantitation cutoff was determined by receiver operator characteristics curve analysis. In the survival analysis, the high‐risk group of a modified NIH classification, a mitotic count >5 per 20 high‐powered fields, and Ki‐67 cutoffs of ≥6% and ...
Source: Pathology International - November 13, 2017 Category: Pathology Authors: Shintaro Sugita, Hiroshi Hirano, Yutaka Hatanaka, Hiromi Fujita, Terufumi Kubo, Noriaki Kikuchi, Yumika Ito, Taro Sugawara, Keiko Segawa, Hiroyuki Hisai, Kentaro Yamashita, Takayuki Nobuoka, Yoshihiro Matsuno, Tadashi Hasegawa Tags: Original Article Source Type: research
Mycotic pseudoaneurysm of a pulmonary artery branch caused by Cladosporium
We report the case of a 53‐year‐old male with a history of acute myelogenous leukemia, who suffered the rupturing of a right‐sided pulmonary artery pseudoaneurysm combined with pneumonia. He underwent a right‐sided lower lobectomy. The resected lung tissue demonstrated a mycotic pseudoaneurysm of a pulmonary artery branch together with a filamentous fungal infection. Pseudoaneurysms are caused by the breaching of all layers of a blood vessel wall. The extravasated blood is trapped by the surrounding extravascular tissue or clots. Cladosporium was detected during a polymerase chain reaction‐based analysis followed...
Source: Pathology International - November 1, 2017 Category: Pathology Authors: Keishin Sunagawa, Yoshihito Uchino, Shinichirou Ishimoto, Shigeki Nakamura, Taku Honma, Yoko Nakanishi, Yoshihiro Hatta, Yoshitsugu Miyazaki, Hiroyuki Sakurai, Hiroyuki Hao, Masahiko Sugitani Tags: Case Report Source Type: research
Novel non ‐alcoholic steatohepatitis model with histopathological and insulin‐resistant features
Although several non‐alcoholic steatohepatitis (NASH) models have been reported to date, few of these models fully reflect the histopathology and pathophysiology of human NASH. The aim of this study was to establish a novel NASH model by feeding a high‐fat (HF) diet and administering both carbon tetrachloride (CCl4) and the Liver X receptor agonist T0901317. Male C57BL/6J mice were divided into four groups (each n = 5): HF, HF + CCl4, HF + T0901317, and the novel NASH model (HF + CCl4 + T0901317). CCl4 (0.1 mL/kg) and T0901317 (2.5 mg/kg) were intraperitoneally administered four times and five t...
Source: Pathology International - November 1, 2017 Category: Pathology Authors: Yohei Owada, Takafumi Tamura, Tomohito Tanoi, Yusuke Ozawa, Yoshio Shimizu, Katsuji Hisakura, Takashi Matsuzaka, Hitoshi Shimano, Noriyuki Nakano, Shingo Sakashita, Toshiya Matsukawa, Hiroko Isoda, Nobuhiro Ohkohchi Tags: Original Article Source Type: research
Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report
We report a case of central MEC arising from GOC diagnosed by MAML2 fusion gene. A 57‐year‐old male presented a multilocular cystic lesion in left molar region of the mandible. Histopathologically, multiple cysts lined by thin cuboidal or non‐keratinized squamous epithelium with small duct‐like structures, mucous cells and ciliated cells were present. It was diagnosed as GOC. The recurrent lesion after nine years showed the proliferation of many cystic and solid nests composed of epidermoid, mucous and intermediated cells. Nested PCR revealed CRTC3‐MAML2 fusion gene in the recurrent lesion, but not in the primary...
Source: Pathology International - November 1, 2017 Category: Pathology Authors: Atsuhiro Nagasaki, Ikuko Ogawa, Yukiko Sato, Kengo Takeuchi, Masae Kitagawa, Toshinori Ando, Shinnichi Sakamoto, Madhu Shrestha, Kaori Uchisako, Koichi Koizumi, Shigeaki Toratani, Masaru Konishi, Takashi Takata Tags: Case Report Source Type: research
Nuclear inverse polarity papillary lesions lacking myoepithelial cells: A report of two cases
Here, cases of a 68‐ (Case 1) and a 44‐year‐old (Case 2) female are presented. They had an abnormality in the breast, and came to our hospital for further examination and treatment. Radiologically, malignancy could not completely excluded so breast excision was performed. Histologically, both cases revealed papillary neoplastic lesions lined by fibrovascular core and nuclear inverse polarity without atypia. Loss of myoepithelial cells was observed by HE, p63, and calponin. Previous report indicate CK5/6, ER, p63 and MUC3 are important for distinguishing between papillary lesions according to the differential index (b...
