IO US and ICG gastroscopy are more useful than preoperative common hepatic artery occlusion for assessment of liver and stomach blood supply during distal pancreatectomy with celiac artery resection. Experience of 115 CHA clampings and 25 DP CARS
Objectives To study stomach and liver collateral arterial supply after common(CHA and celiac artery(CA) temporary occlusion. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Viacheslav Egorov, Roman Petrov, Julia Zhurina Tags: 8. Pancreatic Cancer I Source Type: research
Preoperative biomarker panel distinguishes PDAC from IPMN
Objectives Pancreatic ductal adenocarcinoma (PDAC) is associated with increased coagulation and venous thrombotic events (VTE). PDAC is often diagnosed late and survival is poor. CA 19-9 is the most used tumor marker for PDAC, but it is more useful in follow-up than diagnosis. Intraductal papillary mucinous neoplasm (IPMN) is a benign tumor of the pancreas, which can become malignant, however pancreatic tumor surgery is extensive and should not be done needlessly. The aim of this study was to study whether PDAC could be distinguished from IPMN preoperatively using coagulation biomarkers and whether combing them in a panel ...
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Nora Mattila, Hanna Sepp änen, Caj Haglund, Harri Mustonen, Beata Przybyla, Riitta Lassila Tags: 8. Pancreatic Cancer I Source Type: research
Stereotactic body radiation therapy for unresectable locally advanced pancreatic cancer: Clinical outcomes on 100 patients
Objectives Pancreatic adenocarcinoma is characterized by a poor prognosis. Surgery is the gold standard of care, however more than 50% of patients are unresectable at the time of diagnosis. In the last years, the role of stereotactic body radiotherapy (SBRT) in the treatment of LAPC was investigated. Higher local control related to the high doses employed, short overall treatment time and sequential integration with systemic therapy, represent the crucial advantages of SBRT over conventional CRT. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Tiziana Comito, Ciro Franzese, Elena Clerici, Lucia Di Brina, Alessandro Zerbi, Marta Scorsetti Tags: 8. Pancreatic Cancer I Source Type: research
Efficacy and safety of nab-paclitaxel in combination with Gemcitabine in Korean patients with metastatic pancreatic cancer
Objectives Metastatic pancreatic cancer is one of the most fatal malignancies. The purpose of this study was to evaluate the efficacy and safety of nab-paclitaxel plus gemcitabine in real clinical practice. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Ji-Kon Ryu, Minsu Yoo, Sang Hyub Lee, Yong-Tae Kim Tags: 8. Pancreatic Cancer I Source Type: research
Patient Stratification and Precision Medicine in Pancreatic cancer: a gene blood-signature for gemcitabine treatment
Objectives Pancreatic cancer (PC) kills 98% of those it afflicts and is one of the most lethal cancers worldwide: patients diagnosed with PC have a poor prognosis partly because the cancer usually causes no symptoms early on, leading to metastatic disease at the time of diagnosis. The high mortality rate is partly due to the difficulty to diagnose and due to the lack of stratified patients to effective treatments. The capability of biomarkers to improve treatment and to reduce healthcare costs is potentially greater than in any other area of current medical research. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: David Piquemal Tags: 8. Pancreatic Cancer I Source Type: research
Alpha smooth muscle actin ( αSMA) immunohistochemistry use in the differentiation of pancreatic cancer from chronic pancreatitis
Objectives In pancreatic cancer (PDAC) and chronic pancreatitis (CP) similar mechanisms of fibrosis occur. The main cells involved in fibrosis are pancreatic stellate cells (PSCs), which constitute about 4-7% of the total pancreatic mass. In response to damage, inflammation or cancer, PSCs are activated and transformed into myofibroblast -like cells, gain the muscle cell phenotype and express alpha smooth muscle actin ( αSMA), which is considered to be the best known fibrosis marker. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Katarzyna Winter, Janusz Strzelczyk, Monika Dzieniecka, Ma łgorzata Wągrowska - Danilewicz, Marian Danilewicz, Ewa Małecka - Panas Tags: 8. Pancreatic Cancer I Source Type: research
Prognostic role of the parenchymal frozen transection margin during pancreaticoduodenectomy for ductal pancreatic adenocarcinoma
Objectives During pancreatectomy (PD) for ductal adenocarcinoma (PDAC) an intra-operative frozen section analysis of the transection margin is usually performed to achieve an R0 resection. An extension of the resection is required for positive margins until a total pancreatectomy (TP). However, it is unclear whether an extended resection up to TP leads to a survival advantage. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Giovanni Guarneri, Stefano Crippa, Domenico Tamburrino, Stefano Partelli, Gianpaolo Balzano, Michele Mazza, Claudio Doglioni, Corrado Rubini, Giuseppe Zamboni, Marco Palucci, Giulia Gasparini, Massimo Falconi Tags: 8. Pancreatic Cancer I Source Type: research
Tumor regression grade (TRG) evaluation of 29 borderline/locally advanced pancreatic cancers (LAPCs) after neoadjuvant chemotherapy (NACT) using different pathological scores: a clinical and prognostic correlation
