Abdominal ultrasound scan for the follow-up of pancreatic cystic lesions: could it play a role as a safe and cost-saving alternative to the routine MRI?
Objectives Patients with pancreatic cystic lesions (PCL) without “worrisome features”(WF) at the diagnosis,usually necessitate a lifetime surveillance with a MRI to monitor cysts size, pancreatic main duct dilatation or mural nodules. Since these parameters can also be evaluated with an ultrasound(US) scan, we studied safety, feasibility and economic impact o f an abdominal US scan follow-up, with a delayed use of MRI. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Luca Morelli, Matteo Palmeri, Simone Guadagni, Roberta Pisano, Valerio Borrelli, Gregorio Di Franco, Niccol ò Furbetta, Desirée Gianardi, Matteo Bianchini, Dario Gambaccini, Santino Marchi, Luca Emanuele Pollina, Niccola Funel, Alessandro Campatelli, Fr Tags: 7. Cystic lesions of the pancreas Source Type: research
SCN, MCN and SPN – Sex specific differences in pancreatic cysts (other than IPMN)
Objectives Solid-pseudopapillar neoplasms (SPN or Frantz tumor) as well as serous and mucinous cystadenomas (SCN and MCN) count for app. 30 % of the cystic neoplasms of the pancreas and are predominantly found in women. SCN show no malignant potential, while this is assumed for 40% of MCN. SPN have an excellent prognosis, but signs of primary malignancy or recurrence (mostly hepatic or peritoneal metastasis) are shown in ∼ 15%. According to the current guidelines, surgical resection is indicated for SCN> 4cm, and as an oncological approach for pancreatic cysts, suspect for MCN or SPN in imaging. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Christin Tjaden, Ulrike Heger, Daniel Schneider, Ulf Hinz, Oliver Strobel, Markus W. B üchler, Thilo Hackert Tags: 7. Cystic lesions of the pancreas Source Type: research
Effect of aspirin, ACE inhibitors/sartans and statins use on the progression of BD-IPMN in follow up: a multicenter study
Objectives Aspirin (ASA), Ace Inibitors/Sartans (ACEI/ARB) and Statins (STAT) inhibit tumoral growth in several clinical and preclinical models, including pancreatic cancer (PDAC). These drugs might, therefore, slow the progression of PDAC precursor lesions, such as IPMNs, but this has been poorly investigated. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Roberto Valente, Stefano Crippa, Giuseppe Vanella, Giulia Zerboni, Alessandro Fogliati, Urban Arnelo, Massimo Falconi, Gabriele Capurso, Marco Del Chiaro Tags: 7. Cystic lesions of the pancreas Source Type: research
Risk factors for malignancy and long term follow-up after resected pancreatic cystic neoplasms in Finland
Objectives The long-term prognostics after all resected pancreatic cystic neoplasms (PCN) on a nationwide level are not well reported. The aim of this study was to determine the nationwide epidemiologic characteristics and long-term survival of all resected pancreatic cystic neoplasms (PCN) in Finland. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Yrj ö Vaalavuo, Anne Antila, Reea Ahola, Antti Siiki, Martine Vornanen, Mika Ukkonen, Juhani Sand, Johanna Laukkarinen Tags: 7. Cystic lesions of the pancreas Source Type: research
Use of ultrasound elastography in differential diagnosis of pancreatic cystic lesions
Objectives Increases in the quality as well as utilization of cross-sectional imaging have led to rising diagnosis of pancreatic cystic lesions (PCL). The differential diagnosis of PCL is an increasingly common clinical challenge. The aim of this study was to evaluate the effectiveness of ultrasound elastography in the differentiation of PCL. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Andrey Koshel, Tatyana Dibina, Evgeny Drozdov Tags: 7. Cystic lesions of the pancreas Source Type: research
Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients
Objectives The number of adult patients with cystic fibrosis (CF) is increasing. The current life expectancy of those patients is over 40 years. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Liudmila Vinokurova, Gulsara Baimakanova, Stanislav Krasovsky, Svetlana Silvestrova, Galina Varvanina, Elena Dubtsova, Dmitry Bordin Tags: 7. Cystic lesions of the pancreas Source Type: research
Intratumour heterogeneity in pancreatic cancer following neoadjuvant chemotherapy
Objectives To investigate the presence and extent of phenotypical intratumour heterogeneity in ductal adenocarcinoma of the pancreas following neoadjuvant treatment. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Caroline Sophie Verbeke, Linda T. Dorg, Ewa Pomianowska, Knut J ørgen Labori, Elin H. Kure, Ole Christian Lingjærde, Ivar Prydz Gladhaug Tags: 8. Pancreatic Cancer I Source Type: research
Postoperative bile fistula after pancreaticoduodenectomy (PD) for malignant tumors of the pancreatic head
Objectives Besides postoperative pancreatic fistula (POPF), postoperative bile fistula (POBF) displays a major complication following PD for malignant tumors of the pancreatic head. While risk factors for the development of POPF are well studied, risk factors for the development of POBF remain elusive. Thus, the aim of the study was to identify risk factors associated with the development of POBF. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Florian Scheufele, Carsten J äger, Ekin Demir, Stephan Schorn, Elke Tieftrunk, Mine Sargut, Helmut Friess, Güralp O. Ceyhan Tags: 8. Pancreatic Cancer I Source Type: research
Pre-diagnostic erythrocyte cadmium, selenium, and zinc levels and pancreatic cancer risk in Europe
