Evaluation of local instillation of antibiotics in infected walled-off pancreatic necrosis
This study evaluates the efficacy of local instillation of antibiotics into WON. (Source: Pancreatology)
Source: Pancreatology - June 19, 2018 Category: Gastroenterology Authors: Mikkel Werge, Srdan Novovic, Stine Roug, Jenny Dahl Knudsen, Erik Feldager, Lise Lotte Gluud, Palle Norblad Schmidt Source Type: research
Ultrasonic/CT image fusion guidance facilitating percutaneous catheter drainage in treatment of acute pancreatitis complicated with infected walled-off necrosis
As the firs-line treatment for acute pancreatitis (AP) related infectious walled-off necrosis (WON), percutaneous catheter drainage (PCD) are usually accomplished under CT or US guidance, either of which has certain disadvantages. It is necessary to verify the clinical effects of using US and CT images fusion as guidance of PCD. (Source: Pancreatology)
Source: Pancreatology - June 15, 2018 Category: Gastroenterology Authors: Hui Zhang, Guang-yu Chen, Le Xiao, Xiao Ma, Li Shi, Tao Wang, Hong-tao Yan, Hong Zou, Qi Chen, Li-jun Tang, Wei-hui Liu Source Type: research
Measurement of copy number of ACTN4 to optimize the therapeutic strategy for locally advanced pancreatic cancer
The standard therapeutic strategy recommended for locally advanced pancreatic cancer (LAPC) is typically chemotherapy or chemoradiotherapy (CRT). Although the clinical benefit of chemotherapy alone versus CRT for LAPC has been compared in a number of clinical trials, the optimal therapy for LAPC remains unclear. Moreover, the clinical benefit derived from treatment in each clinical trial is a matter of controversy, and the superiority of one treatment over another has yet to be definitively demonstrated. (Source: Pancreatology)
Source: Pancreatology - June 13, 2018 Category: Gastroenterology Authors: Hirokazu Shoji, Nami Miura, Hideki Ueno, Kazufumi Honda Source Type: research
Improving the accuracy of pancreatic cancer clinical staging by exploitation of nanoparticle-blood interactions: A pilot study
Pancreatic ductal adenocarcinoma (PDAC) early diagnosis is crucial and new, cheap and user-friendly techniques for biomarker identification are needed. “Protein corona” (PC) is emerging a new bio-interface potentially useful in tumor early diagnosis. In a previous investigation, we showed that relevant differences between the protein pat terns of PCs formed on lipid NPs after exposure to PDAC and non-cancer plasma samples exist. To extend that research, We performed this pilot study to investigate the effect of PDAC tumor size and distant metastases on PC composition. (Source: Pancreatology)
Source: Pancreatology - June 12, 2018 Category: Gastroenterology Authors: D. Caputo, M. Cartillone, C. Cascone, D. Pozzi, L. Digiacomo, S. Palchetti, G. Caracciolo, R. Coppola Source Type: research
Incidence and reasons of pancreatic resection in patients with asymptomatic serous cystadenoma
Despite diagnostic refinements, pancreatic resection (PR) is eventually performed in some patients with asymptomatic serous cystadenoma (A-SCA). The aim of this study was to define incidence and reasons of PR in A-SCA. (Source: Pancreatology)
Source: Pancreatology - June 8, 2018 Category: Gastroenterology Authors: Carlo Lombardo, Sara Iacopi, Francesca Menonna, Niccol ò Napoli, Emanuele Kauffmann, Juri Bernardini, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Carla Cappelli, Daniela Campani, Davide Caramella, Ugo Boggi Source Type: research
Pancreatic cyst surveillance imposes low psychological burden: preliminary results of the PACYFIC study
Objectives To evaluate the perception and psychological burden of pancreatic cyst surveillance from a participant ’s perspective. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Kasper Overbeek, Anne Kamps, Priscilla Van Riet, Mariacristina Di Marco, Giulia Zerboni, Jeanin Van Hooft, Silvia Carrara, Claudio Ricci, Tamas Gonda, Erik Schoon, Marcin Polkowski, Georg Beyer, Pieter Honkoop, Laurens Van der Waaij, Riccardo Casadei, Gab Tags: Session 1: IPMN and cystic lesions of the pancreas - free papers Source Type: research