Objectives Only 20-30% of patients with pancreatic cancer (PC) are candidate for surgery at diagnosis. In LAPC resectability can be achieved in a small proportion of patients after chemotherapy and chemoradiotherapy. Pathology report has an essential role in assessing the efficacy of therapy and the completeness of surgery. Determining the TRG in patients with PC is challenging. Numerous TRG scores are currently used without a general agreement on the most reliable and almost all data available regard patients treated with both chemo and radiotherapy. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Andrea Cacciato Insilla, Caterina Vivaldi, Carlo Lombardo, Ugo Boggi, Enrico Vasile, Daniela Campani Tags: 8. Pancreatic Cancer I Source Type: research
Perineural Invasion in Pancreatic Ductal Adenocarcinoma
Objectives Perineural Invasion (PNI), the pathological identification of cancer cells along nerves, is highly prevalent in pancreatic ductal cancer (PDAC) and is associated with recurrence, pain and metastasis. In this project we sought to characterize PNI pathological and molecular features to develop novel therapeutical approaches. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Giulia Gasparini, Rosa La Marca, Marco Schiavo Lena, Stefano Crippa, Claudio Doglioni, Massimo Falconi, Carla Taveggia Tags: 9. Experimental pancreatic cancer I Source Type: research
Tissue characterization of components of the antigen processing machinery in pancreatic ductal adenocarcinoma
Objectives The molecules composing the antigen processing machinery (APM) have a crucial role in tumor immune evasion. Defects at different steps of the APM correlate with increased disease aggressiveness and worse clinical outcome in many solid tumors. With the aim of describing novel prognostic biomarkers to better stratify tumor patients, we have characterized the expression of different components of the APM in pancreatic ductal adenocarcinoma (PDAC) specimens. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Greta Donisi, Giovanni Francesco Castino, Giovanni Capretti, Nina Cortese, Francesca Gavazzi, Cristina Ridolfi, Gennaro Nappo, Giulia Maggi, Cristina R. Ferrone, Soldano Ferrone, Federica Marchesi, Alessandro Zerbi Tags: 9. Experimental pancreatic cancer I Source Type: research
Epigenetic reprogramming to overcome heterogeneity of pancreatic tumor cell subtypes
Objectives Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumor entities. The identification of distinct PDAC subtypes with a similar genetic background had given a first impression that probably epigenetic alterations promote tumor cell heterogeneity. Epigenetic modifications, such as histone modifications, are reversible and therefore attractive targets for cancer therapy. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Anna Kirmayr, Ujjwal Mukund Mahajan, Svenja Pichlmeier, Simone Benitz, Jan D'Haese, Julia Mayerle, Ivonne Regel Tags: 9. Experimental pancreatic cancer I Source Type: research
Pancreatic cancer cells enrich phospho-paxillin in their filopodia during neural invasion
Objectives Neural invasion (NI) is a leading cause of local recurrence, neuropathic pain sensation in pancreatic ductal adenocarcinoma (PDAC) and is encountered in up to 100% of PDAC cases. The changes that occur in the cytoskeleton of neuro-invasive PDAC cells has, however, never been analyzed. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Xiaobo Wang, Steffen Teller, Ihsan Ekin Demir, Helmut Friess, G üralp O. Ceyhan Tags: 9. Experimental pancreatic cancer I Source Type: research
High PRDX3 expression is associated with pancreatic adenocarcinoma aggressiveness and can be targeted by a novel therapeutic strategy
Objectives Ageing and inflammation have been linked to the development of pancreatic adenocarcinoma (PDAC). PDAC has a dense and poorly vascularised stroma resulting in severe hypoxia. This suggests that oxidative stress plays a major role in tumor development and aggressiveness. The aim of this study was to assess oxidative stress-related protein damage and its role in PDAC. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Jerome Raffenne, Fernando A. Martin, Marina Conta, Alain Sauvanet, Pascal Hammel, Pierre Bedossa, Valerie Paradis, Anne Couvelard, Jerome Cros Tags: 9. Experimental pancreatic cancer I Source Type: research
Pancreatic stellate cells augment neural invasion in pancreatic cancer
Objectives Neural invasion is one of most unfavorable prognostic factors in pancreatic cancer (PCa). Neural invasion in PCa is particularly frequent in desmoplastic tissue areas. Pancreatic stellate cells (PSC) emerged in recent years as the main actor for the generation of pancreatic fibrosis in PCa. Thus, here, we investigated whether pancreatic stellate cells (PSC) can augment neural invasion in PCa. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Xiaobo Wang, Steffen Teller, Ihsan Ekin Demir, Helmut Friess, G üralp O. Ceyhan Tags: 9. Experimental pancreatic cancer I Source Type: research
Mutational burden of resectable pancreatic cancer by whole-transcriptome and whole-exome sequencing could predict a poor prognosis
Objectives Despite pancreatic cancer (PC) genomic characterization, true advances in the development of prognosis classification and new therapeutic strategies have yet to come. We aimed to better understand genomic alterations of invasive phenotype in order to improve patient selection for treatment options. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Elisa Grassi, Sandra Durante, Annalisa Astolfi, Giuseppe Tarantino, Valentina Indio, Eva Freier, Riccardo Casadei, Claudio Ricci, Francesca Comito, Daria Filippini, Francesca Formica, Carla Serra, Donatella Santini, Antonietta D'Errico, Francesco Minni, G Tags: 9. Experimental pancreatic cancer I Source Type: research
