Minimally invasive versus open treatment for benign sporadic insulinoma Comparison of short term and long term outcomes
Objectives Benign insulinoma is the most common functioning neuroendocrine tumor of the pancreas, its incidence is estimated at 0,4 %. The treatment of choice is organ-preserving resection. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Giulio Belfiori, Dominik Wiese, Stefano Partelli, Sabine W ächter, Elisabeth Maurer, Stefano Crippa, Massimo Falconi, Detlef Klaus Bartsch Tags: 10. Pancreatic surgery I Source Type: research
The effect of pasireotide on post-operative pancreatic fistulas after pancreatic distal resections
Objectives Complications in pancreatic surgery are potentially life-treathing. Post operative pancreatic fistulas can form in pancreatic tissue after surgery, and can cause peripancreatic fluid collections and infections. In addition, pancreatic fluid is corrosive and can lead to post-operative bleeding in the operative area. Clinically significant class B and C fistulas increase post-operative morbidity and can lead to prolonged hospital stay. Delaying of adjuvant therapy beacuse of fistula formation in cancer patients can effect their prognosis. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Tiina Vuorela, Harri Mustonen, Caj Haglund, Hanna Sepp änen Tags: 10. Pancreatic surgery I Source Type: research
Laparoscopic distal pancreatectomy: which factors are related to open conversion? Lessons learned from 68 consecutive procedures in a high volume pancreatic center
Objectives Laparoscopic distal pancreatectomy represents a difficult surgical procedure with an high conversion rate to open procedure. The factors related to its difficulty and to conversion to open distal pancreatectomy were rarely reported. The aim of the present study was to identify which factors are related to conversion from laparoscopic to open distal pancreatectomy. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Carlo Alberto Pacilio, Claudio Ricci, Carlo Ingaldi, Francesco Minni, Riccardo Casadei Tags: 10. Pancreatic surgery I Source Type: research
The implication of induction chemotherapy followed by chemoradiotherapy for locally advanced pancreatic cancer, intended conversion surgery
Objectives In recent years, options for conducting Conversion Surgery are attracting attention for cases in which chemotherapy and chemoradiotherapy have been successful in locally advanced nonresectable pancreatic cancer (UR - LA). Cases in which Conversion Surgery could be performed are expected to have a certain prognosis from the previous report. It seems that there is a possibility that the treatment strategy for UR-LA we are working on and the treatment combined appropriately in the previous report may possibly greatly improve the prognosis, but to show the results is a future issue. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Daisuke Ban, Tomotaka Kato, Jun Yoshino, Atsushi Kudo, Minoru Tanabe Tags: 10. Pancreatic surgery I Source Type: research
VMP1 dependent selective mitophagy and mitochondrial fragmentation are protective cellular mechanisms in pancreatitis
Objectives We analyzed mitophagy in Acute Pancreatitis (AP), its molecular mechanisms and its relationship with mitochondrial dynamics during selective autophagy in animal and cellular models. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Virginia Vanasco, Alejandro Ropolo, Daniel Grasso, Silvia Alvarez, Maria Ines Vaccaro Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research
L-histidine but not other basic amino acid-induced pancreatitis in mice involves inositol trisphosphate receptor signalling and mitochondrial permeability transition
Objectives The basic amino acids L-arginine, L-ornithine and L-lysine can trigger acute pancreatitis (AP), but the mechanisms of toxicity are not well understood. We compared a newly developed L-histidine model of AP with standard L-arginine and L-ornithine models and found remarkable differences in the mechanisms of toxicity and pharmacological profiles. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Xiaoying Zhang, Linbo Yao, Na Shi, Xinmin Yang, Dan Du, Tingting Liu, Peter Szatmary, Rajarshi Mukherjee, Qing Xia, David Criddle, Wei Huang, Michael Chvanov, Alexey Tepikin, Robert Sutton Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research
Adaptive immune response during acute pancreatitis is regulated by NLRP3 inflammasome activation via interleukin 18
Objectives The Systemic Inflammatory Response Syndrome (SIRS) is responsible for the severity and mortality in acute pancreatitis. Inflammasome activation within phagocytosing macrophages via damage-associated-molecular-patterns (DAMPs) could play an important role for the cross talk between the innate and adaptive immune system. Here we investigated the cross talk between pancreatic macrophages and T-cells via inflammasome-mediated cytokine response. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Matthias Sendler, Cindy van den Brandt, Juliane Glaubitz, Anika Wilden, F. Ulrich Weiss, Janine Golchert, Georg Homuth, Lukas Bossaller, Julia Mayerle, Markus M. Lerch Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research
Reduced expression of mutant trypsinogen delays disease onset in a spontaneous mouse model of pancreatitis