Objectives Cadmium (Cd) is a naturally occurring heavy metal that has no known biological function and is considered a Group 1 human carcinogen by IARC. Diet is considered the major source of exposure in the general non-smoking population. The increasing use of Cd-batteries is projected to increase environmental contamination. Cd body burden is twice as high in smokers as non-smokers, and interferes with essential elements such as zinc (Zn) and selenium (Se). Cd exposure in vivo induces pancreatic tumors in rats. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Eric Duell, Leila Lujan-Barroso, Malene Outzen, Ole Raaschou-Nielsen, Mazda Jenab, Malin Sund, Ingvar Bergdahl, on behalf of EPIC investigators Tags: 8. Pancreatic Cancer I Source Type: research
Small pancreatic ductal adenocarcinoma: our experience with emphasis on clinical and oncological outcomes
Objectives Pancreatic ductal adenocarcinoma (PDAC) is frequently unresectable and the prognosis is very poor despite recent advances. More than 50% of cases presents systemic disease while only around 6% of patients shows early PDAC. Even in the contest of early stage disease (Stage IA), complete resection may improve partially the long-term survival and only about 40% of treated patients survives 5 years or longer. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Federico Selvaggi, Manuela Bellobono, Antonio Umbriano, Severino Cericola, Vincenzo Casolino, Erica De Nicola, Fabio Marchionni, Eleonora Angelini, Simone Di Russo, Cinzia Baccaro, Roberto Cotellese, Lorenzo Mazzola Tags: 8. Pancreatic Cancer I Source Type: research
Impact of preoperative Body Mass Index on postoperative outcome and long-term survival in 1,675 patients undergoing pancreatic resections for underlying malignancy
Objectives With all progress in surgical techniques and interdisciplinary management pancreatic resections may nowadays be performed safely. However, individual prognostic markers may still be associated with an increased risk for postoperative morbidity and mortality. The aim of our study was to analyze the impact of Body Mass Index (BMI) in patients undergoing pancreatic resections for underlying malignancy with regard to postoperative outcome and overall survival. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Philippa Seika, Fritz Klein, Johann Pratschke, Marcus Bahra, Thomas Malinka Tags: 8. Pancreatic Cancer I Source Type: research
Pylorus preserving duodenopancreatectomy with pancreaticogastrostomy-initial experiences
Objectives The most harmful complication of pylorus preserving duodenopancreatectomy (PPD) with pancreaticogastrostomy is the development of the postoperative pancreatic fistula (POPF). The risk of POPF increases in the case of a “soft” pancreas with a narrow Wirsung duct. Postoperative hemorrhage can be also the complication of this surgical procedure. The aim of this study was to present our initial experiences with PPD procedure. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Vladimir Djordjevic, Nebojsa Lekic, Aleksandar Ninic, Nemanja Zaric, Mirko Kerkez, Dejan Radenkovic Tags: 8. Pancreatic Cancer I Source Type: research
Stroma and Immune cell infiltration are increased in pancreatic carcinoma after neoadjuvant therapy
Objectives The role of pancreatic tumor stroma and inflammation in neoadjuvant therapy efficacy remains controversial. The aim of this study was to evaluate the role of pancreatic ductal adenocarcinoma (PDAC) stroma and infiltrating immune cells after neoadjuvant therapy (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Li Xie, Leizhou Xia, Ulla Klaiber, Milena Sachsenmaier, Oliver Strobel, Markus W. B üchler, Franco Fortunato, Thilo Hackert Tags: 8. Pancreatic Cancer I Source Type: research
Increased incidence of postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) in patients with distal bile duct cancer and ampullary cancer vs. adenocarcinoma of the pancreas
Objectives Malignant tumors of the pancreatic head can rise from different entities. Most of the patients suffer from pancreatic ductal adenocarcinoma (PDAC), while distal bile duct cancer (dCCC) or ampullary cancer (AmpC) is less common. For a curative approach, the treatment of choice is a PD. This procedure - even when performed at specialized centers - is still associated with a significant burden of morbidity and mortality. Due to subtle differences in localization and tumor biology of the underling entities, the aim of the study was to compare postoperative outcome and long-term survival after PD in those patients. (...
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Florian Scheufele, Carsten J äger, Ekin Demir, Stephan Schorn, Elke Tieftrunk, Mine Sargut, Helmut Friess, Güralp O. Ceyhan Tags: 8. Pancreatic Cancer I Source Type: research
A multidisciplinary approach to familial pancreatic cancer enriches the proportion of patients with genetically confirmed pancreatic cancer susceptibility
Objectives The risk of pancreatic cancer(PC)increases with the number of affected first degree relatives(FDR)from 4-7% with only one or two relatives to 17-32% with three or more.FPC accounts for 4-10% of all PCs, with a germline mutation described in 5-10% of cases. In absence of other cancers to suggest one of the known syndromes associated with PC,genetic testing and instrumental screening is rarely offered to FPC families.This may change with the emergence of genetic tests that use panels of cancer susceptibility genes and with screening of high risk individuals. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Giulia Martina Cavestro, Alessandro Mannucci, Raffaella Alessia Zuppardo, Stefano Crippa, Michele Reni, Silvia Zanon, Milvia Zambetti, Maria Grazia Patricelli, Annalisa Russo Raucci, Milena di Leo, Francesco de Cobelli, Paolo Giorgio Arcidiacono, Luca Gia Tags: 8. Pancreatic Cancer I Source Type: research
