Stem cell-derived exosomes as a potential therapy for schistosomal hepatic fibrosis in experimental animals
In conclusion, MSCs-derived exosomes are a promising agent for the treatment of schistosomal hepatic fibrosis, and their combination with PZQ shows a synergistic action including antifibrotic and anti-inflammatory effects. However, further studies are required to establish their functional components and their mechanisms of action.PMID:37519008 | DOI:10.1080/20477724.2023.2240085 (Source: Pathogens and Global Health)
Source: Pathogens and Global Health - July 31, 2023 Category: International Medicine & Public Health Authors: Asmaa R Ellakany Hanan El Baz Zeinab S Shoheib Mohamed Elzallat Dalia S Ashour Nabila A Yassen Source Type: research

Evolution of COVID-19 infection characteristics in a Lebanese cohort of inpatients during different pandemic periods
This study aims to describe COVID-19 patients characteristics, laboratory and imaging results, and the different outcomes of patients admitted to the Lebanese American University Medical Center-Rizk Hospital over a period of 9 months. In this observational retrospective study, data were obtained from electronic medical records of 491 male and female patients from the ages of 17 to 97. Analysis of the patients was performed in 3 periods: August 2020 to October 20 November 202020 to January 2021 and February 2021 to April 2021 corresponding with 3 waves of newly diagnosed cases during this period. The sample showed a male pr...
Source: Pathogens and Global Health - July 24, 2023 Category: International Medicine & Public Health Authors: Tony Haykal Jonathan Mina Mohamad Fleifel Hani Dimassi Janane Nasr Ahmad Mahdi Ranime Harb Ghida El Hout Elissar Franjieh Jacques Mokhbat Anna Farra Mariana Helou Rola Husni Source Type: research

Evolutionary trajectories of beta-lactamase NDM and DLST cluster in < em > Pseudomonas aeruginosa < /em > : finding the putative ancestor
Pathog Glob Health. 2023 Jul 18:1-12. doi: 10.1080/20477724.2023.2236416. Online ahead of print.ABSTRACTPseudomonas aeruginosa has different antibiotic resistance pathways, such as broad-spectrum lactamases and metallo-β-lactamases (MBL), penicillin-binding protein (PBP) alteration, and active efflux pumps. Polymerase chain reaction (PCR) and sequencing methods were applied for double-locus sequence typing (DLST) and New Delhi metallo-β-lactamase (NDM) typing. We deduced the evolutionary pathways for DLST and NDM genes of P. aeruginosa using phylogenetic network. Among the analyzed isolates, 62.50% of the P. aeruginosa i...
Source: Pathogens and Global Health - July 19, 2023 Category: International Medicine & Public Health Authors: Parisa Sadeghi Karim Mahnam Azhar Salari-Jazi Ashok Aspatwar Jamshid Faghri Source Type: research

Malaria diagnosis using a combined system of a simple and fast extraction method with a lyophilised Dual-LAMP assay in a non-endemic setting
This study aims to solve some limitations of LAMP method with the optimization and validation of six LAMP assays, genus and species-specific, using an easy and fast extraction method, the incorporation of a reaction control assay, two ways (Dual) of result reading and reagent lyophilization. The Dual-LAMP assays were validated against the Nested-Multiplex Malaria PCR. A conventional column and saline extraction methods, and the use of lyophilized reaction tubes were also assessed. A new reaction control Dual-LAMP-RC assay was designed. Dual-LAMP-Pspp assay showed no cross-reactivity with other parasites, repeatability and ...
Source: Pathogens and Global Health - July 7, 2023 Category: International Medicine & Public Health Authors: Alexandra Mart ín Ramírez Lourdes Bar ón Argos Marta Lanza Su árez Claudia Carmona Rubio Ana P érez-Ayala Shamilah R Hisam Jos é M Rubio Source Type: research