The natural history of intraductal papillary mucinous neoplasms of the pancreas: Reappraisal of the indolent precursor of pancreatic cancer
Objectives Evidences from surgical series have been condensed into several guidelines for the management of Intraductal Papillary Mucinous Neoplasms of the pancreas (IPMNs). However, still a gap must be filled to better understand their biological behavior. Aim of the present study is to describe the natural history of IPMNs observed at a high-volume center for thirty years. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Giovanni Marchegiani, Stefano Andrianello, Tommaso Pollini, Andrea Caravati, Marco Biancotto, Giuseppe Malleo, Claudio Bassi, Roberto Salvia Tags: Session 1: IPMN and cystic lesions of the pancreas - free papers Source Type: research
Risk score for early prediction of invasive cancer of BD-IPMN according to morphological characterization in EUS in patients who underwent to pancreatic surgery
Objectives The management of Branch-Duct Intraductal Papillary Mucinous Neoplasms (BD-IPMN) is determined by a number of guidelines, which advocate a series of criteria for deciding on the handling such as “worrisome features” and “high-risk stigmata”. Endoscopic ultrasound (EUS) is considered one of the most effective diagnostic techniques due to its accuracy in the morphological diagnosis. Aim:To develop a risk score for early prediction of invasive cancer of BD-IPMN according to morphologic al characterization in EUS, using the surgical specimens as gold standard (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Laura Uribarri-Gonzalez, Enrique Perez-Cuadrado Robles, Soraya L ópez-López, Jose Lariño-Noia, Emma Martinez-Moneo, Julio Iglesias-García, Federico Bolado-Concejo, J. Enrique Dominguez-Muñoz, Juan J. Vila-Costas Tags: Session 1: IPMN and cystic lesions of the pancreas - free papers Source Type: research
Main pancreatic duct involvement in IPMN without enhancing mural nodule: Low- risk of Malignancy in duct diameter of less than 10 mm and segmental involvement of dilatation: national wide multicenter study in Korea
Objectives Most studies reported that mural nodule (MN) of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas on CT or MRI was the most associated with malignant pathology. However, there is very little information regarding the malignancy risk of MD and mixed type IPMNs without enhancing MNs in the main pancreatic duct (MPD) and branch duct cyst on radiologic imaging. We attempted to identify clinical and morphologic features associated with low-risk subgroup of MD and mixed type IPMN. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Tae Hyeon Kim, Myung Hwan Kim, Jong Ho Moon, Seung Ok Lee, Chang Hwan Park, Tae Jun Song, Yun Jung Yang Tags: Session 1: IPMN and cystic lesions of the pancreas - free papers Source Type: research
Molecular characterization of early precursor lesions of pancreatic ductal adenocarcinoma
Objectives Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with high mortality rates due to late diagnosis and rapid progression. Therefore, better tools for earlier detection are urgently needed. The most common PDAC precursor lesions are pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMN). The gastric subtype of IPMN shares morphological homologies with PanIN and the two lesions are currently distinguished only according to their size. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Lisa Frohn, Lena H äberle, Wolfgang Göring, Matthias Wirth, Irene Esposito Tags: Session 1: IPMN and cystic lesions of the pancreas - free papers Source Type: research
Preoperative biliary stenting is associated with detrimental perioperative morbidity – a propensity matched analysis of over 900 patients from the German pancreas registry