Objectives Premature intrapancreatic activation of trypsinogen has been implicated in pancreatic injury and chronic pancreatitis. Biochemical analyses of hereditary pancreatitis associated mutations in the trypsinogen activation peptide revealed that the common phenotypic change is a markedly increased propensity for autoactivation. We recently generated two different knock-in mice (T7D23A Cre and T7D23A Neo), carrying the same heterozygous D23A mutation in the activation peptide of mouse T7 trypsinogen. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Andrea Geisz, Anna Orekhova, Miklos Sahin-Toth Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research
Mast cell stabilizers can serve as “co-analgesics” in acute and chronic pancreatitis
Objectives Severe abdominal pain is the leading symptom of acute (AP) and chronic pancreatitis (CP). We could recently show that neuropathic pain in CP is linked to perineural accumulation of acitivated mast cells. Therefore, we now hypothesized that inhibition/stabilization of mast cells may lead to improvement of pancreatitis-associated pain and tested mast cell stabilizers (i.e., ketotifen and cromoglycate) as potential “co-analgesics” in AP and CP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Hendrik Steenfadt, Sarah Klauss, Stephan Schorn, Helmut Friess, Gueralp Onur Ceyhan, Ekin Ihsan Demir Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research
Increased 1-deoxy-sphingolipids in diabetes are cytotoxic for pancreatic acinar cells
Objectives Exocrine pancreatic insufficiency and exocrine function alterations are frequent in diabetes mellitus (DM) patients with a prevalence up to 50%. DM is associated with increased plasma levels of 1-deoxy-sphingolipids (1-dSLs), atypical sphingolipids with demonstrated cytotoxicity on several cell types. Our results showed that 1-dSLs are also cytotoxic for acinar cells in vitro. Furthermore, the high level of 1-dSLs in diabetic animal model aggravated acinar cell damage whereas lowering levels of 1-dSLs improved cell deterioration. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Rong Chen, Thorsten Hornemann, Yu Wei, Simone Camargo, Rolf Graf, Sabrina Sonda Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research
Mesenchymal Wt1 positive stellate cells represent a source of the fibrotic response in pancreatitis
Objectives Severe pancreatitis is accompanied by a strong fibrotic response characterized through the presence of activated myofibroblasts. Beside hematopoietic stem cells and resident fibroblasts, pancreatic stellate cells are traded as the main cell population giving rise to activated myofibroblasts. The origin of myofibroblasts is highly under debate and so far not successfully clarified. In vivo evidences that stellate cells are predominantly responsible for the stromal reaction are still missing. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Ivonne Regel, Tobias Dreyer, Georg Beyer, Steffen Teller, Alexander Wuschek, Simone Hausmann, Simone Benitz, Katja Steiger, Irene Esposito, Julia Mayerle, Christoph Michalski, J örg Kleeff Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research
Pancreatogenic diabetes (T3cDM): An underestimated disease
Objectives To learn about the prevalence and relevance of pancreatogenic diabetes (T3cDM). (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Philip Hardt, Dana Andersen, Nils Ewald Tags: Session 9. Dieabetes and the pancreas Source Type: research
Relationships between adipocytokinemia and antropometric indicators in patients with combined course of type 2 diabetes mellitus and chronic pancreatitis
Objectives Adipocytokinemia and changes of antropometric data associated with cardiovascular risk and metabolic disease in patients with chronic pancreatitis (CP) and type 2 diabetes mellitus (T2DM). (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Iuliia Shekhovtsova, Larysa Zhuravlyova Tags: Session 9. Dieabetes and the pancreas Source Type: research
Gene, environment and Surgical risk of diabetes mellitus in patients with chronic pancreatitis from the North American pancreatitis study 2 (NAPS2)
Objectives Diabetes Mellitus (DM) occurs in a third of patients with chronic pancreatitis (CP). Type 3c DM (T3cDM) represents a type of DM caused by dysfunction or destruction of the islets from exocrine pancreatic disease or surgical removal. However, some individuals may have islets that are more sensitive to DM than others, resulting in early DM in some and resistance to DM in others as in Type 2 DM (T2DM). Our Aim was to evaluate patients in the North American Pancreatitis Study 2 (NAPS2) with CP and with and without DM to determine associations with known genes and environmental risk factors. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Tanvi Nagpal, Melina Bellin, Dhiraj Yadav, Phil Greer, Mark O. Goodarzi, David Whitcomb, for the NAPS2 consortium and the NIDDK/NCI Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Tags: Session 9. Dieabetes and the pancreas Source Type: research
Incidence and Risk Factor of New-Onset Diabetes After Distal Pancreatectomy
Objectives Introduction: The occurrence of new-onset diabetes (NODM) after distal pancreatectomy (DP) has gained interest due to the increasing life expectancy of patients undergoing pancreatic resection. Although some risk factors have been described, the exact contribution of each perioperative variable remains poorly characterized. The study aims to assess the frequency and the risk factors of the development of NODM after DP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Matteo De Pastena, Alvaro Andres Duarte Garces, Tommaso Pollini, Sara Nobile, Roberta Piccolo, Stefano Andrianello, Giovanni Marchegiani, Giuseppe Malleo, Claudio Bassi, Roberto Salvia Tags: Session 9. Dieabetes and the pancreas Source Type: research