Source: Pathology International - November 1, 2017 Category: Pathology Authors: Shinya Tajima, Ichiro Maeda, Yoshio Aida, Akio Kazama, Hirotaka Koizumi, Masatomo Doi, Akira Endo, Motohiro Chosokabe, Keiko Kishimoto, Takafumi Ono, Koichiro Tsugawa, Masayuki Takagi Tags: Case Report Source Type: research
A Case of Congenital Infantile Fibrosarcoma of the Bowel Presenting as a Neonatal Intussusception
We report a case that presented with neonatal intussusception with a congenital infantile fibrosarcoma as the lead point. The detection of ETV6‐NTRK3 gene fusion was useful, although the definitive diagnosis was achieved by a comprehensive evaluation including this gene analysis, standard histology and immunohistochemistry. Neonatal intussusception should be suspected to be caused by a neoplasm. If pathological diagnosis is difficult, molecular analysis should be utilized to diagnose congenital infantile fibrosarcoma. (Source: Pathology International)
Source: Pathology International - November 1, 2017 Category: Pathology Authors: Juma Obayashi, Hirotaka Koizumi, Masahiro Hoshikawa, Munechika Wakisaka, Fujikawa Atsuko, Hiroaki Kitagawa, Masayuki Takagi Tags: Case Report Source Type: research
The potential significance of alpha ‐enolase (ENO1) in lung adenocarcinomas – A utility of the immunohistochemical expression in pathologic diagnosis
We herein analyzed the relationships among the immunohistochemical expression of alpha‐enolase (ENO1) and clinicopathological factors in order to define the significance of ENO1 in lung adenocarcinomas (ADCs). ENO1 expression was detected in most of the ADCs examined (95.8%), but not in bronchial and alveolar epithelia. ENO1 expression was typically observed in the cytoplasm among most ADCs (95.8%), but was also detected in the nucleus (56.3%). The levels were significantly higher in terminal respiratory unit (TRU) cytological subtype ADCs. Neither cytoplasmic nor nuclear expression was associated with any other clinicop...
Source: Pathology International - November 1, 2017 Category: Pathology Authors: Koji Okudela, Hideaki Mitsui, Mai Matsumura, Hiromasa Arai, Kimihisa Shino, Akimasa Sekine, Tetsukan Woo, Takehisa Suzuki, Yoshihiro Ishikawa, Shigeaki Umeda, Michihiko Tajiri, Munetaka Masuda, Kenichi Ohashi Tags: Original Article Source Type: research
Relationship between gastric lanthanum deposition and Helicobacter pylori ‐associated chronic gastritis: is it rare or common?
(Source: Pathology International)
Source: Pathology International - October 19, 2017 Category: Pathology Authors: Masaya Iwamuro, Haruo Urata, Hiroyuki Okada Tags: Letter to the Editor Source Type: research
Cyclophilin A expression and its prognostic significance in lung adenocarcinoma
Cyclophilin A (CypA) has been reported to be upregulated in malignant tumors. CypA expression is thought to be associated with acquisition of tumor growth and anti‐apoptotic function. Although upregulation of CypA has been reported in lung adenocarcinoma, its clinicopathological significance and roles in malignant progression remain unclear. Here we investigated the implications of CypA expression for outcome in patients with lung adenocarcinoma. Lung adenocarcinoma specimens from 198 cases were selected and reclassified according to the World Health Organization classification (4th edition) and the Noguchi classificatio...
Source: Pathology International - October 12, 2017 Category: Pathology Authors: Noriyuki Nakano, Shingo Sakashita, Ryota Matsuoka, Yoshihiko Murata, Aya Shiba ‐Ishii, Naohiro Kobayashi, Yukio Sato, Masayuki Noguchi Tags: Original Article Source Type: research
The re ‐emerging importance of radiologic–pathologic correlation in reaching the pathology diagnosis
(Source: Pathology International)
Source: Pathology International - October 12, 2017 Category: Pathology Authors: Monica Sze man Chan, Ryoko Saito, Kei Takase, Yasuhiro Nakamura, Hironobu Sasano Tags: Editorial Source Type: research
Animal models for analyzing metabolic syndrome ‐associated liver diseases
Metabolic syndrome (MS) is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases affecting the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease (NAFLD) and its progressive variant, nonalcoholic steatohepatitis (NASH). NASH is known to progress to liver cirrhosis and hepatocellular carcinoma (HCC). Excellent animal models for determining the mechanism of pathogenesis and establishing therapeutic treatment of NASH/HCC are strongly required worldwide. We recently reported that two previously established mouse models of obesity and diabetes melli...