Objectives The impact of preoperative biliary stenting (PBS) on postoperative complication rates in patients undergoing pancreatoduodenectomy (PD) for pancreatic cancer is controversially discussed. We aimed to assess perioperative morbidity of PBS prior to PD for pancreatic ductal adenocarcinoma in a large-scale multi-center German DGAV-STUDOQ registry study. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Louisa Bolm, Ekaterina Petrova, Lukas Woehrmann, Jens Werner, Waldemar Uhl, Natascha Nuessler, Michael Ghadimi, Dirk Bausch, Hryhoriy Lapshyn, Jochen Gaedcke, Orlin Belyaev, Jan G. D'Haese, Thomas Klier, Tobias Keck, Ulrich F. Wellner, German DGAV-StuDoQ Tags: Session 4. Surgical issues of pancreatic tumor resection - free papers Source Type: research
Randomized clinical trial exploring the optimal duration of antimicrobial prophylaxis in patients undergoing pancreaticoduodenectomy following biliary drainage
Objectives The aim of this dual-center randomized controlled trial was to determine the optimal duration of antimicrobial prophylaxis in patients treated with pancreaticoduodenectomy (PD) who underwent preoperative biliary drainage (PBD) but were without cholangitis. Some reports revealed that PBD in patients undergoing pancreatectomy increased the rate of peri-operative complications. However, no clinical trial has evaluated the optimal duration of antimicrobial prophylaxis with a focus on patients who underwent PD following PBD. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Sohei Satoi, Yomohisa Yamamoto, Tsutomu Fujii, Suguru Yamada, Hiroaki Yanagimoto, So Yamaki, Hideki Takami, Satoshi Hirooka, Hisashi Kosaka, Masaya Kotsuka, Yasuhiro Kodera Tags: Session 4. Surgical issues of pancreatic tumor resection - free papers Source Type: research
Preoperative prediction of postoperative survival with a novel prognostic score in potentially resectable pancreatic cancer
Objectives Accurate preoperative staging and prediction of prognosis in potentially resectable pancreatic cancer (PDAC) is challenging due to small metastases detectable only by surgical exploration or subclinical metastases. To inform treatment decisions and facilitate clinical trials comparing strategies of upfront resection and neoadjuvant therapy better tools for pre-therapeutic prediction of survival are urgently needed. We aimed to develop a prognostic score based on objective and easily reproducible preoperative parameters. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Oliver Strobel, Thomas Hank, Ulf Hinz, Thomas Reiner, Anna-Katharina K önig, Willem Niesen, Jörg Kaiser, Thilo Hackert, Markus Büchler Tags: Session 4. Surgical issues of pancreatic tumor resection - free papers Source Type: research
Characteristics of postoperative pancreatic fistula on CT scan: A multicenter cohort study
Objectives Pancreatic fistula is a potentially severe complication after pancreatic resection. There is currently only little known on the diagnostic accuracy of radiologic characteristics of pancreatic fistula. Our aim was to describe the characteristics of clinically relevant postoperative pancreatic fistula on abdominal imaging in the early postoperative phase. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: F. Jasmijn Smits, Coert Kok, Casper van Eijck, Thomas Bollen, Frank Wessels, Bas Groot Koerkamp, Olivier Busch, Marc Besselink, Hjalmar van Santvoort, Quintus Molenaar, Dutch Pancreatic Cancer Group Tags: Session 4. Surgical issues of pancreatic tumor resection - free papers Source Type: research
Neo-adjuvant treatment for borderline and locally advanced pancreatic cancer: A single institution experience
Objectives Neo-adjuvant chemo-(radio-) therapy (NAT) is commonly accepted as part of the multimodality treatment for borderline/locally advanced pancreatic cancer (BR/LA-PC), however data on outcome from large surgical series is few. The aim of the study is to analyze the short and long-term outcome of patients with BR/LA-PC planned for NAT. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Elena Rangelova, Agnes Wefer, Saga Persson, Roberto Valente, Ralf Segersv ärd, Urban Arnelo, Marco Del Chiaro Tags: Session 4. Surgical issues of pancreatic tumor resection - free papers Source Type: research