Source: Pathology International - October 12, 2017 Category: Pathology Authors: Koichi Tsuneyama, Kazuchika Nishitsuji, Minoru Matsumoto, Tomoko Kobayashi, Yuki Morimoto, Takaaki Tsunematsu, Hirohisa Ogawa Tags: Review Article Source Type: research
Abstracts of A − Presentation by the winners of The Japanese Society of Pathology; Pathology Research Award in 2017 (in program order)
(Source: Pathology International)
Source: Pathology International - October 5, 2017 Category: Pathology Tags: Abstract Source Type: research
Clinicopathological features of neuroblastic tumors with opsoclonus ‐myoclonus‐ataxia syndrome: Follicular structure predicts a better neurological outcome
Neuroblastic tumors (NT) with opsoclonus‐myoclonus syndrome (OMS) display characteristic histological features, such as lymphocytic infiltration with lymphoid follicles, indicating an underlying immune response. We retrospectively assessed NT patients from 2001 to 2016. Five cases of NT with OMS and 76 cases of NT without OMS were histopathologically reviewed in this study. The grade of lymphocytic infiltration was evaluated. The number of follicles was counted and the presence or absence of lymphoid follicles was recorded for each case. We also confirmed the presence or absence of follicular dendritic cells (FDCs). We i...
Source: Pathology International - October 3, 2017 Category: Pathology Authors: Hiroko Fukushima, Takeshi Inoue, Yuichi Takama, Naomi Ishii, Takahiro Okuno, Yasutsugu Kobayashi, Akihiro Yoneda, Tetsuro Nakamura, Ichiro Kuki, Junichi Hara Tags: Original Article Source Type: research
Chondroblastoma of extra ‐craniofacial bones: Clinicopathological analyses of 103 cases
We elucidated clinicopathological characteristics of chondroblastoma (CB) in Japan, and reliable clinicopathologic parameters predicting local recurrence and/or metastasis. Clinicopathological profiles of 103 CB (80 male, 23 female) in extra‐craniofacial bones were retrieved. Numerical scoring of nine pathological and five radiological features was statistically analyzed to determine prognostic significance. Age ranged 8–61 years (average 19.6 years). Frequently involved sites were femur, tibia, calcaneus, patella and humerus. Radiologically, tumors were 2–80 mm (average 31.1 mm) in size. Marginal sclerosis and c...
Source: Pathology International - October 3, 2017 Category: Pathology Authors: Eiichi Konishi, Yasuaki Nakashima, Masayuki Mano, Yasuhiko Tomita, Toshikazu Kubo, Nobuhito Araki, Eiichi Morii, Hideki Yoshikawa, Hironori Haga, Junya Toguchida, Takafumi Ueda, Masahiko Osawa, Manabu Hoshi, Takeshi Inoue, Masanari Aono, Akio Yanagisawa Tags: Original Article Source Type: research
Primordial Odontogenic Tumor: A case report with histopathological analyses
Primordial odontogenic tumor (POT) is a benign mixed epithelial and mesenchymal odontogenic tumor included into the current World Health Organization (WHO) classification of Head and Neck tumours in 2017. As far as the authors have confirmed, only eight cases of this tumor have been reported so far. This paper reports a case of POT that occurred in the right mandible of a 5‐year‐old patient. Panoramic radiograph showed a well‐defined homogeneous radiolucency displacing the unerupted second deciduous molar to the deep part of the mandible. Histopathologically, the tumor was composed of cell‐rich mesenchymal tissue w...
Source: Pathology International - October 1, 2017 Category: Pathology Authors: Toshinari Mikami, Yu Ohashi, Ronell Bologna ‐Molina, Adalberto Mosqueda‐Taylor, Naoki Fujiwara, Naoko Tsunoda, Hiroyuki Yamada, Yasunori Takeda Tags: Case Report Source Type: research
